Research graph
References from Screening of Forsythia suspensa-derived compounds identifies amentoflavone as a ciprofloxacin-potentiating candidate against MRSA. Local targets link to admitted publications; unresolved targets remain external evidence.
Thymoquinone' potent impairment of multidrug-resistant Staphylococcus aureus NorA efflux pump activity
10.1038/s41598-024-65991-5 · 2024 · External reference
Lupeol as a potential inhibitor of NorA efflux pumps in Staphylococcus aureus: in silico and in vitro evidence
10.1002/open.202500227 · 2025 · External reference
Structural basis for inhibition of the drug efflux pump NorA from Staphylococcus aureus
10.1038/s41589-022-00994-9 · 2022 · External reference
NorA efflux pump inhibitors: expanding SAR knowledge of pyrazolo[4,3-c][1,2]benzothiazine 5,5-dioxide derivatives
10.1002/ardp.70000 · 2025 · External reference
Efflux pump inhibitory potential of indole derivatives as an arsenal against NorA-overexpressing Staphylococcus aureus
10.1128/spectrum.04876-22 · 2023 · External reference
Naringenin as potentiator of norfloxacin efficacy through inhibition of the NorA efflux pump in Staphylococcus aureus
10.1016/j.micpath.2025.107504 · 2025 · External reference
Effect of carvacrol and thymol on NorA efflux pump inhibition in multidrug-resistant (MDR) Staphylococcus aureus strains
10.1007/s10863-021-09906-3 · 2021 · External reference
Novel inhibitory activity of the Staphylococcus aureus NorA efflux pump by a kaempferol rhamnoside isolated from Persea lingue Nees
10.1093/jac/dks005 · External reference
Chalcone inhibitors of the NorA efflux pump in Staphylococcus aureus whole cells and enriched everted membrane vesicles
10.1016/j.bmc.2012.05.025 · External reference
Topoisomerase inhibitors: fluoroquinolone mechanisms of action and resistance
10.1101/cshperspect.a025320 · 2016 · External reference
Antibacterial effect of amentoflavone and its synergistic effect with antibiotics
10.4014/jmb.1302.02045 · 2013 · External reference
Capsaicin, a novel inhibitor of the NorA efflux pump, reduces the intracellular invasion of Staphylococcus aureus
10.1093/jac/dks232 · 2012 · External reference
Methicillin-resistant Staphylococcus aureus
10.1038/nrdp.2018.33 · 2018 · External reference
CB-Dock2: improved protein–ligand blind docking by integrating cavity detection, docking and homologous template fitting
10.1093/nar/gkac394 · 2022 · External reference
Repurposing approved drugs as fluoroquinolone potentiators to overcome efflux pump resistance in Staphylococcus aureus
10.1128/spectrum.00951-21 · 2021 · External reference
Evaluating the ciprofloxacin potentiation efficacy of repurposed drug flupentixol through efflux pump inhibition of pathogenic bacteria
10.1038/s41598-025-24167-5 · 2025 · External reference
Efflux pump activity potentiates the evolution of antibiotic resistance across S. aureus isolates
10.1038/s41467-020-17735-y · 2020 · External reference
Methicillin-resistant and susceptible Staphylococcus aureus: tolerance, immune evasion and treatment
10.1038/s41579-025-01226-2 · 2026 · External reference
Ethidium bromide MIC screening for enhanced efflux pump gene expression or efflux activity in Staphylococcus aureus
10.1128/aac.01058-10 · 2010 · External reference
Resveratrol as an inhibitor of the NorA efflux pump and resistance modulator in Staphylococcus aureus
10.3390/antibiotics12071168 · 2023 · External reference
Boeravinone B, a novel dual inhibitor of NorA bacterial efflux pump of Staphylococcus aureus and human P-glycoprotein, reduces the biofilm formation and intracellular invasion of bacteria
10.3389/fmicb.2017.01868 · 2017 · External reference
Inhibition of the norA gene expression and the NorA efflux pump by the tannic acid
10.1038/s41598-023-43038-5 · 2023 · External reference
Staphylococcus aureus infections: epidemiology, pathophysiology, clinical manifestations, and management
10.1128/cmr.00134-14 · 2015 · External reference
Flavonoids as inhibitors of bacterial efflux pumps
10.3390/molecules26226904 · 2021 · External reference
Phytochemistry, pharmacology, quality control and future research of Forsythia suspensa (Thunb.) Vahl: a review
10.1016/j.jep.2017.08.040 · 2018 · External reference
A fiducial-assisted strategy compatible with resolving small MFS transporter structures in multiple conformations using cryo-EM
10.1038/s41467-024-54986-5 · 2025 · External reference
FitDock: protein–ligand docking by template fitting
10.1093/bib/bbac087 · 2022 · External reference
