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References from Redox biology underlying the efficacy and toxicity of colistin as a last-resort antibiotic. Local targets link to admitted publications; unresolved targets remain external evidence.
Oxidative Stress-driven mechanisms and biomarkers of drug-induced nephrotoxicity: Translational insights and therapeutic implications.
10.3390/antiox15040412 · 2026 · External reference
The potential role of adjunctive ascorbic acid in the prevention of colistin-induced nephrotoxicity in critically ill patients: A retrospective study.
10.1016/j.jsps.2022.10.003 · 2022 · External reference
Global burden of bacterial antimicrobial resistance in 2019: A systematic analysis.
10.1016/s0140-6736(21)02724-0 · 2022 · External reference
Mechanisms of polymyxin-induced nephrotoxicity.
10.1007/978-3-030-16373-0_18 · 2019 · External reference
Translating preclinical models to humans.
10.1126/science.aay8086 · 2020 · External reference
Exploring immune redox modulation in bacterial infections: Insights into thioredoxin-mediated interactions and implications for understanding host-pathogen dynamics.
10.3390/antiox13050545 · 2024 · External reference
Colistin-associated acute kidney injury in severely ill patients: A step toward a better renal care? A prospective cohort study.
10.1093/cid/civ717 · 2015 · External reference
Will 10 million people die a year due to antimicrobial resistance by 2050?
10.1371/journal.pmed.1002184 · 2016 · External reference
Colistin: Lights and shadows of an older antibiotic.
10.3390/molecules29132969 · 2024 · External reference
Implications of bacterial exposure to reactive oxygen and chlorine species.
10.1128/iai.00010-23 · 2026 · External reference
Rational design of mitochondria-targeted antioxidants: From molecular determinants to clinical perspectives.
10.3390/ddc5010009 · 2026 · External reference
Molecular mechanisms of colistin-induced nephrotoxicity.
10.3390/molecules24030653 · 2019 · External reference
Oxidative stress: From molecular studies to clinical intervention strategies.
10.3389/fmolb.2025.1638042 · 2025 · External reference
Oxidative stress fundamentals: Unraveling the pathophysiological role of redox imbalance in non-communicable diseases.
10.3390/app151810191 · 2025 · External reference
Antimicrobial resistance: A concise update.
10.1016/j.lanmic.2024.07.010 · 2025 · External reference
Prevention of colistin induced nephrotoxicity: A review of preclinical and clinical data.
10.1080/17512433.2021.1933436 · 2021 · External reference
Natural compounds targeting multidrug-resistant Acinetobacter baumannii: Anti-biofilm, anti-resistance, and synergistic strategies.
10.1016/j.micpath.2026.108621 · 2026 · External reference
Killing by bactericidal antibiotics does not depend on reactive oxygen species.
10.1126/science.1232688 · 2013 · External reference
A common mechanism of cellular death induced by bactericidal antibiotics.
10.1016/j.cell.2007.06.049 · 2007 · External reference
Redox regulation: Mechanisms, biology and therapeutic targets in diseases.
10.1038/s41392-024-02095-6 · 2025 · External reference
Molecular mechanisms attributed to colistin renal proximal tubular epithelial cytotoxicity.
10.1007/s44446-025-00049-9 · 2025 · External reference
Poor translatability of biomedical research using animals - a narrative review.
10.1177/02611929231157756 · 2023 · External reference
Pharmacological agents for the prevention of colistin-induced nephrotoxicity.
10.1186/s40001-022-00689-w · 2022 · External reference
Optimizing preclinical models of ageing for translation to clinical trials.
10.1111/bcp.15902 · 2025 · External reference
Evaluation of the effectiveness of n-acetylcysteine in the prevention of colistin-induced nephrotoxicity: A randomized controlled clinical trial.
10.4103/jrpp.jrpp_90_21 · 2022 · External reference
How the redox state regulates immunity.
10.1016/j.freeradbiomed.2019.12.022 · 2020 · External reference
Advancements in mitochondrial-targeted antioxidants: Organelle-specific drug delivery for disease management.
10.1016/j.arres.2025.100142 · 2025 · External reference
Polymyxin acute kidney injury: Dosing and other strategies to reduce toxicity.
10.3390/antibiotics8010024 · 2019 · External reference
Unresolved reference
2016 · External reference
The scope of the antimicrobial resistance challenge.
10.1016/s0140-6736(24)00876-6 · 2024 · External reference
The role of oxidative stress in kidney injury.
10.3390/antiox12091772 · 2023 · External reference
Increasing rigor of preclinical research to maximize opportunities for translation.
10.1007/s13311-023-01400-5 · 2023 · External reference
Oxidative stress in health and disease.
10.3390/biomedicines11112925 · 2023 · External reference
Reduce, induce, thrive: Bacterial redox sensing during pathogenesis.
10.1128/jb.00128-18 · 2018 · External reference
Colistin: From the shadows to a one health approach for addressing antimicrobial resistance.
10.1016/j.ijantimicag.2023.106713 · 2023 · External reference
Mechanisms of Keap1/Nrf2 modulation in bacterial infections: Implications in persistence and clearance.
10.3389/fimmu.2024.1508787 · 2024 · External reference
Colistin resistance in the era of antimicrobial resistance: Challenges and strategic countermeasures.
10.1007/s12223-025-01322-z · 2025 · External reference
The effects of vitamin E on colistin-induced nephrotoxicity in treatment of drug-resistant gram-negative bacterial infections: A randomized clinical trial.
10.1016/j.jiac.2021.03.013 · 2021 · External reference
Mitochondrial reactive oxygen species as major effectors of antimicrobial immunity.
10.1371/journal.ppat.1008470 · 2020 · External reference
The simultaneous prevention of multiple diseases: A “one ring to rule them all” framework for redox-driven health and longevity.
10.3390/nu18061007 · 2026 · External reference
Understanding antimicrobial resistance (AMR) mechanisms and advancements in AMR diagnostics.
10.1016/j.diagmicrobio.2025.116949 · 2025 · External reference
Microbial antioxidant defense enzymes.
10.1016/j.micpath.2017.06.015 · 2017 · External reference
Reviving colistin.
10.1038/s41579-023-00907-0 · 2023 · External reference
Antimicrobial resistance (AMR).
10.3389/bjbs.2023.11387 · 2023 · External reference
Polymyxin: Alternative mechanisms of action and resistance.
10.1101/cshperspect.a025288 · 2016 · External reference
International consensus guidelines for the optimal use of the polymyxins: Endorsed by the American college of clinical pharmacy (ACCP), European society of clinical microbiology and infectious diseases (ESCMID), infectious diseases society of America (IDSA), international society for anti-infective pharmacology (ISAP), Society of critical care medicine (SCCM), and society of infectious diseases pharmacists (SIDP).
10.1002/phar.2209 · 2019 · External reference
Oxidative stress induced by polymyxin e is involved in rapid killing of paenibacillus polymyxa.
10.1155/2017/5437139 · 2017 · External reference
Synergistic strategies to rescue the last-resort antibiotic colistin.
10.1007/s00203-026-04972-w · 2026 · External reference
