Research graph
References from Calcium homeostasis imbalance in sepsis: molecular mechanisms and therapeutic perspectives. Local targets link to admitted publications; unresolved targets remain external evidence.
Sepsis and septic shock
10.1056/nejmra2403213 · 2024 · External reference
Viral sepsis: diagnosis, clinical features, pathogenesis, and clinical considerations
10.1186/s40779-024-00581-0 · 2024 · External reference
Sepsis and post-sepsis syndrome: a multisystem challenge requiring comprehensive care and management-a review
10.3389/fmed.2025.1560737 · 2025 · External reference
Current perspectives in the management of sepsis and septic shock
10.3389/fmed.2024.1431791 · 2024 · External reference
The epidemiology of sepsis in Brazilian intensive care units (the Sepsis PREvalence Assessment Database, SPREAD): an observational study
10.1016/s1473-3099(17)30322-5 · 2017 · External reference
Global, regional, and national sepsis incidence and mortality, 1990-2017: analysis for the global burden of disease study
10.1016/s0140-6736(19)32989-7 · 2020 · External reference
Circulating toll-like receptor and cytokine profiles and genetic polymorphisms in a Chinese sepsis cohort: potential links to neuroinflammation and blood-brain barrier dysfunction
10.3389/fimmu.2026.1762637 · 2026 · External reference
Aldh2 in autophagy and cell death: molecular mechanisms and implications for diseases
10.1186/s40779-025-00646-8 · 2025 · External reference
The “cytokine storm” in infection and sepsis: win the battle but lose the war
10.1186/s40779-025-00678-0 · 2025 · External reference
Damps and NETs in sepsis
10.3389/fimmu.2019.02536 · 2019 · External reference
Retreg1/FAM134B-mediated ERGICphagy regulates GSDME-dependent dendritic cell pyroptosis during sepsis
10.1080/15548627.2026.2641614 · 2026 · External reference
Advances in immune monitoring approaches for sepsis-induced immunosuppression
10.3389/fimmu.2022.891024 · 2022 · External reference
The association between coagulation function and prognosis in patients with sepsis: a meta-analysis of predictive performance introduction
10.3389/fmed.2025.1706082 · 2025 · External reference
U-shaped association between serum calcium levels and 28-day mortality in patients with sepsis: a retrospective analysis of the MIMIC-III database
10.1097/shk.0000000000002203 · 2023 · External reference
Targeting matrix metalloproteinase-9 to alleviate T cell exhaustion and improve sepsis prognosis
10.34133/research.0996 · 2025 · External reference
Dantrolene repurposed to treat sepsis or septic shock and COVID-19 patients
10.26355/eurrev_202104_25569 · 2021 · External reference
Ca(2+) signals in plant immunity
10.15252/embj.2022110741 · 2022 · External reference
Calcium homeostasis and cancer: insights from endoplasmic reticulum-centered organelle communications
10.1016/j.tcb.2022.07.004 · 2023 · External reference
Calcium dynamics as a machine for decoding signals
10.1016/j.tcb.2018.01.002 · 2018 · External reference
Full focus on calcium
10.1126/scisignal.aaz0961 · 2019 · External reference
Store-operated calcium channels: from function to structure and back again
10.1101/cshperspect.a035055 · 2020 · External reference
The ion channels of endomembranes
10.1152/physrev.00025.2023 · 2024 · External reference
Primary structure and functional expression of the inositol 1,4,5-trisphosphate-binding protein P400
10.1038/342032a0 · 1989 · External reference
The Sendai virus P gene expresses both an essential protein and an inhibitor of RNA synthesis by shuffling modules via mRNA editing
10.1002/j.1460-2075.1991.tb07860.x · 1991 · External reference
Tocotrienols regulate cholesterol production in mammalian cells by post-transcriptional suppression of 3-hydroxy-3-methylglutaryl-coenzyme A reductase
10.1016/s0021-9258(18)82115-9 · 1993 · External reference
IP(3) receptors: toward understanding their activation
10.1101/cshperspect.a004010 · 2010 · External reference
Redox regulation of type-I inositol trisphosphate receptors in intact mammalian cells
10.1074/jbc.ra118.005624 · 2018 · External reference
Inositol trisphosphate receptor: phosphorylation by protein kinase C and calcium calmodulin-dependent protein kinases in reconstituted lipid vesicles
10.1073/pnas.88.6.2232 · 1991 · External reference
Protein kinase C: structural and spatial regulation by phosphorylation, cofactors, and macromolecular interactions
10.1021/cr0002801 · 2001 · External reference
Pka phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): defective regulation in failing hearts
10.1016/s0092-8674(00)80847-8 · 2000 · External reference
Cardiac excitation-contraction coupling
10.1038/415198a · 2002 · External reference
Structural and functional features and significance of the physical linkage between ER and mitochondria
10.1083/jcb.200604016 · 2006 · External reference
Close contacts with the endoplasmic reticulum as determinants of mitochondrial Ca2+ responses
10.1126/science.280.5370.1763 · 1998 · External reference
Balancing ER-mitochondrial Ca(2+) fluxes in health and disease
10.1016/j.tcb.2021.02.003 · 2021 · External reference
Phospholipid transfer function of PTPIP51 at mitochondria-associated ER membranes
10.15252/embr.202051323 · 2021 · External reference
Role of mitochondria-associated ER in apoptosis
10.1002/cbf.70105 · 2025 · External reference
Calcium signaling around mitochondria associated membranes (MAMs)
10.1186/1478-811x-9-19 · 2011 · External reference
The mitochondrial calcium uniporter: balancing tumourigenic and anti-tumourigenic responses
10.1113/jp285515 · 2024 · External reference
The mitochondrial calcium uniporter is a multimer that can include a dominant-negative pore-forming subunit
10.1038/emboj.2013.157 · 2013 · External reference
Micu1 and MICU2 finely tune the mitochondrial Ca2+ uniporter by exerting opposite effects on MCU activity
10.1016/j.molcel.2014.01.013 · 2014 · External reference
Micu2 restricts spatial crosstalk between InsP(3)R and MCU channels by regulating threshold and gain of MICU1-mediated inhibition and activation of MCU
10.1016/j.celrep.2017.11.064 · 2017 · External reference
Imaging interorganelle contacts and local calcium dynamics at the ER-mitochondrial interface
10.1016/j.molcel.2010.06.029 · 2010 · External reference
Quasi-synaptic calcium signal transmission between endoplasmic reticulum and mitochondria
10.1093/emboj/18.1.96 · 1999 · External reference
A mechanism of lysosomal calcium entry
10.1126/sciadv.adk2317 · 2024 · External reference
Ip(3) receptors preferentially associate with ER-lysosome contact sites and selectively deliver Ca(2+) to lysosomes
10.1016/j.celrep.2018.11.064 · 2018 · External reference
Activation of lysosomal retrograde transport triggers TPC1-IP3R1 Ca(2+) crosstalk at lysosome-ER MCSs leading to lethal depleting of ER calcium
10.1002/advs.202415313 · 2025 · External reference
Reconstituted human TPC1 is a proton-permeable ion channel and is activated by NAADP or Ca2+
10.1126/scisignal.2004854 · 2014 · External reference
An endosomal NAADP-sensitive two-pore Ca(2+) channel regulates ER-endosome membrane contact sites to control growth factor signaling
10.1016/j.celrep.2017.01.052 · 2017 · External reference
Trpm2, linking oxidative stress and Ca(2+) permeation to NLRP3 inflammasome activation
10.1016/j.coi.2020.01.005 · 2020 · External reference
CaMKII-dependent ryanodine receptor phosphorylation mediates sepsis-induced cardiomyocyte apoptosis
10.1111/jcmm.15470 · 2020 · External reference
IL-6/STAT3 signaling promotes cardiac dysfunction by upregulating FUNDC1-dependent mitochondria-associated endoplasmic reticulum membranes formation in sepsis mice
10.3389/fcvm.2021.790612 · 2021 · External reference
Tmbim6 prevents VDAC1 multimerization and improves mitochondrial quality control to reduce sepsis-related myocardial injury
10.1016/j.metabol.2022.155383 · 2023 · External reference
Erbin protects against sepsis-associated encephalopathy by attenuating microglia pyroptosis via IRE1alpha/Xbp1s-Ca(2+) axis
10.1186/s12974-022-02598-5 · 2022 · External reference
Sepsis restructures the mitochondrial calcium uniporter complex in the lymphoid tissues of mice and humans
10.1038/s42003-025-08475-0 · 2025 · External reference
Sepsis-associated encephalopathy: from pathophysiology to clinical management
10.1016/j.intimp.2023.110800 · 2023 · External reference
Aqp4 aggravates cognitive impairment in sepsis-associated encephalopathy through inhibiting Na(v) 1.6-mediated astrocyte autophagy
10.1002/advs.202205862 · 2023 · External reference
Dysfunction of cholinergic neuron in nucleus ambiguous aggravates sepsis-induced lung injury via a GluA1-dependment mechanism
10.1016/j.bbi.2025.05.006 · 2025 · External reference
Organellophagy regulates cell death:a potential therapeutic target for inflammatory diseases
10.1016/j.jare.2024.05.012 · 2025 · External reference
Ca(2+) signaling and cell death
10.1016/j.ceca.2023.102759 · 2023 · External reference
Mlkl overexpression leads to Ca(2+) and metabolic dyshomeostasis in a neuronal cell model
10.1016/j.ceca.2024.102854 · 2024 · External reference
The molecular mechanisms of MLKL-dependent and MLKL-independent necrosis
10.1093/jmcb/mjaa055 · 2021 · External reference
Activation of STIM1/Orai1-mediated SOCE in sepsis-induced myocardial depression
10.3892/mmr.2022.12775 · 2022 · External reference
IP3R2-mediated Ca(2+) release promotes LPS-induced cardiomyocyte pyroptosis via the activation of NLRP3/Caspase-1/GSDMD pathway
10.1038/s41420-024-01840-8 · 2024 · External reference
Protective role of triiodothyronine in sepsis-induced cardiomyopathy through phospholamban downregulation
10.3892/ijmm.2025.5488 · 2025 · External reference
Activation of Toll-like receptor 7 provides cardioprotection in septic cardiomyopathy-induced systolic dysfunction
10.1002/ctm2.266 · 2021 · External reference
Succinylation of SERCA2a at K352 promotes its ubiquitinoylation and degradation by proteasomes in sepsis-induced heart dysfunction
10.1161/circheartfailure.124.012180 · 2025 · External reference
A novel mechanism of chlorogenic acid in cardioprotection: blocking NLRP3 inflammasome via Ca(2+)/CaMKIIalpha signaling in sepsis-induced cardiomyopathy
10.1096/fj.202502567rr · 2025 · External reference
Endothelial cell dynamics in sepsis-induced acute lung injury and acute respiratory distress syndrome: pathogenesis and therapeutic implications
10.1186/s12964-024-01620-y · 2024 · External reference
Acute respiratory distress syndrome: causes, pathophysiology, and phenotypes
10.1016/s0140-6736(22)01485-4 · 2022 · External reference
Neutrophil-specific ORAI1 calcium channel inhibition reduces pancreatitis-associated acute lung injury
10.1093/function/zqad061 · 2024 · External reference
Aqueous extract of descuraniae semen attenuates lipopolysaccharide-induced inflammation by inhibiting ER stress and WNK4-SPAK-NKCC1 pathway
10.1111/jcmm.18589 · 2024 · External reference
Endothelial mechanosensitive transcription factor BHLHE40 induced by Piezo1 suppresses endothelial ferroptosis and inflammation via SLC7A11
10.1038/s41420-025-02909-8 · 2026 · External reference
Memantine alleviates acute lung injury via inhibiting macrophage pyroptosis
10.1097/shk.0000000000001790 · 2021 · External reference
Intestinal Piezo1 aggravates intestinal barrier dysfunction during sepsis by mediating Ca(2+) influx
10.1186/s12967-024-05076-z · 2024 · External reference
Acute kidney injury in sepsis
10.3390/ijms25115924 · 2024 · External reference
The role of endotoxin in septic shock
10.1186/s13054-023-04690-5 · 2023 · External reference
Transient receptor vanilloid subtype 4-mediated Ca2+ influx promotes glomerular endothelial inflammation in sepsis-associated acute kidney injury
10.1016/j.labinv.2023.100126 · 2023 · External reference
Trpm7 mediates kidney injury, endothelial hyperpermeability and mortality during endotoxemia
10.1038/s41374-019-0304-z · 2020 · External reference
Dexmedetomidine ameliorates acute kidney injury by regulating mitochondrial dynamics via the alpha2-AR/SIRT1/PGC-1alpha pathway activation in rats
10.1186/s10020-024-00964-y · 2024 · External reference
Camkiv regulates mitochondrial dynamics during sepsis
10.1016/j.ceca.2020.102286 · 2020 · External reference
Sepsis-induced immunosuppression: mechanisms, diagnosis and current treatment options
10.1186/s40779-022-00422-y · 2022 · External reference
Dexamethasone upregulates macrophage PIEZO1 via SGK1, suppressing inflammation and increasing ROS and apoptosis
10.1016/j.bcp.2024.116050 · 2024 · External reference
Lipin-1-derived diacylglycerol activates intracellular TRPC3 which is critical for inflammatory signaling
10.1007/s00018-021-03999-0 · 2021 · External reference
Grancalcin hydrogel microneedle patches alleviate sepsis via modulation of calcium signaling to augment immune cell phagocytosis
10.1002/adhm.202501218 · 2025 · External reference
Fc gamma receptor IIB deficient mice: a lupus model with increased endotoxin tolerance-related sepsis susceptibility
10.1097/shk.0000000000000796 · 2017 · External reference
Pathological role of the calcium-sensing receptor in sepsis-induced hypotensive shock: therapeutic possibilities and unanswered questions
10.1002/ddr.21959 · 2022 · External reference
Impact of Ca2+ signaling on B cell function
10.1016/j.it.2011.09.004 · 2011 · External reference
C2 domains of Munc13-4 are crucial for Ca(2+)-dependent degranulation and cytotoxicity in NK cells
10.4049/jimmunol.1800426 · 2018 · External reference
ADP-ribose/TRPM2-mediated Ca2+ signaling is essential for cytolytic degranulation and antitumor activity of natural killer cells
10.1038/srep09482 · 2015 · External reference
A novel Nlrp3 knock-in mouse model with hyperactive inflammasome in development of lethal inflammation
10.1093/cei/uxad097 · 2024 · External reference
Selenium, iodine and iron-essential trace elements for thyroid hormone synthesis and metabolism
10.3390/ijms24043393 · 2023 · External reference
Dexamethasone: insights into pharmacological aspects, therapeutic mechanisms, and delivery systems
10.1021/acsbiomaterials.2c00026 · 2022 · External reference
Melatonin protects RPE cells from necroptosis and NLRP3 activation via promoting SERCA2-related intracellular Ca(2+) homeostasis
10.1016/j.phymed.2024.156088 · 2024 · External reference
Estrogen and calcium handling proteins: new discoveries and mechanisms in cardiovascular diseases
10.1152/ajpheart.00734.2019 · 2020 · External reference
Effects of leptin on Na+/Ca2+ exchanger in PC12 cells
10.1159/000453203 · 2016 · External reference
Dexmedetomidine: present and future directions
10.4097/kja.19259 · 2019 · External reference
Effects of dexmedetomidine on perioperative stress, inflammation, and immune function: systematic review and meta-analysis
10.1016/j.bja.2019.07.027 · 2019 · External reference
Memantine in neurological disorders—schizophrenia and depression
10.1007/s00109-020-01982-z · 2021 · External reference
Elucidating novel mechanism of action of spiperone for drug repurposing to prevent and treat murine colitis and sepsis
10.1016/j.lfs.2024.123268 · 2025 · External reference
Esketamine mitigates endotoxin-induced hippocampal injury by regulating calcium transient and synaptic plasticity via the NF-alpha1/CREB pathway
10.1016/j.neuropharm.2025.110362 · 2025 · External reference
Magnesium sulfate alleviates sepsis-associated acute kidney injury by reducing inflammation, oxidative stress, and apoptosis via inhibiting the NF-kappaB pathway
10.1096/fj.202502733r · 2026 · External reference
