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References from Microglia-neuron communication in ischemic stroke: from homeostatic signaling to pathological remodeling and therapeutic targeting. Local targets link to admitted publications; unresolved targets remain external evidence.
Modulation of post-stroke degenerative and regenerative processes and subacute protection by site-targeted inhibition of the alternative pathway of complement
10.1186/s12974-015-0464-8 · 2015 · External reference
Complement-dependent synaptic uptake and cognitive decline after stroke and reperfusion therapy
10.1523/jneurosci.2462-19.2020 · 2020 · External reference
Regulation of microglia by neuromodulators: modulations in major and minor modes
10.1016/j.neulet.2020.135000 · 2020 · External reference
Need for a paradigm shift in the treatment of ischemic stroke: the blood-brain barrier
10.3390/ijms23169486 · 2022 · External reference
Negative feedback control of neuronal activity by microglia
10.1038/s41586-020-2777-8 · 2020 · External reference
Mechanisms of microglia-mediated synapse turnover and synaptogenesis
10.1016/j.pneurobio.2022.102336 · 2022 · External reference
Intranasal delivery of extracellular vesicles derived from human bone marrow mesenchymal stem cells dampens neuroinflammation and ameliorates motor deficits in a mouse model of cortical stroke
10.1016/j.expneurol.2025.115540 · 2026 · External reference
Delayed NLRP3 inflammasome inhibition ameliorates subacute stroke progression in mice
10.1186/s12974-022-02674-w · 2023 · External reference
Neuronal loss after stroke due to microglial phagocytosis of stressed neurons
10.3390/ijms222413442 · 2021 · External reference
Microglial phagocytosis of neurons in neurodegeneration, and its regulation
10.1111/jnc.15327 · 2021 · External reference
Different roles of mitochondria in cell death and inflammation: focusing on mitochondrial quality control in ischemic stroke and reperfusion
10.3390/biomedicines9020169 · 2021 · External reference
Molecular mechanism of the protective effects of M2 microglia on neurons: a review focused on exosomes and secretory proteins
10.1007/s11064-022-03760-4 · 2022 · External reference
Microglial phagocytosis and regulatory mechanisms after stroke
10.1177/0271678x221098841 · 2022 · External reference
Microglia monitor and protect neuronal function through specialized somatic purinergic junctions
10.1126/science.aax6752 · 2020 · External reference
Complement in neurological disorders and emerging complement-targeted therapeutics
10.1038/s41582-020-0400-0 · 2020 · External reference
Pathobiology of ischaemic stroke: an integrated view
10.1016/s0166-2236(99)01401-0 · 1999 · External reference
Spatial and temporal mapping of neuron-microglia interaction modes in acute ischemic stroke
10.1016/j.bcp.2023.115772 · 2023 · External reference
P2Y6 receptor-dependent microglial phagocytosis of synapses mediates synaptic and memory loss in aging
10.1111/acel.13761 · 2023 · External reference
Signaling pathways controlling microglia chemotaxis
10.14348/molcells.2017.0011 · 2017 · External reference
Time-dependent dual effect of microglia in ischemic stroke
10.1016/j.neuint.2023.105584 · 2023 · External reference
Pharmacological brain cytoprotection in acute ischaemic stroke-renewed hope in the reperfusion era
10.1038/s41582-021-00605-6 · 2022 · External reference
CX3CL1 inhibits NLRP3 inflammasome-induced microglial pyroptosis and improves neuronal function in mice with experimentally-induced ischemic stroke
10.1016/j.lfs.2022.120564 · 2022 · External reference
The roles of high mobility group box 1 in cerebral ischemic injury
10.3389/fncel.2020.600280 · 2020 · External reference
Danger signals in stroke and their role on microglia activation after ischemia
10.1177/1756286418774254 · 2018 · External reference
Integrating spatial and single-cell transcriptomics to characterize the molecular and cellular architecture of the ischemic mouse brain
10.1126/scitranslmed.adg1323 · 2024 · External reference
Complement C1q/C3-CR3 signaling pathway mediates abnormal microglial phagocytosis of synapses in a mouse model of depression
10.1016/j.bbi.2024.04.018 · 2024 · External reference
Targeting CX3CR1 signaling dynamics: a critical determinant in the temporal regulation of post-stroke neurorepair
10.3390/brainsci15070759 · 2025 · External reference
Extracellular vesicles as a next-generation drug delivery platform
10.1038/s41565-021-00931-2 · 2021 · External reference
Regulation of microglial functions by purinergic mechanisms in the healthy and diseased CNS
10.3390/cells9051108 · 2020 · External reference
Microglial intervention in ischemic stroke: roles and intervention strategies
10.4103/nrr.nrr-d-24-01166 · 2026 · External reference
The role of microglial phagocytosis in ischemic stroke
10.3389/fimmu.2021.790201 · 2022 · External reference
Prolyl hydroxylase inhibitor desidustat improves stroke outcomes via enhancing efferocytosis in mice with chronic kidney disease
10.1016/j.expneurol.2025.115181 · 2025 · External reference
Mechanisms of microglia-mediated neurotoxicity in a new model of the stroke penumbra
10.1523/jneurosci.5643-07.2008 · 2008 · External reference
Neuroinflammation in neurodegenerative disorders: the roles of microglia and astrocytes
10.1186/s40035-020-00221-2 · 2020 · External reference
CD47 protects synapses from excess microglia-mediated pruning during development
10.1016/j.neuron.2018.09.017 · 2018 · External reference
Microglia-neuron-vascular interactions in ischemia
10.1002/glia.24487 · 2024 · External reference
Acute ischemia induces spatially and transcriptionally distinct microglial subclusters
10.1186/s13073-023-01257-5 · 2023 · External reference
Glycolytic reprogramming during microglial polarization in neurological diseases
10.3389/fimmu.2025.1648887 · 2025 · External reference
Mitochondrial transplantation and immune response of human bone marrow mesenchymal stem cells for the therapy of ischemic stroke
10.2174/1574888x18666230505103407 · 2024 · External reference
Pseudoginsenoside-F11 accelerates microglial phagocytosis of myelin debris and attenuates cerebral ischemic injury through complement receptor 3
10.1016/j.neuroscience.2019.11.010 · 2020 · External reference
The role of the complement system in synaptic pruning after stroke
10.14336/ad.2024.0373 · 2024 · External reference
Role of mitochondrial Ca2+ in stroke: from molecular mechanism to treatment strategy
10.3892/mmr.2025.13636 · 2025 · External reference
Extracellular vesicles as vehicles for small non-coding RNA therapeutics: standardization challenges for clinical translation
10.20517/evcna.2025.33 · 2025 · External reference
Ion channels and transporters in microglial function in physiology and brain diseases
10.1016/j.neuint.2020.104925 · 2021 · External reference
Examining the impact of microglia on ischemic stroke with an emphasis on the metabolism of immune cells
10.1111/cns.70229 · 2025 · External reference
Ischemic stroke: pathophysiology and evolving treatment approaches
10.1177/26331055241292600 · 2024 · External reference
Microglia-neuron crosstalk: signaling mechanism and control of synaptic transmission. Semin
10.1016/j.semcdb.2019.05.017 · 2019 · External reference
Contemplating IL-6, a double-edged sword cytokine: which side to use for stroke pathology?
10.1111/cns.14041 · 2023 · External reference
Mesenchymal stromal/stem cell-derived extracellular vesicles in brain disorders: mechanisms of repair and recovery
10.3389/fncel.2026.1819046 · 2026 · External reference
Phagocytosis executes delayed neuronal death after focal brain ischemia
10.1073/pnas.1308679110 · 2013 · External reference
Peripheral CD200R signaling: a critical regulator of post-stroke inflammation in aged mice
10.1016/j.brainresbull.2025.111686 · 2026 · External reference
2026 heart disease and stroke statistics: a report of us and global data from the american heart association
10.1161/cir.0000000000001412 · 2026 · External reference
Role of NLRP3 inflammasome in stroke pathobiology: current therapeutic avenues and future perspective
10.1021/acschemneuro.3c00536 · 2024 · External reference
Cell-to-cell communication by extracellular vesicles: focus on microglia
10.1016/j.neuroscience.2018.04.003 · 2019 · External reference
The impact of the CX3CL1/CX3CR1 axis in neurological disorders
10.3390/cells9102277 · 2020 · External reference
Microglial tissue surveillance: the never-resting gardener in the developing and adult CNS
10.1002/eji.202250232 · 2023 · External reference
Intercellular mitochondrial transfer: a novel neuroprotective strategy in stroke management
10.1016/j.ejphar.2025.178433 · 2026 · External reference
Role of microglia in stroke
10.1002/glia.24501 · 2024 · External reference
The implications of microglial regulation in neuroplasticity-dependent stroke recovery
10.3390/biom13030571 · 2023 · External reference
Dual functions of microglia in ischemic stroke
10.1007/s12264-019-00388-3 · 2019 · External reference
Regenerative medicine therapies for targeting neuroinflammation after stroke
10.3389/fneur.2018.00734 · 2018 · External reference
Regulatory mechanisms of natural compounds from traditional Chinese herbal medicines on the microglial response in ischemic stroke
10.1016/j.phymed.2023.154889 · 2023 · External reference
Role of alarmins in poststroke inflammation and neuronal repair
10.1007/s00281-022-00961-5 · 2023 · External reference
Microglia sculpt postnatal neural circuits in an activity and complement-dependent manner
10.1016/j.neuron.2012.03.026 · 2012 · External reference
Microglia rescue neurons from aggregate-induced neuronal dysfunction and death through tunneling nanotubes
10.1016/j.neuron.2024.06.029 · 2024 · External reference
The complement cascade repurposed in the brain
10.1038/s41577-021-00621-z · 2021 · External reference
The classical complement cascade mediates CNS synapse elimination
10.1016/j.cell.2007.10.036 · 2007 · External reference
The CD200/CD200R signaling pathway contributes to spontaneous functional recovery by enhancing synaptic plasticity after stroke
10.1186/s12974-020-01845-x · 2020 · External reference
Mitochondrial transplantation confers protection against the effects of ischemic stroke by repressing microglial pyroptosis and promoting neurogenesis
10.4103/1673-5374.385313 · 2024 · External reference
Extracellular ADP augments microglial inflammasome and NF-κB activation via the P2Y12 receptor
10.1002/eji.201848013 · 2020 · External reference
CX3CR1 deficiency suppresses activation and neurotoxicity of microglia/macrophage in experimental ischemic stroke
10.1186/1742-2094-11-26 · 2014 · External reference
How to pick a neuroprotective drug in stroke without losing your mind?
10.3390/life15060883 · 2025 · External reference
Heterogeneity of microglia in ischemic stroke from the perspective of single-cell RNA sequencing: subset characteristics, mechanisms and therapeutic potential
10.1177/11795735261452744 · 2026 · External reference
The neurovascular unit and systemic biology in stroke-implications for translation and treatment
10.1038/s41582-022-00703-z · 2022 · External reference
Snapshot of microglial physiological functions
10.1016/j.neuint.2021.104960 · 2021 · External reference
Regulation of microglia polarization after cerebral ischemia
10.3389/fncel.2023.1182621 · 2023 · External reference
Soluble triggering receptor expressed on myeloid cells 2 as a promising biomarker for poststroke depression after acute ischemic stroke
10.1161/jaha.124.040555 · 2025 · External reference
A narrative review of reperfusion therapy in acute ischemic stroke: emerging advances, current challenges, and future directions
10.4103/bc.bc_161_24 · 2025 · External reference
Dynamic brain lipid profiles modulate microglial lipid droplet accumulation and inflammation under ischemic conditions in mice
10.1002/advs.202306863 · 2024 · External reference
Diversity of microglia-derived molecules with neurotrophic properties that support neurons in the central nervous system and other tissues
10.3390/molecules29235525 · 2024 · External reference
Uncovering the dual roles of peripheral immune cells and their connections to brain cells in stroke and post-stroke stages through single-cell sequencing
10.3389/fnins.2024.1443438 · 2024 · External reference
Enhanced treatment of ischemic stroke by scutellarin loaded Angiopep-2-modified milk exosomes via multiple pathological pathways regulation
10.1186/s12951-026-04536-6 · 2026 · External reference
Melatonin rescues cerebral ischemic events through upregulated tunneling nanotube-mediated mitochondrial transfer and downregulated mitochondrial oxidative stress in rat brain
10.1016/j.biopha.2021.111593 · 2021 · External reference
Investigation of long-term metabolic alteration after stroke in tMCAO (transient middle cerebral artery occlusion) mouse model using metabolomics approach
10.1016/j.neulet.2022.136492 · 2022 · External reference
Phagocytic microglia and macrophages in brain injury and repair
10.1111/cns.13899 · 2022 · External reference
TREM2-mediated regulation of microglial activity: a promising target for the treatment of ischemic stroke
10.1186/s12967-025-06799-3 · 2025 · External reference
Glycolytic reprogramming in microglia: a potential therapeutic target for ischemic stroke
10.1016/j.cellsig.2024.111466 · 2024 · External reference
Formononetin attenuates cerebral ischemia-reperfusion injury by regulating microglial glycolysis through AMPK
10.1016/j.jep.2026.121576 · 2026 · External reference
CD200-CD200R interaction: an important regulator after stroke
10.3389/fnins.2019.00840 · 2019 · External reference
CD200-CD200R1 signaling pathway regulates neuroinflammation after stroke
10.1002/brb3.1882 · 2020 · External reference
Tuning neural circuits and behaviors by microglia in the adult brain
10.1016/j.tins.2023.12.003 · 2024 · External reference
The role of TREM2 after stroke: from mechanisms to therapeutic potential
10.1007/s12035-025-05622-w · 2025 · External reference
Exosomes from polarized microglia: proteomic insights into potential mechanisms affecting intracerebral hemorrhage
10.1016/j.gene.2024.149080 · 2025 · External reference
Microglia and neuroinflammation: function, heterogeneity, and crosstalk
10.1038/s41423-026-01438-3 · 2026 · External reference