Research graph
References from Mucosal microbiota and intraepithelial lymphocyte remodeling link maternal immune activation to neuroimmune outcomes in female and male offspring. Local targets link to admitted publications; unresolved targets remain external evidence.
The fetal origins of mental illness
10.1016/j.ajog.2019.06.013 · 2019 · External reference
Maternal immune activation and abnormal brain development across CNS disorders
10.1038/nrneurol.2014.187 · 2014 · External reference
Maternal immune activation: Implications for neuropsychiatric disorders
10.1126/science.aag3194 · 2016 · External reference
Schizophrenia
10.1016/j.schres.2022.01.040 · 2015 · External reference
The neurobiology and treatment of first-episode schizophrenia
10.1038/mp.2014.66 · 2015 · External reference
Gene-environment interactions in schizophrenia: A literature review
10.3390/genes12121850 · 2021 · External reference
Multi-omics analysis reveals aberrant gut-metabolome-immune network in schizophrenia
10.3389/fimmu.2022.812293 · 2022 · External reference
Associations of gut microbiota alterations with clinical, metabolic, and immune-inflammatory characteristics of chronic schizophrenia
10.1016/j.jpsychires.2024.01.036 · 2024 · External reference
Altered gut microbiota and mucosal immunity in patients with schizophrenia
10.1016/j.bbi.2019.06.039 · 2020 · External reference
The light and dark sides of intestinal intraepithelial lymphocytes
10.1038/nri3007 · 2011 · External reference
Intraepithelial lymphocytes of the intestine
10.1146/annurev-immunol-090222-100246 · 2024 · External reference
Diverse developmental pathways of intestinal intraepithelial lymphocytes
10.1038/s41577-018-0013-7 · 2018 · External reference
Induction of intestinal Th17 cells by segmented filamentous bacteria
10.1016/j.cell.2009.09.033 · 2009 · External reference
Segmented filamentous bacteria interact with intraepithelial mononuclear cells
10.1128/iai.70.6.3277-3280.2002 · 2002 · External reference
Segmented filamentous bacteria are indigenous intestinal bacteria that activate intraepithelial lymphocytes and induce MHC class II molecules and fucosyl asialo GM1 glycolipids on the small intestinal epithelial cells in the ex-germ-free mouse
10.1111/j.1348-0421.1995.tb02242.x · 1995 · External reference
Microbiota modulate behavioral and physiological abnormalities associated with neurodevelopmental disorders
10.1016/j.cell.2013.11.024 · 2013 · External reference
Maternal gut bacteria drive intestinal inflammation in offspring with neurodevelopmental disorders by altering the chromatin landscape of CD4(+) T cells
10.4324/9781003266181-17 · 2022 · External reference
Prenatal poly(i:C) exposure and other developmental immune activation models in rodent systems
10.1016/j.biopsych.2013.07.011 · 2014 · External reference
LPS versus Poly I:C model: comparison of long-term effects of bacterial and viral maternal immune activation on the offspring
10.1152/ajpregu.00087.2021 · 2022 · External reference
Strain-dependent effects of prenatal maternal immune activation on anxiety- and depression-like behaviors in offspring
10.1016/j.bbi.2013.12.003 · 2014 · External reference
Acute in utero exposure to lipopolysaccharide induces inflammation in the pre- and postnatal brain and alters the glial cytoarchitecture in the developing amygdala
10.1186/s12974-017-0981-8 · 2017 · External reference
The role of cytokines in mediating effects of prenatal infection on the fetus: implications for schizophrenia
10.1038/sj.mp.4001748 · 2006 · External reference
Effects of prenatal infection on brain development and behavior: a review of findings from animal models
10.1016/j.bbi.2010.03.005 · 2010 · External reference
ezTrack: An open-source video analysis pipeline for the investigation of animal behavior
10.1038/s41598-019-56408-9 · 2019 · External reference
BORIS: a free, versatile open-source event-logging software for video/audio coding and live observations
10.1111/2041-210x.12584 · 2016 · External reference
Microbial and functional diversity of a subterrestrial high pH groundwater associated to serpentinization
10.1111/1462-2920.12034 · 2013 · External reference
Every base matters: assessing small subunit rRNA primers for marine microbiomes with mock communities, time series and global field samples
10.1111/1462-2920.13023 · 2016 · External reference
Introducing mothur: open-source, platform-independent, community-supported software for describing and comparing microbial communities
10.1128/aem.01541-09 · 2009 · External reference
25 years of serving the community with ribosomal RNA gene reference databases and tools
10.1016/j.jbiotec.2017.06.1198 · 2017 · External reference
Welcome to the tidyverse
10.21105/joss.01686 · 2019 · External reference
phyloseq: an R package for reproducible interactive analysis and graphics of microbiome census data
10.1371/journal.pone.0061217 · 2013 · External reference
Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2
10.1186/s13059-014-0550-8 · 2014 · External reference
Modeling microbial abundances and dysbiosis with beta-binomial regression
10.1214/19-aoas1283 · 2020 · External reference
QuPath: Open source software for digital pathology image analysis
10.1038/s41598-017-17204-5 · 2017 · External reference
Isolation and Characterization of Innate Lymphoid Cells within the Murine Tumor Microenvironment
10.1007/978-1-0716-0338-3_14 · 2020 · External reference
Generation of regulatory dendritic cells and CD4+Foxp3+ T cells by probiotics administration suppresses immune disorders
10.1073/pnas.0904055107 · 2010 · External reference
Maternal inflammation and neurodevelopmental programming: A review of preclinical outcomes and implications for translational psychiatry
10.1016/j.biopsych.2018.08.008 · 2019 · External reference
Maternal immune activation and neuroinflammation in human neurodevelopmental disorders
10.1038/s41582-021-00530-8 · 2021 · External reference
Intestinal epithelial and intraepithelial T cell crosstalk mediates a dynamic response to infection
10.1016/j.cell.2017.08.046 · 2017 · External reference
Mechanisms of activation of innate-like intraepithelial T lymphocytes
10.1038/s41385-020-0294-6 · 2020 · External reference
Regulatory T cells and immune tolerance
10.1016/j.cell.2008.05.009 · 2008 · External reference
TCRalphabeta(+)CD3(+)CD4(-)CD8(-) (double negative) T cells in autoimmunity
10.1016/j.autrev.2018.02.001 · 2018 · External reference
CD3(+)CD4(-)CD8(-) (Double-negative) T cells in inflammation, immune disorders and cancer
10.3389/fimmu.2022.816005 · 2022 · External reference
Development and function of natural TCR+CD8aa+ intraepithelial lymphocytes
10.3389/fimmu.2022.1059042 · 2022 · External reference
The increased expression of IL-23 in inflammatory bowel disease promotes intraepithelial and lamina propria lymphocyte inflammatory responses and cytotoxicity
10.1189/jlb.0810456 · 2011 · External reference
Th17 cells and the IL-23/IL-17 axis in the pathogenesis of periodontitis and immune-mediated inflammatory diseases
10.3390/ijms20143394 · 2019 · External reference
Expression of interleukin-10 in intestinal lymphocytes detected by an interleukin-10 reporter knockin tiger mouse
10.1016/j.immuni.2006.09.013 · 2006 · External reference
Uncontrolled IL-17 Production by Intraepithelial Lymphocytes in a Case of non-IPEX Autoimmune Enteropathy
10.1038/ctg.2016.41 · 2016 · External reference
Interleukin-22 regulates the homeostasis of the intestinal epithelium during inflammation
10.3892/ijmm.2019.4092 · 2019 · External reference
Gut-residing segmented filamentous bacteria drive autoimmune arthritis via T helper 17 cells
10.1016/j.immuni.2010.06.001 · 2010 · External reference
The intestine harbors functionally distinct homeostatic tissue-resident and inflammatory Th17 cells
10.1016/j.immuni.2019.05.004 · 2019 · External reference
Intestinal microbiota-specific Th17 cells possess regulatory properties and suppress effector T cells via c-MAF and IL-10
10.1016/j.immuni.2023.11.003 · 2023 · External reference
Maternal gut bacteria promote neurodevelopmental abnormalities in mouse offspring
10.1038/nature23910 · 2017 · External reference
Inducible Foxp3+ regulatory T-cell development by a commensal bacterium of the intestinal microbiota
10.1073/pnas.0909122107 · 2010 · External reference
The role of Lactobacillus in inflammatory bowel disease: from actualities to prospects
10.1038/s41420-023-01666-w · 2023 · External reference
Perturbed maternal microbiota shapes offspring microbiota during early colonization period in mice
10.2183/pjab.100.020 · 2024 · External reference
Maternal immune activation alters fetal brain development through interleukin-6
10.1523/jneurosci.2178-07.2007 · 2007 · External reference
The placental interleukin-6 signaling controls fetal brain development and behavior
10.1016/j.bbi.2016.11.007 · 2017 · External reference
The maternal interleukin-17a pathway in mice promotes autism-like phenotypes in offspring
10.1126/science.aad0314 · 2016 · External reference
At the crux of maternal immune activation: Viruses, microglia, microbes, and IL-17A
10.1111/imr.13125 · 2022 · External reference
Meta-analysis of cytokine alterations in schizophrenia: clinical status and antipsychotic effects
10.1016/j.biopsych.2011.04.013 · 2011 · External reference
Developmental functions of microglia: Impact of psychosocial and physiological early life stress
10.1016/j.neuropharm.2024.110084 · 2024 · External reference
Single-cell mass cytometry of microglia in major depressive disorder reveals a non-inflammatory phenotype with increased homeostatic marker expression
10.1038/s41398-020-00992-2 · 2020 · External reference
Microglia sculpt postnatal neural circuits in an activity and complement-dependent manner
10.1016/j.neuron.2012.03.026 · 2012 · External reference
IL-1R/C3aR signaling regulates synaptic pruning in the prefrontal cortex of depression
10.1186/s13578-022-00832-4 · 2022 · External reference
Cortical excitation:inhibition imbalance causes abnormal brain network dynamics as observed in neurodevelopmental disorders
10.1093/cercor/bhaa084 · 2020 · External reference
Increasing the excitatory drive rescues excitatory/inhibitory imbalance and mismatch negativity deficit caused by parvalbumin specific GluA1 deletion
10.1016/j.neuroscience.2022.06.027 · 2022 · External reference
Schizophrenia
10.1016/s0140-6736(09)60722-4 · 2022 · External reference
Isolation and Characterization of Innate Lymphoid Cells within the Murine Tumor Microenvironment
10.1007/978-1-0716-0338-3_14 · ExternalCitation · doi-reference
The fetal origins of mental illness
10.1016/j.ajog.2019.06.013 · ExternalCitation · doi-reference
TCRalphabeta(+)CD3(+)CD4(-)CD8(-) (double negative) T cells in autoimmunity
10.1016/j.autrev.2018.02.001 · ExternalCitation · doi-reference
Effects of prenatal infection on brain development and behavior: a review of findings from animal models
10.1016/j.bbi.2010.03.005 · ExternalCitation · doi-reference
Strain-dependent effects of prenatal maternal immune activation on anxiety- and depression-like behaviors in offspring
10.1016/j.bbi.2013.12.003 · ExternalCitation · doi-reference
The placental interleukin-6 signaling controls fetal brain development and behavior
10.1016/j.bbi.2016.11.007 · ExternalCitation · doi-reference
Altered gut microbiota and mucosal immunity in patients with schizophrenia
10.1016/j.bbi.2019.06.039 · ExternalCitation · doi-reference
Meta-analysis of cytokine alterations in schizophrenia: clinical status and antipsychotic effects
10.1016/j.biopsych.2011.04.013 · ExternalCitation · doi-reference
Prenatal poly(i:C) exposure and other developmental immune activation models in rodent systems
10.1016/j.biopsych.2013.07.011 · ExternalCitation · doi-reference
Maternal inflammation and neurodevelopmental programming: A review of preclinical outcomes and implications for translational psychiatry
10.1016/j.biopsych.2018.08.008 · ExternalCitation · doi-reference
Regulatory T cells and immune tolerance
10.1016/j.cell.2008.05.009 · ExternalCitation · doi-reference
Induction of intestinal Th17 cells by segmented filamentous bacteria
10.1016/j.cell.2009.09.033 · ExternalCitation · doi-reference
Microbiota modulate behavioral and physiological abnormalities associated with neurodevelopmental disorders
10.1016/j.cell.2013.11.024 · ExternalCitation · doi-reference
Intestinal epithelial and intraepithelial T cell crosstalk mediates a dynamic response to infection
10.1016/j.cell.2017.08.046 · ExternalCitation · doi-reference
Expression of interleukin-10 in intestinal lymphocytes detected by an interleukin-10 reporter knockin tiger mouse
10.1016/j.immuni.2006.09.013 · ExternalCitation · doi-reference
Gut-residing segmented filamentous bacteria drive autoimmune arthritis via T helper 17 cells
10.1016/j.immuni.2010.06.001 · ExternalCitation · doi-reference
The intestine harbors functionally distinct homeostatic tissue-resident and inflammatory Th17 cells
10.1016/j.immuni.2019.05.004 · ExternalCitation · doi-reference
Intestinal microbiota-specific Th17 cells possess regulatory properties and suppress effector T cells via c-MAF and IL-10
10.1016/j.immuni.2023.11.003 · ExternalCitation · doi-reference
25 years of serving the community with ribosomal RNA gene reference databases and tools
10.1016/j.jbiotec.2017.06.1198 · ExternalCitation · doi-reference
Associations of gut microbiota alterations with clinical, metabolic, and immune-inflammatory characteristics of chronic schizophrenia
10.1016/j.jpsychires.2024.01.036 · ExternalCitation · doi-reference
Microglia sculpt postnatal neural circuits in an activity and complement-dependent manner
10.1016/j.neuron.2012.03.026 · ExternalCitation · doi-reference
Developmental functions of microglia: Impact of psychosocial and physiological early life stress
10.1016/j.neuropharm.2024.110084 · ExternalCitation · doi-reference
Increasing the excitatory drive rescues excitatory/inhibitory imbalance and mismatch negativity deficit caused by parvalbumin specific GluA1 deletion
10.1016/j.neuroscience.2022.06.027 · ExternalCitation · doi-reference
Schizophrenia
10.1016/j.schres.2022.01.040 · ExternalCitation · doi-reference
Schizophrenia
10.1016/s0140-6736(09)60722-4 · ExternalCitation · doi-reference
Uncontrolled IL-17 Production by Intraepithelial Lymphocytes in a Case of non-IPEX Autoimmune Enteropathy
10.1038/ctg.2016.41 · ExternalCitation · doi-reference
The neurobiology and treatment of first-episode schizophrenia
10.1038/mp.2014.66 · ExternalCitation · doi-reference
Maternal gut bacteria promote neurodevelopmental abnormalities in mouse offspring
10.1038/nature23910 · ExternalCitation · doi-reference
The light and dark sides of intestinal intraepithelial lymphocytes
10.1038/nri3007 · ExternalCitation · doi-reference
Maternal immune activation and abnormal brain development across CNS disorders
10.1038/nrneurol.2014.187 · ExternalCitation · doi-reference
Mechanisms of activation of innate-like intraepithelial T lymphocytes
10.1038/s41385-020-0294-6 · ExternalCitation · doi-reference
Single-cell mass cytometry of microglia in major depressive disorder reveals a non-inflammatory phenotype with increased homeostatic marker expression
10.1038/s41398-020-00992-2 · ExternalCitation · doi-reference
The role of Lactobacillus in inflammatory bowel disease: from actualities to prospects
10.1038/s41420-023-01666-w · ExternalCitation · doi-reference
Diverse developmental pathways of intestinal intraepithelial lymphocytes
10.1038/s41577-018-0013-7 · ExternalCitation · doi-reference
Maternal immune activation and neuroinflammation in human neurodevelopmental disorders
10.1038/s41582-021-00530-8 · ExternalCitation · doi-reference
QuPath: Open source software for digital pathology image analysis
10.1038/s41598-017-17204-5 · ExternalCitation · doi-reference
ezTrack: An open-source video analysis pipeline for the investigation of animal behavior
10.1038/s41598-019-56408-9 · ExternalCitation · doi-reference
The role of cytokines in mediating effects of prenatal infection on the fetus: implications for schizophrenia
10.1038/sj.mp.4001748 · ExternalCitation · doi-reference
Generation of regulatory dendritic cells and CD4+Foxp3+ T cells by probiotics administration suppresses immune disorders
10.1073/pnas.0904055107 · ExternalCitation · doi-reference
Inducible Foxp3+ regulatory T-cell development by a commensal bacterium of the intestinal microbiota
10.1073/pnas.0909122107 · ExternalCitation · doi-reference
Cortical excitation:inhibition imbalance causes abnormal brain network dynamics as observed in neurodevelopmental disorders
10.1093/cercor/bhaa084 · ExternalCitation · doi-reference
Microbial and functional diversity of a subterrestrial high pH groundwater associated to serpentinization
10.1111/1462-2920.12034 · ExternalCitation · doi-reference
Every base matters: assessing small subunit rRNA primers for marine microbiomes with mock communities, time series and global field samples
10.1111/1462-2920.13023 · ExternalCitation · doi-reference
BORIS: a free, versatile open-source event-logging software for video/audio coding and live observations
10.1111/2041-210x.12584 · ExternalCitation · doi-reference
At the crux of maternal immune activation: Viruses, microglia, microbes, and IL-17A
10.1111/imr.13125 · ExternalCitation · doi-reference
Segmented filamentous bacteria are indigenous intestinal bacteria that activate intraepithelial lymphocytes and induce MHC class II molecules and fucosyl asialo GM1 glycolipids on the small intestinal epithelial cells in the ex-germ-free mouse
10.1111/j.1348-0421.1995.tb02242.x · ExternalCitation · doi-reference
The maternal interleukin-17a pathway in mice promotes autism-like phenotypes in offspring
10.1126/science.aad0314 · ExternalCitation · doi-reference
Maternal immune activation: Implications for neuropsychiatric disorders
10.1126/science.aag3194 · ExternalCitation · doi-reference
Introducing mothur: open-source, platform-independent, community-supported software for describing and comparing microbial communities
10.1128/aem.01541-09 · ExternalCitation · doi-reference
Segmented filamentous bacteria interact with intraepithelial mononuclear cells
10.1128/iai.70.6.3277-3280.2002 · ExternalCitation · doi-reference
Intraepithelial lymphocytes of the intestine
10.1146/annurev-immunol-090222-100246 · ExternalCitation · doi-reference
LPS versus Poly I:C model: comparison of long-term effects of bacterial and viral maternal immune activation on the offspring
10.1152/ajpregu.00087.2021 · ExternalCitation · doi-reference
Acute in utero exposure to lipopolysaccharide induces inflammation in the pre- and postnatal brain and alters the glial cytoarchitecture in the developing amygdala
10.1186/s12974-017-0981-8 · ExternalCitation · doi-reference
Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2
10.1186/s13059-014-0550-8 · ExternalCitation · doi-reference
IL-1R/C3aR signaling regulates synaptic pruning in the prefrontal cortex of depression
10.1186/s13578-022-00832-4 · ExternalCitation · doi-reference
The increased expression of IL-23 in inflammatory bowel disease promotes intraepithelial and lamina propria lymphocyte inflammatory responses and cytotoxicity
10.1189/jlb.0810456 · ExternalCitation · doi-reference
Modeling microbial abundances and dysbiosis with beta-binomial regression
10.1214/19-aoas1283 · ExternalCitation · doi-reference
phyloseq: an R package for reproducible interactive analysis and graphics of microbiome census data
10.1371/journal.pone.0061217 · ExternalCitation · doi-reference
Maternal immune activation alters fetal brain development through interleukin-6
10.1523/jneurosci.2178-07.2007 · ExternalCitation · doi-reference
Welcome to the tidyverse
10.21105/joss.01686 · ExternalCitation · doi-reference
Perturbed maternal microbiota shapes offspring microbiota during early colonization period in mice
10.2183/pjab.100.020 · ExternalCitation · doi-reference
Development and function of natural TCR+CD8aa+ intraepithelial lymphocytes
10.3389/fimmu.2022.1059042 · ExternalCitation · doi-reference
Multi-omics analysis reveals aberrant gut-metabolome-immune network in schizophrenia
10.3389/fimmu.2022.812293 · ExternalCitation · doi-reference
CD3(+)CD4(-)CD8(-) (Double-negative) T cells in inflammation, immune disorders and cancer
10.3389/fimmu.2022.816005 · ExternalCitation · doi-reference
Gene-environment interactions in schizophrenia: A literature review
10.3390/genes12121850 · ExternalCitation · doi-reference
Th17 cells and the IL-23/IL-17 axis in the pathogenesis of periodontitis and immune-mediated inflammatory diseases
10.3390/ijms20143394 · ExternalCitation · doi-reference
Interleukin-22 regulates the homeostasis of the intestinal epithelium during inflammation
10.3892/ijmm.2019.4092 · ExternalCitation · doi-reference
Maternal gut bacteria drive intestinal inflammation in offspring with neurodevelopmental disorders by altering the chromatin landscape of CD4(+) T cells
10.4324/9781003266181-17 · ExternalCitation · doi-reference
