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References from Klebsiella pneumoniae in inflammatory bowel disease and rectal cancer: from gut inflammation to a potential driver of carcinogenesis. Local targets link to admitted publications; unresolved targets remain external evidence.
Targeting signal-transducer-and-activator-of-transcription-3 for prevention and therapy of cancer: Modern target but ancient solution.
10.1196/annals.1378.063 · 2006 · External reference
Within-host genetic diversity of extended-spectrum beta-lactamase-producing Enterobacterales in long-term colonized patients.
10.1038/s41467-023-44285-w · 2023 · External reference
Numerical ecology validates a biogeographical distribution and gender-based effect on mucosa-associated bacteria along the human colon.
10.1038/ismej.2010.177 · 2011 · External reference
Secondary bile acids: An underrecognized cause of colon cancer.
10.1186/1477-7819-12-164 · 2014 · External reference
The Klebsiella pneumoniae Type VI secretion system as a key determinant of inflammation and tumorigenesis.
10.1093/ecco-jcc/jjaf231.1529 · 2026 · External reference
Biofilm formation and associated gene expression in multidrug-resistant Klebsiella pneumoniae isolated from clinical specimens.
10.1007/s00284-022-02766-z · 2022 · External reference
Th17 cell induction by adhesion of microbes to intestinal epithelial cells.
10.1016/j.cell.2015.08.058 · 2015 · External reference
Microbial dysbiosis drives colorectal carcinogenesis via integrated inflammatory, metabolic, and biofilm pathways.
10.3389/fmicb.2026.1795882 · 2026 · External reference
Klebsiella pneumoniae yersiniabactin promotes respiratory tract infection through evasion of lipocalin 2.
10.1128/iai.05114-11 · 2011 · External reference
Crypt stem cells as the cells-of-origin of intestinal cancer.
10.1038/nature07602 · 2009 · External reference
CEACAM6 acts as a receptor for adherent-invasive E. coli, supporting ileal mucosa colonization in Crohn disease.
10.1172/jci30504 · 2007 · External reference
Emerging role of gut microbiota in modulating response to therapies in IBD.
10.3390/microorganisms14051082 · 2026 · External reference
Addressing current limitations of colonoscopy for colorectal cancer screening.
10.1080/17474124.2026.2628015 · 2026 · External reference
The colibactin genotoxin generates DNA interstrand cross-links in infected cells.
10.1128/mbio.02393-17 · 2018 · External reference
A20’s linear ubiquitin-binding motif restrains pathogenic activation of Th17 cells and IL-22-driven enteritis.
10.1172/jci187499 · 2025 · External reference
Microbiotas from humans with inflammatory bowel disease alter the balance of gut Th17 and RORγt+ regulatory T cells and exacerbate colitis in mice.
10.1016/j.immuni.2018.12.015 · 2019 · External reference
Bacterial oncotraits rather than spatial organization are associated with dysplasia in ulcerative colitis.
10.1093/ecco-jcc/jjad092 · 2023 · External reference
Inflammatory bowel disease.
10.1016/j.pop.2023.03.009 · 2023 · External reference
Detection of tissue colonizing bacteria and their association with clinicopathological and molecular features of inflammatory bowel disease.
10.1186/s12967-025-07095-w · 2025 · External reference
The siderophore yersiniabactin binds copper to protect pathogens during infection.
10.1038/nchembio.1020 · 2012 · External reference
Revisiting bacterial cytolethal distending toxin structure and function.
10.3389/fcimb.2023.1289359 · 2023 · External reference
A Klebsiella-phage cocktail to broaden the host range and delay bacteriophage resistance both in vitro and in vivo.
10.1038/s41522-024-00603-8 · 2024 · External reference
Two ST11 Klebsiella pneumoniae strains exacerbate colorectal tumorigenesis in a colitis-associated mouse model.
10.1080/19490976.2021.1980348 · 2021 · External reference
Towards standards for human fecal sample processing in metagenomic studies.
10.1038/nbt.3960 · 2017 · External reference
Assessing the role of Escherichia coli and Klebsiella pneumoniae in colorectal cancer oncogene expression: Insights from microbial colonization phenotypes.
10.1007/s11033-025-10921-5 · 2025 · External reference
Hypermucoviscous carbapenem-resistant Klebsiella pneumoniae ST25 infect human intestinal epithelial cells and induce moderate inflammation.
10.3390/ijms24108804 · 2023 · External reference
Synthetic colibactins reveal the structural and biological mode-of-action of a microbial carcinogen.
10.1158/1538-7445.am2023-1215 · 2023 · External reference
In vivo single-cell transcriptomics reveal Klebsiella pneumoniae skews lung macrophages to promote infection.
10.15252/emmm.202216888 · 2022 · External reference
Fusobacterium nucleatum transports noninvasive Streptococcus cristatus into human epithelial cells.
10.1128/iai.74.1.654-662.2006 · 2006 · External reference
Cancer-associated fecal microbial markers in colorectal cancer detection.
10.1002/ijc.31011 · 2017 · External reference
Cancer in inflammatory bowel disease.
10.1016/j.gtc.2022.05.003 · 2022 · External reference
Targeted suppression of human IBD-associated gut microbiota commensals by phage consortia for treatment of intestinal inflammation.
10.1016/j.cell.2022.07.003 · 2022 · External reference
Targeted phage hunting to specific Klebsiella pneumoniae clinical isolates is an efficient antibiotic resistance and infection control strategy.
10.1128/spectrum.00254-24 · 2024 · External reference
Klebsiella pneumoniae contributes to altered cytotoxicity of thiopurines in vitro: Possible implications of biotransformation and bacterial metabolism.
10.1111/bph.70089 · 2025 · External reference
Colitis-associated colorectal cancer driven by T-bet deficiency in dendritic cells.
10.1016/j.ccr.2009.07.015 · 2009 · External reference
The treatment-naive microbiome in new-onset Crohn’s disease.
10.1016/j.chom.2014.02.005 · 2014 · External reference
Experimental phage evolution results in expanded host ranges against antibiotic resistant Klebsiella pneumoniae isolates.
10.1038/s41467-025-66062-7 · 2025 · External reference
Hospital-adapted inhaled phage therapy for ventilator-associated pneumonia caused by multidrug-resistant Klebsiella pneumoniae: A comparative pilot study.
10.1186/s13054-026-05839-8 · 2026 · External reference
IL-6 and Stat3 are required for survival of intestinal epithelial cells and development of colitis-associated cancer.
10.1016/j.ccr.2009.01.001 · 2009 · External reference
Integration of metagenome-assembled genomes with clinical isolates expands the genomic landscape of gut-associated Klebsiella pneumoniae.
10.1038/s41467-025-64950-6 · 2025 · External reference
Pediatric Crohn disease patients exhibit specific ileal transcriptome and microbiome signature.
10.1172/jci75436 · 2014 · External reference
Genomic analysis of diversity, population structure, virulence, and antimicrobial resistance in Klebsiella pneumoniae, an urgent threat to public health.
10.1073/pnas.1501049112 · 2015 · External reference
Coexistence of c-rmpA with p-rmpA and p-rmpA2 rather than excessive siderophores confers higher virulence in K1 Klebsiella pneumoniae.
10.1016/j.pathol.2023.07.007 · 2023 · External reference
Carbapenem-resistant Klebsiella pneumoniae capsular types, antibiotic resistance and virulence factors in China: A longitudinal, multi-centre study.
10.1038/s41564-024-01612-1 · 2024 · External reference
Klebsiella pneumoniae l-Fucose metabolism promotes gastrointestinal colonization and modulates its virulence determinants.
10.1128/iai.00206-22 · 2022 · External reference
Secukinumab, a human anti-IL-17A monoclonal antibody, for moderate to severe Crohn’s disease: Unexpected results of a randomised, double-blind placebo-controlled trial.
10.1136/gutjnl-2011-301668 · 2012 · External reference
Risk of colorectal cancer in patients with ulcerative colitis: A meta-analysis of population-based cohort studies.
10.1016/j.cgh.2012.01.010 · 2012 · External reference
Autophagy in colitis-associated colon cancer: Exploring its potential role in reducing initiation and preventing IBD-Related CAC development.
10.1080/15548627.2023.2259214 · 2024 · External reference
Presence of Polyketide Synthase (PKS) gene and counterpart virulence determinants in Klebsiella pneumoniae strains enhances colorectal cancer progression in-vitro.
10.3390/microorganisms11020443 · 2023 · External reference
Cancer development and progression through a vicious cycle of DNA damage and inflammation.
10.3390/ijms26073352 · 2025 · External reference
High prevalence of mucosa-associated extended-spectrum β-Lactamase-producing Escherichia coli and Klebsiella pneumoniae among Iranain patients with inflammatory bowel disease (IBD).
10.1186/s12941-023-00630-x · 2023 · External reference
Hypervirulent Klebsiella pneumoniae: An update on epidemiology, detection and antibiotic resistance.
10.1556/030.2023.02186 · 2023 · External reference
Fusobacterium nucleatum potentiates intestinal tumorigenesis and modulates the tumor-immune microenvironment.
10.1016/j.chom.2013.07.007 · 2013 · External reference
Combining mucosal microbiome and host multi-omics data shows prognostic potential in paediatric ulcerative colitis.
10.1038/s41467-025-62533-z · 2025 · External reference
Colorectal cancer biofilm composition reveals distinct bacterial species signature.
10.1007/s00253-025-13537-8 · 2025 · External reference
Genotoxic Klebsiella pneumoniae in Taiwan.
10.1371/journal.pone.0096292 · 2014 · External reference
Population genomics of hypervirulent Klebsiella pneumoniae clonal-group 23 reveals early emergence and rapid global dissemination.
10.1038/s41467-018-05114-7 · 2018 · External reference
Phage therapy for Klebsiella pneumoniae: Understanding bacteria-phage interactions for therapeutic innovations.
10.1371/journal.ppat.1012971 · 2025 · External reference
Klebsiella pneumoniae is able to trigger epithelial-mesenchymal transition process in cultured airway epithelial cells.
10.1371/journal.pone.0146365 · 2016 · External reference
Inflammation, antibiotics, and diet as environmental stressors of the gut microbiome in pediatric Crohn’s disease.
10.1016/j.chom.2017.07.011 · 2017 · External reference
Differences in gene expression profiles and carcinogenesis pathways between colon and rectal cancer.
10.1111/j.1751-2980.2011.00551.x · 2012 · External reference
Klebsiella pneumoniae outer membrane vesicles induce strong IL-8 expression via NF-κB activation in normal pulmonary bronchial cells.
10.1016/j.intimp.2023.110352 · 2023 · External reference
Insights into the roles of macrophages in Klebsiella pneumoniae infections: A comprehensive review.
10.1186/s11658-025-00717-7 · 2025 · External reference
Tumour-associated and non-tumour-associated bacteria co-abundance groups in colorectal cancer.
10.1186/s12866-024-03402-5 · 2024 · External reference
Gut microbiome in primary sclerosing cholangitis: A review.
10.3748/wjg.v26.i21.2768 · 2020 · External reference
Multi-region and single-cell sequencing reveal variable genomic heterogeneity in rectal cancer.
10.1186/s12885-017-3777-4 · 2017 · External reference
Formation of propionate and butyrate by the human colonic microbiota.
10.1111/1462-2920.13589 · 2017 · External reference
Klebsiella phage KP34gp57 capsular depolymerase structure and function: From a serendipitous finding to the design of active mini-enzymes against K. pneumoniae.
10.1128/mbio.01329-23 · 2023 · External reference
Formulation, stabilisation and encapsulation of bacteriophage for phage therapy.
10.1016/j.cis.2017.05.014 · 2017 · External reference
Colonization, infection, and the accessory genome of Klebsiella pneumoniae.
10.3389/fcimb.2018.00004 · 2018 · External reference
Identification of pathogenicity-associated loci in Klebsiella pneumoniae from hospitalized patients.
10.1128/msystems.00015-18 · 2018 · External reference
Biological and structural characterization of the Type 3 fimbrial subunit MrkA from Klebsiella pneumoniae.
10.1002/pro.70343 · 2025 · External reference
Molecular characterization of the convergent carbapenem-resistant and hypervirulent Klebsiella pneumoniae strain K1-ST23, collected in chile during the COVID-19 pandemic.
10.1128/spectrum.00540-23 · 2023 · External reference
Microcin MccI47 selectively inhibits enteric bacteria and reduces carbapenem-resistant Klebsiella pneumoniae colonization in vivo when administered via an engineered live biotherapeutic.
10.1080/19490976.2022.2127633 · 2022 · External reference
Dietary fat, bile acid metabolism and colorectal cancer.
10.1016/j.semcancer.2020.10.003 · 2021 · External reference
Klebsiella oxytoca causes colonization resistance against multidrug-resistant K. pneumoniae in the gut via cooperative carbohydrate competition.
10.1016/j.chom.2021.09.003 · 2021 · External reference
Risk factors for early-onset colorectal cancer: A systematic review and meta-analysis.
10.1016/j.cgh.2021.01.037 · 2022 · External reference
Hypervirulent Klebsiella pneumoniae induces liver abscess by promoting neutrophil extracellular trap formation through NLRP3 inflammasome activation.
10.1128/spectrum.02376-25 · 2026 · External reference
Absence of the glycosyltransferase WcaJ in Klebsiella pneumoniae ATCC13883 affects biofilm formation, increases polymyxin resistance and reduces murine macrophage activation.
10.1099/mic.0.000827 · 2019 · External reference
Association between gut microbiota and CpG island methylator phenotype in colorectal cancer.
10.1080/19490976.2024.2363012 · 2024 · External reference
Mutational signature in colorectal cancer caused by genotoxic pks+ E. coli.
10.1038/s41586-020-2080-8 · 2020 · External reference
Combining genotoxic gut bacterial strains increases tumor burden and accelerates onset in a germ-free mouse model of colon carcinogenesis.
10.1016/j.celrep.2026.117645 · 2026 · External reference
Genetic structure and distribution of the colibactin genomic island among members of the family Enterobacteriaceae.
10.1128/iai.00522-09 · 2009 · External reference
Significance of tumor infiltrating granulocytes and neutrophil extracellular traps in colorectal cancer.
10.1038/s41416-026-03409-x · 2026 · External reference
Inflammation-Driven genomic instability: A pathway to cancer development and therapy resistance.
10.3390/ph18091406 · 2025 · External reference
Bile salt biotransformations by human intestinal bacteria.
10.1194/jlr.r500013-jlr200 · 2006 · External reference
Strain specificity in fusobacterial co-aggregation with colorectal cancer-relevant species.
10.1016/j.anaerobe.2023.102758 · 2023 · External reference
Improved detection of colibactin-induced mutations by genotoxic E. coli in organoids and colorectal cancer.
10.1016/j.ccell.2024.02.009 · 2024 · External reference
Gut microbiome influences efficacy of PD-1-based immunotherapy against epithelial tumors.
10.1126/science.aan3706 · 2018 · External reference
Fusobacterium nucleatum promotes colorectal carcinogenesis by modulating E-cadherin/β-catenin signaling via its FadA adhesin.
10.1016/j.chom.2013.07.012 · 2013 · External reference
Gut microbiota serves as a crucial independent biomarker in Inflammatory Bowel Disease (IBD).
10.3390/ijms26062503 · 2025 · External reference
Habitual ultra-processed food intake is associated with gut dysbiosis and pro-inflammatory metabolite profiles in korean patients with IBD.
10.1007/s10620-026-10066-w · 2026 · External reference
Helicobacter pylori activates and expands Lgr5(+) stem cells through direct colonization of the gastric glands.
10.1053/j.gastro.2015.02.049 · 2015 · External reference
LPS O antigen plays a key role in Klebsiella pneumoniae capsule retention.
10.1128/spectrum.01517-21 · 2022 · External reference
Bacteriophage-mediated restoration of epithelial integrity, DNA damage response, and transcriptomic homeostasis in colon organoids exposed to ETBF and pks + E. coli.
10.1038/s41598-026-56205-1 · 2026 · External reference
Selective depletion of uropathogenic E. coli from the gut by a FimH antagonist.
10.1038/nature22972 · 2017 · External reference
Ultra-Processed foods, gut microbiota, and inflammatory bowel disease: A critical review of emerging evidence.
10.3390/nu17162677 · 2025 · External reference
Population variability of the FimH type 1 fimbrial adhesin in Klebsiella pneumoniae.
10.1128/jb.00601-08 · External reference
Comparative structure-function analysis of mannose-specific FimH adhesins from Klebsiella pneumoniae and Escherichia coli.
10.1128/jb.00786-09 · External reference
Klebsiella pneumoniae producing bacterial toxin colibactin as a risk of colorectal cancer development - A systematic review.
10.1016/j.toxicon.2021.04.007 · 2021 · External reference
Sequential phage delivery can outperform cocktails by delaying cross-resistance evolution.
10.3390/v18040404 · 2026 · External reference
Hypervirulent Klebsiella pneumoniae employs genomic island encoded toxins against bacterial competitors in the gut.
10.1093/ismejo/wrae054 · 2024 · External reference
Differential mucosal tropism and dissemination of classical and hypervirulent Klebsiella pneumoniae infection.
10.1016/j.isci.2024.108875 · 2024 · External reference
Enrichment of colibactin-associated mutational signatures in unexplained colorectal polyposis patients.
10.1186/s12885-024-11849-y · 2024 · External reference
Metagenomic analysis of colorectal cancer datasets identifies cross-cohort microbial diagnostic signatures and a link with choline degradation.
10.1038/s41591-019-0405-7 · 2019 · External reference
Polystyrene nanoplastics promote colitis-associated cancer by disrupting lipid metabolism and inducing DNA damage.
10.1016/j.envint.2025.109258 · 2025 · External reference
A small molecule inhibitor prevents gut bacterial genotoxin production.
10.1038/s41589-022-01147-8 · 2023 · External reference
Absence of Escherichia coli, Listeria monocytogenes, and Klebsiella pneumoniae antigens within inflammatory bowel disease tissues.
10.1136/jcp.51.9.657 · 1998 · External reference
Integrative analysis of multi-omics data and gut microbiota composition reveals prognostic subtypes and predicts immunotherapy response in colorectal cancer using machine learning.
10.1038/s41598-025-08915-1 · 2025 · External reference
Molecular epidemiology of carbapenem-resistant hypervirulent Klebsiella pneumoniae: Risk factors and resistance mechanism of ceftazidime/avibactam in China.
10.3389/fcimb.2025.1698033 · 2025 · External reference
Sphingosine 1-Phosphate activation of EGFR as a novel target for meningitic Escherichia coli penetration of the blood-brain barrier.
10.1371/journal.ppat.1005926 · 2016 · External reference
Meta-analysis of fecal metagenomes reveals global microbial signatures that are specific for colorectal cancer.
10.1038/s41591-019-0406-6 · 2019 · External reference
A human colonic commensal promotes colon tumorigenesis via activation of T helper type 17 T cell responses.
10.1038/nm.2015 · 2009 · External reference
Klebsiella pneumoniae population genomics and antimicrobial-resistant clones.
10.1016/j.tim.2016.09.007 · 2016 · External reference
Distinct evolutionary dynamics of horizontal gene transfer in drug resistant and virulent clones of Klebsiella pneumoniae.
10.1371/journal.pgen.1008114 · 2019 · External reference
Myeloid-derived suppressor cell inhibits T-cell-based defense against Klebsiella pneumoniae infection via IDO1 production.
10.1371/journal.ppat.1012979 · 2025 · External reference
Agonist signaling drives neutrophil subpopulations to promote/inhibit colorectal cancer liver metastasis.
10.1038/s41467-025-67579-7 · 2025 · External reference
Metagenomic and metabolomic analyses reveal distinct stage-specific phenotypes of the gut microbiota in colorectal cancer.
10.1038/s41591-019-0458-7 · 2019 · External reference
Upregulation of occludin by cytolethal distending toxin facilitates Glaesserella parasuis adhesion to respiratory tract cells.
10.1128/iai.00351-23 · 2023 · External reference
Engineering a T7 bacteriophage to attenuate LPS-driven inflammatory responses during bacteriolysis.
10.1128/aem.02303-25 · 2026 · External reference
Risk and incidence of colorectal stricture progressing to colorectal neoplasia in patients with inflammatory bowel disease: A systematic review and meta-analysis.
10.1097/meg.0000000000002614 · 2023 · External reference
The inhibition mechanism of co-cultured probiotics on biofilm formation of Klebsiella pneumoniae.
10.1093/jambio/lxae138 · 2024 · External reference
Echinacoside attenuates Klebsiella pneumoniae-induced pneumonia via inhibition of the TLR4/NF-κB signaling.
10.1111/apm.13507 · 2025 · External reference
Klebsiella pneumoniae induces inflammatory bowel disease through Caspase-11-Mediated IL18 in the gut epithelial cells.
10.1016/j.jcmgh.2022.11.005 · 2023 · External reference
Inosine and D-Mannose secreted by drug-resistant Klebsiella pneumoniae affect viability of lung epithelial cells.
10.3390/molecules27092994 · 2022 · External reference
Gut microbiota in different treatment response types of Crohn’s disease patients treated with biologics over a long disease course.
10.3390/biomedicines13030708 · 2025 · External reference
A multi-omics spatial framework for host-microbiome dissection within the intestinal tissue microenvironment.
10.1038/s41467-025-56237-7 · 2025 · External reference
