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References from Integrative computational approach to elucidate the efficacy of cordyceps in managing lupus nephritis: from molecular targets to clinical applications. Local targets link to admitted publications; unresolved targets remain external evidence.
Chronic kidney disease and the global public health agenda: an international consensus
10.1038/s41581-024-00820-6 · 2024 · External reference
Advances and challenges in kidney fibrosis therapeutics
10.1038/s41581-025-00934-5 · 2025 · External reference
Crosstalk between glomeruli and tubules
10.1038/s41581-024-00907-0 · 2025 · External reference
Kidney immunology from pathophysiology to clinical translation
10.1038/s41577-025-01131-y · 2025 · External reference
Systemic lupus erythematosus: a review
10.1001/jama.2024.2315 · 2024 · External reference
Pathogenic cellular and molecular mediators in lupus nephritis
10.1038/s41581-023-00722-z · 2023 · External reference
Lupus nephritis-related chronic kidney disease
10.1038/s41584-024-01158-w · 2024 · External reference
The role of complement in kidney disease
10.1038/s41581-023-00766-1 · 2023 · External reference
Fungi as a source of bioactive molecules for the development of longevity medicines
10.1016/j.arr.2023.101929 · 2023 · External reference
The genus Cordyceps: a chemical and pharmacological review
10.1111/j.2042-7158.2012.01601.x · 2013 · External reference
Bioactive compounds from Cordyceps and their therapeutic potential
10.1080/07388551.2023.2231139 · 2024 · External reference
Efficacy of a pure compound H1-A extracted from cordyceps sinensis on autoimmune disease of MRL lpr/lpr mice
10.1016/s0022-2143(99)90171-3 · 1999 · External reference
Cordyceps proteins alleviate lupus nephritis through modulation of the STAT3/mTOR/NF-кB signaling pathway
10.1016/j.jep.2023.116284 · 2023 · External reference
Cordyceps cicadae ameliorates inflammatory responses, oxidative stress, and fibrosis by targeting the PI3K/mTOR-mediated autophagy pathway in the renal of MRL/lpr mice
10.1002/iid3.1168 · 2024 · External reference
TCMSP: a database of systems pharmacology for drug discovery from herbal medicines
10.1186/1758-2946-6-13 · 2014 · External reference
Pubchem in 2021: new data content and improved web interfaces
10.1093/nar/gkaa971 · 2021 · External reference
Pharmmapper server: a web server for potential drug target identification using pharmacophore mapping approach
10.1093/nar/gkq300 · 2010 · External reference
Enhancing the enrichment of pharmacophore-based target prediction for the polypharmacological profiles of drugs
10.1021/acs.jcim.5b00690 · 2016 · External reference
Pharmmapper 2017 update: a web server for potential drug target identification with a comprehensive target pharmacophore database
10.1093/nar/gkx374 · 2017 · External reference
UniProt: the Universal Protein Knowledgebase in 2023
10.1093/nar/gkac1052 · 2023 · External reference
Genecards: integrating information about genes, proteins and diseases
10.1016/s0168-9525(97)01103-7 · 1997 · External reference
OMIM.Org: online Mendelian inheritance in man (OMIM®), an online catalog of human genes and genetic disorders
10.1093/nar/gku1205 · 2015 · External reference
DisGeNET: a comprehensive platform integrating information on human disease-associated genes and variants
10.1093/nar/gkw943 · 2017 · External reference
TTD: therapeutic target database describing target druggability information
10.1093/nar/gkad751 · 2024 · External reference
DAVID: a web server for functional enrichment analysis and functional annotation of gene lists (2021 update)
10.1093/nar/gkac194 · 2022 · External reference
RCSB Protein data bank: biological macromolecular structures enabling research and education in fundamental biology, biomedicine, biotechnology and energy
10.1093/nar/gky1004 · 2019 · External reference
Derivation and validation of the systemic lupus international collaborating clinics classification criteria for systemic lupus erythematosus
10.1002/art.34473 · 2012 · External reference
KDIGO 2024 Clinical practice guideline for the management of LUPUS NEPHRITIS
10.1016/j.kint.2023.09.002 · 2024 · External reference
Efficacy and safety of obinutuzumab in active lupus nephritis
10.1056/nejmoa2410965 · 2025 · External reference
Comparison of protective effects between cultured Cordyceps militaris and natural Cordyceps sinensis against oxidative damage
10.1021/jf053111w · 2006 · External reference
Cordycepin from cordyceps militaris ameliorates diabetic nephropathy via the miR-193b-5p/MCL-1 axis
10.1186/s13020-023-00842-5 · 2023 · External reference
Cordyceps cicadae mycelia ameliorate cisplatin-induced acute kidney injury by suppressing the TLR4/NF-κB/MAPK and activating the HO-1/Nrf2 and sirt-1/AMPK pathways in mice
10.1155/2020/7912763 · 2020 · External reference
Cordyceps sinensis extract protects against acute kidney injury by inhibiting perforin expression in NK cells via the STING/IRF3 pathway
10.18632/aging.205676 · 2024 · External reference
Down-regulation of apoptotic and inflammatory genes by cordyceps Sinensis extract in rat kidney following ischemia/reperfusion
10.1016/s0041-1345(01)02282-5 · 2001 · External reference
Cordyceps sinensis decreases TGF-β1 dependent epithelial to mesenchymal transdifferentiation and attenuates renal fibrosis
10.1016/j.foodhyd.2011.12.016 · 2012 · External reference
Protective effect of Cordyceps sinensis against acute and chronic cyclosporin A-induced nephrotoxicity
1993 · External reference
Cordyceps cicadae ameliorates renal hypertensive injury and fibrosis through the regulation of SIRT1-mediated autophagy
10.3389/fphar.2021.801094 · 2021 · External reference
Mammalian MAPK signal transduction pathways activated by stress and inflammation: a 10-year update
10.1152/physrev.00028.2011 · 2012 · External reference
Extracellular signal-regulated kinase: a regulator of cell growth, inflammation, chondrocyte and bone cell receptor-mediated gene expression
10.3390/ijms20153792 · 2019 · External reference
Mitogen-activated protein kinases and hypoxic/ischemic nephropathy
10.1159/000447812 · 2016 · External reference
Renalase prevents AKI independent of amine oxidase activity
10.1681/asn.2013060665 · 2014 · External reference
Effect of glucose on stress-activated protein kinase activity in mesangial cells and diabetic glomeruli
10.1046/j.1523-1755.1999.00488.x · 1999 · External reference
MAPK1 mediates MAM disruption and mitochondrial dysfunction in diabetic kidney disease via the PACS-2-dependent mechanism
10.7150/ijbs.89291 · 2024 · External reference
Modulation of renal epithelial barrier function by mitogen-activated protein kinases (MAPKs): mechanism of cyclosporine A-induced increase in transepithelial resistance
10.1046/j.1523-1755.2003.00804.x · 2003 · External reference
Tumor necrosis factor-like weak inducer of apoptosis (TWEAK) mediates p38 mitogen-activated protein kinase activation and signal transduction in peripheral blood mononuclear cells from patients with lupus nephritis
10.1007/s10753-011-9396-3 · 2012 · External reference
Regulated expression of complement factor B in the human kidney
10.1038/ki.1996.344 · 1996 · External reference
Local extrahepatic expression of complement genes C3, factor B, C2, and C4 is increased in murine lupus nephritis
10.1172/jci113780 · 1988 · External reference
Advances in immunology: complement (first of two parts)
10.1056/nejm200104053441406 · 2001 · External reference
Advances in immunology: complement (second of two parts)
10.1056/nejm200104123441506 · 2001 · External reference
Decipher the immunopathological mechanisms and set up potential therapeutic strategies for patients with lupus nephritis
10.3390/ijms241210066 · 2023 · External reference
Modulation of renal disease in MRL/lpr mice genetically deficient in the alternative complement pathway factor B
10.4049/jimmunol.164.2.786 · 2000 · External reference
Initiation of complement activation
10.1007/bf01893018 · 1984 · External reference
Complement factor B inhibitor LNP023 improves lupus nephritis in MRL/lpr mice
10.1016/j.biopha.2022.113433 · 2022 · External reference
MrgD as a novel modeling and treatment target for pulmonary hypertension
10.1161/atvbaha.124.322337 · 2025 · External reference
Injectable BMSC-based extracellular matrix-mimicking microtissue for myocardial infarction repair
10.1002/advs.202500299 · 2026 · External reference
Total panax notoginseng saponins treats diabetic kidney disease in mice by regulating the TXNIP/NLRP3 signaling pathway
10.1016/j.ctmp.2025.200245 · 2025 · External reference
Oxidative stress and inflammation are mediated via aryl hydrocarbon receptor signalling in idiopathic membranous nephropathy
10.1016/j.freeradbiomed.2023.07.014 · 2023 · External reference
YY1/HIF-1α/mROS positive-feedback loop exacerbates glomerular mesangial cell proliferation in mouse early diabetic kidney disease
10.1038/s41401-025-01498-7 · 2025 · External reference
Sirtuin 6 protects against podocyte injury by blocking the renin-angiotensin system by inhibiting the Wnt1/β-catenin pathway
10.1038/s41401-023-01148-w · 2024 · External reference
SKP Alleviates the ferroptosis in diabetic kidney disease through suppression of HIF-1α/HO-1 pathway based on network pharmacology analysis and experimental validation
10.1186/s13020-024-00901-5 · 2024 · External reference
Cardiorenal syndrome: clinical diagnosis, molecular mechanisms and therapeutic strategies
10.1038/s41401-025-01476-z · 2025 · External reference
Renal fibrosis is induced by hyperactive Wnt/β-catenin pathway via microbial-mediated tryptophan metabolism-driven AhR signaling in rodents and humans
10.1007/s00018-026-06176-3 · 2026 · External reference
Managing lupus nephritis in children and adolescents
10.1007/s40272-023-00609-3 · 2024 · External reference
Renal relapse in children and adolescents with childhood-onset lupus nephritis: a 20-year study
10.1093/rheumatology/kead447 · 2024 · External reference