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References from Associations of tear mediators with ocular surface symptoms, signs, and corneal nerve morphology in dry eye disease: a cross-sectional study. Local targets link to admitted publications; unresolved targets remain external evidence.
TFOS DEWS II definition and classification report
10.1016/j.jtos.2017.05.008 · 2017 · External reference
TFOS DEWS III: diagnostic methodology
10.1016/j.ajo.2025.05.033 · 2025 · External reference
Corneal nerve pathway function in individuals with dry eye symptoms
10.1016/j.ophtha.2020.07.061 · 2021 · External reference
TFOS DEWS II epidemiology report
10.1016/j.jtos.2017.05.003 · 2017 · External reference
Variations of dry eye disease prevalence by age, sex and geographic characteristics in China: a systematic review and meta-analysis
10.7189/jogh.08.020503 · 2018 · External reference
Dry eye disease and work productivity loss in visual display users: the Osaka study
10.1016/j.ajo.2013.10.014 · 2014 · External reference
Impact of dry eye disease on work productivity, and patients’ satisfaction with over-the-counter dry eye treatments
10.1167/iovs.16-19419 · 2016 · External reference
Epidemiology of discordance between symptoms and signs of dry eye
10.1136/bjophthalmol-2017-310633 · 2018 · External reference
TFOS DEWS II pain and sensation report
10.1016/j.jtos.2017.05.002 · 2017 · External reference
The core mechanism of dry eye disease is inflammation
10.1097/icl.0000000000000042 · 2014 · External reference
Pathophysiology of dry eye disease and novel therapeutic targets
10.1016/j.exer.2022.108944 · 2022 · External reference
Tear cytokine levels in Sjogren’s syndrome-related dry eye disease compared with non-Sjogren’s syndrome-related dry eye disease patients: a meta-analysis
10.1097/md.0000000000040669 · 2024 · External reference
A latent profile analysis of tear cytokines and their association with severity of dry eye disease in the dry eye assessment and management (DREAM) study
10.1038/s41598-024-51241-1 · 2024 · External reference
Tear fluid biomarkers and quality of life in people with type 2 diabetes and dry eye disease
10.3390/metabo13060733 · 2023 · External reference
Matrix metalloproteinase 9 testing in dry eye disease using a commercially available point-of-care immunoassay
10.1016/j.ophtha.2016.07.028 · 2016 · External reference
Specific clinical phenotypes of dry eye disease can predict the presence of matrix metalloproteinase-9 in the ocular surface
10.1016/j.clae.2025.102475 · 2025 · External reference
Long-term effects of LASIK on corneal innervation and tear neuropeptides and the associations with dry eye
10.3928/1081597x-20160603-01 · 2016 · External reference
Corneal nerve morphology, sensitivity, and tear neuropeptides in contact lens wear
10.1097/opx.0000000000001063 · 2017 · External reference
Long-term clinical and molecular changes in dry eye disease and chronic ocular pain
10.3390/ijms26188918 · 2025 · External reference
Alterations of tear neuromediators in dry eye disease
10.1001/archophthalmol.2011.200 · 2011 · External reference
The role of nerve growth factor on the ocular surface: a review of the current experimental research and clinical practices
10.3390/ijms26136012 · 2025 · External reference
New perspectives in the pathophysiology and treatment of pain in patients with dry eye disease
10.3390/jcm11010108 · 2021 · External reference
Analysis of clinical characteristics and neuropeptides in patients with dry eye with and without chronic ocular pain after FS-LASIK
10.1007/s40123-023-00861-3 · 2024 · External reference
Elevated neuropeptides in dry eye disease and their clinical correlations
10.1097/ico.0000000000003069 · 2023 · External reference
The utility of oral vitamin B1 and mecobalamin to improve corneal nerves in dry eye disease: an in vivo confocal microscopy study
10.3390/nu14183750 · 2022 · External reference
Comparison of intense pulsed light and near-infrared light in the treatment of dry eye disease: a prospective randomized study
10.1111/aos.14833 · 2021 · External reference
Reliability and validity of the Japanese version of the ocular surface disease Index for dry eye disease
10.1136/bmjopen-2019-033940 · 2019 · External reference
Artificial intelligence-assisted tear meniscus height measurement: a multicenter study
10.21037/qims-24-1948 · 2025 · External reference
Review and analysis of grading scales for ocular surface staining
10.1016/j.jtos.2019.01.004 · 2019 · External reference
Tear luminex analysis in dry eye patients
10.12659/msm.912010 · 2018 · External reference
Discovery of the analgesic action of beta-endorphin: a subjective account
2001 · External reference
Neuropathic corneal pain: approaches for management
10.1016/j.ophtha.2017.08.004 · 2017 · External reference
Evaluation of point-of-care test for elevated tear matrix metalloproteinase 9 in post-LASIK dry eyes
10.1136/bjophthalmol-2015-307607 · 2016 · External reference
The matrix metalloproteinase 9 point-of-care test in dry eye
10.1016/j.jtos.2015.10.004 · 2016 · External reference
Role of matrix metalloproteinase 9 in ocular surface disorders
10.1097/icl.0000000000000668 · 2020 · External reference
Involvement of the proinflammatory cytokines tumor necrosis factor-alpha, IL-1 beta, and IL-6 but not IL-8 in the development of heat hyperalgesia: effects on heat-evoked calcitonin gene-related peptide release from rat skin
10.1523/jneurosci.20-16-06289.2000 · 2000 · External reference
Topical treatment with nerve growth factor for neurotrophic keratitis
10.1016/s0161-6420(00)00163-9 · 2000 · External reference
Effect of recombinant human nerve growth factor eye drops in patients with dry eye: a phase IIa, open label, multiple-dose study
10.1136/bjophthalmol-2018-312470 · 2020 · External reference
Corneal nerve morphology and tear film substance P in diabetes
10.1097/opx.0000000000001096 · 2017 · External reference
Influence of video display terminal use and meibomian gland dysfunction on the ocular surface and tear neuromediators
10.1007/s10792-022-02549-2 · 2023 · External reference
Tear neuropeptides are associated with clinical symptoms and signs of dry eye patients
10.1080/07853890.2025.2451194 · 2025 · External reference
The PEDF neuroprotective domain plus DHA induces corneal nerve regeneration after experimental surgery
10.1167/iovs.15-16755 · 2015 · External reference
Inflammatory cytokines in normal human tears
10.1080/02713689808951242 · 1998 · External reference
Clinical associations of corneal neuromas with ocular surface diseases
10.4103/1673-5374.375308 · 2024 · External reference
Identification of presumed corneal neuromas and microneuromas using laser-scanning in vivo confocal microscopy: a systematic review
10.1136/bjophthalmol-2020-318156 · 2022 · External reference
Corneal confocal microscopy features and tear molecular profile in study participants with discordance between ocular surface disease clinical signs and discomfort
10.3390/jcm11092407 · 2022 · External reference
The relationship between corneal nerve morphology and inflammatory mediators and neuropeptides in healthy individuals
10.1097/opx.0000000000001484 · 2020 · External reference
The role of substance P in corneal homeostasis
10.3390/biom15050729 · 2025 · External reference
CGRP released by corneal sensory nerve maintains tear secretion of the lacrimal gland
10.1167/iovs.65.4.30 · 2024 · External reference
Meibomian gland density: an effective evaluation Index of meibomian gland dysfunction based on deep learning and transfer learning
10.3390/jcm11092396 · 2022 · External reference
Association of tear cytokine ratios with symptoms and signs of dry eye disease: biomarker data from the dry eye assessment and management study
10.1080/02713683.2023.2262168 · 2024 · External reference
Artificial intelligence applications in ophthalmic optical coherence tomography: a 12-year bibliometric analysis
10.18240/ijo.2024.12.19 · 2024 · External reference
