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IRF1-mediated upregulation of PARP12 promotes cartilage degradation by inhibiting PINK1/Parkin dependent mitophagy through ISG15 attenuating ubiquitylation and SUMOylation of MFN1/2

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IL-10 alleviates ulcerative colitis by regulating mitochondrial function through reducing ISG15 expression

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ISGylation of DRP1 closely balances other post-translational modifications to mediate mitochondrial fission

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ISG15 dysregulates endoplasmic reticulum-mitochondrial contacts and calcium homeostasis in Ataxia telangiectasia

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ISG15 blocks cardiac glycolysis and ensures sufficient mitochondrial energy production during Coxsackievirus B3 infection

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Impaired peripheral blood mononuclear cell (PBMC) mitochondrial respiration is associated with mortality and long COVID syndrome severity in COVID-19 patients

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DRD4 alleviates acute kidney injury by suppressing ISG15/NOX4 axis-associated oxidative stress

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ISG15 deficiency features a complex cellular phenotype that responds to treatment with itaconate and derivatives

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ISG15 inhibits cancer cell growth and promotes apoptosis

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SARS-CoV-2 S, M, and E structural glycoproteins differentially modulate endoplasmic reticulum stress responses

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Leishmania Braziliensis infection induces dendritic cell activation, ISG15 transcription, and the generation of protective immune responses

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Type I interferon imposes a TSG101/ISG15 checkpoint at the Golgi for glycoprotein trafficking during influenza virus infection

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Human N-Alpha-Acetyltransferase 60 promotes influenza A virus infection by dampening the interferon alpha signaling

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ISGylation of zebrafish STING at lysines 221 and 276 activates innate immunity

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Induced TRIM21 ISGylation by IFN-β enhances p62 ubiquitination to prevent its autophagosome targeting

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Microglial NLRC5 drives lysosomal dysfunction to disrupt autophagic flux and promote post-stroke neuroinflammation

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PRRSV nonstructural protein 11 degrades swine ISG15 by its endoribonuclease activity to antagonize antiviral immune response

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The papain-like protease of coronaviruses cleaves ULK1 to disrupt host autophagy

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ISGylation controls exosome secretion by promoting lysosomal degradation of MVB proteins

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ISG15 mediates the function of extracellular vesicles in promoting ovarian cancer progression and metastasis

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The effect of the WKYMVm peptide on promoting mBMSC secretion of exosomes to induce M2 macrophage polarization through the FPR2 pathway

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Peroxiredoxin II regulates exosome secretion from dermal mesenchymal stem cells through the ISGylation signaling pathway

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Type I IFN is siloed in endosomes

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SARS-CoV-2 spike receptor-binding domain is internalized and promotes protein ISGylation in human induced pluripotent stem cell-derived cardiomyocytes

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Evidence for an involvement of the ubiquitin-like modifier ISG15 in MHC class I antigen presentation

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Bioinformatics analysis and identification of genes and molecular pathways involved in venous thromboembolism (VTE)

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Bioinformatics analyses of significant genes, related pathways, and candidate diagnostic biomarkers and molecular targets in SARS-CoV-2/COVID-19

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ISG15 modification of the eIF4E cognate 4EHP enhances cap structure-binding activity of 4EHP

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RNA-dependent RNA polymerase of SARS-CoV-2 regulate host mRNA translation efficiency by hijacking eEF1A factors

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Epigenetic downregulation of the ISG15-conjugating enzyme UbcH8 impairs lipolysis and correlates with poor prognosis in nasopharyngeal carcinoma

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Ring finger protein 213 assembles into a sensor for ISGylated proteins with antimicrobial activity

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Hexokinase 2 promotes ISGylation of Acyl-CoA synthetase long-chain family member 4 in sepsis-induced microglia cells

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Interferon-linked lipid and bile acid imbalance uncovered in ankylosing spondylitis in a sibling-controlled multi-omics study

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Design of a SARS-CoV-2 papain-like protease inhibitor with antiviral efficacy in a mouse model

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