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References from Gut microbiota and microbiota-derived metabolites in radiation-induced injury: mechanisms and therapeutic opportunities. Local targets link to admitted publications; unresolved targets remain external evidence.
Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation
10.1038/nature12726 · 2013 · External reference
Treg induction by a rationally selected mixture of Clostridia strains from the human microbiota
10.1038/nature12331 · 2013 · External reference
Chromosomal instability drives metastasis through a cytosolic DNA response
10.1038/nature25432 · 2018 · External reference
DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation
10.1038/nature01368 · 2003 · External reference
Identification of stem cells in small intestine and colon by marker gene Lgr5
10.1038/nature06196 · 2007 · External reference
Role of the microbiota in response to and recovery from cancer therapy
10.1038/s41577-023-00951-0 · 2024 · External reference
Emerging pathogenic links between microbiota and the gut-lung axis
10.1038/nrmicro.2016.142 · 2017 · External reference
European consensus conference on faecal microbiota transplantation in clinical practice
10.1136/gutjnl-2016-313017 · 2017 · External reference
Butyrate ameliorated ferroptosis in ulcerative colitis through modulating Nrf2/GPX4 signal pathway
10.1016/j.bbadis.2023.166984 · 2024 · External reference
Gut microbiota-derived l-histidine/imidazole propionate axis fights against the radiation-induced cardiopulmonary injury
10.3390/ijms222111436 · 2021 · External reference
Advances in research on the effects of bile acids and their receptors on intestinal function
10.3389/fnut.2026.1821418 · 2026 · External reference
Lactobacillus probiotic protects intestinal epithelium from radiation injury in a TLR-2/cyclo-oxygenase-2-dependent manner
10.1136/gutjnl-2011-300367 · 2012 · External reference
Microbial regulation of intestinal radiosensitivity
10.1073/pnas.0504830102 · 2005 · External reference
The microbiota-gut-brain axis
10.1152/physrev.00018.2018 · 2019 · External reference
Faecal microbiota transplantation protects against radiation-induced toxicity
10.15252/emmm.201606932 · 2017 · External reference
Gut microbial metabolism in ferroptosis and colorectal cancer
10.1016/j.tcb.2024.08.006 · 2025 · External reference
Drug-resistant Escherichia coli bacteremia transmitted by fecal microbiota transplant
10.1056/nejmoa1910437 · 2019 · External reference
Use of probiotics for prevention of radiation-induced diarrhea
10.3748/wjg.v13.i6.912 · 2007 · External reference
The effects of probiotic supplementation on the incidence of diarrhea in cancer patients receiving radiation therapy: a systematic review with meta-analysis and trial sequential analysis of randomized controlled trials
10.3390/nu11122886 · 2019 · External reference
Fecal microbiota transplantation: a promising treatment for radiation enteritis?
10.1016/j.radonc.2020.01.011 · 2020 · External reference
Ferroptosis: an iron-dependent form of nonapoptotic cell death
10.1016/j.cell.2012.03.042 · 2012 · External reference
ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition
10.1038/nchembio.2239 · 2017 · External reference
Commensal microbiota in the digestive tract: a review of its roles in carcinogenesis and radiotherapy
10.20892/j.issn.2095-3941.2020.0476 · 2022 · External reference
Exploiting dietary fibre and the gut microbiota in pelvic radiotherapy patients
10.1038/s41416-022-01980-7 · 2022 · External reference
Unmasking senescence: context-dependent effects of SASP in cancer
10.1038/s41568-019-0156-2 · 2019 · External reference
Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells
10.1038/nature12721 · 2013 · External reference
Propionate-engineered probiotics reduce radiation-induced intestinal damage
10.1186/s40643-026-01020-9 · 2026 · External reference
Effect of inulin and fructo-oligosaccharide on the prevention of acute radiation enteritis
10.1038/ejcn.2015.192 · 2016 · External reference
Gut microbiota-derived 3-hydroxybutyrate blocks GPR43-mediated IL6 signaling to ameliorate radiation proctopathy
10.1002/advs.202306217 · 2024 · External reference
Multi-omics analyses of radiation survivors identify radioprotective microbes and metabolites
10.1126/science.aay9097 · 2020 · External reference
Formation of clustered DNA damage after high-LET irradiation: a review
10.1269/jrr.07123 · 2008 · External reference
Radiation-induced lung injury: assessment and management
10.1016/j.chest.2019.03.033 · 2019 · External reference
Radiation enteropathy: pathogenesis, treatment and prevention
10.1038/nrgastro.2014.46 · 2014 · External reference
Akkermansia muciniphila protects the intestine from irradiation-induced injury by secretion of propionic acid
10.1080/19490976.2023.2293312 · 2023 · External reference
Cannabidiol alleviates radiation-induced intestinal ferroptosis via facilitating RUNX3-CBFbeta heterodimerization
10.1016/j.freeradbiomed.2024.05.047 · 2024 · External reference
Intestinal microbiota composition is predictive of radiotherapy-induced acute gastrointestinal toxicity in prostate cancer patients
10.1016/j.ebiom.2024.105246 · 2024 · External reference
The DNA-damage response in human biology and disease
10.1038/nature08467 · 2009 · External reference
Puma is an essential mediator of p53-dependent and -independent apoptotic pathways
10.1016/s1535-6108(03)00244-7 · 2003 · External reference
Indole-3-lactic acid protects the gut vascular barrier following intestinal ischemia injury
10.1186/s12964-025-02454-y · 2025 · External reference
Lactobacillus plantarum alleviates irradiation-induced intestinal injury by activation of FXR-FGF15 signaling
10.1002/jcp.30651 · 2022 · External reference
Ferroptosis: mechanisms, biology and role in disease
10.1038/s41580-020-00324-8 · 2021 · External reference
Raffinose-metabolizing bacteria impair radiation-associated hematopoietic recovery via the bile acid/FXR/NF-kappaB signaling pathway
10.1080/19490976.2025.2488105 · 2025 · External reference
Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis
10.1038/nchembio.2238 · 2017 · External reference
The AhR/IL-22 axis in chronic gut inflammation
10.3389/fimmu.2025.1668173 · 2025 · External reference
The role of microbiome and probiotics in chemo-radiotherapy-induced diarrhea
10.1002/cnr2.70029 · 2024 · External reference
From dietary fiber to host physiology: short-chain fatty acids as key bacterial metabolites
10.1016/j.cell.2016.05.041 · 2016 · External reference
Dual effect of p53 on radiation sensitivity in vivo
10.1038/sj.onc.1207494 · 2004 · External reference
Microbiota-derived lactate accelerates intestinal stem-cell-mediated epithelial development
10.1016/j.chom.2018.11.002 · 2018 · External reference
The role of ferroptosis in ionizing radiation-induced cell death and tumor suppression
10.1038/s41422-019-0263-3 · 2020 · External reference
Berberine inhibits acute radiation intestinal syndrome in human with abdomen radiotherapy
10.1007/s12032-009-9307-8 · 2010 · External reference
Gut microbiota and radiation-induced injury: mechanistic insights and microbial therapies
10.1080/19490976.2025.2528429 · 2025 · External reference
Tea polyphenols mitigate radiation-induced ferroptosis and intestinal injury by targeting the Nrf2/HO-1/GPX4 signaling pathway
10.3390/antiox14050580 · 2025 · External reference
Phytate enhances gut Parasutterella colonization to alleviate radiation injury
10.1016/j.chembiol.2025.10.009 · 2025 · External reference
Differences in the establishment of gut microbiota and metabolome characteristics between Balb/c and C57BL/6J mice after proton irradiation
10.3389/fmicb.2022.874702 · 2022 · External reference
Alterations of the gut microbiome composition and lipid metabolic profile in radiation enteritis
10.3389/fcimb.2020.541178 · 2020 · External reference
Interleukin-22 promotes intestinal stem cell-mediated epithelial regeneration
10.1038/nature16460 · 2015 · External reference
Oral konjac glucomannan for prevention of ionizing radiation-induced injury
10.1016/j.ijbiomac.2023.124402 · 2023 · External reference
Formation of propionate and butyrate by the human colonic microbiota
10.1111/1462-2920.13589 · 2017 · External reference
Effects of total abdominal irradiation on gut microbiota and metabolome during acute tissue injury
10.3389/fmicb.2025.1702694 · 2025 · External reference
Microbiome in radiotherapy: an emerging approach to enhance treatment efficacy and reduce tissue injury
10.1186/s10020-024-00873-0 · 2024 · External reference
Impact of gut microbiota on radiation-associated cognitive dysfunction and neuroinflammation in mice
10.1667/rade-21-00006.1 · 2022 · External reference
Predictive biomarkers in the gut microbiome and metabolome for severe acute radiation enteritis in cervical cancer radiotherapy
10.1007/s12672-025-03077-y · 2025 · External reference
The association between the gut microbiome and development and progression of cancer treatment adverse effects
10.3390/cancers15174301 · 2023 · External reference
The diet-microbiota-polyamine axis in intestinal aging: microbial pathways, functional foods, and physiological implications
10.3390/nu18040578 · 2026 · External reference
Ferroptosis: a potential bridge linking gut microbiota and chronic kidney disease
10.1038/s41420-024-02000-8 · 2024 · External reference
MIIST305 mitigates gastrointestinal acute radiation syndrome injury
10.1080/19490976.2025.2458189 · 2025 · External reference
Crosstalk between oxidative stress and inflammation induced by ionizing radiation
10.2174/0929867330666230407104208 · 2024 · External reference
Gut microbiota controlling radiation-induced enteritis and intestinal regeneration
10.1016/j.tem.2023.05.006 · 2023 · External reference
Ferroptosis: regulation by competition between NRF2 and BACH1
10.1111/febs.16382 · 2023 · External reference
Inhibition of ferroptosis by microbiota-derived lithocholic acid underlies the intestinal radioprotection of a host defensin-derived oligopeptide
10.1002/imt2.70113 · 2026 · External reference
The bidirectional impact of cancer radiotherapy and human microbiome
10.21873/invivo.13803 · 2025 · External reference
Short chain fatty acids (SCFAs)-mediated gut epithelial and immune regulation
10.3389/fimmu.2019.01486 · 2019 · External reference
Growth factors protect intestinal stem cells from radiation-induced apoptosis
10.1038/onc.2009.451 · 2010 · External reference
Lactobacillus rhamnosus GG protects the intestinal epithelium from radiation injury through release of lipoteichoic acid
10.1136/gutjnl-2018-316226 · 2019 · External reference
Advances in mitochondrial dysfunction in radiation tissue injury
10.3389/fphys.2025.1660330 · 2025 · External reference
Microbiota-derived metabolites suppress arthritis by amplifying aryl-hydrocarbon receptor activation in regulatory B cells
10.1016/j.cmet.2020.03.003 · 2020 · External reference
Activation of Gpr109a, receptor for niacin and the commensal metabolite butyrate, suppresses colonic inflammation and carcinogenesis
10.1016/j.immuni.2013.12.007 · 2014 · External reference
The microbial metabolites, short-chain fatty acids, regulate colonic Treg cell homeostasis
10.1126/science.1241165 · 2013 · External reference
Ferroptosis turns 10: emerging mechanisms, physiological functions, and therapeutic applications
10.1016/j.cell.2022.06.003 · 2022 · External reference
Ferroptosis: a regulated cell death nexus linking metabolism, redox biology, and disease
10.1016/j.cell.2017.09.021 · 2017 · External reference
Proposed minimum reporting standards for chemical analysis: chemical analysis working group (CAWG) Metabolomics Standards Initiative (MSI)
10.1007/s11306-007-0082-2 · 2007 · External reference
The role of short-chain fatty acids in health and disease
10.1016/b978-0-12-800100-4.00003-9 · 2014 · External reference
The role of the gut microbiota in radiation enteritis: from mechanistic insights to therapeutic applications
10.1038/s42003-026-10263-3 · 2026 · External reference
Dietary fibre supplementation enhances radiotherapy tumour control and alleviates intestinal radiation toxicity
10.1186/s40168-024-01804-1 · 2024 · External reference
Association of Bacteroides acidifaciens relative abundance with high-fibre diet-associated radiosensitisation
10.1186/s12915-020-00836-x · 2020 · External reference
Topical butyrate for acute radiation proctitis: randomised, crossover trial
10.1016/s0140-6736(00)02787-2 · 2000 · External reference
Indole lactic acid derived from Akkermansia muciniphila activates the aryl hydrocarbon receptor to inhibit ferroptosis in ischemic stroke
10.1016/j.freeradbiomed.2025.04.020 · 2025 · External reference
A bioadhesive antioxidase-overexpressed probiotic prevents radiation enteritis
10.1016/j.freeradbiomed.2024.12.013 · 2025 · External reference
Adrenergic nerves regulate intestinal regeneration through IL-22 signaling from type 3 innate lymphoid cells
10.1016/j.stem.2023.07.013 · 2023 · External reference
Radiation-induced injury and the gut microbiota
10.1177/17562848251347347 · 2025 · External reference
Radiation injury and gut microbiota-based treatment
10.1093/procel/pwad044 · 2024 · External reference
Holdemanella biformis augments washed microbiota transplantation for the treatment of radiation enteritis
10.1136/gutjnl-2025-335230 · 2026 · External reference
DNA. damage produced by ionizing radiation in mammalian cells
10.1016/s0079-6603(08)60611-x · 1988 · External reference
Succinate metabolism and its regulation of host-microbe interactions
10.1080/19490976.2023.2190300 · 2023 · External reference
A phase II randomized clinical trial and mechanistic studies using improved probiotics to prevent oral mucositis
10.3389/fimmu.2021.618150 · 2021 · External reference
Microbiota-derived I3A protects the intestine against radiation injury via AhR/IL-10/Wnt signaling
10.1080/19490976.2024.2347722 · 2024 · External reference
Pathogenesis and therapy of radiation enteritis with gut microbiota
10.3389/fphar.2023.1116558 · 2023 · External reference
Regulation of ferroptotic cancer cell death by GPX4
10.1016/j.cell.2013.12.010 · 2014 · External reference
Radiation-induced skin injury: pathogenesis, treatment, and management
10.18632/aging.103932 · 2020 · External reference
A phase II clinical trial of Bifidobacterium longum subsp. longum BL21 for preventing acute radiation enteritis
10.3389/fnut.2025.1626169 · 2025 · External reference
The gut microbiota as a booster for radiotherapy: novel insights into radio-protection and radiation injury
10.1186/s40164-023-00410-5 · 2023 · External reference
The radioprotective role of human Alistipes onderdonkii identified by multi-omic analysis in patients with prostate cancer
10.1007/s12672-025-02992-4 · 2025 · External reference
Tryptophan catabolites from microbiota engage aryl hydrocarbon receptor and balance mucosal reactivity via interleukin-22
10.1016/j.immuni.2013.08.003 · 2013 · External reference
Microalgae-based oral microcarriers for gut microbiota homeostasis in cancer radiotherapy
10.1038/s41467-022-28744-4 · 2022 · External reference
Activation of pyroptosis and ferroptosis is involved in radiation-induced intestinal injury in mice
10.1016/j.bbrc.2022.09.073 · 2022 · External reference
A potential marker of radiation based on 16S rDNA in the rat model: intestinal flora
10.1371/journal.pone.0286026 · 2023 · External reference
Lactobacillus rhamnosus GG alleviates radiation-induced intestinal injury by modulating intestinal immunity
10.1016/j.micres.2024.127821 · 2024 · External reference
Ginger-derived vesicle-like nanoparticles loaded with curcumin to alleviate ionizing radiation-induced intestinal damage
10.1080/19490976.2025.2531210 · 2025 · External reference
Second-generation probiotics producing IL-22 increase survival of mice after total body irradiation
10.21873/invivo.11743 · 2020 · External reference
Gut metabolite urolithin A mitigates ionizing radiation-induced intestinal damage
10.1111/jcmm.16951 · 2021 · External reference
Inflammation and chronic oxidative stress in radiation-induced late normal tissue injury
10.2174/092986709787002790 · 2009 · External reference
Faecalibaculum rodentium alleviates ionizing radiation-induced damage in mice by improving intestinal integrity and hematopoiesis via its metabolite butyrate
10.1002/advs.202509383 · 2026 · External reference
The role of gut microbiota and its metabolites in mitigating radiation damage
10.3390/microorganisms13092151 · 2025 · External reference
