Research graph
References from Non-immune regulation of tertiary lymphoid structures in cancer. Local targets link to admitted publications; unresolved targets remain external evidence.
Tertiary lymphoid structures in diseases: immune mechanisms and therapeutic advances
10.1038/s41392-024-01947-5 · 2024 · External reference
Relationship between tertiary lymphoid structure and the prognosis and clinicopathologic characteristics in solid tumors
10.7150/ijms.56347 · 2021 · External reference
Mature tertiary lymphoid structures: important contributors to anti-tumor immune efficacy
10.3389/fimmu.2024.1413067 · 2024 · External reference
Tertiary lymphoid structures in cancer: maturation and induction
10.3389/fimmu.2024.1369626 · 2024 · External reference
Tertiary lymphoid structures in cancer: spatiotemporal heterogeneity, immune orchestration, and translational opportunities
10.1186/s13045-025-01754-7 · 2025 · External reference
Cancer-associated fibroblasts in the single-cell era
10.1038/s43018-022-00411-z · 2022 · External reference
Diversity and biology of cancer-associated fibroblasts
10.1152/physrev.00048.2019 · 2021 · External reference
A framework for advancing our understanding of cancer-associated fibroblasts
10.1038/s41568-019-0238-1 · 2020 · External reference
Immune mechanisms orchestrate tertiary lymphoid structures in tumors via cancer-associated fibroblasts
10.1016/j.celrep.2021.109422 · 2021 · External reference
Fibroblastic reticular cells at the nexus of innate and adaptive immune responses
10.1111/imr.12748 · 2019 · External reference
A local subset of mesenchymal cells expressing the transcription factor Osr1 orchestrates lymph node initiation
10.1016/j.immuni.2023.04.014 · 2023 · External reference
Tertiary lymphoid structures in cancer: immune mechanisms and clinical implications
10.1002/mco2.489 · 2024 · External reference
Fibroblastic reticular cells generate protective intratumoral T cell environments in lung cancer
10.1016/j.cell.2024.10.042 · 2025 · External reference
Myofibroblast programming blocks differentiation of TLS-organizing fibroblastic reticular cells in pancreatic cancer
10.1016/j.ccell.2026.03.004 · 2026 · External reference
Single-cell and spatial transcriptome analyses reveal tertiary lymphoid structures linked to tumour progression and immunotherapy response in nasopharyngeal carcinoma
10.1038/s41467-024-52153-4 · 2024 · External reference
Association of CCL21+ CAFs with B-cell recruitment and TLS maturation in penile squamous cell carcinoma
10.1007/s00262-026-04348-5 · 2026 · External reference
Cancer-associated fibroblasts in the tumor microenvironment: heterogeneity, crosstalk mechanisms, and therapeutic implications
10.1186/s12943-025-02533-1 · 2025 · External reference
Spatiotemporal mapping of tertiary lymphoid structure heterogeneity shapes immune niches and clinical outcomes in intrahepatic cholangiocarcinoma
10.64898/2026.01.02.697439 · 2026 · External reference
Mesothelial cell-derived antigen-presenting cancer-associated fibroblasts induce expansion of regulatory T cells in pancreatic cancer
10.1016/j.ccell.2022.04.011 · 2022 · External reference
Single-cell resolution spatial analysis of antigen-presenting cancer-associated fibroblast niches
10.1016/j.ccell.2025.09.001 · 2025 · External reference
Lung tumor MHCII immunity depends on in situ antigen presentation by fibroblasts
10.1084/jem.20210815 · 2022 · External reference
Exploring the diversity of cancer-associated fibroblasts: insights into mechanisms of drug resistance
10.3389/fcell.2024.1403122 · 2024 · External reference
Cross-species single-cell analysis of pancreatic ductal adenocarcinoma reveals antigen-presenting cancer-associated fibroblasts
10.1158/2159-8290.cd-19-0094 · 2019 · External reference
Cancer-associated fibroblasts: heterogeneity, tumorigenicity and therapeutic targets
10.1186/s43556-024-00233-8 · 2024 · External reference
The tumor microenvironment is an ecosystem sustained by metabolic interactions
10.1016/j.celrep.2025.115432 · 2025 · External reference
Regulation, maintenance, and remodeling of high endothelial venules in homeostasis, inflammation, and cancer
10.1016/j.cophys.2023.100705 · 2023 · External reference
High endothelial venules abundance in tertiary lymphoid structures: a prognostic biomarker in non-small cell lung cancer with neoadjuvant immunochemotherapy
10.1186/s12885-025-15529-3 · 2026 · External reference
Tumor-associated high endothelial venules mediate lymphocyte entry into tumors and predict response to PD-1 plus CTLA-4 combination immunotherapy
10.1016/j.ccell.2022.01.002 · 2022 · External reference
Tertiary lymphoid structures in anticancer immunity
10.1038/s41568-024-00728-0 · 2024 · External reference
Cancer immunotherapies transition endothelial cells into HEVs that generate TCF1+ T lymphocyte niches through a feed-forward loop
10.1016/j.ccell.2022.11.002 · 2022 · External reference
Single-cell and spatial transcriptomics implicate a prognostic function of tertiary lymphoid structures in gastric cancer
10.1038/s41467-025-65421-8 · 2025 · External reference
Human solid tumors contain high endothelial venules: association with T- and B-lymphocyte infiltration and favorable prognosis in breast cancer
10.1158/0008-5472.can-11-0431 · 2011 · External reference
Lymphotoxin-beta receptor signaling is required for the homeostatic control of HEV differentiation and function
10.1016/j.immuni.2005.10.002 · 2005 · External reference
Lymphotoxin in physiology of lymphoid tissues - implication for antiviral defense
10.1016/j.cyto.2016.08.018 · 2018 · External reference
High endothelial venules: a vascular perspective on tertiary lymphoid structures in cancer
10.3389/fimmu.2021.736670 · 2021 · External reference
Role of the lymphotoxin/LIGHT system in the development and maintenance of reticular networks and vasculature in lymphoid tissues
10.3389/fimmu.2014.00047 · 2014 · External reference
VEGFD/VEGFR2 axis induces the dedifferentiation of high endothelial venules and impairs lymphocyte homing
10.1172/jci.insight.191041 · 2025 · External reference
Interferon-responsive HEVs drive tumor tertiary lymphoid structure formation and predict immunotherapy response in nasopharyngeal carcinoma
10.1016/j.xcrm.2025.102200 · 2025 · External reference
Single-cell spatial analysis identifies ID1-high endothelial cells in tertiary lymphoid structures as predictors of durable response to immunotherapy in non-small cell lung cancer
10.1186/s12935-025-04161-7 · 2026 · External reference
Interstitial dendritic cell guidance by haptotactic chemokine gradients
10.1126/science.1228456 · 2013 · External reference
Targeting chemokine—glycosaminoglycan interactions to inhibit inflammation
10.3389/fimmu.2020.00483 · 2020 · External reference
B cell zone reticular cell microenvironments shape CXCL13 gradient formation
10.1038/s41467-020-17135-2 · 2020 · External reference
Tumoral and stromal hMENA isoforms impact tertiary lymphoid structure localization in lung cancer and predict immune checkpoint blockade response in patients with cancer
10.1016/j.ebiom.2024.105003 · 2024 · External reference
Extracellular matrix stiffness: mechanotransduction and mechanobiological response-driven strategies for biomedical applications targeting fibroblast inflammation
10.3390/polym17060822 · 2025 · External reference
Mechanotransduction and YAP-dependent matrix remodelling is required for the generation and maintenance of cancer-associated fibroblasts
10.1038/ncb2756 · 2013 · External reference
Mechanical microenvironment in tumor immune evasion: bidirectional regulation between matrix stiffness and immune cells and its therapeutic implications
10.7150/ijbs.121356 · 2026 · External reference
Multi-omic profiling highlights factors associated with resistance to immuno-chemotherapy in non-small-cell lung cancer
10.1038/s41588-024-01998-y · 2025 · External reference
Germinal center hypoxia in tumor-draining lymph nodes negatively regulates tumor-induced humoral immune responses in mouse models of breast cancer
10.1080/2162402x.2021.1959978 · 2021 · External reference
Germinal center hypoxia potentiates immunoglobulin class switch recombination
10.4049/jimmunol.1601401 · 2016 · External reference
Lactate blocks tertiary lymphoid structure formation by inhibiting B cell chemotaxis
10.1101/2025.08.30.673054 · 2025 · External reference
Spatial transcriptomics reveals tryptophan metabolism restricting maturation of intratumoral tertiary lymphoid structures
10.1016/j.ccell.2025.03.011 · 2025 · External reference
L-Arginine modulates T cell metabolism and enhances survival and anti-tumor activity
10.1016/j.cell.2016.09.031 · 2016 · External reference
Selective glutamine metabolism inhibition in tumor cells improves antitumor T lymphocyte activity in triple-negative breast cancer
10.1172/jci140100 · 2021 · External reference
Organization of the invading lymphoid tissue in human lymphoid thyroiditis
10.1111/j.1365-3083.1974.tb01260.x · 1974 · External reference
Heberden oration, 1964. Some immunologic aspects of the connective tissue diseases
10.1136/ard.24.2.103 · 1965 · External reference
The emerging role of tertiary lymphoid structures in breast cancer: A narrative review
10.3390/cancers16020396 · 2024 · External reference
T cell activation in rheumatoid synovium is B cell dependent
10.4049/jimmunol.167.8.4710 · 2001 · External reference
Tertiary lymphoid structures, drivers of the anti-tumor responses in human cancers
10.1111/imr.12405 · 2016 · External reference
Development and validation of a machine learning model for detection and classification of tertiary lymphoid structures in gastrointestinal cancers
10.1001/jamanetworkopen.2022.52553 · 2023 · External reference
Picturing of the lung tumor cellular composition by multispectral flow cytometry
10.3389/fimmu.2022.827719 · 2022 · External reference
Comprehensive analysis of scRNA-seq and bulk RNA-seq identified TIMP1 as a prognostic marker in colorectal cancer
10.4110/in.2025.25.e38 · 2025 · External reference
Analyzing the tumor microenvironment by flow cytometry
10.1007/978-1-4939-3801-8_8 · 2016 · External reference
Proteomic profiling of the tumor microenvironment: recent insights and the search for biomarkers
10.1186/gm529 · 2014 · External reference
A tertiary lymphoid structure-related gene signature predicts prognosis and treatment response in hepatocellular carcinoma
10.14740/wjon2646 · 2025 · External reference
Comprehensive analysis of single-cell and bulk RNA sequencing data reveals an EGFR signature for predicting immunotherapy response and prognosis in pan-cancer
10.3389/fimmu.2025.1604394 · 2025 · External reference
Applications of immunohistochemistry
10.4103/0975-7406.100281 · 2012 · External reference
Multiplex immunofluorescence: A powerful tool in cancer immunotherapy
10.3390/ijms24043086 · 2023 · External reference
The activity of tertiary lymphoid structures in high grade serous ovarian cancer is governed by site, stroma, and cellular interactions
10.1016/j.ccell.2024.09.007 · 2024 · External reference
Automated quantification of tertiary lymphoid structures in human tumor samples using immunofluorescence and AI-powered analysis pipeline
10.1007/978-1-0716-4184-2_11 · 2025 · External reference
Mature tertiary lymphoid structures indicate good chemotherapy response and prognosis in advanced colorectal cancer
10.1002/ags3.70142 · 2025 · External reference
Maturation and abundance of tertiary lymphoid structures are associated with the efficacy of neoadjuvant chemoimmunotherapy in resectable non-small cell lung cancer
10.1136/jitc-2022-005531 · 2022 · External reference
A tertiary lymphoid structures-based pathological score predicts survival and recurrence in colorectal cancer patients
10.1016/j.imbio.2025.152911 · 2025 · External reference
Comparison of imaging based single-cell resolution spatial transcriptomics profiling platforms using formalin-fixed paraffin-embedded tumor samples
10.1038/s41467-025-63414-1 · 2025 · External reference
An introduction to spatial transcriptomics for biomedical research
10.1186/s13073-022-01075-1 · 2022 · External reference
Deep visual proteomics defines single-cell identity and heterogeneity
10.1038/s41587-022-01302-5 · 2022 · External reference
PD-1 regulates germinal center B cell survival and the formation and affinity of long-lived plasma cells
10.1038/ni.1877 · 2010 · External reference
Deciphering functional tumor-immune crosstalk through highly multiplexed imaging and deep visual proteomics
10.1016/j.molcel.2024.12.023 · 2025 · External reference
Normalization of tumor vasculature: An emerging concept in antiangiogenic therapy
10.1126/science.1104819 · 2005 · External reference
Normalizing tumor microenvironment to treat cancer: Bench to bedside to biomarkers
10.1200/jco.2012.46.3653 · 2013 · External reference
Dual angiopoietin-2 and VEGFA inhibition elicits antitumor immunity that is enhanced by PD-1 checkpoint blockade
10.1126/scitranslmed.aak9670 · 2017 · External reference
Combined antiangiogenic and anti–PD-L1 therapy stimulates tumor immunity through HEV formation
10.1126/scitranslmed.aak9679 · 2017 · External reference
Pembrolizumab plus axitinib versus sunitinib for advanced renal-cell carcinoma
10.1056/nejmoa1816714 · 2019 · External reference
Atezolizumab plus bevacizumab in unresectable hepatocellular carcinoma
10.1056/nejmoa1915745 · 2020 · External reference
Atezolizumab for first-line treatment of metastatic nonsquamous NSCLC
10.1056/nejmoa1716948 · 2018 · External reference
Stromal elements act to restrain, rather than support, pancreatic ductal adenocarcinoma
10.1016/j.ccr.2014.04.021 · 2014 · External reference
Tertiary lymphoid structures generate and propagate anti-tumor antibody-producing plasma cells in renal cell cancer
10.1016/j.immuni.2022.02.001 · 2022 · External reference
TGFβ attenuates tumour response to PD-L1 blockade by contributing to exclusion of T cells
10.1038/nature25501 · 2018 · External reference
Targeting CXCL12 from FAP-expressing carcinoma-associated fibroblasts synergizes with anti–PD-L1 immunotherapy in pancreatic cancer
10.1073/pnas.1320318110 · 2013 · External reference
Cancer-associated fibroblasts suppress CD8+ T-cell infiltration and confer resistance to immune-checkpoint blockade
10.1158/0008-5472.can-21-4141 · 2022 · External reference
Molecular remodeling of cancer-associated fibroblasts in breast cancer patients receiving anti–PD-1 immunotherapy
10.3389/fonc.2026.1754311 · 2026 · External reference
Matrix crosslinking forces tumor progression by enhancing integrin signaling
10.1016/j.cell.2009.10.027 · 2009 · External reference
Targeting focal adhesion kinase renders pancreatic cancers responsive to checkpoint immunotherapy
10.1038/nm.4123 · 2016 · External reference
Enzymatic targeting of the stroma ablates physical barriers to treatment of pancreatic ductal adenocarcinoma
10.1016/j.ccr.2012.01.007 · 2012 · External reference
Predicting immunotherapy response of advanced bladder cancer through a meta-analysis of six independent cohorts
10.1038/s41467-025-56462-0 · 2025 · External reference
Tertiary lymphoid structural heterogeneity determines tumour immunity and prospects for clinical application
10.1186/s12943-024-01980-6 · 2024 · External reference
GABA promotes resistance to immunotherapy in patients with TLS-positive tumors
10.1016/j.ccell.2026.06.006 · 2026 · External reference
Development and validation of a machine learning model for detection and classification of tertiary lymphoid structures in gastrointestinal cancers
10.1001/jamanetworkopen.2022.52553 · ExternalCitation · doi-reference
Mature tertiary lymphoid structures indicate good chemotherapy response and prognosis in advanced colorectal cancer
10.1002/ags3.70142 · ExternalCitation · doi-reference
Tertiary lymphoid structures in cancer: immune mechanisms and clinical implications
10.1002/mco2.489 · ExternalCitation · doi-reference
Automated quantification of tertiary lymphoid structures in human tumor samples using immunofluorescence and AI-powered analysis pipeline
10.1007/978-1-0716-4184-2_11 · ExternalCitation · doi-reference
Analyzing the tumor microenvironment by flow cytometry
10.1007/978-1-4939-3801-8_8 · ExternalCitation · doi-reference
Association of CCL21+ CAFs with B-cell recruitment and TLS maturation in penile squamous cell carcinoma
10.1007/s00262-026-04348-5 · ExternalCitation · doi-reference
Tumor-associated high endothelial venules mediate lymphocyte entry into tumors and predict response to PD-1 plus CTLA-4 combination immunotherapy
10.1016/j.ccell.2022.01.002 · ExternalCitation · doi-reference
Mesothelial cell-derived antigen-presenting cancer-associated fibroblasts induce expansion of regulatory T cells in pancreatic cancer
10.1016/j.ccell.2022.04.011 · ExternalCitation · doi-reference
Cancer immunotherapies transition endothelial cells into HEVs that generate TCF1+ T lymphocyte niches through a feed-forward loop
10.1016/j.ccell.2022.11.002 · ExternalCitation · doi-reference
The activity of tertiary lymphoid structures in high grade serous ovarian cancer is governed by site, stroma, and cellular interactions
10.1016/j.ccell.2024.09.007 · ExternalCitation · doi-reference
Spatial transcriptomics reveals tryptophan metabolism restricting maturation of intratumoral tertiary lymphoid structures
10.1016/j.ccell.2025.03.011 · ExternalCitation · doi-reference
Single-cell resolution spatial analysis of antigen-presenting cancer-associated fibroblast niches
10.1016/j.ccell.2025.09.001 · ExternalCitation · doi-reference
Myofibroblast programming blocks differentiation of TLS-organizing fibroblastic reticular cells in pancreatic cancer
10.1016/j.ccell.2026.03.004 · ExternalCitation · doi-reference
GABA promotes resistance to immunotherapy in patients with TLS-positive tumors
10.1016/j.ccell.2026.06.006 · ExternalCitation · doi-reference
Enzymatic targeting of the stroma ablates physical barriers to treatment of pancreatic ductal adenocarcinoma
10.1016/j.ccr.2012.01.007 · ExternalCitation · doi-reference
Stromal elements act to restrain, rather than support, pancreatic ductal adenocarcinoma
10.1016/j.ccr.2014.04.021 · ExternalCitation · doi-reference
Matrix crosslinking forces tumor progression by enhancing integrin signaling
10.1016/j.cell.2009.10.027 · ExternalCitation · doi-reference
L-Arginine modulates T cell metabolism and enhances survival and anti-tumor activity
10.1016/j.cell.2016.09.031 · ExternalCitation · doi-reference
Fibroblastic reticular cells generate protective intratumoral T cell environments in lung cancer
10.1016/j.cell.2024.10.042 · ExternalCitation · doi-reference
Immune mechanisms orchestrate tertiary lymphoid structures in tumors via cancer-associated fibroblasts
10.1016/j.celrep.2021.109422 · ExternalCitation · doi-reference
The tumor microenvironment is an ecosystem sustained by metabolic interactions
10.1016/j.celrep.2025.115432 · ExternalCitation · doi-reference
Regulation, maintenance, and remodeling of high endothelial venules in homeostasis, inflammation, and cancer
10.1016/j.cophys.2023.100705 · ExternalCitation · doi-reference
Lymphotoxin in physiology of lymphoid tissues - implication for antiviral defense
10.1016/j.cyto.2016.08.018 · ExternalCitation · doi-reference
Tumoral and stromal hMENA isoforms impact tertiary lymphoid structure localization in lung cancer and predict immune checkpoint blockade response in patients with cancer
10.1016/j.ebiom.2024.105003 · ExternalCitation · doi-reference
A tertiary lymphoid structures-based pathological score predicts survival and recurrence in colorectal cancer patients
10.1016/j.imbio.2025.152911 · ExternalCitation · doi-reference
Lymphotoxin-beta receptor signaling is required for the homeostatic control of HEV differentiation and function
10.1016/j.immuni.2005.10.002 · ExternalCitation · doi-reference
Tertiary lymphoid structures generate and propagate anti-tumor antibody-producing plasma cells in renal cell cancer
10.1016/j.immuni.2022.02.001 · ExternalCitation · doi-reference
A local subset of mesenchymal cells expressing the transcription factor Osr1 orchestrates lymph node initiation
10.1016/j.immuni.2023.04.014 · ExternalCitation · doi-reference
Deciphering functional tumor-immune crosstalk through highly multiplexed imaging and deep visual proteomics
10.1016/j.molcel.2024.12.023 · ExternalCitation · doi-reference
Interferon-responsive HEVs drive tumor tertiary lymphoid structure formation and predict immunotherapy response in nasopharyngeal carcinoma
10.1016/j.xcrm.2025.102200 · ExternalCitation · doi-reference
TGFβ attenuates tumour response to PD-L1 blockade by contributing to exclusion of T cells
10.1038/nature25501 · ExternalCitation · doi-reference
Mechanotransduction and YAP-dependent matrix remodelling is required for the generation and maintenance of cancer-associated fibroblasts
10.1038/ncb2756 · ExternalCitation · doi-reference
PD-1 regulates germinal center B cell survival and the formation and affinity of long-lived plasma cells
10.1038/ni.1877 · ExternalCitation · doi-reference
Targeting focal adhesion kinase renders pancreatic cancers responsive to checkpoint immunotherapy
10.1038/nm.4123 · ExternalCitation · doi-reference
Tertiary lymphoid structures in diseases: immune mechanisms and therapeutic advances
10.1038/s41392-024-01947-5 · ExternalCitation · doi-reference
B cell zone reticular cell microenvironments shape CXCL13 gradient formation
10.1038/s41467-020-17135-2 · ExternalCitation · doi-reference
Single-cell and spatial transcriptome analyses reveal tertiary lymphoid structures linked to tumour progression and immunotherapy response in nasopharyngeal carcinoma
10.1038/s41467-024-52153-4 · ExternalCitation · doi-reference
Predicting immunotherapy response of advanced bladder cancer through a meta-analysis of six independent cohorts
10.1038/s41467-025-56462-0 · ExternalCitation · doi-reference
Comparison of imaging based single-cell resolution spatial transcriptomics profiling platforms using formalin-fixed paraffin-embedded tumor samples
10.1038/s41467-025-63414-1 · ExternalCitation · doi-reference
Single-cell and spatial transcriptomics implicate a prognostic function of tertiary lymphoid structures in gastric cancer
10.1038/s41467-025-65421-8 · ExternalCitation · doi-reference
A framework for advancing our understanding of cancer-associated fibroblasts
10.1038/s41568-019-0238-1 · ExternalCitation · doi-reference
Tertiary lymphoid structures in anticancer immunity
10.1038/s41568-024-00728-0 · ExternalCitation · doi-reference
Deep visual proteomics defines single-cell identity and heterogeneity
10.1038/s41587-022-01302-5 · ExternalCitation · doi-reference
Multi-omic profiling highlights factors associated with resistance to immuno-chemotherapy in non-small-cell lung cancer
10.1038/s41588-024-01998-y · ExternalCitation · doi-reference
Cancer-associated fibroblasts in the single-cell era
10.1038/s43018-022-00411-z · ExternalCitation · doi-reference
Atezolizumab for first-line treatment of metastatic nonsquamous NSCLC
10.1056/nejmoa1716948 · ExternalCitation · doi-reference
Pembrolizumab plus axitinib versus sunitinib for advanced renal-cell carcinoma
10.1056/nejmoa1816714 · ExternalCitation · doi-reference
Atezolizumab plus bevacizumab in unresectable hepatocellular carcinoma
10.1056/nejmoa1915745 · ExternalCitation · doi-reference
Targeting CXCL12 from FAP-expressing carcinoma-associated fibroblasts synergizes with anti–PD-L1 immunotherapy in pancreatic cancer
10.1073/pnas.1320318110 · ExternalCitation · doi-reference
Germinal center hypoxia in tumor-draining lymph nodes negatively regulates tumor-induced humoral immune responses in mouse models of breast cancer
10.1080/2162402x.2021.1959978 · ExternalCitation · doi-reference
Lung tumor MHCII immunity depends on in situ antigen presentation by fibroblasts
10.1084/jem.20210815 · ExternalCitation · doi-reference
Lactate blocks tertiary lymphoid structure formation by inhibiting B cell chemotaxis
10.1101/2025.08.30.673054 · ExternalCitation · doi-reference
Tertiary lymphoid structures, drivers of the anti-tumor responses in human cancers
10.1111/imr.12405 · ExternalCitation · doi-reference
Fibroblastic reticular cells at the nexus of innate and adaptive immune responses
10.1111/imr.12748 · ExternalCitation · doi-reference
Organization of the invading lymphoid tissue in human lymphoid thyroiditis
10.1111/j.1365-3083.1974.tb01260.x · ExternalCitation · doi-reference
Normalization of tumor vasculature: An emerging concept in antiangiogenic therapy
10.1126/science.1104819 · ExternalCitation · doi-reference
Interstitial dendritic cell guidance by haptotactic chemokine gradients
10.1126/science.1228456 · ExternalCitation · doi-reference
Dual angiopoietin-2 and VEGFA inhibition elicits antitumor immunity that is enhanced by PD-1 checkpoint blockade
10.1126/scitranslmed.aak9670 · ExternalCitation · doi-reference
Combined antiangiogenic and anti–PD-L1 therapy stimulates tumor immunity through HEV formation
10.1126/scitranslmed.aak9679 · ExternalCitation · doi-reference
Heberden oration, 1964. Some immunologic aspects of the connective tissue diseases
10.1136/ard.24.2.103 · ExternalCitation · doi-reference
Maturation and abundance of tertiary lymphoid structures are associated with the efficacy of neoadjuvant chemoimmunotherapy in resectable non-small cell lung cancer
10.1136/jitc-2022-005531 · ExternalCitation · doi-reference
Diversity and biology of cancer-associated fibroblasts
10.1152/physrev.00048.2019 · ExternalCitation · doi-reference
Human solid tumors contain high endothelial venules: association with T- and B-lymphocyte infiltration and favorable prognosis in breast cancer
10.1158/0008-5472.can-11-0431 · ExternalCitation · doi-reference
Cancer-associated fibroblasts suppress CD8+ T-cell infiltration and confer resistance to immune-checkpoint blockade
10.1158/0008-5472.can-21-4141 · ExternalCitation · doi-reference
Cross-species single-cell analysis of pancreatic ductal adenocarcinoma reveals antigen-presenting cancer-associated fibroblasts
10.1158/2159-8290.cd-19-0094 · ExternalCitation · doi-reference
VEGFD/VEGFR2 axis induces the dedifferentiation of high endothelial venules and impairs lymphocyte homing
10.1172/jci.insight.191041 · ExternalCitation · doi-reference
Selective glutamine metabolism inhibition in tumor cells improves antitumor T lymphocyte activity in triple-negative breast cancer
10.1172/jci140100 · ExternalCitation · doi-reference
Proteomic profiling of the tumor microenvironment: recent insights and the search for biomarkers
10.1186/gm529 · ExternalCitation · doi-reference
High endothelial venules abundance in tertiary lymphoid structures: a prognostic biomarker in non-small cell lung cancer with neoadjuvant immunochemotherapy
10.1186/s12885-025-15529-3 · ExternalCitation · doi-reference
Single-cell spatial analysis identifies ID1-high endothelial cells in tertiary lymphoid structures as predictors of durable response to immunotherapy in non-small cell lung cancer
10.1186/s12935-025-04161-7 · ExternalCitation · doi-reference
Tertiary lymphoid structural heterogeneity determines tumour immunity and prospects for clinical application
10.1186/s12943-024-01980-6 · ExternalCitation · doi-reference
Cancer-associated fibroblasts in the tumor microenvironment: heterogeneity, crosstalk mechanisms, and therapeutic implications
10.1186/s12943-025-02533-1 · ExternalCitation · doi-reference
Tertiary lymphoid structures in cancer: spatiotemporal heterogeneity, immune orchestration, and translational opportunities
10.1186/s13045-025-01754-7 · ExternalCitation · doi-reference
An introduction to spatial transcriptomics for biomedical research
10.1186/s13073-022-01075-1 · ExternalCitation · doi-reference
Cancer-associated fibroblasts: heterogeneity, tumorigenicity and therapeutic targets
10.1186/s43556-024-00233-8 · ExternalCitation · doi-reference
Normalizing tumor microenvironment to treat cancer: Bench to bedside to biomarkers
10.1200/jco.2012.46.3653 · ExternalCitation · doi-reference
A tertiary lymphoid structure-related gene signature predicts prognosis and treatment response in hepatocellular carcinoma
10.14740/wjon2646 · ExternalCitation · doi-reference
Exploring the diversity of cancer-associated fibroblasts: insights into mechanisms of drug resistance
10.3389/fcell.2024.1403122 · ExternalCitation · doi-reference
Role of the lymphotoxin/LIGHT system in the development and maintenance of reticular networks and vasculature in lymphoid tissues
10.3389/fimmu.2014.00047 · ExternalCitation · doi-reference
Targeting chemokine—glycosaminoglycan interactions to inhibit inflammation
10.3389/fimmu.2020.00483 · ExternalCitation · doi-reference
High endothelial venules: a vascular perspective on tertiary lymphoid structures in cancer
10.3389/fimmu.2021.736670 · ExternalCitation · doi-reference
Picturing of the lung tumor cellular composition by multispectral flow cytometry
10.3389/fimmu.2022.827719 · ExternalCitation · doi-reference
Tertiary lymphoid structures in cancer: maturation and induction
10.3389/fimmu.2024.1369626 · ExternalCitation · doi-reference
Mature tertiary lymphoid structures: important contributors to anti-tumor immune efficacy
10.3389/fimmu.2024.1413067 · ExternalCitation · doi-reference
Comprehensive analysis of single-cell and bulk RNA sequencing data reveals an EGFR signature for predicting immunotherapy response and prognosis in pan-cancer
10.3389/fimmu.2025.1604394 · ExternalCitation · doi-reference
Molecular remodeling of cancer-associated fibroblasts in breast cancer patients receiving anti–PD-1 immunotherapy
10.3389/fonc.2026.1754311 · ExternalCitation · doi-reference
The emerging role of tertiary lymphoid structures in breast cancer: A narrative review
10.3390/cancers16020396 · ExternalCitation · doi-reference
Multiplex immunofluorescence: A powerful tool in cancer immunotherapy
10.3390/ijms24043086 · ExternalCitation · doi-reference
Extracellular matrix stiffness: mechanotransduction and mechanobiological response-driven strategies for biomedical applications targeting fibroblast inflammation
10.3390/polym17060822 · ExternalCitation · doi-reference
Germinal center hypoxia potentiates immunoglobulin class switch recombination
10.4049/jimmunol.1601401 · ExternalCitation · doi-reference
T cell activation in rheumatoid synovium is B cell dependent
10.4049/jimmunol.167.8.4710 · ExternalCitation · doi-reference
Applications of immunohistochemistry
10.4103/0975-7406.100281 · ExternalCitation · doi-reference
Comprehensive analysis of scRNA-seq and bulk RNA-seq identified TIMP1 as a prognostic marker in colorectal cancer
10.4110/in.2025.25.e38 · ExternalCitation · doi-reference
Spatiotemporal mapping of tertiary lymphoid structure heterogeneity shapes immune niches and clinical outcomes in intrahepatic cholangiocarcinoma
10.64898/2026.01.02.697439 · ExternalCitation · doi-reference
Mechanical microenvironment in tumor immune evasion: bidirectional regulation between matrix stiffness and immune cells and its therapeutic implications
10.7150/ijbs.121356 · ExternalCitation · doi-reference
Relationship between tertiary lymphoid structure and the prognosis and clinicopathologic characteristics in solid tumors
10.7150/ijms.56347 · ExternalCitation · doi-reference