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References from Engram cell vulnerability in neurodegeneration: from mechanistic insights to therapeutic horizons. Local targets link to admitted publications; unresolved targets remain external evidence.
Aβ oligomers induce pathophysiological mGluR5 signaling in Alzheimer’s disease model mice in a sex-selective manner.
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Morris water maze and contextual fear conditioning tasks to evaluate cognitive functions associated with adult hippocampal neurogenesis.
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Exploring the therapeutic potential of BBB-penetrating phytochemicals with p38 MAPK modulatory activity in addressing oxidative stress-induced neurodegenerative disorders, with a focus on Alzheimer’s Disease.
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Unresolved reference
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Unresolved reference
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Astrocytes contribute to remote memory formation by modulating hippocampal-cortical communication during learning.
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Emerging and novel functions of complement protein C1q.
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Astrocyte ryanodine receptors facilitate gliotransmission and astroglial modulation of synaptic plasticity.
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Acute targeting of N-terminal tau protein has long-lasting beneficial effects in Tg2576 APP/Aβ mouse model by reducing cognitive impairment, cerebral Aβ-amyloidosis, synaptic remodeling and microgliosis later in life.
10.1186/s40478-025-02022-y · 2025 · External reference
The role of neuronal excitability, allocation to an engram and memory linking in the behavioral generation of a false memory in mice.
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Memory circuits in dementia: the engram, hippocampal neurogenesis and Alzheimer’s disease.
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Cell type-specific transcriptomics reveals that mutant huntingtin leads to mitochondrial RNA release and neuronal innate immune activation.
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Normal aging induces changes in the brain and neurodegeneration progress: review of the structural, biochemical, metabolic, cellular, and molecular changes.
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Neocortical synaptic engrams for remote contextual memories.
10.1038/s41593-022-01223-1 · 2023 · External reference
Age-dependent elevation of Nr4a1 attenuates PI3K/AKT/GSK3β pathway and mediates tau hyperphosphorylation and cognitive impairments.
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10.1126/science.aav1250 · 2018 · External reference
Defective memory engram reactivation underlies impaired fear memory recall in Fragile X syndrome.
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Navigating the hurdles of intra-articular AAV gene therapy.
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Spatial memory requires hypocretins to elevate medial entorhinal gamma oscillations.
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Mutant Huntingtin alters retrograde transport of TrkB receptors in striatal dendrites.
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Creation of neuronal ensembles and cell-specific homeostatic plasticity through chronic sparse optogenetic stimulation.
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Brain microglia activation and peripheral adaptive immunity in Parkinson’s disease: a multimodal PET study.
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10.1186/s13045-024-01596-9 · 2024 · External reference
Optogenetic stimulation of a hippocampal engram activates fear memory recall.
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Structural magnetic resonance imaging for the early diagnosis of dementia due to Alzheimer’s disease in people with mild cognitive impairment.
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Cortical representations of visual stimuli shift locations with changes in memory states.
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Multisensory integration, brain plasticity and optogenetics in visual rehabilitation.
10.3389/fneur.2025.1590305 · 2025 · External reference
Roadmap for direct and indirect translation of optogenetics into discoveries and therapies for humans.
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Circuit-based neuromodulation enhances delayed recall in amnestic mild cognitive impairment.
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Aβ/tau oligomer interplay at human synapses supports shifting therapeutic targets for Alzheimer’s disease.
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Differences in discounting behavior and brain responses for food and money reward.
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Complementary roles of differential medial entorhinal cortex inputs to the hippocampus for the formation and integration of temporal and contextual memory (Systems Neuroscience).
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Brain rhythms during sleep and memory consolidation: neurobiological insights.
10.1152/physiol.00004.2019 · 2020 · External reference
PET imaging of synaptic density in Parkinsonian disorders.
10.1002/jnr.25253 · 2024 · External reference
Amyloid-β-induced dendritic spine elimination requires Ca(2+)-permeable AMPA receptors, AKAP-Calcineurin-NFAT signaling, and the NFAT target gene Mdm2.
10.1523/eneuro.0175-23.2024 · 2024 · External reference
Synaptic RTP801 contributes to motor-learning dysfunction in Huntington’s disease.
10.1038/s41419-020-02775-5 · 2020 · External reference
Multi-sensory gamma stimulation ameliorates Alzheimer’s-associated pathology and improves cognition.
10.1016/j.cell.2019.02.014 · 2019 · External reference
Exploring the role of neuroplasticity in development, aging, and neurodegeneration.
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Medial and lateral entorhinal cortex differentially excite deep versus superficial CA1 pyramidal neurons.
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Stress effects on neuronal structure: hippocampus, amygdala, and prefrontal cortex.
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10.1002/mds.29228 · 2022 · External reference
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Directed brain connectivity identifies widespread functional network abnormalities in Parkinson’s Disease.
10.1093/cercor/bhab237 · 2022 · External reference
Retrieval of contextual memory can be predicted by CA3 remapping and is differentially influenced by NMDAR activity in rat hippocampus subregions.
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Augmenting neurogenesis rescues memory impairments in Alzheimer’s disease by restoring the memory-storing neurons.
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Exercise, neuroprotective exerkines, and Parkinson’s Disease: a narrative review.
10.3390/biom14101241 · 2024 · External reference
De novo inter-regional coactivations of preconfigured local ensembles support memory.
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Excitability mediates allocation of pre-configured ensembles to a hippocampal engram supporting contextual conditioned threat in mice.
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Multisensory gamma stimulation promotes glymphatic clearance of amyloid.
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Connectivity disruption, atrophy, and hypometabolism within posterior cingulate networks in Alzheimer’s Disease.
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CaMKII metaplasticity drives Aβ oligomer-mediated synaptotoxicity.
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Amyloid β / PKC-dependent alterations in NMDA receptor composition are detected in early stages of Alzheimer’s disease.
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The role of Twist1 in mutant huntingtin-induced transcriptional alterations and neurotoxicity.
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The Na(+)/Ca(2+)exchanger in Alzheimer’s disease.
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The effect of hippocampal function, volume and connectivity on posterior cingulate cortex functioning during episodic memory fMRI in mild cognitive impairment.
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Cortical axonal secretion of BDNF in the striatum is disrupted in the mutant-huntingtin knock-in mouse model of Huntington’s Disease.
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Optogenetic stimulation of dentate gyrus engrams restores memory in Alzheimer’s disease mice.
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Engram cell excitability state determines the efficacy of memory retrieval.
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Amyloid pathology disrupts gliotransmitter release in astrocytes.
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