Research graph
References from Immunological dysregulation of follicular helper T cells, follicular regulatory T cells, and follicular cytotoxic T cells is associated with disease activity and identifies exploratory immune patterns in rheumatoid arthritis. Local targets link to admitted publications; unresolved targets remain external evidence.
Rheumatoid arthritis
10.1016/s0140-6736(23)01525-8 · 2023 · External reference
Autoantibodies in rheumatoid arthritis: Historical background and novel findings
10.1007/s12016-021-08890-1 · 2022 · External reference
Rheumatoid arthritis: Pathogenic roles of diverse immune cells
10.3390/ijms23020905 · 2022 · External reference
Impaired immune tolerance mediated by reduced Tfr cells in rheumatoid arthritis linked to gut microbiota dysbiosis and altered metabolites
10.1186/s13075-023-03260-y · 2024 · External reference
The immunology of rheumatoid arthritis
10.1038/s41590-020-00816-x · 2021 · External reference
Germinal centers
10.1146/annurev-immunol-120419-022408 · 2022 · External reference
Germinal centers output clonally diverse plasma cell populations expressing high- and low-affinity antibodies
10.1016/j.cell.2023.10.022 · 2023 · External reference
The germinal center milieu in rheumatoid arthritis: The immunological drummer or dancer
10.3390/ijms221910514 · 2021 · External reference
T follicular helper cell heterogeneity
10.1146/annurev-immunol-090222-102834 · 2024 · External reference
T follicular helper cells in autoimmune diseases
10.1016/j.jaut.2022.102976 · 2023 · External reference
T follicular helper cells and T follicular regulatory cells in autoimmune diseases
10.3389/fimmu.2023.1178792 · 2023 · External reference
Follicular regulatory T cell biology and its role in immune-mediated diseases
10.1002/jlb.1mr0321-601rr · 2021 · External reference
Altered distribution of circulating T follicular helper-like cell subsets in rheumatoid arthritis patients
10.3389/fmed.2021.690100 · 2021 · External reference
An imbalance between blood CD4+CXCR5+Foxp3+ Tfr cells and CD4+CXCR5+Tfh cells may contribute to the immunopathogenesis of rheumatoid arthritis
10.1016/j.molimm.2020.06.003 · 2020 · External reference
T-follicular helper cells and their role in autoimmune diseases
10.3390/life15040666 · 2025 · External reference
CXCR5+ CCR7– CD8 T cells are early effector memory cells that infiltrate tonsil B cell follicles
10.1002/eji.200636746 · 2007 · External reference
CD8 follicular T cells localize throughout the follicle during germinal center reactions and maintain cytolytic and helper properties
10.1016/j.jaut.2021.102690 · 2021 · External reference
Altered levels of circulating CD8+CXCR5+PD-1+T follicular cytotoxic cells in primary Sjögren’s syndrome
10.1007/s10067-022-06098-y · 2022 · External reference
A portrait of CXCR5+ follicular cytotoxic CD8+ T cells
10.1016/j.it.2018.10.002 · 2018 · External reference
Biology and clinical relevance of follicular cytotoxic T cells
10.3389/fimmu.2022.1036616 · 2022 · External reference
Intratumoural CD8+ CXCR5+ follicular cytotoxic T cells have prognostic value and are associated with CD19+ CD38+ B cells and tertiary lymphoid structures in colorectal cancer
10.1007/s00262-024-03887-z · 2024 · External reference
Role of CXCR5+CD8+ T cells in human hepatitis B virus infection
10.1111/jvh.13840 · 2023 · External reference
Defining CD8+ T cells that provide the proliferative burst after PD-1 therapy
10.1038/nature19330 · 2016 · External reference
Human CXCR5+PD‐1+ CD8 T cells in healthy individuals and patients with hematologic Malignancies
10.1002/eji.202048761 · 2021 · External reference
Follicular CD8+ T cells promote immunoglobulin production and demyelination in multiple sclerosis and a murine model
10.1016/j.bbadis.2024.167303 · 2024 · External reference
Increased frequency of CD4+ follicular helper T and CD8+ follicular T cells in human lymph node biopsies during the earliest stages of rheumatoid arthritis
10.3390/cells11071104 · 2022 · External reference
Antitumor CD8 T cell responses in glioma patients are effectively suppressed by T follicular regulatory cells
10.1016/j.yexcr.2021.112808 · 2021 · External reference
T cell immune response within B-cell follicles
10.1016/bs.ai.2019.08.008 · 2019 · External reference
Frontiers of autoantibodies in autoimmune disorders: Crosstalk between Tfh/Tfr and regulatory B cells
10.3389/fimmu.2021.641013 · 2021 · External reference
Oxymatrine ameliorates rheumatoid arthritis by regulation of Tfr/Tfh cell balance via the TLR9-MyD88-STAT3 signaling pathway
10.1002/jsfa.12674 · 2023 · External reference
Human circulating T follicular helper cell subsets in health and disease
10.1007/s10875-016-0268-3 · 2016 · External reference
Developmental bifurcation of human T follicular regulatory cells
10.1126/sciimmunol.abd8411 · 2021 · External reference
T follicular regulatory (Tfr) cells: Dissecting the complexity of Tfr‐cell compartments
10.1111/imr.12739 · 2019 · External reference
T follicular helper cells and T follicular regulatory cells in rheumatic diseases
10.1038/s41584-019-0254-2 · 2019 · External reference
Proportion of T follicular helper cells in peripheral blood of rheumatoid arthritis patients: a systematic review and meta-analysis
10.1080/1744666x.2021.1915770 · 2021 · External reference
EULAR recommendations for terminology and research in individuals at risk of rheumatoid arthritis: Report from the Study Group for Risk Factors for Rheumatoid Arthritis
10.1136/annrheumdis-2011-200990 · 2012 · External reference
The soluble interleukin-2 receptor: Biology, function, and clinical application
10.7326/0003-4819-113-8-619 · 1990 · External reference
Soluble interleukin-2 receptor predicts treatment outcome in patients with autoimmune tubulointerstitial nephritis. A preliminary study
10.3389/fmed.2022.827388 · 2022 · External reference
Aberrant subsets of regulatory T cells and their correlations with serum IL-2 in patients with rheumatoid arthritis
10.1007/s10753-025-02248-x · 2025 · External reference
The soluble IL‐2 receptor α/CD25 as a modulator of IL‐2 function
10.1111/imm.13723 · 2024 · External reference
The IL-2 – IL-2 receptor pathway in health and disease: The role of the soluble IL-2 receptor
10.1016/j.clim.2020.108515 · 2020 · External reference
Low-dose IL-2 restores Tfh/Tfr imbalance and modulates B cell subset distribution in the pre-arthritis phase of the collagen-induced arthritis model
10.1007/s10067-025-07455-3 · 2025 · External reference
Serum soluble interleukin-2 receptor is a biomarker for Pneumocystis jirovecii pneumonia among patients with rheumatoid arthritis under methotrexate therapy
10.1620/tjem.248.209 · 2019 · External reference
Relationship of hematological profiles with the serum complement system in patients with systemic lupus erythematosus
10.3390/biomedicines12050967 · 2024 · External reference
The diagnosis and management of the haematologic manifestations of lupus
10.1016/j.jaut.2016.07.001 · 2016 · External reference
Sex difference in primary Sjögren syndrome
10.1097/rhu.0000000000001962 · 2023 · External reference
Felty’s syndrome
10.3389/fmed.2023.1238405 · 2023 · External reference
Follicular regulatory T cell subsets in mice and humans: Origins, antigen specificity and function
10.1093/intimm/dxad031 · 2023 · External reference
IL-10 revisited in systemic lupus erythematosus
10.3389/fimmu.2022.970906 · 2022 · External reference
