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References from Spatial multi-omics decoding of the fracture nonunion niche: from immune–vascular–skeletal crosstalk to precision regeneration. Local targets link to admitted publications; unresolved targets remain external evidence.
Immunomodulation pathogenesis and treatment of bone nonunion
10.1111/os.14131 · 2024 · External reference
Fracture non-union in osteoporotic bones: current practice and future directions
2024 · External reference
Multimodal analyses of immune cells during bone repair identify macrophages as a therapeutic target in musculoskeletal trauma
10.1038/s41413-024-00347-3 · 2024 · External reference
The vascularization paradox of non-union formation
10.1007/s10456-022-09832-x · 2022 · External reference
Current cutting-edge omics techniques on musculoskeletal tissues and diseases
10.1038/s41413-025-00442-z · 2025 · External reference
Advances in spatial transcriptomics and its application in the musculoskeletal system
10.1038/s41413-025-00429-w · 2025 · External reference
Reduced angiogenesis and delayed endochondral ossification in CD163−/− mice highlights a role of M2 macrophages during bone fracture repair
10.1002/jor.25564 · 2023 · External reference
T cells and macrophages jointly modulate osteogenesis of mesenchymal stromal cells
10.1002/jbm.a.37771 · 2024 · External reference
Single-nucleus transcriptomics reveal the differentiation trajectories of periosteal skeletal/stem progenitor cells in bone regeneration
10.7554/elife.92519 · 2024 · External reference
Mesenchymal stromal cell-derived septoclasts resorb cartilage during developmental ossification and fracture healing
10.1038/s41467-022-28142-w · 2022 · External reference
Single-cell RNA sequencing unravels heterogeneity of skeletal progenitors and cell-cell interactions underlying the bone repair process
10.1016/j.reth.2022.05.001 · 2022 · External reference
Coupling of angiogenesis and osteogenesis by a specific vessel subtype in bone
10.1038/nature13145 · 2014 · External reference
Type H blood vessels in coupling angiogenesis–osteogenesis and its application in bone tissue engineering
10.1002/jbm.b.35243 · 2023 · External reference
Angiogenesis is uncoupled from osteogenesis during calvarial bone regeneration
10.1038/s41467-024-48579-5 · 2024 · External reference
Unresolved reference
External reference
Integrating spatial and single-cell transcriptomics to characterize mouse long bone fracture healing process
10.1038/s42003-025-08316-0 · 2025 · External reference
A multiomic atlas of human early skeletal development
10.1038/s41586-024-08189-z · 2024 · External reference
Unique spatial transcriptomic profiling of the murine femoral fracture callus: a preliminary report
10.3390/cells13060522 · 2024 · External reference
Spatial transcriptomics implicates impaired BMP signaling in NF1 fracture pseudarthrosis in murine and patient tissues
10.1172/jci.insight.176802 · 2024 · External reference
Spatial transcriptomics in bone mechanomics: exploring the mechanoregulation of fracture healing in the era of spatial omics
10.1126/sciadv.adp8496 · 2025 · External reference
Towards deciphering the bone marrow microenvironment with spatial multi-omics
10.1016/j.semcdb.2025.01.001 · 2025 · External reference
Single-cell RNAseq provides insight into altered immune cell populations in human fracture nonunions
2022 · External reference
DNA methylation-mediated rbpjk suppression protects against fracture nonunion caused by systemic inflammation
10.1172/jci168558 · 2023 · External reference
Rejuvenating age-impaired fracture healing
2025 · External reference
Bone-targeted nanoparticle drug delivery system-mediated macrophage modulation for enhanced fracture healing
10.1002/smll.202305336 · 2024 · External reference
Controlled delivery of immunomodulatory factors for mineralized tissue formation in an inflammatory microenvironment
10.1002/adhm.202502466 · 2025 · External reference
Treatment of bone defects and nonunion via novel delivery mechanisms, growth factors, and stem cells: a review
2024 · External reference
Modern approaches and emerging biological therapies to treat fracture nonunion
2025 · External reference
Revolutionizing nonunion treatment: the expanding role of local biological therapies
10.52965/001c.141405 · 2025 · External reference
A systematic scoping review of the latest data on orthobiologics in the surgical treatment of non-union
2024 · External reference
Application of single-cell and spatial omics in musculoskeletal disorder research
10.3390/ijms24032271 · 2023 · External reference
Unresolved reference
External reference
A human embryonic limb cell atlas resolved in space and time
10.1038/s41586-023-06806-x · 2023 · External reference
YAP And TAZ mediate osteocyte perilacunar/canalicular remodeling
10.1002/jbmr.3876 · 2020 · External reference
External mechanical stability regulates hematoma vascularization in bone healing rather than endothelial YAP/TAZ mechanotransduction
10.1002/advs.202307050 · 2024 · External reference
Age-related secretion of grancalcin by macrophages induces skeletal stem/progenitor cell senescence during fracture healing
10.1038/s41413-023-00309-1 · 2024 · External reference
Effects of aging on the immune and periosteal response to fracture injury
10.1016/j.bone.2025.117524 · 2025 · External reference
Spatially resolved multiomics: data analysis from monoomics to multiomics
2025 · External reference
Making space for spatial biology in the clinic
10.1038/s41587-024-02543-2 · 2025 · External reference
Endothelial notch activity promotes angiogenesis and osteogenesis in bone
10.1038/nature13146 · 2014 · External reference
The diversification of methods for studying cell–cell interactions and communication
10.1038/s41576-023-00685-8 · 2024 · External reference
Age-associated callus senescent cells produce TGF-β1 that inhibits fracture healing in aged mice
10.1172/jci148073 · 2022 · External reference
Role of Wnt signaling and sclerostin in bone and as therapeutic targets in skeletal disorders
10.1007/s00198-022-06523-7 · 2023 · External reference
A bone-targeting hydrogen sulfide delivery system for treatment of osteoporotic fracture via macrophage reprogramming and osteoblast-osteoclast coupling
10.1002/adfm.202418822 · 2025 · External reference
Downregulation of krüppel-like factor 15 expression delays endochondral bone ossification during fracture healing
10.1016/j.bone.2024.117302 · 2025 · External reference
Exogenous PTH 1–34 attenuates impaired fracture healing in endogenous PTH deficiency mice via activating Indian hedgehog signaling pathway and accelerating endochondral ossification
10.3389/fcell.2021.750878 · 2022 · External reference
A practical protocol of processing mineralized tissue for visium spatial transcriptomics
10.1016/j.mbm.2025.100163 · 2025 · External reference
Benchmarking spatial and single-cell transcriptomics integration methods for transcript distribution prediction and cell type deconvolution
10.1038/s41592-022-01480-9 · 2022 · External reference
Ageing-related bone and immunity changes: insights into the complex interplay between the skeleton and the immune system
10.1038/s41413-024-00346-4 · 2024 · External reference
Type H blood vessels in coupling angiogenesis-osteogenesis and its application in bone tissue engineering
10.1002/jbm.b.35243 · 2023 · External reference
Incidence, costs and predictors of non-union, delayed union and mal-union following long bone fracture
10.3390/ijerph15122845 · 2018 · External reference
Current cutting-edge omics techniques on musculoskeletal tissues and diseases
10.1038/s41413-025-00442-z · 2025 · External reference
An in silico micro-multiphysics agent-based approach for simulating bone regeneration in a mouse femur defect model
10.3389/fbioe.2023.1289127 · 2023 · External reference
