References

Janus-faced: Molecular mechanisms and versatile nature of renal fibrosis

10.34067/kid.0001972020 · 2020 · External reference

Kidney fibrosis: from mechanisms to therapeutic medicines

10.1038/s41392-023-01379-7 · 2023 · External reference

Single-cell multi-omic and spatial profiling of human kidneys implicates the fibrotic microenvironment in kidney disease progression

10.1038/s41588-024-01802-x · 2024 · External reference

Single-cell transcriptomics reveals common epithelial response patterns in human acute kidney injury

10.1186/s13073-022-01108-9 · 2022 · External reference

cGAS-STING signaling pathway promotes hypoxia-induced renal fibrosis by regulating PFKFB3-mediated glycolysis

10.1016/j.freeradbiomed.2023.09.011 · 2023 · External reference

PTEN-induced kinase 1 is associated with renal aging, via the cGAS-STING pathway

10.1111/acel.13865 · 2023 · External reference

The pseudokinase MLKL mediates necroptosis via a molecular switch mechanism

10.1016/j.immuni.2013.06.018 · 2013 · External reference

Human RIPK3 maintains MLKL in an inactive conformation prior to cell death by necroptosis

10.1038/s41467-021-27032-x · 2021 · External reference

MLKL trafficking and accumulation at the plasma membrane control the kinetics and threshold for necroptosis

10.1038/s41467-020-16887-1 · 2020 · External reference

RIPK3-MLKL-mediated necroinflammation contributes to AKI progression to CKD

10.1038/s41419-018-0936-8 · 2018 · External reference

RIPK3-mediated necroptosis and apoptosis contributes to renal tubular cell progressive loss and chronic kidney disease progression in rats

10.1371/journal.pone.0156729 · 2016 · External reference

Nephropathy is aggravated by fatty acids in diabetic kidney disease through tubular epithelial cell necroptosis and is alleviated by an RIPK-1 inhibitor

10.1159/000529995 · 2023 · External reference

Inhibition of RIPK1 or RIPK3 kinase activity post ischemia-reperfusion reduces the development of chronic kidney injury

10.1042/bcj20240569 · 2025 · External reference

RIPK3 causes mitochondrial dysfunction and albuminuria in diabetic podocytopathy through PGAM5-Drp1 signaling

10.1016/j.metabol.2024.155982 · 2024 · External reference

MLKL: functions beyond serving as the executioner of necroptosis

10.7150/thno.54072 · 2021 · External reference

RIP3 translocation into mitochondria promotes Mitofilin degradation to increase inflammation and kidney injury after renal ischemia-reperfusion

10.3390/cells11121894 · 2022 · External reference

Priming of dendritic cells by DNA-containing extracellular vesicles from activated T cells through antigen-driven contacts

10.1038/s41467-018-05077-9 · 2018 · External reference

Cell intrinsic immunity spreads to bystander cells via the intercellular transfer of cGAMP

10.1038/nature12640 · 2013 · External reference

Exosomes shuttle TREX1-sensitive IFN-stimulatory dsDNA from irradiated cancer cells to DCs

10.1158/2326-6066.cir-17-0581 · 2018 · External reference

The inhibitory receptor TIM-3 limits activation of the cGAS-STING pathway in intra-tumoral dendritic cells by suppressing extracellular DNA uptake

10.1016/j.immuni.2021.04.019 · 2021 · External reference

Hallmarks of aging: an expanding universe

10.1016/j.cell.2022.11.001 · 2023 · External reference

Mitochondria know no boundaries: mechanisms and functions of intercellular mitochondrial transfer

10.3389/fcell.2016.00107 · 2016 · External reference

Interleukin-1beta induces mtDNA release to activate innate immune signaling via cGAS-STING

10.1016/j.molcel.2019.02.038 · 2019 · External reference

Cellular senescence in renal ischemia-reperfusion injury

10.1097/cm9.0000000000003698 · 2025 · External reference

Defective mitophagy in aged macrophages promotes mitochondrial DNA cytosolic leakage to activate STING signaling during liver sterile inflammation

10.1111/acel.13622 · 2022 · External reference

Cytoplasmic chromatin triggers inflammation in senescence and cancer

10.1038/nature24050 · 2017 · External reference

Activation of cGAS-STING signaling in senescent cells promotes the aging process by remodeling the functions of the immune system

10.1007/s10522-025-10353-5 · 2025 · External reference

DNA damage in proximal tubules triggers systemic metabolic dysfunction through epigenetically altered macrophages

10.1038/s41467-025-59297-x · 2025 · External reference

PFKFB3-mediated glycolysis boosts fibroblast activation and subsequent kidney fibrosis

10.3390/cells12162081 · 2023 · External reference

Myeloid PFKFB3-mediated glycolysis promotes kidney fibrosis

10.3389/fimmu.2023.1259434 · 2023 · External reference

The glycolytic enzyme PFKFB3 drives kidney fibrosis through promoting histone lactylation-mediated NF-kappaB family activation

10.1016/j.kint.2024.04.016 · 2024 · External reference

Increased SUMO-activating enzyme subunit 1 promotes glycolysis and fibrotic phenotype of diabetic nephropathy

10.1016/j.bcp.2025.116920 · 2025 · External reference

Metabolic reprogramming and renal fibrosis

10.3389/fmed.2021.746920 · 2021 · External reference

Metabolism at the crossroads of inflammation and fibrosis in chronic kidney disease

10.1038/s41581-024-00889-z · 2025 · External reference

The nuclear factor kappa B signaling pathway is a master regulator of renal fibrosis

10.3389/fphar.2023.1335094 · 2023 · External reference

NF-kappaB in renal inflammation

10.1681/asn.2010020218 · 2010 · External reference

Control of the senescence-associated secretory phenotype by NF-kappaB promotes senescence and enhances chemosensitivity

10.1101/gad.17276711 · 2011 · External reference

Exosomal CMTM4 induces immunosuppressive macrophages to promote ovarian Cancer progression and attenuate anti-PD-1 immunotherapy

10.1002/advs.202504436 · 2025 · External reference

TNFalpha-senescence initiates a STAT-dependent positive feedback loop, leading to a sustained interferon signature, DNA damage, and cytokine secretion

10.18632/aging.101328 · 2017 · External reference

Tubular cell senescence promotes maladaptive kidney repair and chronic kidney disease after cisplatin nephrotoxicity

10.1172/jci.insight.166643 · 2023 · External reference

TGF-beta/SMAD signaling in renal fibrosis

10.3389/fphys.2015.00082 · 2015 · External reference

TGF-beta signaling in fibrosis

10.3109/08977194.2011.595714 · 2011 · External reference

Targeting CTGF, EGF and PDGF pathways to prevent progression of kidney disease

10.1038/nrneph.2014.184 · 2014 · External reference

Generation of a conditional cellular senescence model using proximal tubule cells and fibroblasts from human kidneys

10.1038/s41420-024-02131-y · 2024 · External reference

Wnt9a promotes renal fibrosis by accelerating cellular senescence in tubular epithelial cells

10.1681/asn.2017050574 · 2018 · External reference

Crosstalk between proximal tubular epithelial cells and other interstitial cells in tubulointerstitial fibrosis after renal injury

10.3389/fendo.2023.1256375 · 2023 · External reference

Senescent renal tubular epithelial cells activate fibroblasts by secreting Shh to promote the progression of diabetic kidney disease

10.3389/fmed.2022.1018298 · 2022 · External reference

Epithelial cell cycle arrest in G2/M mediates kidney fibrosis after injury

10.1038/nm.2144 · 2010 · External reference

Kidney single-cell atlas reveals myeloid heterogeneity in progression and regression of kidney disease

10.1681/asn.2020060806 · 2020 · External reference

Platelet-instructed SPP1(+) macrophages drive myofibroblast activation in fibrosis in a CXCL4-dependent manner

10.1016/j.celrep.2023.112131 · 2023 · External reference

Canonical Wnt signaling promotes macrophage proliferation during kidney fibrosis

10.1159/000488984 · 2018 · External reference

The role of macrophages in renal fibrosis and therapeutic prospects

10.7717/peerj.19769 · 2025 · External reference

Inflammatory macrophages can transdifferentiate into myofibroblasts during renal fibrosis

10.1038/cddis.2016.402 · 2016 · External reference

Chemokine CCL2 from proximal tubular epithelial cells contributes to sepsis-induced acute kidney injury

10.1152/ajprenal.00037.2022 · 2022 · External reference

Tumor necrosis factor-alpha up-regulates the expression of CCL2 and adhesion molecules of human proximal tubular epithelial cells through MAPK signaling pathways

10.1016/j.imbio.2008.01.003 · 2008 · External reference

Oncogenic CMTM6 drives M2a macrophages formation and fuels cervical cancer progression

10.3389/fimmu.2025.1621816 · 2025 · External reference

Role of MCP-1/CCR2 axis in renal fibrosis: mechanisms and therapeutic targeting

10.1097/md.0000000000035613 · 2023 · External reference

Endothelial to mesenchymal transition in kidney fibrosis

10.1093/ndt/gfad238 · 2024 · External reference

Endothelial-to-mesenchymal transition compromises vascular integrity to induce Myc-mediated metabolic reprogramming in kidney fibrosis

10.1126/scisignal.aaz2597 · 2020 · External reference

Snail1-induced partial epithelial-to-mesenchymal transition drives renal fibrosis in mice and can be targeted to reverse established disease

10.1038/nm.3901 · 2015 · External reference

Epithelial-to-mesenchymal transition induces cell cycle arrest and parenchymal damage in renal fibrosis

10.1038/nm.3902 · 2015 · External reference

Decoding myofibroblast origins in human kidney fibrosis

10.1038/s41586-020-2941-1 · 2021 · External reference

Comprehensive single-cell transcriptional profiling defines shared and unique epithelial injury responses during kidney fibrosis

10.1016/j.cmet.2022.09.026 · 2022 · External reference

Role of perivascular cells in kidney homeostasis, inflammation, repair and fibrosis

10.1038/s41581-023-00752-7 · 2023 · External reference

Senolytics, dasatanib plus quercetin, reduce kidney inflammation, senescent cell abundance, and injury while restoring geroprotective factors in murine diabetic kidney disease

10.1016/j.ebiom.2026.106124 · 2026 · External reference

Response to inhibition of receptor-interacting protein kinase 1 (RIPK1) in active plaque psoriasis: a randomized placebo-controlled study

10.1002/cpt.1852 · 2020 · External reference

A randomised, placebo-controlled study of RIPK1 inhibitor GSK2982772 in patients with active ulcerative colitis

10.1136/bmjgast-2021-000680 · 2021 · External reference

Mitigating pro-inflammatory SASP and DAMP with Urolithin a: a novel Senomorphic strategy

10.1111/acel.70237 · 2025 · External reference

Natural products: potential drugs for the treatment of renal fibrosis

10.1186/s13020-022-00646-z · 2022 · External reference

Collagen V regulates renal function after kidney injury and can be pharmacologically targeted to enhance kidney repair in mice

10.1126/scitranslmed.ads7714 · 2025 · External reference

Spatiotemporal control of intercellular crosstalk: a new therapeutic paradigm for halting acute kidney injury to chronic kidney disease transition

10.3390/biom16040559 · 2026 · External reference

Autophagy activates EGR1 via MAPK/ERK to induce FGF2 in renal tubular cells for fibroblast activation and fibrosis during maladaptive kidney repair

10.1080/15548627.2023.2281156 · 2024 · External reference

Cyclin G1 and TASCC regulate kidney epithelial cell G2-M arrest and fibrotic maladaptive repair

10.1126/scitranslmed.aav4754 · 2019 · External reference

Macrophage-to-myofibroblast transition contributes to interstitial fibrosis in chronic renal allograft injury

10.1681/asn.2016050573 · 2017 · External reference

Renal clearance of quantum dots

10.1038/nbt1340 · 2007 · External reference