Research graph
References from Placental dysfunction drives fetal growth restriction: mechanisms and translational perspectives. Local targets link to admitted publications; unresolved targets remain external evidence.
The added value of the sFlt-1/PlGF ratio in pregnant women with intrauterine growth restriction (IUGR) with or without preeclampsia on adverse pregnancy outcomes and neonatal morbidities: a retrospective study
10.1186/s12884-025-08057-2 · 2025 · External reference
The human placenta and its role in reproductive outcomes revisited
10.1152/physrev.00039.2024 · 2025 · External reference
The developmental origins of adult disease
10.1080/07315724.2004.10719428 · 2004 · External reference
Neurodevelopment outcome in children with fetal growth restriction at six years of age: a retrospective cohort study
10.3390/ijerph191711043 · 2022 · External reference
Decidual macrophages and Hofbauer cells in fetal growth restriction
10.3389/fimmu.2024.1379537 · 2024 · External reference
Understanding the impact of placental oxidative and nitrative stress in pregnancies complicated by fetal growth restriction
10.1016/j.placenta.2024.11.005 · 2024 · External reference
Pathophysiology of placental-derived fetal growth restriction
10.1016/j.ajog.2017.11.577 · 2018 · External reference
Optimising sample collection for placental research
10.1016/j.placenta.2013.11.005 · 2014 · External reference
Sex-specific placental gene expression signatures of small for gestational age at birth
10.1016/j.placenta.2022.03.004 · 2022 · External reference
Diagnostic capacity of sFlt-1/PlGF ratio in fetal growth restriction: a systematic review and meta-analysis
10.1016/j.placenta.2022.07.020 · 2022 · External reference
Metabolomic signatures associated with fetal growth restriction and small for gestational age: a systematic review
10.1038/s41467-024-53597-4 · 2024 · External reference
Placental-specific IGF-II is a major modulator of placental and fetal growth
10.1038/nature00819 · 2002 · External reference
Decidual NK cells transfer granulysin to selectively kill bacteria in trophoblasts
10.1016/j.cell.2020.07.019 · 2020 · External reference
Long-term implications of fetal growth restriction
10.12998/wjcc.v11.i13.2855 · 2023 · External reference
Arsenic induces ferroptosis in HTR-8/SVneo cells and placental damage
10.1016/j.scitotenv.2024.176885 · 2024 · External reference
Placental single cell transcriptomics: opportunities for endocrine disrupting chemical toxicology
10.1016/j.mce.2023.112066 · 2023 · External reference
Current practice in the diagnosis and management of fetal growth restriction: an international survey
10.1111/aogs.14466 · 2022 · External reference
Update on the diagnosis and classification of fetal growth restriction and proposal of a stage-based management protocol
10.1159/000357592 · 2014 · External reference
Stage-based approach to the management of fetal growth restriction
10.1002/pd.4412 · 2014 · External reference
Screening for fetal growth restriction using fetal biometry combined with maternal biomarkers
10.1016/j.ajog.2017.12.002 · 2018 · External reference
Increased placental sFLT1 (soluble fms-Like tyrosine kinase Receptor-1) drives the antiangiogenic profile of maternal serum preceding Preeclampsia but not fetal growth restriction
10.1161/hypertensionaha.122.19482 · 2023 · External reference
Decoding placental dysfunction with a new angiogenic classification of PlGF and sFlt-1
10.1016/j.ejogrb.2025.114539 · 2025 · External reference
Consensus definition of fetal growth restriction: a Delphi procedure
10.1002/uog.15884 · 2016 · External reference
Differential miRNA expression profiles between the first and third trimester human placentas
10.1152/ajpendo.00660.2012 · 2013 · External reference
Self-Renewing trophoblast Organoids Recapitulate the Developmental Program of the early human placenta
10.1016/j.stemcr.2018.07.004 · 2018 · External reference
Nrf2-mediated ferroptosis inhibition: a novel approach for managing inflammatory diseases
10.1007/s10787-024-01519-7 · 2024 · External reference
Role of microRNAs in trophoblast invasion and spiral artery remodeling: implications for preeclampsia
10.3389/fcell.2022.995462 · 2022 · External reference
Clinical implementation of the sFlt-1/PlGF ratio to identify preeclampsia and fetal growth restriction: a prospective cohort study
10.1016/j.preghy.2018.06.017 · 2018 · External reference
International Consensus Guideline on small for gestational Age: etiology and management from infancy to early adulthood
10.1210/endrev/bnad002 · 2023 · External reference
Angiopoietin 2 stimulates trophoblast invasion via a mechanism associated with JNK signaling
10.1093/molehr/gaab014 · 2021 · External reference
The prediction of gestational hypertension, Preeclampsia and fetal growth restriction via the first trimester screening of Plasma exosomal C19MC microRNAs
10.3390/ijms20122972 · 2019 · External reference
Mitochondrial dysfunction and oxidative stress in selective fetal growth restriction
10.1016/j.placenta.2024.09.005 · 2024 · External reference
Single-cell RNA sequencing reveals association of aberrant placental trophoblasts and FN1 reduction in late-onset fetal growth restriction
10.1016/j.placenta.2023.12.022 · 2024 · External reference
In suspected fetal growth restriction, sFlt-1/PlGF and PlGF May have value in risk stratification for preterm birth and birthweight < 3rd centile: a blinded cohort study
10.1111/ajo.70003 · 2025 · External reference
Characterization of regulatory T cells in decidua of miscarriage cases with abnormal or normal fetal chromosomal content
10.1016/j.jri.2012.12.001 · 2013 · External reference
Role of placental nutrient sensing in developmental programming
10.1097/grf.0b013e3182993a2e · 2013 · External reference
Glucose transporter protein expression in human placenta throughout gestation and in intrauterine growth retardation
10.1210/jcem.77.6.8263141 · 1993 · External reference
Down-regulation of placental mTOR, insulin/IGF-I signaling, and nutrient transporters in response to maternal nutrient restriction in the baboon
10.1096/fj.13-242271 · 2014 · External reference
Consensus definition and essential reporting parameters of selective fetal growth restriction in twin pregnancy: a Delphi procedure
10.1002/uog.19013 · 2019 · External reference
Inadequate maternal vascular response to placentation in pregnancies complicated by pre-eclampsia and by small-for-gestational age infants
10.1111/j.1471-0528.1986.tb07830.x · 1986 · External reference
Guideline No. 442: fetal growth restriction: screening, diagnosis, and management in singleton pregnancies
10.1016/j.jogc.2023.05.022 · 2023 · External reference
microRNA signatures associated with fetal growth restriction: a systematic review
10.1038/s41430-021-01041-x · 2022 · External reference
The effects of Nrf2 deletion on placental morphology and exchange capacity in the mouse
10.1080/14767058.2016.1236251 · 2017 · External reference
Placental transfer of fatty acids and fetal implications
10.3945/ajcn.110.001230 · 2011 · External reference
Stillbirths: rates, risk factors, and acceleration towards 2030
10.1016/s0140-6736(15)00837-5 · 2016 · External reference
Th17 and regulatory T cells in women with recurrent pregnancy loss
10.1111/j.1600-0897.2012.01116.x · 2012 · External reference
Perinatal morbidity and mortality in early-onset fetal growth restriction: cohort outcomes of the trial of randomized umbilical and fetal flow in Europe (TRUFFLE)
10.1002/uog.13190 · 2013 · External reference
ISUOG practice guidelines: diagnosis and management of small-for-gestational-age fetus and fetal growth restriction
10.1002/uog.22134 · 2020 · External reference
Clinical opinion: the diagnosis and management of suspected fetal growth restriction: an evidence-based approach
10.1016/j.ajog.2021.11.1357 · 2022 · External reference
Fetal growth restriction followed by very preterm birth is associated with smaller kidneys but preserved kidney function in adolescence
10.1007/s00467-022-05785-x · 2023 · External reference
Spiral artery remodeling and trophoblast invasion in preeclampsia and fetal growth restriction: relationship to clinical outcome
10.1161/hypertensionaha.113.01892 · 2013 · External reference
FIGO (international Federation of gynecology and obstetrics) initiative on fetal growth: best practice advice for screening, diagnosis, and management of fetal growth restriction
10.1002/ijgo.13522 · 2021 · External reference
Machine learning applied in maternal and fetal health: a narrative review focused on pregnancy diseases and complications
10.3389/fendo.2023.1130139 · 2023 · External reference
Placental exosomes profile in maternal and fetal circulation in intrauterine growth restriction - liquid biopsies to monitoring fetal growth
10.1016/j.placenta.2018.02.006 · 2018 · External reference
Management of fetuses with apparent normal growth and abnormal cerebroplacental ratio: a risk-based approach near term
10.1111/aogs.14732 · 2024 · External reference
Perinatal and 2-year neurodevelopmental outcome in late preterm fetal compromise: the TRUFFLE 2 randomised trial protocol
10.1136/bmjopen-2021-055543 · 2022 · External reference
The Nrf2-antioxidant response element signaling pathway and its activation by oxidative stress
10.1074/jbc.r900010200 · 2009 · External reference
Spatial multiomic landscape of the human placenta at molecular resolution
10.1038/s41591-024-03073-9 · 2024 · External reference
The INTERGROWTH-21(st) fetal growth standards: toward the global integration of pregnancy and pediatric care
10.1016/j.ajog.2018.01.011 · 2018 · External reference
Management of late-onset fetal growth restriction: pragmatic approach
10.1002/uog.26190 · 2023 · External reference
Maternal sildenafil vs placebo in pregnant women with severe early-onset fetal growth restriction: a randomized clinical trial
10.1001/jamanetworkopen.2020.5323 · 2020 · External reference
Molecular epidemiology of pregnancy using omics data: advances, success stories, and challenges
10.1186/s12967-024-04876-7 · 2024 · External reference
Hofbauer cells: their role in healthy and complicated pregnancy
10.3389/fimmu.2018.02628 · 2018 · External reference
Aspirin for the prevention of preterm and term preeclampsia: systematic review and metaanalysis
10.1016/j.ajog.2017.11.561 · 2018 · External reference
Low-molecular-weight heparin and recurrent placenta-mediated pregnancy complications: a meta-analysis of individual patient data from randomised controlled trials
10.1016/s0140-6736(16)31139-4 · 2016 · External reference
Aspirin versus placebo in pregnancies at high risk for Preterm Preeclampsia
10.1056/nejmoa1704559 · 2017 · External reference
Mammalian target of rapamycin in the human placenta regulates leucine transport and is down-regulated in restricted fetal growth
10.1113/jphysiol.2007.129676 · 2007 · External reference
Epigenetics beyond fetal growth restriction: a comprehensive overview
10.1007/s40291-022-00611-4 · 2022 · External reference
Proteinuria in preterm neonates: influence of fetal growth restriction
10.1038/s41372-025-02306-0 · 2025 · External reference
Maternal sildenafil for severe fetal growth restriction (STRIDER): a multicentre, randomised, placebo-controlled, double-blind trial
10.1016/s2352-4642(17)30173-6 · 2018 · External reference
Clinical utility of sFlt-1 and PlGF in screening, prediction, diagnosis and monitoring of pre-eclampsia and fetal growth restriction
10.1002/uog.26032 · 2023 · External reference
A single-cell survey of the human first-trimester placenta and decidua
10.1126/sciadv.aau4788 · 2018 · External reference
Single-cell and spatial transcriptomics: discovery of human placental development and disease
10.1096/fba.2024-00133 · 2024 · External reference
Optimizing the definition of intrauterine growth restriction: the multicenter prospective PORTO Study
10.1016/j.ajog.2013.02.007 · 2013 · External reference
Paradigms for investigating invasive trophoblast cell development and contributions to uterine spiral artery remodeling
10.1016/j.placenta.2021.04.012 · 2021 · External reference
Single-cell reconstruction of the early maternal-fetal interface in humans
10.1038/s41586-018-0698-6 · 2018 · External reference
Clinical interpretation and implementation of the sFlt-1/PlGF ratio in the prediction, diagnosis and management of preeclampsia
10.1016/j.preghy.2021.12.003 · 2022 · External reference
Fetal monitoring indications for delivery and 2-year outcome in 310 infants with fetal growth restriction delivered before 32 weeks' gestation in the TRUFFLE study
10.1002/uog.17361 · 2017 · External reference
Prognostic accuracy of cerebroplacental ratio and middle cerebral artery Doppler for adverse perinatal outcome: systematic review and meta-analysis
10.1002/uog.18809 · 2018 · External reference
The human placenta shapes the phenotype of decidual macrophages
10.1016/j.celrep.2022.111977 · 2023 · External reference
Mitochondrial quality control alterations and placenta-related disorders
10.3389/fphys.2024.1344951 · 2024 · External reference
Paired maternal and fetal metabolomics reveal a differential fingerprint in preeclampsia versus fetal growth restriction
10.1038/s41598-021-93936-9 · 2021 · External reference
Exposure to carbon black nanoparticles during pregnancy persistently damages the cerebrovascular function in female mice
10.1016/j.tox.2019.04.014 · 2019 · External reference
Gestational exposure to black phosphorus nanoparticles induces placental trophoblast dysfunction by triggering reactive oxygen species-regulated mitophagy
10.1021/acsnano.4c18731 · 2025 · External reference
AI-based analysis of fetal growth restriction in a prospective obstetric cohort quantifies compound risks for perinatal morbidity and mortality and identifies previously unrecognized high risk clinical scenarios
10.1186/s12884-024-07095-6 · 2025 · External reference
H19 long noncoding RNA alters trophoblast cell migration and invasion by regulating TβR3 in placentae with fetal growth restriction
10.18632/oncotarget.9534 · 2016 · External reference
