Research graph
References from Elevated ALT correlates with severe liver injury, monocyte infiltration, and Pro-inflammatory immune dysregulation in chronic hepatitis B virus infection. Local targets link to admitted publications; unresolved targets remain external evidence.
Hepatitis B virus infection
10.1038/nrdp.2018.35 · 2018 · External reference
Hepatitis B virus infection: overview
10.1007/978-981-13-9151-4_1 · 2020 · External reference
Global, regional, and national burden of hepatitis B, 1990–2019: a systematic analysis for the global burden of disease study 2019
10.1016/s2468-1253(22)00124-8 · 2022 · External reference
Fibrosis assessment in patients with chronic hepatitis B virus (HBV) infection
10.21037/atm.2017.01.28 · 2017 · External reference
Management of HBV and HBV/HDV-associated liver cirrhosis
10.1159/000445518 · 2016 · External reference
Hepatitis B-induced hepatocellular carcinoma: understanding viral carcinogenesis and disease management
10.3390/jcm14072505 · 2025 · External reference
Serum activity of alanine aminotransferase (ALT) as an indicator of health and disease
10.1002/hep.22109 · 2008 · External reference
Patients with chronic hepatitis B who have persistently normal alanine aminotransferase or aged < 30 years may exhibit significant histologic damage
10.1186/s12876-024-03208-9 · 2024 · External reference
2024 Latest report on hepatitis B virus epidemiology in China: current status, changing trajectory, and challenges
10.21037/hbsn-2024-754 · 2025 · External reference
Hyper-activated pro-inflammatory CD16 monocytes correlate with the severity of liver injury and fibrosis in patients with chronic hepatitis B
10.1371/journal.pone.0017484 · 2011 · External reference
Increase of infiltrating monocytes in the livers of patients with chronic liver diseases
2016 · External reference
Characterization of the liver immune microenvironment in liver biopsies from patients with chronic HBV infection
10.1016/j.jhepr.2021.100388 · 2022 · External reference
Highly multiplexed 2-dimensional imaging mass cytometry analysis of HBV-infected liver
10.1172/jci.insight.146883 · 2021 · External reference
Single-cell profiling reveals monocyte heterogeneity and association with liver fibrosis in patients with chronic HBV
10.1097/hc9.0000000000000672 · 2025 · External reference
Single-cell multimodal analysis reveals the dynamic immunopathogenesis of HBV-ACLF progression
10.1136/gutjnl-2024-333308 · 2026 · External reference
Virus-associated inflammation imprints an inflammatory profile on monocyte-derived macrophages in the human liver
10.1172/jci175241 · 2025 · External reference
Wnt signaling regulates chemokine production and cell migration of circulating human monocytes
10.1186/s12964-024-01608-8 · 2024 · External reference
The role of inflammation in the pathogenesis of viral respiratory infections
10.3390/microorganisms12122526 · 2024 · External reference
Immune response in hepatitis B virus infection
10.1101/cshperspect.a021428 · 2015 · External reference
Innate immune recognition in hepatitis B virus infection
10.1080/21505594.2025.2492371 · 2025 · External reference
Immune response and treatment targets of chronic hepatitis B virus infection: innate and adaptive immunity
10.3389/fcimb.2023.1206720 · 2023 · External reference
HBV DNA integration and clonal hepatocyte expansion in chronic hepatitis B patients considered immune tolerant
10.1053/j.gastro.2016.07.012 · 2016 · External reference
Wnt/β-catenin signalling: function, biological mechanisms, and therapeutic opportunities
10.1038/s41392-021-00762-6 · 2022 · External reference
Wnt-β-catenin signalling in liver development, health and disease
10.1038/s41575-018-0075-9 · 2019 · External reference
Advances and challenges in molecular understanding, early detection, and targeted treatment of liver cancer
10.4254/wjh.v17.i1.102273 · 2025 · External reference
Xcell: digitally portraying the tissue cellular heterogeneity landscape
10.1186/s13059-017-1349-1 · 2017 · External reference
Cell-Type enrichment analysis of bulk transcriptomes using xCell
10.1007/978-1-0716-0327-7_19 · 2020 · External reference
Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles
10.1073/pnas.0506580102 · 2005 · External reference
Identification of tumor mutation burden-related hub genes and the underlying mechanism in melanoma
10.7150/jca.53697 · 2021 · External reference
The current state of serum biomarkers of hepatotoxicity
10.1016/j.tox.2007.11.021 · 2008 · External reference
AASLD Guidelines for treatment of chronic hepatitis B
10.1002/hep.28156 · 2016 · External reference
Diagnosis and management of chronic hepatitis B in children, young people, and adults: summary of NICE guidance
10.1136/bmj.f3893 · 2013 · External reference
East Asia expert opinion on treatment initiation for chronic hepatitis B
10.1111/apt.16097 · 2020 · External reference
Characterization of gene expression profiles in HBV-related liver fibrosis patients and identification of ITGBL1 as a key regulator of fibrogenesis
10.1038/srep43446 · 2017 · External reference
Monocytes and macrophages as viral targets and reservoirs
10.3390/ijms19092821 · 2018 · External reference
Monocyte and macrophage differentiation: circulation inflammatory monocyte as biomarker for inflammatory diseases
10.1186/2050-7771-2-1 · 2014 · External reference
Monocyte dysregulation: consequences for hepatic infections
10.1007/s00281-021-00852-1 · 2021 · External reference
Monocytes and macrophages as unique cellular compartments governing non-alcoholic fatty liver disease and inflammation
10.18502/ajmb.v17i2.18560 · 2025 · External reference
IL-4 treatment induces apoptosis of blood monocytes and proliferation of recruited injury-associated macrophages to resolve liver injury
10.1016/j.celrep.2026.117136 · 2026 · External reference
Wnt signaling pathway: a comprehensive review
10.1002/cbin.11797 · 2022 · External reference
Wnt/-catenin signaling and disease
10.1016/j.cell.2012.05.012 · 2012 · External reference
The innate immune response to hepatitis B virus infection: implications for pathogenesis and therapy
10.1016/j.antiviral.2012.10.001 · 2012 · External reference
The interaction of innate immune and adaptive immune system
10.1002/mco2.714 · 2024 · External reference
Infiltrating monocytes in liver injury and repair
10.1038/cti.2016.62 · 2016 · External reference
Dysregulation in the microbiota by HBV and HCV infection induces an altered cytokine profile in the pathobiome of infection
10.1016/j.bjid.2024.104468 · 2025 · External reference
Role of persistent necroinflammation in chronic tissue remodeling and organ fibrosis
10.1152/ajpcell.00416.2025 · 2026 · External reference
