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References from Poor prognosis of acute kidney injury superimposed on chronic kidney disease: potential mechanisms, risk factors and novel biomarkers. Local targets link to admitted publications; unresolved targets remain external evidence.
Contemporary contrast media dosing during percutaneous coronary intervention in patients with pre-existing renal impairment
10.25270/jic/24.00313 · 2025 · External reference
Acute kidney injury in patients continued on renin-angiotensin system blockers during hospitalization
10.1016/j.amjms.2016.09.012 · 2017 · External reference
Structural renal changes in obesity and diabetes
10.1016/j.semnephrol.2012.12.003 · 2013 · External reference
Endothelial function, CRP and oxidative stress in chronic kidney disease
10.1093/joneph/18.6.721 · 2005 · External reference
Renal safety and survival among acutely ill hospitalized patients treated by blockers of the renin-angiotensin axis or loop diuretics: a single-center retrospective analysis
10.1080/0886022x.2023.2282707 · 2023 · External reference
Contrast-induced nephropathy: from pathophysiology to preventive strategies
10.1016/j.cjca.2015.05.013 · 2016 · External reference
Adding insult to injury: the spectrum of tubulointerstitial responses in acute kidney injury
10.1172/jci188358 · 2025 · External reference
Neutrophil gelatinase-associated lipocalin (NGAL) for the prediction of acute kidney injury in chronic kidney disease patients treated with primary percutaneous coronary intervention
10.1016/j.ijcha.2020.100695 · 2021 · External reference
Pathophysiology of acute kidney injury
10.1002/j.2040-4603.2012.tb00431.x · 2012 · External reference
Progression after AKI: understanding maladaptive repair processes to predict and identify therapeutic treatments
10.1681/asn.2015030309 · 2016 · External reference
Protein-bound uremic toxins from gut microbiota and inflammatory markers in chronic kidney disease
10.1053/j.jrn.2016.07.005 · 2016 · External reference
Proenkephalin for the early detection of acute kidney injury in hospitalized patients with chronic kidney disease
10.1111/eci.12999 · 2018 · External reference
Circulating proenkephalin, acute kidney injury, and its improvement in patients with severe sepsis or shock
10.1373/clinchem.2018.288068 · 2018 · External reference
Mitochondrial dysfunction and metabolic reprogramming in acute kidney injury: mechanisms, therapeutic advances, and clinical challenges
10.3389/fphys.2025.1623500 · 2025 · External reference
Tubular disease: mistargeted protein disrupts mitochondrial metabolism in inherited Fanconi syndrome
10.1038/nrneph.2014.6 · 2014 · External reference
Chronic kidney disease and superimposed acute kidney injury: greater impact of acute insults on outcomes
10.1155/ijne/1353892 · 2026 · External reference
High plasma C-terminal FGF-23 levels predict poor outcomes in patients with chronic kidney disease superimposed with acute kidney injury
10.1177/2040622320964161 · 2020 · External reference
Mitochondrial signaling, the mechanisms of AKI-to-CKD transition and potential treatment targets
10.3390/ijms25031518 · 2024 · External reference
Acute kidney injury and chronic kidney disease: an integrated clinical syndrome
10.1038/ki.2012.208 · 2012 · External reference
Acute kidney injury and chronic kidney disease as interconnected syndromes
10.1056/nejmra1214243 · 2014 · External reference
Increased plasma fibroblast growth factor 23 and In-hospital acute kidney injury after cardiac surgery
10.1097/aln.0000000000005605 · 2025 · External reference
Sepsis-associated acute kidney disease incidence, trajectory, and outcomes
10.1016/j.xkme.2024.100959 · 2025 · External reference
Chronic kidney disease after acute kidney injury: a systematic review and meta-analysis
10.1038/ki.2011.379 · 2012 · External reference
Urinary KIM-1 correlates with the subclinical sequelae of tubular damage persisting after the apparent functional recovery from intrinsic acute kidney injury
10.3390/biomedicines10051106 · 2022 · External reference
Proenkephalin expression and enkephalin release are widely observed in non-neuronal tissues
10.1016/j.peptides.2007.11.004 · 2008 · External reference
Plasma neutrophil gelatinase-associated lipocalin in acute kidney injury superimposed on chronic kidney disease after cardiac surgery: a multicenter prospective study
10.1186/cc13104 · 2013 · External reference
Pathophysiological implications of fibroblast growth factor-23 and klotho and their potential role as clinical biomarkers
10.1373/clinchem.2013.206649 · 2014 · External reference
Vancomycin-induced nephrotoxicity: mechanism, incidence, risk factors and special populations. A literature review
10.1007/s00228-012-1259-9 · 2012 · External reference
Prediction of mortality and need for renal replacement therapy in patients of acute kidney injury using fibroblast growth factor 23
10.4103/1319-2442.270259 · 2019 · External reference
Mechanisms of maladaptive repair after AKI leading to accelerated kidney ageing and CKD
10.1038/nrneph.2015.3 · 2015 · External reference
Inflammation in kidney repair: mechanism and therapeutic potential
10.1016/j.pharmthera.2022.108240 · 2022 · External reference
Drug-induced acute kidney injury: a cohort study on incidence, identification of pathophysiological mechanisms, and prognostic factors
10.3389/fmed.2024.1459170 · 2024 · External reference
The role of interleukin-4 in acute kidney injury and chronic kidney disease: a literature review
10.1186/s12882-026-04879-0 · 2026 · External reference
Chronic kidney disease and aging: dissecting the p53/p21 pathway as a therapeutic target
10.1007/s10522-024-10173-z · 2024 · External reference
Mechanisms of NLRP3 priming in inflammaging and age related diseases
10.1016/j.cytogfr.2020.08.003 · 2020 · External reference
Mitochondrial dysfunction in the pathophysiology of renal diseases
10.1152/ajprenal.00189.2023 · 2024 · External reference
New insights into acute-on-chronic kidney disease in nephrology patients: the CKD-REIN study
10.1093/ndt/gfab249 · 2022 · External reference
Kidney injury Molecule-1 (KIM-1): a novel biomarker for human renal proximal tubule injury
10.1046/j.1523-1755.2002.00433.x · 2002 · External reference
Urinary biomarkers in the early diagnosis of acute kidney injury
10.1038/sj.ki.5002715 · 2008 · External reference
AKI on CKD: heightened injury, suppressed repair, and the underlying mechanisms
10.1016/j.kint.2017.06.030 · 2017 · External reference
Prevalence, risk factors, and short-term outcome of contrast-induced nephropathy among patients with chronic kidney disease: a cross-sectional study from Sri Lanka
10.1097/md.0000000000043892 · 2025 · External reference
High prevalence of renal dysfunction and its impact on outcome in 118,465 patients hospitalized with acute decompensated heart failure: a report from the ADHERE database
10.1016/j.cardfail.2007.03.011 · 2007 · External reference
The risk of acute renal failure in patients with chronic kidney disease
10.1038/ki.2008.107 · 2008 · External reference
Kidney fibrosis: from mechanisms to therapeutic medicines
10.1038/s41392-023-01379-7 · 2023 · External reference
Chronic epithelial kidney injury molecule-1 expression causes murine kidney fibrosis
10.1172/jci45361 · 2013 · External reference
Clinical adoption of nephrocheck® in the early detection of acute kidney injury
10.1177/0004563220970032 · 2021 · External reference
A meta-analysis of the association of estimated GFR, albuminuria, diabetes mellitus, and hypertension with acute kidney injury
10.1053/j.ajkd.2015.02.338 · 2015 · External reference
Cardiovascular disease in chronic kidney disease: pathophysiological insights and therapeutic options
10.1161/circulationaha.120.050686 · 2021 · External reference
Novel predictive biomarkers for acute injury superimposed on chronic kidney disease
10.1016/j.nefroe.2021.05.001 · 2021 · External reference
US renal data system 2023 annual data report: epidemiology of kidney disease in the United States
10.1053/j.ajkd.2024.01.001 · 2024 · External reference
The role of inflammation in CKD
10.3390/cells12121581 · 2023 · External reference
Vancomycin-associated acute kidney injury: a narrative review from pathophysiology to clinical application
10.3390/ijms23042052 · 2022 · External reference
Discovery and validation of cell cycle arrest biomarkers in human acute kidney injury
10.1186/cc12503 · 2013 · External reference
Clinical significance of the interval change of plasma neutrophil gelatinase-associated lipocalin in acute kidney injury and acute kidney injury superimposed on chronic kidney disease
10.4068/cmj.2019.55.1.68 · 2019 · External reference
Kidney fibrosis: emerging diagnostic and therapeutic strategies
10.1016/j.mam.2023.101206 · 2023 · External reference
Distant organ dysfunction in acute kidney injury: a review
10.1053/j.ajkd.2018.03.028 · 2018 · External reference
Cardiorenal syndrome: acute kidney injury secondary to cardiovascular disease and role of protein-bound uraemic toxins
10.1113/jphysiol.2014.273078 · 2014 · External reference
The impact of preexisting chronic kidney disease on the severity and recovery of acute kidney injury
10.1159/000487492 · 2018 · External reference
Early predictors of acute kidney injury: a narrative review
10.1159/000447937 · 2016 · External reference
Disturbance of mitochondrial dynamics and mitophagy in sepsis-induced acute kidney injury
10.1016/j.lfs.2019.116828 · 2019 · External reference
Mechanisms of cisplatin-induced acute kidney injury: the role of NRF2 in mitochondrial dysfunction and metabolic reprogramming
10.3390/antiox14070775 · 2025 · External reference
New insights into the mechanism of aminoglycoside nephrotoxicity: an integrative point of view
10.1038/ki.2010.337 · 2011 · External reference
Diagnostic and short-term prognostic utility of plasma pro-enkephalin (pro-ENK) for acute kidney injury in patients admitted with sepsis in the emergency department
10.1007/s40620-014-0163-z · 2015 · External reference
10.1080/0886022x.2025.2556295 · 2025 · Admitted local publication
Importance of the renal medullary circulation in the control of sodium excretion and blood pressure
10.1152/ajpregu.00321.2002 · 2003 · External reference
Therapeutic and mechanistic insights on mitochondrial transplantation in kidney disease
10.1038/s41581-026-01072-2 · 2026 · External reference
Plasma and urinary KIM-1 in chronic kidney disease: prognostic value, associations with albuminuria, and implications for kidney failure and mortality
10.1159/000547867 · 2025 · External reference
Metabolism at the crossroads of inflammation and fibrosis in chronic kidney disease
10.1038/s41581-024-00889-z · 2025 · External reference
Elevated soluble urokinase plasminogen activator receptor and proenkephalin serum levels predict the development of acute kidney injury after cardiac surgery
10.3390/ijms18081662 · 2017 · External reference
Thrombospondin-1 regulation of latent TGF-β activation: a therapeutic target for fibrotic disease
10.1016/j.matbio.2017.12.009 · 2018 · External reference
Calcium and phosphate disorders: core curriculum 2024
10.1053/j.ajkd.2023.04.017 · 2024 · External reference
Hospital-acquired renal insufficiency
10.1053/ajkd.2002.32766 · 2002 · External reference
Calcium signaling mediates cell death and crosstalk with autophagy in kidney disease
10.3390/cells10113204 · 2021 · External reference
Contrast-induced nephropathy in endovascular patients: a retrospective cohort study from a vascular surgery clinic in eastern Europe
10.3390/jcm14041172 · 2025 · External reference
Cisplatin nephrotoxicity: mechanisms and renoprotective strategies
10.1038/sj.ki.5002786 · 2008 · External reference
Modification of outcomes after acute kidney injury by the presence of CKD
10.1053/j.ajkd.2011.01.028 · 2011 · External reference
NGAL-siderocalin in kidney disease
10.1016/j.bbamcr.2012.06.014 · 2012 · External reference
Recovery from renal ischemia-reperfusion injury is associated with altered renal hemodynamics, blunted pressure natriuresis, and sodium-sensitive hypertension
10.1152/ajpregu.91022.2008 · 2009 · External reference
Cell and gene therapy for kidney disease
10.1038/s41581-023-00702-3 · 2023 · External reference
Acute kidney injury from sepsis: current concepts, epidemiology, pathophysiology, prevention and treatment
10.1016/j.kint.2019.05.026 · 2019 · External reference
Renal vulnerability to drug toxicity
10.2215/cjn.02050309 · 2009 · External reference
Pharmacology behind common drug nephrotoxicities
10.2215/cjn.00150118 · 2018 · External reference
Drug-induced acute kidney injury
10.2215/cjn.11290821 · 2022 · External reference
Microvascular rarefaction and hypertension in the impaired recovery and progression of kidney disease following AKI in preexisting CKD states
10.1152/ajprenal.00419.2018 · 2018 · External reference
Severe renal mass reduction impairs recovery and promotes fibrosis after AKI
10.1681/asn.2013040359 · 2014 · External reference
Sepsis associated acute kidney injury
10.1136/bmj.k4891 · 2019 · External reference
NAD(+) homeostasis in renal health and disease
10.1038/s41581-019-0216-6 · 2020 · External reference
Regulated cell death pathways in kidney disease
10.1038/s41581-023-00694-0 · 2023 · External reference
Long-term prognosis after acute kidney injury (AKI): what is the role of baseline kidney function and recovery? A systematic review
10.1136/bmjopen-2014-006497 · 2015 · External reference
Heart failure and kidney dysfunction: epidemiology, mechanisms and management
10.1038/nrneph.2016.113 · 2016 · External reference
Metabolomics reveals signature of mitochondrial dysfunction in diabetic kidney disease
10.1681/asn.2013020126 · 2013 · External reference
The inhibition of ZC3H13 attenuates G2/M arrest and apoptosis by alleviating NABP1 m6A modification in cisplatin-induced acute kidney injury
10.1007/s00018-025-05596-x · 2025 · External reference
Septic acute kidney injury in critically ill patients - a single-center study on its incidence, clinical characteristics, and outcome predictors
10.3109/0886022x.2016.1157749 · 2016 · External reference
Pre-existing renal failure worsens the outcome after intestinal ischaemia and reperfusion in rats
10.1093/ndt/gfq281 · 2010 · External reference
Risk factors for community-acquired acute kidney injury in patients with and without chronic kidney injury and impact of its initial management on prognosis: a prospective observational study
10.1186/s12882-017-0792-2 · 2017 · External reference
Thrombospondin1 in tissue repair and fibrosis: tgf-β-dependent and independent mechanisms
10.1016/j.matbio.2012.01.006 · 2012 · External reference
Immune dysfunction and risk of infection in chronic kidney disease
10.1053/j.ackd.2019.01.004 · 2019 · External reference
Mitochondrial quality control in kidney injury and repair
10.1038/s41581-020-00369-0 · 2021 · External reference
Calcium phosphate-induced injury in kidney tubular cells-supersaturated solution vs preformed crystals
10.1002/jbt.70145 · 2025 · External reference
Role of renal hypoxia in the progression from acute kidney injury to chronic kidney disease
10.1016/j.semnephrol.2019.10.006 · 2019 · External reference
Failed tubule recovery, AKI-CKD transition, and kidney disease progression
10.1681/asn.2015010006 · 2015 · External reference
Nephrotoxicity of nonsteroidal anti-inflammatory drugs: physiologic foundations and clinical implications
10.1016/s0002-9343(99)00113-8 · 1999 · External reference
Sepsis-associated acute kidney injury in patients with chronic kidney disease: patient characteristics, prevalence, timing, trajectory, treatment and associated outcomes
10.1111/nep.14392 · 2024 · External reference
Proenkephalin predicts kidney function and major adverse kidney events in CKD
10.1093/ndt/gfaf214 · 2026 · External reference
Targeted degradation of kidney injury molecule 1 ameliorates acute kidney injury
10.1016/j.ijbiomac.2026.150099 · 2026 · External reference
Epithelial cell cycle arrest in G2/M mediates kidney fibrosis after injury
10.1038/nm.2144 · 2010 · External reference
KIM-1-mediated phagocytosis reduces acute injury to the kidney
10.1172/jci75417 · 2015 · External reference
Autophagy in diabetic kidney disease: regulation, pathological role and therapeutic potential
10.1007/s00018-017-2639-1 · 2018 · External reference
Ceftriaxone calcium crystals induce acute kidney injury by NLRP3-Mediated inflammation and oxidative stress injury
10.1155/2020/6428498 · 2020 · External reference
Repeated administration of cisplatin transforms kidney fibroblasts through G2/M arrest and cellular senescence
10.3390/cells11213472 · 2022 · External reference
Sepsis-associated acute kidney injury: consensus report of the 28th acute disease quality initiative workgroup
10.1038/s41581-023-00683-3 · External reference
Epidemiology of surgery associated acute kidney injury (EPIS-AKI): a prospective international observational multi-center clinical study
10.1007/s00134-023-07169-7 · External reference
Disruption of renal tubular mitochondrial quality control by Myo-inositol oxygenase in diabetic kidney disease
10.1681/asn.2014050457 · 2015 · External reference
Kidney injury molecule-1 (KIM-1) mediates renal epithelial cell repair via ERK MAPK signaling pathway
10.1007/s11010-016-2700-7 · 2016 · External reference
From acute tubular injury to tubular repair and chronic kidney diseases - KIM-1 as a promising biomarker for predicting renal tubular pathology
10.1016/j.crphys.2025.100152 · 2025 · External reference
Risk factors and prognosis of acute kidney injury after cardiac surgery in patients with chronic kidney disease
10.1159/000526120 · 2023 · External reference
Transition from acute kidney injury to chronic kidney disease: mechanisms, models, and biomarkers
10.1152/ajprenal.00184.2024 · 2024 · External reference
Acute kidney injury in critically ill patients with sepsis: clinical characteristics and outcomes
10.1080/08941939.2018.1453891 · 2019 · External reference
Acute and acute-on-chronic kidney injury of patients with decompensated heart failure: impact on outcomes
10.1186/1471-2369-13-51 · 2012 · External reference
Acute kidney injury, acute kidney disease and chronic kidney disease: challenges and research perspectives
10.1093/ndt/gfaf090 · 2025 · External reference
