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References from Long non-coding RNAs in glial cells: key drivers of neuroinflammation in cognitive disorders. Local targets link to admitted publications; unresolved targets remain external evidence.
Implications of glial metabolic dysregulation in the pathophysiology of neurodegenerative diseases
10.1016/j.nbd.2022.105874 · 2022 · External reference
Microglia: scapegoat, saboteur, or something else?
10.1126/science.1227901 · 2013 · External reference
A single cell but many different transcripts: a journey into the world of long non-coding RNAs
10.3390/ijms21010302 · 2020 · External reference
Long non-coding RNA (lncRNA) roles in cell biology, neurodevelopment and neurological disorders
10.3390/ncrna7020036 · 2021 · External reference
Glia as architects of central nervous system formation and function
10.1126/science.aat0473 · 2018 · External reference
Role of metabolic dysfunction and inflammation along the liver-brain axis in animal models with obesity-induced neurodegeneration
10.4103/nrr.nrr-d-23-01770 · 2025 · External reference
Analysis of differentially expressed long non-coding RNAs in LPS-induced human HMC3 microglial cells
10.1186/s12864-022-09083-6 · 2022 · External reference
A long nuclear-retained non-coding RNA regulates synaptogenesis by modulating gene expression
10.1038/emboj.2010.199 · 2010 · External reference
Glia crosstalk in Neuroinflammatory diseases
10.3389/fncel.2020.00209 · 2020 · External reference
Signalling, metabolic pathways and iron homeostasis in endothelial cells in health, atherosclerosis and Alzheimer's disease
10.3390/cells9092055 · 2020 · External reference
Astrocyte contribution to dysfunction, risk and progression in neurodegenerative disorders
10.1038/s41583-022-00641-1 · 2023 · External reference
Long noncoding RNA NEAT1 mediates neuronal histone methylation and age-related memory impairment
10.1126/scisignal.aaw9277 · 2019 · External reference
LncRNA MALAT1 facilitates inflammasome activation via epigenetic suppression of Nrf2 in Parkinson's disease
10.1186/s13041-020-00656-8 · 2020 · External reference
Inhibition of long non-coding RNA HOXA11-AS against neuroinflammation in Parkinson's disease model via targeting miR-124-3p mediated FSTL1/NF-κB axis
10.18632/aging.202837 · 2021 · External reference
MiR-29c-3p may promote the progression of Alzheimer's disease through BACE1
10.1155/2021/2031407 · 2021 · External reference
Long noncoding RNA SNHG1 promotes Neuroinflammation in Parkinson's disease via regulating miR-7/NLRP3 pathway
10.1016/j.neuroscience.2018.07.019 · 2018 · External reference
Astrocyte biomarkers in Alzheimer's disease
10.1016/j.molmed.2018.11.006 · 2019 · External reference
Small and long non-coding RNAs: past, present, and future
10.1016/j.cell.2024.10.024 · 2024 · External reference
Long non-coding RNAs and circular RNAs: insights into microglia and astrocyte mediated neurological diseases
10.3389/fnmol.2021.745066 · 2021 · External reference
Silencing of lncRNA PRR34-AS1 alleviates Alzheimer's disease by targeting miR-29c-3p to regulate microglia inflammation
10.1111/psyg.70043 · 2025 · External reference
The role of lncRNA TUG1 in the Parkinson disease and its effect on microglial inflammatory response
10.1007/s12017-020-08626-y · 2021 · External reference
Cordycepin mitigates MPTP-induced Parkinson's disease through inhibiting TLR/NF-κB signaling pathway
10.1016/j.lfs.2019.02.037 · 2019 · External reference
Long non-coding RNAs in humans: classification, genomic organization and function
10.1016/j.ncrna.2025.01.004 · 2025 · External reference
Microglia clear neuron-released α-synuclein via selective autophagy and prevent neurodegeneration
10.1038/s41467-020-15119-w · 2020 · External reference
Elevated NLRP3 Inflammasome activation is associated with motor neuron degeneration in ALS
10.3390/cells13120995 · 2024 · External reference
Synaptic plasticity: multiple forms, functions, and mechanisms
10.1038/sj.npp.1301559 · 2008 · External reference
Microglia function in the central nervous system during health and neurodegeneration
10.1146/annurev-immunol-051116-052358 · 2017 · External reference
Unmet needs for family caregivers of elderly people with dementia living in Italy: what do we know so far and what should we do next?
10.1177/0046958017713708 · 2017 · External reference
Differentiating protein-coding and noncoding RNA: challenges and ambiguities
10.1371/journal.pcbi.1000176 · 2008 · External reference
Angiotensin-(1-7) analogue AVE0991 modulates astrocyte-mediated neuroinflammation via lncRNA SNHG14/miR-223-3p/NLRP3 pathway and offers neuroprotection in a transgenic mouse model of Alzheimer's disease
10.2147/jir.s343575 · 2021 · External reference
A computational exploration of the molecular network associated to Neuroinflammation in Alzheimer's disease
10.3389/fphar.2021.630003 · 2021 · External reference
Apoptosis: a review of programmed cell death
10.1080/01926230701320337 · 2007 · External reference
SINEUP non-coding RNA targeting GDNF rescues motor deficits and neurodegeneration in a mouse model of Parkinson's disease
10.1016/j.ymthe.2019.08.005 · 2020 · External reference
Expression of a noncoding RNA is elevated in Alzheimer's disease and drives rapid feed-forward regulation of beta-secretase
10.1038/nm1784 · 2008 · External reference
Analyzing alternative splicing in Alzheimer's disease postmortem brain: a cell-level perspective
10.3389/fnmol.2023.1237874 · 2023 · External reference
Circulating long noncoding RNA ANRIL downregulation correlates with increased risk, higher disease severity and elevated pro-inflammatory cytokines in patients with acute ischemic stroke
10.1002/jcla.22629 · 2019 · External reference
LncRNA 4344 promotes NLRP3-related neuroinflammation and cognitive impairment by targeting miR-138-5p
10.1016/j.bbi.2021.08.230 · 2021 · External reference
Toll-like receptors in Alzheimer's disease: a therapeutic perspective
10.2174/1871527313666140806124850 · 2014 · External reference
LncRNA AK148321 alleviates neuroinflammation in LPS-stimulated BV2 microglial cell through regulating microRNA-1199-5p/HSPA5 axis
10.1016/j.lfs.2020.118863 · 2021 · External reference
Star-like cells spark behavioural hyperactivity in mice
10.1038/d41586-019-01949-2 · 2019 · External reference
Microglia in neurodegenerative diseases: mechanism and potential therapeutic targets
10.1038/s41392-023-01588-0 · 2023 · External reference
The emerging role of long non-coding RNAs and MicroRNAs in neurodegenerative diseases: a perspective of machine learning
10.3390/biom11081132 · 2021 · External reference
Long noncoding RNAs antisense noncoding RNA in the INK4 locus (ANRIL) correlates with lower acute exacerbation risk, decreased inflammatory cytokines, and mild GOLD stage in patients with chronic obstructive pulmonary disease
10.1002/jcla.22678 · 2019 · External reference
MALAT1 mediates α-Synuclein expression through miR-23b-3p to induce Autophagic impairment and the inflammatory response in microglia to promote apoptosis in dopaminergic neuronal cells
10.1155/2023/4477492 · 2023 · External reference
Recent insights on the putative role of autophagy in autoimmune diseases
10.1016/j.autrev.2013.10.007 · 2014 · External reference
Competing endogenous RNAs in human astrocytes: crosstalk and interacting networks in response to lipotoxicity
10.3389/fnins.2023.1195840 · 2023 · External reference
Brain clearance of protein aggregates: a close-up on astrocytes
10.1186/s13024-024-00703-1 · 2024 · External reference
Neuropilin-1 as therapeutic target for malignant melanoma
10.3389/fonc.2015.00125 · 2015 · External reference
The β-secretase BACE1 in Alzheimer's disease
10.1016/j.biopsych.2020.02.001 · 2021 · External reference
Role of NLRP3 inflammasome-mediated neuronal pyroptosis and neuroinflammation in neurodegenerative diseases
10.1007/s00011-023-01790-4 · 2023 · External reference
The role of toll-like receptors and neuroinflammation in Parkinson's disease
10.1186/s12974-022-02496-w · 2022 · External reference
Complement and microglia mediate early synapse loss in Alzheimer mouse models
10.1126/science.aad8373 · 2016 · External reference
Ageing as a risk factor for neurodegenerative disease
10.1038/s41582-019-0244-7 · 2019 · External reference
Follistatin-like protein 1 (FSTL1) promotes chondrocyte expression of matrix metalloproteinase and inflammatory factors via the NF-κB pathway
10.1111/jcmm.14155 · 2019 · External reference
Silencing SOX2-OT alleviates a β-induced damage to neurons and microglial cells by targeting miR-143-3p in Alzheimer's disease
10.1093/toxres/tfaf159 · 2025 · External reference
TREM2 deficiency aggravates NLRP3 Inflammasome activation and Pyroptosis in MPTP-induced Parkinson's disease mice and LPS-induced BV2 cells
10.1007/s12035-023-03713-0 · 2024 · External reference
The lncRNA Neat1 is associated with astrocyte reactivity and memory deficits in a mouse model of Alzheimer's disease
10.1101/2023.05.03.539260 · 2023 · External reference
Glial cells
10.1016/j.biocel.2004.02.023 · 2004 · External reference
Non-coding RNAs: the Neuroinflammatory regulators in neurodegenerative diseases
10.3389/fneur.2022.929290 · 2022 · External reference
Combining multifunctional delivery system with blood-brain barrier reversible opening strategy for the enhanced treatment of Alzheimer's disease
10.1002/adhm.202302939 · 2024 · External reference
Astrocytic autophagy plasticity modulates aβ clearance and cognitive function in Alzheimer's disease
10.1186/s13024-024-00740-w · 2024 · External reference
Comprehensive investigation of the expression profiles of common long noncoding RNAs during microglial activation
10.5808/gi.22061 · 2023 · External reference
Astrocytes in amyloid generation and alcohol metabolism: implications of alcohol use in neurological disorder(s)
10.3390/cells13141173 · 2024 · External reference
The role of noncoding RNAs in Parkinson's disease: biomarkers and associations with pathogenic pathways
10.1186/s12929-021-00775-x · 2021 · External reference
Small extracellular vesicles secreted by nigrostriatal astrocytes rescue cell death and preserve mitochondrial function in Parkinson's disease
10.1002/adhm.202201203 · 2022 · External reference
Innate immunity and neuroinflammation in the CNS: the role of microglia in toll-like receptor-mediated neuronal injury
10.1002/glia.20928 · 2010 · External reference
Coding or noncoding, the converging concepts of RNAs
10.3389/fgene.2019.00496 · 2019 · External reference
LncRNA KCNQ1OT1 promotes NLRP3 inflammasome activation in Parkinson's disease by regulating pri-miR-186/mature miR-186/NLRP3 axis
10.1016/j.bbadis.2024.167454 · 2024 · External reference
lncRNA NEAT1: key player in neurodegenerative diseases
10.1016/j.arr.2023.101878 · 2023 · External reference
Knockdown of lncRNA MIAT attenuated lipopolysaccharide-induced microglial cells injury by sponging miR-613
10.1007/s00335-022-09946-z · 2022 · External reference
Neurotoxic reactive astrocytes are induced by activated microglia
10.1038/nature21029 · 2017 · External reference
LncRNA MEG8 ameliorates Parkinson's disease neuro-inflammation through miR-485-3p/FBXO45 axis
10.1007/s13760-023-02388-7 · 2024 · External reference
Decoding Parkinson's disease: the interplay of cell death pathways, oxidative stress, and therapeutic innovations
10.1016/j.redox.2025.103787 · 2025 · External reference
Profiling of long non-coding RNAs in hippocampal-entorhinal system subfields: impact of RN7SL1 on neuroimmune response modulation in Alzheimer's disease
10.1186/s12974-024-03083-x · 2024 · External reference
Interactions of glial cells with neuronal synapses, from astrocytes to microglia and oligodendrocyte lineage cells
10.1002/glia.24343 · 2023 · External reference
Autophagy: regulator of cell death
10.1038/s41419-023-06154-8 · 2023 · External reference
LncRNA DLX6-AS1 promotes microglial inflammatory response in Parkinson's disease by regulating the miR-223-3p/NRP1 axis
10.1016/j.bbr.2022.113923 · 2022 · External reference
Microglial glycolytic reprogramming in alzheimer's disease: association with impaired phagocytic function and altered vascular proximity
10.1186/s12974-025-03546-9 · 2025 · External reference
Long RNA profiles of human brain extracellular vesicles provide new insights into the pathogenesis of Alzheimer's disease
10.14336/ad.2022.0607 · 2023 · External reference
Molecular analysis of NPAS3 functional domains and variants
10.1186/s12867-018-0117-4 · 2018 · External reference
On the classification of long non-coding RNAs
10.4161/rna.24604 · 2013 · External reference
Down-regulated long non-coding RNA RMST ameliorates dopaminergic neuron damage in Parkinson's disease rats via regulation of TLR/NF-κB signaling pathway
10.1016/j.brainresbull.2021.04.026 · 2021 · External reference
Circulatory miR-223-3p discriminates between Parkinson's and Alzheimer's patients
10.1038/s41598-019-45687-x · 2019 · External reference
Glia-derived extracellular vesicles in Parkinson's disease
10.3390/jcm9061941 · 2020 · External reference
Long non-coding RNAs: definitions, functions, challenges and recommendations
10.1038/s41580-022-00566-8 · 2023 · External reference
An overview of the relationship between inflammation and cognitive function in humans, molecular pathways and the impact of nutraceuticals
10.1016/j.neuint.2024.105900 · 2024 · External reference
Interplay between miRNAs and lncRNAs: mode of action and biological roles in plant development and stress adaptation
10.1016/j.csbj.2021.04.062 · 2021 · External reference
MicroRNAs and synaptic plasticity: from their molecular roles to response to therapy
10.1007/s12035-022-02907-2 · 2022 · External reference
MicroRNA-223 protects neurons from degeneration in experimental autoimmune encephalomyelitis
10.1093/brain/awz245 · 2019 · External reference
Long non-coding RNAs and Alzheimer's disease: towards personalized diagnosis
10.3390/ijms25147641 · 2024 · External reference
Neurodegenerative diseases – is metabolic deficiency the root cause?
10.3389/fnins.2020.00213 · 2020 · External reference
Lnc-MEG3 acts as a potential biomarker for predicting increased disease risk, systemic inflammation, disease severity, and poor prognosis of sepsis via interacting with miR-21
10.1002/jcla.23123 · 2020 · External reference
LncRNA HOTAIR regulates lipopolysaccharide-induced cytokine expression and inflammatory response in macrophages
10.1038/s41598-018-33722-2 · 2018 · External reference
Construction of long noncoding RNA-associated ceRNA networks reveals potential biomarkers in Alzheimer's disease
10.3233/jad-210068 · 2021 · External reference
Functional roles of reactive astrocytes in neuroinflammation and neurodegeneration
10.1038/s41582-023-00822-1 · 2023 · External reference
Evolution and functions of long noncoding RNAs
10.1016/j.cell.2009.02.006 · 2009 · External reference
Unique features of long non-coding RNA biogenesis and function
10.1038/nrg.2015.10 · 2016 · External reference
NLRP3 inflammasome: a key player in the pathogenesis of life-style disorders
10.1038/s12276-024-01261-8 · 2024 · External reference
PRDM16-DT is a novel lncRNA that regulates astrocyte function in Alzheimer's disease
10.1007/s00401-024-02787-x · 2024 · External reference
LncRNA 3222401L13Rik is upregulated in aging astrocytes and regulates neuronal support function through interaction with Npas3
10.3390/ncrna11010002 · 2025 · External reference
HIV-1 tat-mediated astrocytic amyloidosis involves the HIF-1α/lncRNA BACE1-AS axis
10.1371/journal.pbio.3000660 · 2020 · External reference
Emerging landscape of lncRNA-miRNA interactions as architects of gene expression patterns
10.1007/s11033-025-10906-4 · 2025 · External reference
NF-κB-mediated Neuroinflammation in Parkinson's disease and potential therapeutic effect of polyphenols
10.1007/s12640-019-00147-2 · 2020 · External reference
Inhibition of long non-coding RNA KCNQ1OT1 attenuates Neuroinflammation and neuronal apoptosis through regulating NLRP3 expression via sponging miR-30e-3p
10.2147/jir.s291274 · 2021 · External reference
Toll-like receptor-mediated neuroinflammation: relevance for cognitive dysfunctions
10.1016/j.tips.2022.05.004 · 2022 · External reference
Gene regulation by long non-coding RNAs and its biological functions
10.1038/s41580-020-00315-9 · 2021 · External reference
Therapeutic potential of astrocyte-derived extracellular vesicles in mitigating cytotoxicity and transcriptome changes in human brain endothelial cells
10.1016/j.neuroscience.2024.09.040 · 2024 · External reference
Expression profiles of long noncoding RNAs in intranasal LPS-mediated Alzheimer's disease model in mice
10.1155/2019/9642589 · 2019 · External reference
Long non-coding RNA NEAT1 modulates microglial NLRP3 inflammasome activation
10.1016/j.jneuroim.2025.578770 · 2025 · External reference
Towards a complete map of the human long non-coding RNA transcriptome
10.1038/s41576-018-0017-y · 2018 · External reference
Disentangling clinical and biological trajectories of neurodegenerative diseases
10.1038/s41582-024-01004-3 · 2024 · External reference
NLRP3 expression in mesencephalic neurons and characterization of a rare NLRP3 polymorphism associated with decreased risk of Parkinson's disease
10.1038/s41531-018-0061-5 · 2018 · External reference
miR-29c-3p attenuates beta-amyloid-induced neurotoxicity in Alzheimer's disease through regulating beta-site amyloid precursor protein-cleaving enzyme 1
10.33549/physiolres.935084 · 2023 · External reference
EPB41L4A-AS1 is required to maintain basal autophagy to modulates aβ clearance
10.1038/s41514-024-00152-6 · 2024 · External reference
LncRNA NEAT1 induces autophagy through epigenetic regulation of autophagy-related gene expression in neuroglial cells
10.1002/jcp.30556 · 2022 · External reference
Overlapping genes in natural and engineered genomes
10.1038/s41576-021-00417-w · 2022 · External reference
Single-nucleus analysis reveals microenvironment-specific neuron and glial cell enrichment in Alzheimer's disease
10.1186/s12864-024-10447-3 · 2024 · External reference
Long non-coding RNAs as key regulators of neurodegenerative protein aggregation
10.1002/alz.14498 · 2025 · External reference
TLR4 promotes microglial pyroptosis via lncRNA-F630028O10Rik by activating PI3K/AKT pathway after spinal cord injury
10.1038/s41419-020-02824-z · 2020 · External reference
Long noncoding RNA GAS5 promotes microglial inflammatory response in Parkinson's disease by regulating NLRP3 pathway through sponging miR-223-3p
10.1016/j.intimp.2020.106614 · 2020 · External reference
Long non-coding RNA MEG3 functions as a competing endogenous RNA to regulate ischemic neuronal death by targeting miR-21/PDCD4 signaling pathway
10.1038/s41419-017-0047-y · 2017 · External reference
Down-regulation of EPB41L4A-AS1 mediated the brain aging and neurodegenerative diseases via damaging synthesis of NAD(+) and ATP
10.1186/s13578-021-00705-2 · 2021 · External reference
Functional characterization of Alzheimer's disease genetic variants in microglia
10.1038/s41588-023-01506-8 · 2023 · External reference
Emerging role of non-coding RNAs in neuroinflammation mediated by microglia and astrocytes
10.1186/s12974-023-02856-0 · 2023 · External reference
LncRNA HOXA-AS2 regulates microglial polarization via recruitment of PRC2 and epigenetic modification of PGC-1α expression
10.1186/s12974-021-02267-z · 2021 · External reference
Upregulation of the lncRNA MEG3 improves cognitive impairment, alleviates neuronal damage, and inhibits activation of astrocytes in hippocampus tissues in Alzheimer's disease through inactivating the PI3K/Akt signaling pathway
10.1002/jcb.29108 · 2019 · External reference
The common LncRNAs of Neuroinflammation-related diseases
10.1124/molpharm.122.000530 · 2023 · External reference
The mechanism of NLRP3 inflammasome activation and its pharmacological inhibitors
10.3389/fimmu.2022.1109938 · 2022 · External reference
Inflammatory lncRNA AK039862 regulates paraquat-inhibited proliferation and migration of microglial and neuronal cells through the Pafah1b1/Foxa1 pathway in co-culture environments
10.1016/j.ecoenv.2020.111424 · 2021 · External reference
Deregulated lncRNA MAGI2-AS3 in Alzheimer's disease attenuates amyloid-β induced neurotoxicity and neuroinflammation by sponging miR-374b-5p
10.1016/j.exger.2020.111180 · 2021 · External reference
Dopaminergic neuron injury in Parkinson's disease is mitigated by interfering lncRNA SNHG14 expression to regulate the miR-133b/ α-synuclein pathway
10.18632/aging.102330 · 2019 · External reference
Role of neuroinflammation in neurodegeneration development
10.1038/s41392-023-01486-5 · 2023 · External reference
LncRNA miR-17-92a-1 cluster host gene (MIR17HG) promotes neuronal damage and microglial activation by targeting the microRNA-153-3p/alpha-synuclein axis in Parkinson's disease
10.1080/21655979.2022.2033409 · 2022 · External reference
TREM2 deficiency aggravates neuroinflammatory response and cognitive impairment via disease-associated microglia in Parkinson's disease models
10.1016/j.neuint.2025.106068 · 2025 · External reference
Long non-coding RNA Opa interacting protein 5-antisense RNA 1 promotes mitochondrial autophagy and protects SH-SY5Y cells from 1-methyl-4-phenylpyridine-induced damage by binding to microRNA-137 and upregulating NIX
10.1002/kjm2.12485 · 2022 · External reference
Coordinated transcriptional waves define the inflammatory response of primary microglial culture
10.3390/ijms241310928 · 2023 · External reference
SINEUPs: a new class of natural and synthetic antisense long non-coding RNAs that activate translation
10.1080/15476286.2015.1060395 · 2015 · External reference
SINEUPs are modular antisense long non-coding RNAs that increase synthesis of target proteins in cells
10.3389/fncel.2015.00174 · 2015 · External reference