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References from Safety profiles of cyclosporine and tacrolimus in pregnancy: a pharmacovigilance analysis using the FDA Adverse Event Reporting System. Local targets link to admitted publications; unresolved targets remain external evidence.
Calcineurin phosphatase activity in T lymphocytes is inhibited by FK 506 and cyclosporin a
10.1073/pnas.89.9.3686 · 1992 · External reference
Calcineurin inhibitor nephrotoxicity
10.2215/cjn.04800908 · 2009 · External reference
The many faces of calcineurin inhibitor toxicity-what the FK?
10.1053/j.ackd.2019.08.006 · 2020 · External reference
A comparison of tacrolimus (FK 506) and cyclosporine for immunosuppression in liver transplantation
10.1056/nejm199410273311702 · 1994 · External reference
Pregnancy outcomes after liver transplantation: a systematic review and meta-analysis
10.14309/ajg.0000000000001105 · 2021 · External reference
Fetal toxicity of immunosuppressive drugs in pregnancy
10.3390/jcm7120552 · 2018 · External reference
Safety of tacrolimus in pregnancy
2014 · External reference
Pregnancy following liver transplantation: review of outcomes and recommendations for management
10.1155/2012/137129 · 2012 · External reference
Review of the course and outcome of 100 pregnancies in 84 women treated with tacrolimus
10.1097/00007890-200012270-00010 · 2000 · External reference
Pregnancy outcomes in kidney transplant recipients: a systematic review and meta-analysis
10.1111/j.1600-6143.2011.03656.x · 2011 · External reference
Pregnancy outcomes in women with kidney transplant: meta-analysis and systematic review
10.1186/s12882-019-1213-5 · 2019 · External reference
European best practice guidelines for renal transplantation sec IV 10: pregnancy in renal transplant recipients
10.1093/ndt/17.suppl_4.50 · 2002 · External reference
Clinical practice guideline on pregnancy and renal disease
10.1186/s12882-019-1560-2 · 2019 · External reference
2020 American College of Rheumatology guideline for the management of reproductive health in rheumatic and musculoskeletal diseases
10.1002/art.41191 · 2020 · External reference
Maternal hemodynamics and pregnancy outcome in women with prior orthotopic liver transplantation
10.1002/lt.500060223 · 2000 · External reference
Cyclosporine use during pregnancy
10.1007/s40264-013-0034-x · 2013 · External reference
Longterm neurodevelopment of children exposed in utero to cyclosporine after maternal renal transplant
10.2165/11316280-000000000-00000 · 2010 · External reference
In utero exposure to immunosuppressive drugs: experimental and clinical studies
10.1007/s00467-001-0776-z · 2002 · External reference
Calcineurin inhibitors: pharmacologic mechanisms impacting both insulin resistance and insulin secretion lading to glucose dysregulation and diabetes mellitus
10.1002/cpt.546 · 2017 · External reference
Pregnancy outcomes in female patients exposed to cyclosporin-based versus tacrolimus-based immunosuppressive regimens after liver/kidney transplantation: a systematic review and meta-analysis
10.1111/jcpt.13340 · 2021 · External reference
Pregnancy and neonatal outcomes in women receiving calcineurin inhibitors: a systematic review and meta-analysis
10.1111/bcp.15414 · 2022 · External reference
Kidney adverse events associated with calcineurin inhibitors: a real-world study based on the FAERS database and network pharmacology
10.3389/fmed.2026.1764130 · 2026 · External reference
Calcineurin inhibitors and risk of CNS infections: a disproportionality analysis of the FDA adverse event reporting system (FAERS)
10.1016/j.clinthera.2025.05.004 · 2025 · External reference
Thrombotic microangiopathy associated with calcineurin inhibitors: a real-world analysis of postmarketing surveillance data
10.1016/j.clinthera.2024.11.017 · 2025 · External reference
A real-world pharmacovigilance study of FDA adverse event reporting system events for sildenafil
10.1111/andr.13533 · 2024 · External reference
Potential safety signal of pregnancy loss with vascular endothelial growth factor inhibitor intraocular injection: a disproportionality analysis using the Food and Drug Administration adverse event reporting system
10.3389/fphar.2022.1063625 · 2022 · External reference
A disproportionality analysis of low molecular weight heparin in the overall population and in pregnancy women using the FDA adverse event reporting system (FAERS) database
10.3389/fphar.2024.1442002 · 2024 · External reference
A disproportionality analysis of insulin glargine in the overall population and in pregnant women using the FDA adverse event reporting system (FAERS) database
10.1371/journal.pone.0331489 · 2024 · External reference
Is pitolisant safe for clinical use? A retrospective pharmacovigilance study focus on the post-marketing safety
10.1002/prp2.1161 · 2024 · External reference
Suspected adverse drug reactions of rivaroxaban reported in the United States food and drug administration adverse event reporting system database: a pharmacovigilance study
10.3389/fphar.2024.1399172 · 2024 · External reference
Post-marketing safety concerns with rimegepant based on a pharmacovigilance study
10.1186/s10194-024-01858-4 · 2024 · External reference
Adverse drug events associated with linezolid administration: a real-world pharmacovigilance study from 2004 to 2023 using the FAERS database
10.3389/fphar.2024.1338902 · 2024 · External reference
Overview of pregnancy in renal transplant patients
10.1155/2016/4539342 · 2016 · External reference
Pharmacologic considerations for solid organ transplant recipients who become pregnant
10.1002/phar.1800 · 2016 · External reference
Usage of tacrolimus and mycophenolic acid during conception, pregnancy, and lactation, and its implications for therapeutic drug monitoring: a systematic critical review
10.1097/ftd.0000000000000769 · 2020 · External reference
Pregnancy in Irish renal transplant recipients in the cyclosporine era
10.1007/bf03170477 · 2000 · External reference
Effect of pregnancy on long-term kidney function in renal transplant recipients treated with cyclosporine and with azathioprine
10.1111/j.1600-6143.2005.01091.x · 2005 · External reference
Preeclampsia after kidney transplantation: rates and association with graft survival and function
10.2215/cjn.0000000000000155 · 2023 · External reference
Double jeopardy: the complicated interplay of preeclampsia risks to mom, baby, and allograft in kidney transplant recipients
10.2215/cjn.0000000000000210 · 2023 · External reference
Immunosuppressant drug tacrolimus inhibits HUVEC angiogenesis and production of placental growth factor
10.1016/j.placenta.2024.12.010 · 2025 · External reference
Pregnancy after organ transplantation: a report from the UK transplant pregnancy registry
10.1097/01.tp.0000263357.44975.d0 · 2007 · External reference
Antiplatelet agents for preventing pre-eclampsia and its complications
10.1002/14651858.cd004659.pub2 · 2007 · External reference
Perinatal outcomes after liver transplantation: is there a role for aspirin treatment?
10.3390/jcm12113733 · 2023 · External reference
Prevalence of major malformations and small for gestational age in newborns of female transplant recipients on tacrolimus-containing regimens during pregnancy
10.1016/j.ajt.2025.07.2472 · 2025 · External reference
What is the teratogenic risk of mycophenolate?
10.1055/s-0036-1597933 · 2017 · External reference
Mycophenolate mofetil embryopathy: a newly recognized teratogenic syndrome
10.1016/j.ejmg.2016.09.014 · 2017 · External reference
Major congenital malformations after first-trimester exposure to ACE inhibitors
10.1056/nejmoa055202 · 2016 · External reference
Adverse pregnancy outcomes associated with first-trimester exposure to angiotensin-converting enzyme inhibitors or angiotensin II receptor blockers: a systematic review and meta-analysis
10.1002/prp2.644 · 2020 · External reference
Pregnancy outcome following exposure to angiotensin-converting enzyme inhibitors or angiotensin receptor antagonists: a systematic review
10.1161/hypertensionaha.112.196352 · 2012 · External reference
Hypertrophic cardiomyopathy secondary to tacrolimus therapy in a kidney transplant patient: a case report and focused review of the literature
10.1002/ccr3.6539 · 2022 · External reference
Tacrolimus-related hypertrophic cardiomyopathy in an adult cardiac transplant patient
2012 · External reference
Pathogenesis of calcineurin inhibitor-induced hypertension
10.5301/jn.5000174 · 2012 · External reference
Comparison of pregnancy outcomes in Dutch kidney recipients with and without calcineurin inhibitor exposure: a retrospective study
10.1111/tri.14156 · 2021 · External reference
Chronic calcineurin inhibitor nephrotoxicity-lest we forget
10.1111/j.1600-6143.2011.03504.x · 2011 · External reference
Nephrotoxicity of calcineurin inhibitors in kidney epithelial cells is independent of NFAT signaling
10.3389/fphar.2021.789080 · 2022 · External reference
Immunosuppression with cyclosporine versus tacrolimus shows distinctive nephrotoxicity profiles within renal compartments
10.1111/apha.14190 · 2024 · External reference
Calcineurin inhibitor nephrotoxicity through the lens of longitudinal histology: comparison of cyclosporine and tacrolimus eras
10.1097/tp.000000000000124 · 2016 · External reference
Cyclosporin a but not FK506 activates the integrated stress response in human cells
10.1074/jbc.ra120.014531 · 2020 · External reference
Tacrolimus versus cyclosporin as primary immunosuppression for kidney transplant recipients
10.1002/14651858.cd003961.pub2 · 2005 · External reference
Conversion from cyclosporine to tacrolimus improves quality-of-life indices, renal graft function and cardiovascular risk profile
10.1111/j.1600-6143.2004.00427.x · 2004 · External reference
Recent topics on the mechanisms of immunosuppressive therapy-related neurotoxicities
10.3390/ijms20133210 · 2019 · External reference
A case of tacrolimus-induced reversible cerebral vasoconstriction syndrome after heart transplantation
10.1007/s11748-020-01309-2 · 2020 · External reference
Reversible cerebral vasoconstriction syndrome post-cardiac transplantation: a therapeutic dilemma: case report
10.1186/s12883-024-03780-3 · 2024 · External reference
Two rare neurologic complications after heart transplantation: posterior reversible encephalopathy syndrome, followed by reversible cerebral vasoconstriction syndrome
10.1016/j.healun.2016.01.1221 · 2016 · External reference
Tacrolimus-induced reversible crebral vasoconstriction syndrome with delayed multi-segmental vasoconstriction
10.1016/j.jstrokecerebrovasdis.2017.03.006 · 2017 · External reference
The clinical and radiological spectrum of reversible cerebral vasoconstriction syndrome. A prospective series of 67 patients
10.1093/brain/awm256 · 2007 · External reference
Perfusion-dependent focal neurologic deficits in a critically ill heart transplant recipient: a case of tacrolimus-associated reversible cerebral vasospasm syndrome?
10.1053/j.jvca.2023.03.044 · 2023 · External reference
Interpreting tacrolimus concentrations during pregnancy and postpartum
10.1097/tp.0b013e318278d367 · 2013 · External reference
Impaired function of cerebral parenchymal arterioles in experimental preeclampsia
10.1016/j.mvr.2018.04.007 · 2018 · External reference
Thrombotic microangiopathy in a pregnant woman with kidney transplantation: a case report
10.1016/j.jogc.2020.10.018 · 2021 · External reference
Cyclosporine-induced thrombotic microangiopathy in pregnant women: a case report and literature review
10.1177/2050313x241308693 · 2025 · External reference
Drug-induced thrombotic microangiopathy: a systematic review of published reports
10.1182/blood-2014-11-611335 · 2015 · External reference
Tacrolimus-associated thrombotic microangiopathy in a lung transplant recipient
10.1136/bcr-2012-007351 · 2013 · External reference
De novo tacrolimus-induced thrombotic microangiopathy in the early stage after renal transplantation successfully treated with conversion to everolimus
10.1007/s00467-014-3036-8 · 2015 · External reference
Thrombotic microangiopathy in pregnancy: current understanding and management strategies
10.1016/j.ekir.2024.05.016 · 2024 · External reference
Drug-induced thrombotic microangiopathy: an updated review of causative drugs, pathophysiology, and management
10.3389/fphar.2022.1088031 · 2023 · External reference