Research graph
References from PYHIN proteins: guardians or contributors to hepatitis B virus pathogenesis?. Local targets link to admitted publications; unresolved targets remain external evidence.
The burden of chronic hepatitis B and C in 2022 and progress towards elimination: a global report
10.1016/s2468-1253(25)00375-9 · 2026 · External reference
WHO's 2024 global hepatitis report
10.1016/s1473-3099(24)00307-4 · 2024 · External reference
Mechanisms of HBV-induced hepatocellular carcinoma
10.1016/j.jhep.2016.02.021 · 2016 · External reference
Current status and challenges in anti-hepatitis B virus agents based on inactivation/inhibition or elimination of hepatitis B virus covalently closed circular DNA
10.3390/v15122315 · 2023 · External reference
Targeting HBV cccDNA levels: key to achieving complete cure of chronic hepatitis B
10.3390/pathogens13121100 · 2024 · External reference
Classifying hepatitis B therapies with insights from covalently closed circular DNA dynamics
10.1016/j.virs.2023.12.005 · 2024 · External reference
Mechanisms underlying the compromised clinical efficacy of interferon in clearing HBV
10.1186/s12985-024-02589-3 · 2024 · External reference
A global scientific strategy to cure hepatitis B
10.1016/s2468-1253(19)30119-0 · 2019 · External reference
Intracellular host restriction of hepatitis B virus replication
10.3390/v16050764 · 2024 · External reference
Innate immune recognition and evasion strategies of hepatitis B virus: from DNA to RNA and viral proteins
10.3389/fimmu.2026.1741620 · 2026 · External reference
The dual roles of human PYHIN family proteins in cancer: mechanisms and therapeutic implications
10.3389/fimmu.2025.1576674 · 2025 · External reference
Emerging role of PYHIN proteins as antiviral restriction factors
10.3390/v12121464 · 2020 · External reference
Lack of immunological DNA sensing in hepatocytes facilitates hepatitis B virus infection
10.1002/hep.28685 · 2016 · External reference
The role of innate immunity in the immunopathology and treatment of HBV infection
10.1016/j.jhep.2016.01.028 · 2016 · External reference
Nuclear PYHIN proteins target the host transcription factor Sp1 thereby restricting HIV-1 in human macrophages and CD4+ T cells
10.1371/journal.ppat.1008752 · 2020 · External reference
The emerging role of human PYHIN proteins in innate immunity: implications for health and disease
10.1016/j.bcp.2014.08.031 · 2014 · External reference
Structural mechanism of dsDNA recognition by the hMNDA HIN domain: New insights into the DNA-binding model of a PYHIN protein
10.1016/j.ijbiomac.2023.125461 · 2023 · External reference
The functional interactome of PYHIN immune regulators reveals IFIX is a sensor of viral DNA
10.15252/msb.20145808 · 2015 · External reference
The DNA sensor IFIX drives proteome alterations to mobilize nuclear and cytoplasmic antiviral responses, with its acetylation acting as a localization toggle
10.1128/msystems.00397-21 · 2021 · External reference
IFI16 is involved in HBV-associated acute-on-chronic liver failure inflammation
10.1186/s12876-018-0791-1 · 2018 · External reference
AIM2 sensors mediate immunity to Plasmodium infection in hepatocytes
10.1073/pnas.2210181120 · 2023 · External reference
MNDA, a PYHIN factor involved in transcriptional regulation and apoptosis control in leukocytes
10.3389/fimmu.2024.1395035 · 2024 · External reference
Regulation and specificity of MNDA expression in monocytes, macrophages, and leukemia/B lymphoma cell lines
10.1002/jcb.240560417 · 1994 · External reference
Purification, characterization and docking studies of the HIN domain of human myeloid nuclear differentiation antigen (MNDA)
10.1007/s10529-013-1432-y · 2014 · External reference
Reconstruction of monocyte transcriptional regulatory network accompanies monocytic functions in human fibroblasts
10.1371/journal.pone.0033474 · 2012 · External reference
Specific and nonhepatotoxic degradation of nuclear hepatitis B virus cccDNA
10.1126/science.1243462 · 2014 · External reference
IFI16 is required for DNA sensing in human macrophages by promoting production and function of cGAMP
10.1038/ncomms14391 · 2017 · External reference
Cloning a novel member of the human interferon-inducible gene family associated with control of tumorigenicity in a model of human melanoma
10.1038/sj.onc.1201206 · 1997 · External reference
STING-mediated IFI16 degradation negatively controls type I interferon production
10.1016/j.celrep.2019.09.069 · 2019 · External reference
IFI16 positively regulates RIG-I-mediated type I interferon production in a STING-independent manner
10.1089/dna.2023.0362 · 2024 · External reference
Nuclear innate sensors for nucleic acids in immunity and inflammation
10.1111/imr.12893 · 2020 · External reference
Viral DNA sensors IFI16 and cyclic GMP-AMP synthase possess distinct functions in regulating viral gene expression, immune defenses, and apoptotic responses during herpesvirus infection
10.1128/mbio.01553-16 · 2016 · External reference
DNA sensing by the cGAS-STING pathway in health and disease
10.1038/s41576-019-0151-1 · 2019 · External reference
The nucleic acid-sensing inflammasomes
10.1111/imr.12281 · 2015 · External reference
Pristimerin suppresses AIM2 inflammasome by modulating AIM2-PYCARD/ASC stability via selective autophagy to alleviate tendinopathy
10.1080/15548627.2023.2249392 · 2024 · External reference
IFI16 targets the transcription factor sp1 to suppress HIV-1 transcription and latency reactivation
10.1016/j.chom.2019.05.002 · 2019 · External reference
PYHIN proteins and HPV: role in the pathogenesis of head and neck squamous cell carcinoma
10.3390/microorganisms8010014 · 2019 · External reference
The nuclear DNA sensor IFI16 indiscriminately binds to and diminishes accessibility of the HSV-1 genome to suppress infection
10.1128/msystems.00198-22 · 2022 · External reference
Short-lived AIM2 inflammasome activation relates to chronic MCMV infection in BALB/c mice
10.1007/s11596-019-2121-4 · 2019 · External reference
Nuclear sensor interferon-inducible protein 16 inhibits the function of hepatitis B virus covalently closed circular DNA by integrating innate immune activation and epigenetic suppression
10.1002/hep.30897 · 2020 · External reference
Recent advances in the mechanisms of NLRP3 inflammasome activation and its inhibitors
10.1038/s41419-019-1413-8 · 2019 · External reference
New insights into the structural basis of DNA recognition by HINa and HINb domains of IFI16
10.1093/jmcb/mjv053 · 2016 · External reference
IFI16 is an innate immune sensor for intracellular DNA
10.1038/ni.1932 · 2010 · External reference
The PYHIN protein family as mediators of host defenses
10.1111/j.1600-065x.2011.01053.x · 2011 · External reference
Poxvirus dsDNA genomes differentially activate AIM2 or NLRP3 inflammasomes in human primary cells
10.1038/s44318-025-00690-z · 2026 · External reference
IFN-α inhibits HBV transcription and replication in cell culture and in humanized mice by targeting the epigenetic regulation of the nuclear cccDNA minichromosome
10.1172/jci58847 · 2012 · External reference
Innate and adaptive immune responses in chronic hepatitis B virus infections: towards restoration of immune control of viral infection
10.1136/postgradmedj-2011-301073rep · 2013 · External reference
AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC
10.1038/nature07725 · 2009 · External reference
Correlation of AIM2 expression in peripheral blood mononuclear cells from humans with acute and chronic hepatitis B
10.1016/j.humimm.2013.01.022 · 2013 · External reference
Expression of AIM2 is correlated with increased inflammation in chronic hepatitis B patients
10.1186/s12985-015-0360-y · 2015 · External reference
The human myeloid cell nuclear differentiation antigen gene is one of at least two related interferon-inducible genes located on chromosome 1q that are expressed specifically in hematopoietic cells
10.1182/blood.v83.8.2153.2153 · 1994 · External reference
Myeloid cell nuclear differentiation antigen controls the pathogen-stimulated type I interferon cascade in human monocytes by transcriptional regulation of IRF7
10.1038/s41467-021-27701-x · 2022 · External reference
cGAS-mediated stabilization of IFI16 promotes innate signaling during herpes simplex virus infection
10.1073/pnas.1424637112 · 2015 · External reference
Herpesvirus genome recognition induced acetylation of nuclear IFI16 is essential for its cytoplasmic translocation, inflammasome and IFN-β responses
10.1371/journal.ppat.1005019 · 2015 · External reference
Regulation of pattern-recognition receptor signaling by HBX during hepatitis B virus infection
10.3389/fimmu.2022.829923 · 2022 · External reference
HBx inhibits DNA sensing signaling pathway via ubiquitination and autophagy of cGAS
10.1186/s12985-022-01785-3 · 2022 · External reference
The HBV web: An insight into molecular interactomes between the hepatitis B virus and its host en route to hepatocellular carcinoma
10.1002/jmv.28436 · 2023 · External reference
HBx-mediated decrease of AIM2 contributes to hepatocellular carcinoma metastasis
10.1002/1878-0261.12090 · 2017 · External reference
Host innate immunity against hepatitis viruses and viral immune evasion
10.3389/fmicb.2021.740464 · 2021 · External reference
Differential activation of NLRP3, AIM2, and IFI16 inflammasomes in humans with acute and chronic hepatitis B
10.1089/vim.2018.0058 · 2018 · External reference
Ubiquitin: A double-edged sword in hepatitis B virus-induced hepatocellular carcinoma
10.1016/j.virol.2024.110199 · 2024 · External reference
HDAC11 restricts HBV replication through epigenetic repression of cccDNA transcription
10.1016/j.antiviral.2019.104619 · 2019 · External reference
Mechanisms of hepatitis B virus cccDNA and minichromosome formation and HBV gene transcription
10.3390/v16040609 · 2024 · External reference
Mechanism of hepatitis B virus cccDNA formation
10.3390/v13081463 · 2021 · External reference
Race between virus and inflammasomes: inhibition or escape, intervention and therapy
10.3389/fcimb.2023.1173505 · 2023 · External reference
Innate and adaptive immune escape mechanisms of hepatitis B virus
10.3389/fcimb.2023.1173505 · 2022 · External reference
The role of AIM2 in inflammation and tumors
10.3389/fimmu.2024.1466440 · 2024 · External reference
IFI16 induces inflammation in hepatitis B virus-associated glomerulonephritis by regulating the caspase-1/ IL-1β pathway
10.1186/s13000-022-01220-9 · 2022 · External reference
IL-17 imbalance promotes the pyroptosis in immune-mediated liver injury through STAT3-IFI16 axis
10.4110/in.2023.23.e46 · 2023 · External reference
Molecular mechanisms and cellular functions of cGAS-STING signalling
10.1038/s41580-020-0244-x · 2020 · External reference
Inflammasome complexes: emerging mechanisms and effector functions
10.1016/j.cell.2016.03.046 · 2016 · External reference
The role of immune regulation in HBV infection and hepatocellular carcinogenesis
10.1016/j.cell.2016.03.046 · 2025 · External reference
Hepatitis B viral load affects prognosis of hepatocellular carcinoma
10.3748/wjg.v20.i34.12039 · 2014 · External reference
Role of AIM2 inflammasome in inflammatory diseases, cancer and infection
10.1002/eji.201848070 · 2019 · External reference
Function and regulation of nuclear DNA sensors during viral infection and tumorigenesis
10.3389/fimmu.2020.624556 · 2020 · External reference
Inflammation-induced cancer: crosstalk between tumours, immune cells and microorganisms
10.1038/nrc3611 · 2013 · External reference
Mechanism and prediction of HCC development in HBV infection
10.1016/j.bpg.2017.04.011 · 2017 · External reference
Overview of the IL-1 family in innate inflammation and acquired immunity
10.1111/imr.12621 · 2018 · External reference
A variety of mouse PYHIN proteins restrict murine and human retroviruses
10.3390/v16040493 · 2024 · External reference
A novel mouse model harboring hepatitis B virus covalently closed circular DNA
10.1016/j.jcmgh.2021.11.011 · 2022 · External reference
Cellular metabolites regulate central nucleic acid sensing pathways
10.3389/fimmu.2021.635738 · 2021 · External reference
DNA sensors in metabolic and cardiovascular diseases: Molecular mechanisms and therapeutic prospects
10.1111/imr.13382 · 2025 · External reference
Lymph node-targeted STING agonist nanovaccine against chronic HBV infection
10.1007/s00018-024-05404-y · 2024 · External reference
Reprogramming the tolerogenic immune response against pancreatic cancer metastases by lipid nanoparticles delivering a STING agonist plus mutant KRAS mRNA
10.1021/acsnano.4c14102 · 2025 · External reference
Treatment of IL-18-binding protein biologics suppresses fibrotic progression in metabolic dysfunction-associated steatohepatitis
10.1016/j.xcrm.2025.102047 · 2025 · External reference
HBx-mediated decrease of AIM2 contributes to hepatocellular carcinoma metastasis
10.1002/1878-0261.12090 · ExternalCitation · doi-reference
Role of AIM2 inflammasome in inflammatory diseases, cancer and infection
10.1002/eji.201848070 · ExternalCitation · doi-reference
Lack of immunological DNA sensing in hepatocytes facilitates hepatitis B virus infection
10.1002/hep.28685 · ExternalCitation · doi-reference
Nuclear sensor interferon-inducible protein 16 inhibits the function of hepatitis B virus covalently closed circular DNA by integrating innate immune activation and epigenetic suppression
10.1002/hep.30897 · ExternalCitation · doi-reference
Regulation and specificity of MNDA expression in monocytes, macrophages, and leukemia/B lymphoma cell lines
10.1002/jcb.240560417 · ExternalCitation · doi-reference
The HBV web: An insight into molecular interactomes between the hepatitis B virus and its host en route to hepatocellular carcinoma
10.1002/jmv.28436 · ExternalCitation · doi-reference
Lymph node-targeted STING agonist nanovaccine against chronic HBV infection
10.1007/s00018-024-05404-y · ExternalCitation · doi-reference
Purification, characterization and docking studies of the HIN domain of human myeloid nuclear differentiation antigen (MNDA)
10.1007/s10529-013-1432-y · ExternalCitation · doi-reference
Short-lived AIM2 inflammasome activation relates to chronic MCMV infection in BALB/c mice
10.1007/s11596-019-2121-4 · ExternalCitation · doi-reference
HDAC11 restricts HBV replication through epigenetic repression of cccDNA transcription
10.1016/j.antiviral.2019.104619 · ExternalCitation · doi-reference
The emerging role of human PYHIN proteins in innate immunity: implications for health and disease
10.1016/j.bcp.2014.08.031 · ExternalCitation · doi-reference
Mechanism and prediction of HCC development in HBV infection
10.1016/j.bpg.2017.04.011 · ExternalCitation · doi-reference
The role of immune regulation in HBV infection and hepatocellular carcinogenesis
10.1016/j.cell.2016.03.046 · ExternalCitation · doi-reference
STING-mediated IFI16 degradation negatively controls type I interferon production
10.1016/j.celrep.2019.09.069 · ExternalCitation · doi-reference
IFI16 targets the transcription factor sp1 to suppress HIV-1 transcription and latency reactivation
10.1016/j.chom.2019.05.002 · ExternalCitation · doi-reference
Correlation of AIM2 expression in peripheral blood mononuclear cells from humans with acute and chronic hepatitis B
10.1016/j.humimm.2013.01.022 · ExternalCitation · doi-reference
Structural mechanism of dsDNA recognition by the hMNDA HIN domain: New insights into the DNA-binding model of a PYHIN protein
10.1016/j.ijbiomac.2023.125461 · ExternalCitation · doi-reference
A novel mouse model harboring hepatitis B virus covalently closed circular DNA
10.1016/j.jcmgh.2021.11.011 · ExternalCitation · doi-reference
The role of innate immunity in the immunopathology and treatment of HBV infection
10.1016/j.jhep.2016.01.028 · ExternalCitation · doi-reference
Mechanisms of HBV-induced hepatocellular carcinoma
10.1016/j.jhep.2016.02.021 · ExternalCitation · doi-reference
Ubiquitin: A double-edged sword in hepatitis B virus-induced hepatocellular carcinoma
10.1016/j.virol.2024.110199 · ExternalCitation · doi-reference
Classifying hepatitis B therapies with insights from covalently closed circular DNA dynamics
10.1016/j.virs.2023.12.005 · ExternalCitation · doi-reference
Treatment of IL-18-binding protein biologics suppresses fibrotic progression in metabolic dysfunction-associated steatohepatitis
10.1016/j.xcrm.2025.102047 · ExternalCitation · doi-reference
WHO's 2024 global hepatitis report
10.1016/s1473-3099(24)00307-4 · ExternalCitation · doi-reference
A global scientific strategy to cure hepatitis B
10.1016/s2468-1253(19)30119-0 · ExternalCitation · doi-reference
The burden of chronic hepatitis B and C in 2022 and progress towards elimination: a global report
10.1016/s2468-1253(25)00375-9 · ExternalCitation · doi-reference
Reprogramming the tolerogenic immune response against pancreatic cancer metastases by lipid nanoparticles delivering a STING agonist plus mutant KRAS mRNA
10.1021/acsnano.4c14102 · ExternalCitation · doi-reference
AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC
10.1038/nature07725 · ExternalCitation · doi-reference
IFI16 is required for DNA sensing in human macrophages by promoting production and function of cGAMP
10.1038/ncomms14391 · ExternalCitation · doi-reference
IFI16 is an innate immune sensor for intracellular DNA
10.1038/ni.1932 · ExternalCitation · doi-reference
Inflammation-induced cancer: crosstalk between tumours, immune cells and microorganisms
10.1038/nrc3611 · ExternalCitation · doi-reference
Recent advances in the mechanisms of NLRP3 inflammasome activation and its inhibitors
10.1038/s41419-019-1413-8 · ExternalCitation · doi-reference
Myeloid cell nuclear differentiation antigen controls the pathogen-stimulated type I interferon cascade in human monocytes by transcriptional regulation of IRF7
10.1038/s41467-021-27701-x · ExternalCitation · doi-reference
DNA sensing by the cGAS-STING pathway in health and disease
10.1038/s41576-019-0151-1 · ExternalCitation · doi-reference
Molecular mechanisms and cellular functions of cGAS-STING signalling
10.1038/s41580-020-0244-x · ExternalCitation · doi-reference
Poxvirus dsDNA genomes differentially activate AIM2 or NLRP3 inflammasomes in human primary cells
10.1038/s44318-025-00690-z · ExternalCitation · doi-reference
Cloning a novel member of the human interferon-inducible gene family associated with control of tumorigenicity in a model of human melanoma
10.1038/sj.onc.1201206 · ExternalCitation · doi-reference
cGAS-mediated stabilization of IFI16 promotes innate signaling during herpes simplex virus infection
10.1073/pnas.1424637112 · ExternalCitation · doi-reference
AIM2 sensors mediate immunity to Plasmodium infection in hepatocytes
10.1073/pnas.2210181120 · ExternalCitation · doi-reference
Pristimerin suppresses AIM2 inflammasome by modulating AIM2-PYCARD/ASC stability via selective autophagy to alleviate tendinopathy
10.1080/15548627.2023.2249392 · ExternalCitation · doi-reference
IFI16 positively regulates RIG-I-mediated type I interferon production in a STING-independent manner
10.1089/dna.2023.0362 · ExternalCitation · doi-reference
Differential activation of NLRP3, AIM2, and IFI16 inflammasomes in humans with acute and chronic hepatitis B
10.1089/vim.2018.0058 · ExternalCitation · doi-reference
New insights into the structural basis of DNA recognition by HINa and HINb domains of IFI16
10.1093/jmcb/mjv053 · ExternalCitation · doi-reference
The nucleic acid-sensing inflammasomes
10.1111/imr.12281 · ExternalCitation · doi-reference
Overview of the IL-1 family in innate inflammation and acquired immunity
10.1111/imr.12621 · ExternalCitation · doi-reference
Nuclear innate sensors for nucleic acids in immunity and inflammation
10.1111/imr.12893 · ExternalCitation · doi-reference
DNA sensors in metabolic and cardiovascular diseases: Molecular mechanisms and therapeutic prospects
10.1111/imr.13382 · ExternalCitation · doi-reference
The PYHIN protein family as mediators of host defenses
10.1111/j.1600-065x.2011.01053.x · ExternalCitation · doi-reference
Specific and nonhepatotoxic degradation of nuclear hepatitis B virus cccDNA
10.1126/science.1243462 · ExternalCitation · doi-reference
Viral DNA sensors IFI16 and cyclic GMP-AMP synthase possess distinct functions in regulating viral gene expression, immune defenses, and apoptotic responses during herpesvirus infection
10.1128/mbio.01553-16 · ExternalCitation · doi-reference
The nuclear DNA sensor IFI16 indiscriminately binds to and diminishes accessibility of the HSV-1 genome to suppress infection
10.1128/msystems.00198-22 · ExternalCitation · doi-reference
The DNA sensor IFIX drives proteome alterations to mobilize nuclear and cytoplasmic antiviral responses, with its acetylation acting as a localization toggle
10.1128/msystems.00397-21 · ExternalCitation · doi-reference
Innate and adaptive immune responses in chronic hepatitis B virus infections: towards restoration of immune control of viral infection
10.1136/postgradmedj-2011-301073rep · ExternalCitation · doi-reference
IFN-α inhibits HBV transcription and replication in cell culture and in humanized mice by targeting the epigenetic regulation of the nuclear cccDNA minichromosome
10.1172/jci58847 · ExternalCitation · doi-reference
The human myeloid cell nuclear differentiation antigen gene is one of at least two related interferon-inducible genes located on chromosome 1q that are expressed specifically in hematopoietic cells
10.1182/blood.v83.8.2153.2153 · ExternalCitation · doi-reference
IFI16 is involved in HBV-associated acute-on-chronic liver failure inflammation
10.1186/s12876-018-0791-1 · ExternalCitation · doi-reference
Expression of AIM2 is correlated with increased inflammation in chronic hepatitis B patients
10.1186/s12985-015-0360-y · ExternalCitation · doi-reference
HBx inhibits DNA sensing signaling pathway via ubiquitination and autophagy of cGAS
10.1186/s12985-022-01785-3 · ExternalCitation · doi-reference
Mechanisms underlying the compromised clinical efficacy of interferon in clearing HBV
10.1186/s12985-024-02589-3 · ExternalCitation · doi-reference
IFI16 induces inflammation in hepatitis B virus-associated glomerulonephritis by regulating the caspase-1/ IL-1β pathway
10.1186/s13000-022-01220-9 · ExternalCitation · doi-reference
Reconstruction of monocyte transcriptional regulatory network accompanies monocytic functions in human fibroblasts
10.1371/journal.pone.0033474 · ExternalCitation · doi-reference
Herpesvirus genome recognition induced acetylation of nuclear IFI16 is essential for its cytoplasmic translocation, inflammasome and IFN-β responses
10.1371/journal.ppat.1005019 · ExternalCitation · doi-reference
Nuclear PYHIN proteins target the host transcription factor Sp1 thereby restricting HIV-1 in human macrophages and CD4+ T cells
10.1371/journal.ppat.1008752 · ExternalCitation · doi-reference
The functional interactome of PYHIN immune regulators reveals IFIX is a sensor of viral DNA
10.15252/msb.20145808 · ExternalCitation · doi-reference
Innate and adaptive immune escape mechanisms of hepatitis B virus
10.3389/fcimb.2023.1173505 · ExternalCitation · doi-reference
Function and regulation of nuclear DNA sensors during viral infection and tumorigenesis
10.3389/fimmu.2020.624556 · ExternalCitation · doi-reference
Cellular metabolites regulate central nucleic acid sensing pathways
10.3389/fimmu.2021.635738 · ExternalCitation · doi-reference
Regulation of pattern-recognition receptor signaling by HBX during hepatitis B virus infection
10.3389/fimmu.2022.829923 · ExternalCitation · doi-reference
MNDA, a PYHIN factor involved in transcriptional regulation and apoptosis control in leukocytes
10.3389/fimmu.2024.1395035 · ExternalCitation · doi-reference
The role of AIM2 in inflammation and tumors
10.3389/fimmu.2024.1466440 · ExternalCitation · doi-reference
The dual roles of human PYHIN family proteins in cancer: mechanisms and therapeutic implications
10.3389/fimmu.2025.1576674 · ExternalCitation · doi-reference
Innate immune recognition and evasion strategies of hepatitis B virus: from DNA to RNA and viral proteins
10.3389/fimmu.2026.1741620 · ExternalCitation · doi-reference
Host innate immunity against hepatitis viruses and viral immune evasion
10.3389/fmicb.2021.740464 · ExternalCitation · doi-reference
PYHIN proteins and HPV: role in the pathogenesis of head and neck squamous cell carcinoma
10.3390/microorganisms8010014 · ExternalCitation · doi-reference
Targeting HBV cccDNA levels: key to achieving complete cure of chronic hepatitis B
10.3390/pathogens13121100 · ExternalCitation · doi-reference
Emerging role of PYHIN proteins as antiviral restriction factors
10.3390/v12121464 · ExternalCitation · doi-reference
Mechanism of hepatitis B virus cccDNA formation
10.3390/v13081463 · ExternalCitation · doi-reference
Current status and challenges in anti-hepatitis B virus agents based on inactivation/inhibition or elimination of hepatitis B virus covalently closed circular DNA
10.3390/v15122315 · ExternalCitation · doi-reference
A variety of mouse PYHIN proteins restrict murine and human retroviruses
10.3390/v16040493 · ExternalCitation · doi-reference
Mechanisms of hepatitis B virus cccDNA and minichromosome formation and HBV gene transcription
10.3390/v16040609 · ExternalCitation · doi-reference
Intracellular host restriction of hepatitis B virus replication
10.3390/v16050764 · ExternalCitation · doi-reference
Hepatitis B viral load affects prognosis of hepatocellular carcinoma
10.3748/wjg.v20.i34.12039 · ExternalCitation · doi-reference
IL-17 imbalance promotes the pyroptosis in immune-mediated liver injury through STAT3-IFI16 axis
10.4110/in.2023.23.e46 · ExternalCitation · doi-reference
