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References from Multi-omics analyses unveil gut microbiota and metabolites signatures in deoxycholic acid-associated intestinal inflammation. Local targets link to admitted publications; unresolved targets remain external evidence.
Microbiota-derived indole metabo-lites promote human and murine intestinal homeostasis through regulation of interleukin-10 receptor
10.1016/j.ajpath.2018.01.011 · 2018 · External reference
Vitamin D and Crohn's disease in the adult patient: a review
10.1177/0148607113506013 · 2014 · External reference
Unique dietary-related mouse model of colitis
10.1097/01.mib.0000209789.14114.63 · 2006 · External reference
Vitamin d deficiency is associated with ulcerative colitis disease activity
10.1007/s10620-012-2531-7 · 2013 · External reference
Oral delivery of pancreatitis-associated protein by Lactococcus lactis displays protective effects in dinitro-benzenesulfonic-acid-induced colitis model and is able to modulate the composition of the microbiota
10.1111/1462-2920.14748 · 2019 · External reference
1,25(OH)2 D3 alleviates DSS-induced ulcerative colitis via inhibiting NLRP3 inflammasome activation
10.1002/jlb.3ma0320-406rr · 2020 · External reference
The effects of a high-fat diet on inflammatory bowel disease
10.3390/biom13060905 · 2023 · External reference
Bacteroides thetaiotaomicron enhances H2S production in Bilophila wadsworthia
10.1080/19490976.2024.2431644 · 2024 · External reference
Interactions between diet, bile acid metabolism, gut microbiota, and inflammatory bowel diseases
10.1159/000371687 · 2015 · External reference
Dietary-fat-induced taurocholic acid promotes pathobiont expansion and colitis in Il10 −/− mice
10.1038/nature11225 · 2012 · External reference
Inflammatory links between high fat diets and diseases
10.3389/fimmu.2018.02649 · 2018 · External reference
Impact of the gut microbiota on intestinal immunity mediated by tryptophan metabolism
10.3389/fcimb.2018.00013 · 2018 · External reference
Vitamin D3 alleviates inflammation in ulcerative colitis by activating the VDR-NLRP6 signaling pathway
10.3389/fimmu.2023.1135930 · 2023 · External reference
Anti-inflammatory effects of tocopherol metabolites
10.1016/j.bbrc.2004.05.082 · 2004 · External reference
Aberrant mucin assembly in mice causes endoplasmic reticulum stress and spontaneous inflammation resembling ulcerative colitis
10.1371/journal.pmed.0050054 · 2008 · External reference
Alpha and gamma tocopherol metabolism in healthy subjects and patients with end-stage renal disease
10.1046/j.1523-1755.2003.00151.x · 2003 · External reference
Maternal Western diet mediates susceptibility of offspring to Crohn’s-like colitis by deoxycholate generation
10.1186/s40168-023-01546-6 · 2023 · External reference
Desulfovibrio vulgaris caused gut inflammation and aggravated DSS-induced colitis in C57BL/6 mice model
10.1186/s13099-024-00632-w · 2024 · External reference
Sulfide as a mucus barrier-breaker in inflammatory bowel disease?
10.1016/j.molmed.2016.01.002 · 2016 · External reference
Deoxycholic acid exacerbates intestinal inflammation by modulating interleukin-1 βexpression and tuft cell proportion in dextran sulfate sodium-induced murine colitis
10.7717/peerj.14842 · 2023 · External reference
Influence of vitamin D receptor Signalling and vitamin D on colonic epithelial cell fate decisions in ulcerative colitis
10.1093/ecco-jcc/jjae074 · 2024 · External reference
Vitamin D deficiency is associated with disease activity in patients with Crohn's disease
10.5217/ir.2018.00022 · 2019 · External reference
Is vitamin E depleted in Crohn’s disease at initial diagnosis?
10.1159/000171459 · 1994 · External reference
Roles of indole as an interspeciesmand interkingdom signaling molecule
10.1016/j.tim.2015.08.001 · 2015 · External reference
Quantitation of rat liver vitamin E metabolites by LC-MS during high-dose vitamin E administration
10.1194/jlr.d400044-jlr200 · 2005 · External reference
A gut microbiota-bile acid axis promotes intestinal homeostasis upon aspirin-mediated damage
10.1016/j.chom.2023.12.015 · 2024 · External reference
Gut microbiota metabolite indole-3-acetic acid maintains intestinal epithelial homeostasis through mucin sulfation
10.1080/19490976.2024.2377576 · 2024 · External reference
Vitamin D deficiency associated with Crohn's disease and ulcerative colitis: a meta-analysis of 55 observational studies
10.1186/s12967-019-2070-5 · 2019 · External reference
Systematic review and meta-analysis: association of a pre-illness Western dietary pattern with the risk of developing inflammatory bowel disease
10.1111/1751-2980.12910 · 2020 · External reference
Gut microbial metabolite deoxycholic acid facilitates Th17 differentiation through modulating cholesterol biosynthesis and participates in high-fat diet-associated colonic inflammation
10.1186/s13578-023-01109-0 · 2023 · External reference
Role of intestinal microbiota and metabolites on gut homeostasis and human diseases
10.1186/s12865-016-0187-3 · 2017 · External reference
Deoxycholic acid disrupts the intestinal mucosal barrier and promotes intestinal tumorigenesis
10.1039/c8fo01143e · 2018 · External reference
The gut microbiota metabolite glycochenodeoxycholate activates TFR-ACSL4-mediated ferroptosis to promote the development of environmental toxin-linked MAFLD
10.1016/j.freeradbiomed.2022.10.270 · 2022 · External reference
Western diet induces Paneth cell defects through microbiome alterations and farnesoid X receptor and type I interferon activation
10.1016/j.chom.2021.04.004 · 2021 · External reference
10.1186/s40170-025-00416-z · 2025 · Admitted local publication
Bile acid alterations associated with indolent course of inflammatory bowel disease
10.1080/00365521.2023.2200518 · 2023 · External reference
A single sulfatase is required to access colonic mucin by a gut bacterium
10.1038/s41586-021-03967-5 · 2021 · External reference
Excess calorie intake early in life increases susceptibility to colitis in adulthood
10.1038/s42255-019-0129-5 · 2019 · External reference
Bile acids induce IL-1α and drive NLRP3 inflammasome-independent production of IL-1β in murine dendritic cells
10.3389/fimmu.2023.1285357 · 2023 · External reference
Identification of urinary biomarkers of colon inflammation in IL10−/− mice using short-column LCMS metabolomics
10.1155/2011/974701 · 2011 · External reference
GYY4137, as a slow-releasing H2S donor, ameliorates sodium deoxycholate-induced chronic intestinal barrier injury and gut microbiota dysbiosis
10.3389/fphar.2024.1476407 · 2024 · External reference
Dietary vitamin D3 deficiency alters intestinal mucosal defense and increases susceptibility to Citrobacter rodentium-induced colitis
10.1152/ajpgi.00006.2015 · 2015 · External reference
Consumption of cooked black beans stimulates a cluster of some Clostridia class bacteria decreasing inflammatory response and improving insulin sensitivity
10.3390/nu12041182 · 2020 · External reference
Signals from the gut micro-biota to distant organs in physiology and disease
10.1038/nm.4185 · 2016 · External reference
Intestinal alkaline phosphatase prevents sulfate-reducing bacteria-induced increased tight junction permeability by inhibiting snail pathway
10.3389/fcimb.2022.882498 · 2022 · External reference
Dysbiosis-induced secondary bile acid deficiency promotes intestinal inflammation
10.1016/j.chom.2020.01.021 · 2020 · External reference
A novel mechanism for gut barrier dysfunction by dietary fat: epithelial disruption by hydrophobic bile acids
10.1152/ajpgi.00267.2012 · External reference
Higher fecal bile acid hydrophobicity is associated with exacerbation of dextran sodium sulfate colitis in mice
10.3945/jn.113.180810 · External reference
High-fat-induced intestinal permeability dysfunction associated with altered fecal bile acids
10.3748/wjg.v18.i9.923 · 2012 · External reference
Characterization of glycosaminoglycan (GAG) sulfatases from the human gut symbiont Bacteroides thetaiotaomicron reveals the first GAG-specific bacterial endosulfatase
10.1074/jbc.m114.573303 · 2014 · External reference
Microbial metabolite deoxycholic acid-mediated ferroptosis exacerbates high-fat diet-induced colonic inflammation
10.1016/j.molmet.2024.101944 · 2024 · External reference
Gut microbial bile acid metabolite skews macrophage polarization and contributes to high-fat diet-induced colonic inflammation
10.1080/19490976.2020.1819155 · 2020 · External reference
Role of vitamin D in ulcerative colitis: an update on basic research and therapeutic applications
10.1080/17474124.2022.2048817 · 2022 · External reference
Gut microbiota contributes to the intestinal and extraintestinal immune homeostasis by balancing Th17/Treg cells
10.1016/j.intimp.2024.113570 · 2024 · External reference
Deletion of both Dectin-1 and Dectin-2 affects the bacterial but not fungal gut microbiota and susceptibility to colitis in mice
10.1186/s40168-022-01273-4 · 2022 · External reference
Host-microbiota interaction in intestinal stem cell homeostasis
10.1080/19490976.2024.2353399 · 2024 · External reference
Deoxycholic acid-induced gut Dysbiosis disrupts bile acid enterohepatic circulation and promotes intestinal inflammation
10.1007/s10620-020-06208-3 · 2021 · External reference
Effects and mechanism of Bifidobacterium on intestinal inflammation resulting from deoxycholic acid-induced M1 polarization of macrophages
10.3748/wjg.v32.i6.113010 · 2026 · External reference
Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome
10.1038/nature12347 · 2013 · External reference
Deoxycholic acid modulates cell-junction gene expression and increases intestinal barrier dysfunction in Caco-2 cell monolayers
10.3390/molecules27030723 · 2022 · External reference
Secondary bile acids and short Chain fatty acids in the Colon: a focus on colonic microbiome, cell proliferation, inflammation, and Cancer
10.3390/ijms20051214 · 2019 · External reference
Effect of gut flora mediated-bile acid metabolism on intestinal immune microenvironment
10.1111/imm.13672 · 2023 · External reference
Deoxycholic acid triggers NLRP3 inflammasome activation and aggravates DSS-induced colitis in mice
10.3389/fimmu.2016.00536 · 2016 · External reference
16α-OHE1 alleviates hypoxia-induced inflammation and myocardial damage via the activation of β2-adrenergic receptor
10.1016/j.mce.2024.112200 · 2024 · External reference
