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References from Spatial multi-omics-guided drug development in inflammatory bowel disease: from mucosal immune niches to precision therapy. Local targets link to admitted publications; unresolved targets remain external evidence.
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10.1016/s0140-6736(17)32448-0 · 2017 · External reference
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10.1016/s2468-1253(19)30333-4 · 2020 · External reference
Pathway paradigms revealed from the genetics of inflammatory bowel disease
10.1038/s41586-020-2025-2 · 2020 · External reference
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10.1038/nrgastro.2015.186 · 2016 · External reference
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10.1056/nejmra2002697 · 2020 · External reference
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10.1016/s0140-6736(16)32126-2 · 2017 · External reference
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10.1053/j.gastro.2020.12.031 · 2021 · External reference
ECCO Guidelines on Therapeutics in Crohn's Disease: medical treatment
10.1093/ecco-jcc/jjae091 · 2024 · External reference
AGA living clinical practice guideline on pharmacological management of moderate-to-severe ulcerative colitis
10.1053/j.gastro.2024.10.001 · 2024 · External reference
ECCO Guidelines on Therapeutics in Ulcerative Colitis: medical treatment
10.1093/ecco-jcc/jjab178 · 2022 · External reference
Risankizumab as induction therapy for Crohn's disease: results from the phase 3 ADVANCE and MOTIVATE induction trials
10.1016/s0140-6736(22)00467-6 · 2022 · External reference
Risankizumab as maintenance therapy for moderately to severely active Crohn's disease: results from the multicentre, randomised, double-blind, placebo-controlled, withdrawal phase 3 FORTIFY maintenance trial
10.1016/s0140-6736(22)00466-4 · 2022 · External reference
Guselkumab in patients with moderately to severely active ulcerative colitis: QUASAR phase 3 induction and maintenance studies
10.1016/s0140-6736(24)01927-5 · 2025 · External reference
Mirikizumab as induction and maintenance therapy for ulcerative colitis
10.1056/nejmoa2207940 · 2023 · External reference
Tofacitinib as induction and maintenance therapy for ulcerative colitis
10.1056/nejmoa1606910 · 2017 · External reference
Upadacitinib induction and maintenance therapy for Crohn's disease
10.1056/nejmoa2212728 · 2023 · External reference
Ozanimod as induction and maintenance therapy for ulcerative colitis
10.1056/nejmoa2033617 · 2021 · External reference
Etrasimod as induction and maintenance therapy for ulcerative colitis (ELEVATE): two randomised, double-blind, placebo-controlled, phase 3 studies
10.1016/s0140-6736(23)00061-2 · 2023 · External reference
Phase 2 trial of anti-TL1A monoclonal antibody tulisokibart for ulcerative colitis
10.1056/nejmoa2314076 · 2024 · External reference
Infliximab for induction and maintenance therapy for ulcerative colitis
10.1056/nejmoa050516 · 2005 · External reference
Predictors of primary response to biologic treatment [anti-TNF, vedolizumab, and ustekinumab] in patients with inflammatory bowel disease: from basic science to clinical practice
10.1093/ecco-jcc/jjz195 · 2020 · External reference
Loss of response to anti-TNFs: definition, epidemiology, and management
10.1038/ctg.2015.63 · 2016 · External reference
HLA-DQA1*05 carriage associated with development of anti-drug antibodies to infliximab and adalimumab in patients with Crohn's disease
10.1053/j.gastro.2019.09.041 · 2020 · External reference
Trough concentrations of infliximab guide dosing for patients with inflammatory bowel disease
10.1053/j.gastro.2015.02.031 · 2015 · External reference
C-reactive protein, fecal calprotectin, and stool lactoferrin for detection of endoscopic activity in symptomatic inflammatory bowel disease patients: a systematic review and meta-analysis
10.1038/ajg.2015.120 · 2015 · External reference
ECCO-ESGAR-ESP-IBUS Guideline on Diagnostics and Monitoring of Patients with Inflammatory Bowel Disease: Part 1: initial diagnosis, monitoring of known inflammatory bowel disease, detection of complications
10.1093/ecco-jcc/jjaf106 · 2025 · External reference
Biomarkers in search of precision medicine in IBD
10.1038/ajg.2016.441 · 2016 · External reference
Challenges in IBD research 2024: precision medicine
10.1093/ibd/izae084 · 2024 · External reference
Intra- and inter-cellular rewiring of the human colon during ulcerative colitis
10.1016/j.cell.2019.06.029 · 2019 · External reference
Single-cell analysis of Crohn's disease lesions identifies a pathogenic cellular module associated with resistance to anti-TNF therapy
10.1016/j.cell.2019.08.008 · 2019 · External reference
An introduction to spatial transcriptomics for biomedical research
10.1186/s13073-022-01075-1 · 2022 · External reference
Museum of spatial transcriptomics
10.1038/s41592-022-01409-2 · 2022 · External reference
Exploring tissue architecture using spatial transcriptomics
10.1038/s41586-021-03634-9 · 2021 · External reference
A single-cell survey of the small intestinal epithelium
10.1038/nature24489 · 2017 · External reference
Colonic epithelial cell diversity in health and inflammatory bowel disease
10.1038/s41586-019-0992-y · 2019 · External reference
Cells of the human intestinal tract mapped across space and time
10.1038/s41586-021-03852-1 · 2021 · External reference
Structural remodeling of the human colonic mesenchyme in inflammatory bowel disease
10.1016/j.cell.2018.08.067 · 2018 · External reference
Distinct microbial and immune niches of the human colon
10.1038/s41590-020-0602-z · 2020 · External reference
Macrophage and neutrophil heterogeneity at single-cell spatial resolution in human inflammatory bowel disease
10.1038/s41467-023-40156-6 · 2023 · External reference
Identification and multimodal characterization of a specialized epithelial cell type associated with Crohn's disease
10.1038/s41467-024-51580-7 · 2024 · External reference
Single-cell integration reveals metaplasia in inflammatory gut diseases
10.1038/s41586-024-07571-1 · 2024 · External reference
Spatial transcriptomics reveals unique inflammatory signatures across all anatomic locations in postoperative Crohn's disease
10.1093/ecco-jcc/jjaf180 · 2025 · External reference
Elucidating a myofibroblast-dominated fibrotic niche in Crohn's disease-associated fibrostenosis through high-resolution spatial transcriptomics
10.1016/j.jcmgh.2025.101701 · 2026 · External reference
Spatial fibroblast niches define Crohn's fistulae
10.1038/s41586-025-09744-y · 2026 · External reference
Stricturing Crohn's disease single-cell RNA sequencing reveals fibroblast heterogeneity and intercellular interactions
10.1053/j.gastro.2023.07.014 · 2023 · External reference
Single-cell and spatial transcriptomics of stricturing Crohn's disease highlights a fibrosis-associated network
10.1038/s41588-025-02225-y · 2025 · External reference
Mucosal profiling of pediatric-onset colitis and IBD reveals common pathogenics and therapeutic pathways
10.1016/j.cell.2019.10.027 · 2019 · External reference
Molecular characterization of limited ulcerative colitis reveals novel biology and predictors of disease extension
10.1053/j.gastro.2021.08.053 · 2021 · External reference
Highly parallel genome-wide expression profiling of individual cells using nanoliter droplets
10.1016/j.cell.2015.05.002 · 2015 · External reference
Massively parallel digital transcriptional profiling of single cells
10.1038/ncomms14049 · 2017 · External reference
Simultaneous epitope and transcriptome measurement in single cells
10.1038/nmeth.4380 · 2017 · External reference
Single-cell chromatin accessibility reveals principles of regulatory variation
10.1038/nature14590 · 2015 · External reference
Chromatin potential identified by shared single-cell profiling of RNA and chromatin
10.1016/j.cell.2020.09.056 · 2020 · External reference
Fast, sensitive and accurate integration of single-cell data with Harmony
10.1038/s41592-019-0619-0 · 2019 · External reference
Comprehensive integration of single-cell data
10.1016/j.cell.2019.05.031 · 2019 · External reference
SCANPY: large-scale single-cell gene expression data analysis
10.1186/s13059-017-1382-0 · 2018 · External reference
Deep generative modeling for single-cell transcriptomics
10.1038/s41592-018-0229-2 · 2018 · External reference
Visualization and analysis of gene expression in tissue sections by spatial transcriptomics
10.1126/science.aaf2403 · 2016 · External reference
Slide-seq: a scalable technology for measuring genome-wide expression at high spatial resolution
10.1126/science.aaw1219 · 2019 · External reference
High-definition spatial transcriptomics for in situ tissue profiling
10.1038/s41592-019-0548-y · 2019 · External reference
Spatiotemporal transcriptomic atlas of mouse organogenesis using DNA nanoball-patterned arrays
10.1016/j.cell.2022.04.003 · 2022 · External reference
RNA imaging. Spatially resolved, highly multiplexed RNA profiling in single cells
10.1126/science.aaa6090 · 2015 · External reference
Spatial transcriptome profiling by MERFISH reveals subcellular RNA compartmentalization and cell cycle-dependent gene expression
10.1073/pnas.1912459116 · 2019 · External reference
Transcriptome-scale super-resolved imaging in tissues by RNA seqFISH+
10.1038/s41586-019-1049-y · 2019 · External reference
High-plex imaging of RNA and proteins at subcellular resolution in fixed tissue by spatial molecular imaging
10.1038/s41587-022-01483-z · 2022 · External reference
High resolution mapping of the tumor microenvironment using integrated single-cell, spatial and in situ analysis
10.1038/s41467-023-43458-x · 2023 · External reference
Multiplex digital spatial profiling of proteins and RNA in fixed tissue
10.1038/s41587-020-0472-9 · 2020 · External reference
Method of the Year: spatially resolved transcriptomics
10.1038/s41592-020-01033-y · 2021 · External reference
Spatially resolved transcriptomes-next generation tools for tissue exploration
10.1002/bies.201900221 · 2020 · External reference
Integrating single-cell and spatial transcriptomics to elucidate intercellular tissue dynamics
10.1038/s41576-021-00370-8 · 2021 · External reference
Systematic comparison of sequencing-based spatial transcriptomic methods
10.1038/s41592-024-02325-3 · 2024 · External reference
Systematic benchmarking of imaging spatial transcriptomics platforms in FFPE tissues
10.1038/s41467-025-64990-y · 2025 · External reference
Highly multiplexed imaging of tumor tissues with subcellular resolution by mass cytometry
10.1038/nmeth.2869 · 2014 · External reference
Imaging mass cytometry
10.1002/cyto.a.23053 · 2017 · External reference
Deep profiling of mouse splenic architecture with CODEX multiplexed imaging
10.1016/j.cell.2018.07.010 · 2018 · External reference
A structured tumor-immune microenvironment in triple negative breast cancer revealed by multiplexed ion beam imaging
10.1016/j.cell.2018.08.039 · 2018 · External reference
A tissue atlas of ulcerative colitis revealing evidence of sex-dependent differences in disease-driving inflammatory cell types and resistance to TNF inhibitor therapy
10.1126/sciadv.add1166 · 2023 · External reference
An untargeted metabolomic study using MALDI-mass spectrometry imaging reveals region-specific biomarkers associated with bowel inflammation
10.1007/s11306-024-02200-4 · 2025 · External reference
Spatial pharmacology using mass spectrometry imaging
10.1016/j.tips.2023.11.003 · 2024 · External reference
Highly multiplexed spatial mapping of microbial communities
10.1038/s41586-020-2983-4 · 2020 · External reference
Integrative multi-omics deciphers the spatial characteristics of host-gut microbiota interactions in Crohn's disease
10.1016/j.xcrm.2023.101050 · 2023 · External reference
A multi-omics spatial framework for host-microbiome dissection within the intestinal tissue microenvironment
10.1038/s41467-025-56237-7 · 2025 · External reference
Deep learning models capture histological disease activity in Crohn’s disease and ulcerative colitis with high fidelity
10.1093/ecco-jcc/jjad171 · 2024 · External reference
Artificial intelligence enabled histological prediction of remission or activity and clinical outcomes in ulcerative colitis
10.1053/j.gastro.2023.02.031 · 2023 · External reference
Artificial intelligence enables quantitative assessment of ulcerative colitis histology
10.1016/j.modpat.2023.100124 · 2023 · External reference
Cell segmentation in imaging-based spatial transcriptomics
10.1038/s41587-021-01044-w · 2022 · External reference
Cell2location maps fine-grained cell types in spatial transcriptomics
10.1038/s41587-021-01139-4 · 2022 · External reference
Robust decomposition of cell type mixtures in spatial transcriptomics
10.1038/s41587-021-00830-w · 2022 · External reference
Deep learning and alignment of spatially resolved single-cell transcriptomes with Tangram
10.1038/s41592-021-01264-7 · 2021 · External reference
Squidpy: a scalable framework for spatial omics analysis
10.1038/s41592-021-01358-2 · 2022 · External reference
Giotto: a toolbox for integrative analysis and visualization of spatial expression data
10.1186/s13059-021-02286-2 · 2021 · External reference
NicheNet: modeling intercellular communication by linking ligands to target genes
10.1038/s41592-019-0667-5 · 2020 · External reference
Inference and analysis of cell-cell communication using CellChat
10.1038/s41467-021-21246-9 · 2021 · External reference
CellPhoneDB: inferring cell-cell communication from combined expression of multi-subunit ligand–receptor complexes
10.1038/s41596-020-0292-x · 2020 · External reference
SpatialData: an open and universal data framework for spatial omics
10.1038/s41592-024-02212-x · 2025 · External reference
Standardized metrics for assessment and reproducibility of imaging-based spatial transcriptomics datasets
10.1038/s41587-025-02811-9 · 2026 · External reference
Inflammatory bowel disease genomics, transcriptomics, proteomics and metagenomics meet artificial intelligence
10.1002/ueg2.12655 · 2024 · External reference
Comparative analysis of multiplexed in situ gene expression profiling technologies
10.7554/elife.96949 · 2024 · External reference
Artificial intelligence guided discovery of a barrier-protective therapy in inflammatory bowel disease
10.1038/s41467-021-24470-5 · 2021 · External reference
Current and emerging therapeutic targets for IBD
10.1038/nrgastro.2016.208 · 2017 · External reference
IL-1-driven stromal-neutrophil interactions define a subset of patients with inflammatory bowel disease that does not respond to therapies
10.1038/s41591-021-01520-5 · 2021 · External reference
Oncostatin M drives intestinal inflammation and predicts response to tumor necrosis factor-neutralizing therapy in patients with inflammatory bowel disease
10.1038/nm.4307 · 2017 · External reference
Oncostatin M is a biomarker of diagnosis, worse disease prognosis, and therapeutic nonresponse in inflammatory bowel disease
10.1093/ibd/izab032 · 2021 · External reference
Single-cell atlas of colonic CD8+ T cells in ulcerative colitis
10.1038/s41591-020-1003-4 · 2020 · External reference
Heterogeneity and clonal relationships of adaptive immune cells in ulcerative colitis revealed by single-cell analyses
10.1126/sciimmunol.abb4432 · 2020 · External reference
Single-cell analyses of Crohn's disease tissues reveal intestinal intraepithelial T cells heterogeneity and altered subset distributions
10.1038/s41467-021-22164-6 · 2021 · External reference
The landscape of immune dysregulation in Crohn's disease revealed through single-cell transcriptomic profiling in the ileum and colon
10.1016/j.immuni.2023.01.002 · 2023 · External reference
Ulcerative colitis is characterized by a plasmablast-skewed humoral response associated with disease activity
10.1038/s41591-022-01680-y · 2022 · External reference
Gut-associated lymphoid tissue attrition associates with response to anti-alpha4beta7 therapy in ulcerative colitis
10.1126/sciimmunol.adg7549 · 2024 · External reference
B cell expansion hinders the stroma-epithelium regenerative cross talk during mucosal healing
10.1016/j.immuni.2022.11.002 · 2022 · External reference
VEGF-C-dependent stimulation of lymphatic function ameliorates experimental inflammatory bowel disease
10.1172/jci72189 · 2014 · External reference
The enteric network: interactions between the immune and nervous systems of the gut
10.1016/j.immuni.2017.05.011 · 2017 · External reference
Mechanisms, management, and treatment of fibrosis in patients with inflammatory bowel diseases
10.1053/j.gastro.2016.09.047 · 2017 · External reference
An expert consensus to standardise definitions, diagnosis and treatment targets for anti-fibrotic stricture therapies in Crohn's disease
10.1111/apt.14853 · 2018 · External reference
Multimodal single-cell analyses reveal mechanisms of perianal fistula in diverse patients with Crohn's disease
10.1016/j.medj.2024.03.021 · 2024 · External reference
Revisiting fibrosis in inflammatory bowel disease: the gut thickens
10.1038/s41575-021-00543-0 · 2022 · External reference
Altered inflammatory mucosal signatures within their spatial and cellular context during active ileal Crohn's disease
10.1172/jci.insight.171783 · 2025 · External reference
In vivo imaging using fluorescent antibodies to tumor necrosis factor predicts therapeutic response in Crohn's disease
10.1038/nm.3462 · 2014 · External reference
Ustekinumab as induction and maintenance therapy for Crohn's disease
10.1056/nejmoa1602773 · 2016 · External reference
Selective IL-23 inhibition by risankizumab modulates the molecular profile in the colon and ileum of patients with active Crohn's disease: results from a randomised phase II biopsy sub-study
10.1093/ecco-jcc/jjy099 · 2018 · External reference
Mucosal IL23A expression predicts the response to ustekinumab in inflammatory bowel disease
10.1007/s00535-021-01819-7 · 2021 · External reference
Vedolizumab as induction and maintenance therapy for ulcerative colitis
10.1056/nejmoa1215734 · 2013 · External reference
Vedolizumab as induction and maintenance therapy for Crohn's disease
10.1056/nejmoa1215739 · 2013 · External reference
Vedolizumab versus adalimumab for moderate-to-severe ulcerative colitis
10.1056/nejmoa1905725 · 2019 · External reference
Insights into TL1A and IBD pathogenesis
10.1007/978-1-4419-6612-4_29 · 2011 · External reference
Secukinumab, a human anti-IL-17A monoclonal antibody, for moderate to severe Crohn's disease: unexpected results of a randomised, double-blind placebo-controlled trial
10.1136/gutjnl-2011-301668 · 2012 · External reference
A living organoid biobank of patients with Crohn's disease reveals molecular subtypes for personalized therapeutics
10.1016/j.xcrm.2024.101748 · 2024 · External reference
Alterations in the epithelial stem cell compartment could contribute to permanent changes in the mucosa of patients with ulcerative colitis
10.1136/gutjnl-2016-312609 · 2017 · External reference
Patient-derived organoids for therapy personalization in inflammatory bowel diseases
10.3748/wjg.v28.i24.2636 · 2022 · External reference
Somatic inflammatory gene mutations in human ulcerative colitis epithelium
10.1038/s41586-019-1844-5 · 2020 · External reference
Human organoids with an autologous tissue-resident immune compartment
10.1038/s41586-024-07791-5 · 2024 · External reference
Patient-derived colon epithelial organoids reveal lipid-related metabolic dysfunction in pediatric ulcerative colitis
10.1038/s41467-025-65988-2 · 2025 · External reference
Development of a human primary gut-on-a-chip to model inflammatory processes
10.1038/s41598-020-78359-2 · 2020 · External reference
Human inflammatory bowel disease-on-a-chip for modelling disease progression, cancer initiation and sex-specific effects
10.1038/s41551-026-01686-8 · 2026 · External reference
Validation and optimization of an ex vivo assay of intestinal mucosal biopsies in Crohn's disease: reflects inflammation and drug effects
10.1371/journal.pone.0155335 · 2016 · External reference
Ex vivo modeling and pharmacological modulation of tissue immune responses in inflammatory bowel disease using precision-cut intestinal slices
10.1002/eji.70013 · 2025 · External reference
A longitudinal single-cell atlas of anti-tumour necrosis factor treatment in inflammatory bowel disease
10.1038/s41590-024-01994-8 · 2024 · External reference
Single-cell and spatial multi-omics highlight effects of anti-integrin therapy across cellular compartments in ulcerative colitis
10.1038/s41467-024-45665-6 · 2024 · External reference
Cell-centred meta-analysis reveals baseline predictors of anti-TNFalpha non-response in biopsy and blood of patients with IBD
10.1136/gutjnl-2017-315494 · 2019 · External reference
Mechanisms of molecular resistance and predictors of response to biological therapy in inflammatory bowel disease
10.1016/s2468-1253(18)30265-6 · 2018 · External reference
How do we predict a patient's disease course and whether they will respond to specific treatments
10.1053/j.gastro.2021.12.245 · 2022 · External reference
Mucosal gene signatures to predict response to infliximab in patients with ulcerative colitis
10.1136/gut.2009.178665 · 2009 · External reference
Low TREM1 expression in whole blood predicts anti-TNF response in inflammatory bowel disease
10.1016/j.ebiom.2019.01.027 · 2019 · External reference
Effect of tight control management on Crohn's disease (CALM): a multicentre, randomised, controlled phase 3 trial
10.1016/s0140-6736(17)32641-7 · 2017 · External reference
Mucosal healing in inflammatory bowel diseases: a systematic review
10.1136/gutjnl-2012-302830 · 2012 · External reference
Development and validation of a histological index for UC
10.1136/gutjnl-2015-310393 · 2017 · External reference
The emerging role of histologic disease activity assessment in ulcerative colitis
10.1016/j.gie.2018.08.018 · 2018 · External reference
Conserved transcriptomic profile between mouse and human colitis allows unsupervised patient stratification
10.1038/s41467-019-10769-x · 2019 · External reference
Biomarker qualification: toward a multiple stakeholder framework for biomarker development, regulatory acceptance, and utilization
10.1002/cpt.136 · 2015 · External reference
The FAIR Guiding Principles for scientific data management and stewardship
10.1038/sdata.2016.18 · 2016 · External reference
BEST (Biomarkers, Endpoints, and Other Tools) Resource
2016 · External reference
Enrichment Strategies for Clinical Trials to Support Determination of Effectiveness of Human Drugs and Biological Products: Guidance for Industry
2019 · External reference
Spatial transcriptomics atlas of inflammatory bowel disease to guide implementation in research consortiums and clinical trials
10.1038/s41467-026-72482-w · 2026 · External reference
Immunopathogenesis of chronic rhinosinusitis and nasal polyposis
10.1146/annurev-pathol-052016-100401 · 2017 · External reference
Mechanisms and pathogenesis of chronic rhinosinusitis
10.1016/j.jaci.2022.02.016 · 2022 · External reference
Allergic inflammatory memory in human respiratory epithelial progenitor cells
10.1038/s41586-018-0449-8 · 2018 · External reference
Single-cell profiling identifies mechanisms of inflammatory heterogeneity in chronic rhinosinusitis
10.1038/s41590-022-01312-0 · 2022 · External reference
Multi-scaled transcriptomics of chronically inflamed nasal epithelium reveals immune-epithelial dynamics and tissue remodeling in nasal polyp formation
10.1016/j.immuni.2025.08.009 · 2025 · External reference
Spatially resolved transcriptomes-next generation tools for tissue exploration
10.1002/bies.201900221 · ExternalCitation · doi-reference
Biomarker qualification: toward a multiple stakeholder framework for biomarker development, regulatory acceptance, and utilization
10.1002/cpt.136 · ExternalCitation · doi-reference
Imaging mass cytometry
10.1002/cyto.a.23053 · ExternalCitation · doi-reference
Ex vivo modeling and pharmacological modulation of tissue immune responses in inflammatory bowel disease using precision-cut intestinal slices
10.1002/eji.70013 · ExternalCitation · doi-reference
Inflammatory bowel disease genomics, transcriptomics, proteomics and metagenomics meet artificial intelligence
10.1002/ueg2.12655 · ExternalCitation · doi-reference
Insights into TL1A and IBD pathogenesis
10.1007/978-1-4419-6612-4_29 · ExternalCitation · doi-reference
Mucosal IL23A expression predicts the response to ustekinumab in inflammatory bowel disease
10.1007/s00535-021-01819-7 · ExternalCitation · doi-reference
An untargeted metabolomic study using MALDI-mass spectrometry imaging reveals region-specific biomarkers associated with bowel inflammation
10.1007/s11306-024-02200-4 · ExternalCitation · doi-reference
Highly parallel genome-wide expression profiling of individual cells using nanoliter droplets
10.1016/j.cell.2015.05.002 · ExternalCitation · doi-reference
Deep profiling of mouse splenic architecture with CODEX multiplexed imaging
10.1016/j.cell.2018.07.010 · ExternalCitation · doi-reference
A structured tumor-immune microenvironment in triple negative breast cancer revealed by multiplexed ion beam imaging
10.1016/j.cell.2018.08.039 · ExternalCitation · doi-reference
Structural remodeling of the human colonic mesenchyme in inflammatory bowel disease
10.1016/j.cell.2018.08.067 · ExternalCitation · doi-reference
Comprehensive integration of single-cell data
10.1016/j.cell.2019.05.031 · ExternalCitation · doi-reference
Intra- and inter-cellular rewiring of the human colon during ulcerative colitis
10.1016/j.cell.2019.06.029 · ExternalCitation · doi-reference
Single-cell analysis of Crohn's disease lesions identifies a pathogenic cellular module associated with resistance to anti-TNF therapy
10.1016/j.cell.2019.08.008 · ExternalCitation · doi-reference
Mucosal profiling of pediatric-onset colitis and IBD reveals common pathogenics and therapeutic pathways
10.1016/j.cell.2019.10.027 · ExternalCitation · doi-reference
Chromatin potential identified by shared single-cell profiling of RNA and chromatin
10.1016/j.cell.2020.09.056 · ExternalCitation · doi-reference
Spatiotemporal transcriptomic atlas of mouse organogenesis using DNA nanoball-patterned arrays
10.1016/j.cell.2022.04.003 · ExternalCitation · doi-reference
Low TREM1 expression in whole blood predicts anti-TNF response in inflammatory bowel disease
10.1016/j.ebiom.2019.01.027 · ExternalCitation · doi-reference
The emerging role of histologic disease activity assessment in ulcerative colitis
10.1016/j.gie.2018.08.018 · ExternalCitation · doi-reference
The enteric network: interactions between the immune and nervous systems of the gut
10.1016/j.immuni.2017.05.011 · ExternalCitation · doi-reference
B cell expansion hinders the stroma-epithelium regenerative cross talk during mucosal healing
10.1016/j.immuni.2022.11.002 · ExternalCitation · doi-reference
The landscape of immune dysregulation in Crohn's disease revealed through single-cell transcriptomic profiling in the ileum and colon
10.1016/j.immuni.2023.01.002 · ExternalCitation · doi-reference
Multi-scaled transcriptomics of chronically inflamed nasal epithelium reveals immune-epithelial dynamics and tissue remodeling in nasal polyp formation
10.1016/j.immuni.2025.08.009 · ExternalCitation · doi-reference
Mechanisms and pathogenesis of chronic rhinosinusitis
10.1016/j.jaci.2022.02.016 · ExternalCitation · doi-reference
Elucidating a myofibroblast-dominated fibrotic niche in Crohn's disease-associated fibrostenosis through high-resolution spatial transcriptomics
10.1016/j.jcmgh.2025.101701 · ExternalCitation · doi-reference
Multimodal single-cell analyses reveal mechanisms of perianal fistula in diverse patients with Crohn's disease
10.1016/j.medj.2024.03.021 · ExternalCitation · doi-reference
Artificial intelligence enables quantitative assessment of ulcerative colitis histology
10.1016/j.modpat.2023.100124 · ExternalCitation · doi-reference
Spatial pharmacology using mass spectrometry imaging
10.1016/j.tips.2023.11.003 · ExternalCitation · doi-reference
Integrative multi-omics deciphers the spatial characteristics of host-gut microbiota interactions in Crohn's disease
10.1016/j.xcrm.2023.101050 · ExternalCitation · doi-reference
A living organoid biobank of patients with Crohn's disease reveals molecular subtypes for personalized therapeutics
10.1016/j.xcrm.2024.101748 · ExternalCitation · doi-reference
Crohn's disease
10.1016/s0140-6736(16)31711-1 · ExternalCitation · doi-reference
Ulcerative colitis
10.1016/s0140-6736(16)32126-2 · ExternalCitation · doi-reference
Worldwide incidence and prevalence of inflammatory bowel disease in the 21st century: a systematic review of population-based studies
10.1016/s0140-6736(17)32448-0 · ExternalCitation · doi-reference
Effect of tight control management on Crohn's disease (CALM): a multicentre, randomised, controlled phase 3 trial
10.1016/s0140-6736(17)32641-7 · ExternalCitation · doi-reference
Risankizumab as maintenance therapy for moderately to severely active Crohn's disease: results from the multicentre, randomised, double-blind, placebo-controlled, withdrawal phase 3 FORTIFY maintenance trial
10.1016/s0140-6736(22)00466-4 · ExternalCitation · doi-reference
Risankizumab as induction therapy for Crohn's disease: results from the phase 3 ADVANCE and MOTIVATE induction trials
10.1016/s0140-6736(22)00467-6 · ExternalCitation · doi-reference
Etrasimod as induction and maintenance therapy for ulcerative colitis (ELEVATE): two randomised, double-blind, placebo-controlled, phase 3 studies
10.1016/s0140-6736(23)00061-2 · ExternalCitation · doi-reference
Guselkumab in patients with moderately to severely active ulcerative colitis: QUASAR phase 3 induction and maintenance studies
10.1016/s0140-6736(24)01927-5 · ExternalCitation · doi-reference
Mechanisms of molecular resistance and predictors of response to biological therapy in inflammatory bowel disease
10.1016/s2468-1253(18)30265-6 · ExternalCitation · doi-reference
The global, regional, and national burden of inflammatory bowel disease in 195 countries and territories, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017
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