Research graph
References from The effects of abused drugs on ferroptosis pathways: potential therapeutic targets for substance use disorders. Local targets link to admitted publications; unresolved targets remain external evidence.
Methamphetamine causes lipid peroxidation and an increase in superoxide dismutase activity in the rat striatum
10.1016/s0006-8993(98)01020-8 · 1998 · External reference
Elevated brain iron in cocaine use disorder as indexed by magnetic field correlation imaging
10.1016/j.bpsc.2018.11.006 · 2019 · External reference
Inflammation-induced up-regulation of hepcidin and down-regulation of ferroportin transcription are dependent on macrophage polarization
10.1016/j.bcmd.2016.07.006 · 2016 · External reference
Oxidative stress and inflammation: essential partners in alcoholic liver disease
10.1155/2012/853175 · 2012 · External reference
Single-nucleus RNA sequencing and functional studies of acute methamphetamine-induced cognitive impairment
10.1038/s42003-026-09728-2 · 2026 · External reference
Methamphetamine decreases levels of glutathione peroxidases 1 and 4 in SH-SY5Y neuronal cells: protective effects of selenium
10.1016/j.neuro.2013.05.009 · 2013 · External reference
Preferential effects of nicotine and 4-(N-methyl-N-nitrosamine)-1-(3-pyridyl)-1-butanone on mitochondrial glutathione S-transferase A4-4 induction and increased oxidative stress in the rat brain
10.1016/s0006-2952(98)00228-7 · 1998 · External reference
Advancements in ferroptosis research and therapeutic strategies for alcoholic liver disease: a narrative review
10.26355/eurrev_202310_33957 · 2023 · External reference
Brain lipidomic changes after morphine, cocaine and amphetamine administration - DESI - MS imaging study
10.1016/j.bbalip.2017.04.003 · 2017 · External reference
Multiple faceted roles of cocaine in potentiation of HAND
10.2174/1570162x14666160324125158 · 2016 · External reference
Lipid metabolism. cold spring harb
10.1101/cshperspect.a040576 · 2021 · External reference
Liproxstatin-1 attenuates morphine tolerance through inhibiting spinal ferroptosis-like cell death
10.1021/acschemneuro.9b00539 · 2019 · External reference
Cocaine upregulates microglial lipid droplet formation through increasing lipid synthesis activity in vitro and in vivo
10.3390/biom16040526 · 2026 · External reference
Long-chain fatty acids as drivers of neuroinflammation in neurodegeneration: mechanistic links to lipid peroxidation, ferroptosis, and mitochondrial dysfunction
10.3390/nu18091392 · 2026 · External reference
Substance Use Disorders in Global Mental Health Delivery: Epidemiology, Treatment Gap, and Implementation of Evidence-Based Treatments
10.1097/hrp.0000000000000271 · 2020 · External reference
Nicotine protects rat brain mitochondria against experimental injuries
10.1016/s0028-3908(03)00041-8 · 2003 · External reference
Mitochondrial complex I dysfunction induced by cocaine and cocaine plus morphine in brain and liver mitochondria
10.1016/j.toxlet.2013.03.025 · 2013 · External reference
Family and social aspects of substance use disorders and treatment
10.1016/j.jfda.2013.09.038 · 2013 · External reference
Alcohol-induced oxidative stress
10.1016/j.lfs.2007.05.005 · 2007 · External reference
Cocaine perturbs neurodevelopment and increases neuroinflammation in a prenatal cerebral organoid model
10.1038/s41398-025-03315-5 · 2025 · External reference
Antioxidant and Neuroprotective Effects Induced by Cannabidiol and Cannabigerol in Rat CTX-TNA2 Astrocytes and Isolated Cortexes
10.3390/ijms21103575 · 2020 · External reference
Alteration of blood-brain barrier function by methamphetamine and cocaine
10.1007/s00441-009-0777-y · 2009 · External reference
Ferroptosis: an iron-dependent form of nonapoptotic cell death
10.1016/j.cell.2012.03.042 · 2012 · External reference
Identification of genotype-selective antitumor agents using synthetic lethal chemical screening in engineered human tumor cells
10.1016/s1535-6108(03)00050-3 · 2003 · External reference
Cannabidiol prevents LPS-induced microglial inflammation by inhibiting ROS/NF-kappaB-dependent signaling and glucose consumption
10.1002/glia.23738 · 2020 · External reference
Disrupted iron regulation in the brain and periphery in cocaine addiction
10.1038/tp.2016.271 · 2017 · External reference
Cannabidiol inhibits inducible nitric oxide synthase protein expression and nitric oxide production in beta-amyloid stimulated PC12 neurons through p38 MAP kinase and NF-kappaB involvement
10.1016/j.neulet.2006.01.047 · 2006 · External reference
Deaths from excessive alcohol use - United States, 2016-2021
10.15585/mmwr.mm7308a1 · 2024 · External reference
Effects of nicotine on hydroxyl free radical formation in vitro and on MPTP-induced neurotoxicity in vivo
10.1007/pl00005264 · 1998 · External reference
FINO(2) initiates ferroptosis through GPX4 inactivation and iron oxidation
10.1038/s41589-018-0031-6 · 2018 · External reference
Dual effects of nicotine on oxidative stress and neuroprotection in PC12 cells
10.1016/s0197-0186(03)00009-3 · 2003 · External reference
Molecular mechanisms of programmed cell death in methamphetamine-induced neuronal damage
10.3389/fphar.2022.980340 · 2022 · External reference
Lifestyle, biological, and genetic factors related to brain iron accumulation across adulthood
10.1016/j.neurobiolaging.2024.09.004 · 2024 · External reference
Mu opioid receptor-mediated release of endolysosome iron increases levels of mitochondrial iron, reactive oxygen species, and cell death
10.1515/nipt-2022-0013 · 2023 · External reference
Nicotine increases in vivo blood-brain barrier permeability and alters cerebral microvascular tight junction protein distribution
10.1016/j.brainres.2004.08.043 · 2004 · External reference
Brain CYP2E1 is induced by nicotine and ethanol in rat and is higher in smokers and alcoholics
10.1038/sj.bjp.0705146 · 2003 · External reference
Iron chelation prevents nigrostriatal neurodegeneration in a chronic methamphetamine mice model
10.1016/j.neuro.2023.09.006 · 2023 · External reference
Insufficient autophagy enables the nuclear factor erythroid 2-related factor 2 (NRF2) to promote ferroptosis in morphine-treated SH-SY5Y cells
10.1007/s00213-023-06485-6 · 2024 · External reference
Metabolic pathway of natural antioxidants, antioxidant enzymes and ROS providence
10.3390/antiox11040761 · 2022 · External reference
Effect of nicotine and polyaromtic hydrocarbons on cerebral endothelial cells
10.1016/j.cellbi.2007.08.026 · 2008 · External reference
The endolysosomal transporter DMT1 is required for morphine regulation of neuronal ferritin heavy chain
10.1007/s11481-023-10082-x · 2023 · External reference
Neuroprotective effect of cannabidiol, a non-psychoactive component from Cannabis sativa, on beta-amyloid-induced toxicity in PC12 cells
10.1111/j.1471-4159.2003.02327.x · 2004 · External reference
Neurotoxicity of methamphetamine: Main effects and mechanisms
10.1016/j.expneurol.2021.113795 · 2021 · External reference
Methamphetamine-induced changes in antioxidant enzymes and lipid peroxidation in copper/zinc-superoxide dismutase transgenic mice
10.1111/j.1749-6632.1998.tb08224.x · 1998 · External reference
Remodeling of brain lipidome in methamphetamine-sensitized mice
10.1016/j.toxlet.2017.07.214 · 2017 · External reference
The chemistry of Reactive Oxygen Species (ROS) Revisited: outlining their role in biological macromolecules (dna, lipids and proteins) and induced pathologies
10.3390/ijms22094642 · 2021 · External reference
Conventional and electronic cigarettes dysregulate the expression of iron transporters and detoxifying enzymes at the brain vascular endothelium: in vivo evidence of a gender-specific cellular response to chronic cigarette smoke exposure
10.1016/j.neulet.2018.05.045 · 2018 · External reference
Inhibition of rat brain mitochondrial electron transport chain activity by dopamine oxidation products during extended in vitro incubation: implications for Parkinson's disease
10.1016/j.bbadis.2005.03.013 · 2005 · External reference
Targeting ferroptosis for neuroprotection: potential therapeutic avenues in neurodegenerative and neuropsychiatric diseases
10.3389/fphys.2025.1641323 · 2025 · External reference
Neuroprotective effect of cannabidiol against hydrogen peroxide in hippocampal neuron culture
10.1089/can.2019.0102 · 2021 · External reference
Ferroptosis under fire: cannabidiol mitigates iron-dependent injury in differentiated human neuroblastoma cells following oxygen-glucose deprivation
10.1016/j.phymed.2026.157868 · 2026 · External reference
Iron accumulation in alcoholic liver diseases
10.1097/01.alc.0000189274.00479.62 · 2005 · External reference
Methamphetamine self-administration results in persistent dopaminergic pathology: implications for Parkinson's disease risk and reward-seeking
10.1111/ejn.12628 · 2014 · External reference
Alterations of mitochondrial structure in methamphetamine toxicity
10.3390/ijms23168926 · 2022 · External reference
Cordycepin ameliorates morphine tolerance by inhibiting spinal cord ferroptosis and inflammation via targeting SIRT1
10.7150/ijms.108518 · 2025 · External reference
NRF2 Antagonizes HIV-1 Tat and Methamphetamine-Induced BV2 Cell Ferroptosis by Regulating SLC7A11
10.1007/s12640-023-00645-4 · 2023 · External reference
In vitro and in vivo studies investigating possible antioxidant actions of nicotine: relevance to Parkinson's and Alzheimer's diseases
10.1016/s0925-4439(99)00029-0 · 1999 · External reference
Ferroptosis in neuropsychiatric, neurodegenerative disorders: shared mechanisms and disease-specific signatures
10.3390/ph19040629 · 2026 · External reference
Cocaine promotes oxidative stress and microglial-macrophage activation in rat cerebellum
10.3389/fncel.2015.00279 · 2015 · External reference
Ferroptosis contributes to ethanol-induced hepatic cell death via labile iron accumulation and GPx4 inactivation
10.1038/s41420-023-01608-6 · 2023 · External reference
The role of reactive oxygen species in morphine addiction of SH-SY5Y cells
10.1016/j.lfs.2015.01.003 · 2015 · External reference
Nicotine alkaloids as antioxidant and potential protective agents against in vitro oxidative haemolysis
10.1016/j.cbi.2015.11.030 · 2016 · External reference
Antioxidants and reactive oxygen species: shaping human health and disease outcomes
10.3390/ijms26157520 · 2025 · External reference
Induction of mitochondrial permeability transition (MPT) pore opening and ROS formation as a mechanism for methamphetamine-induced mitochondrial toxicity
10.1007/s00210-013-0919-3 · 2014 · External reference
Neuroimmune signaling: a key component of alcohol abuse
10.1016/j.conb.2013.01.024 · 2013 · External reference
Alcohol-induced generation of lipid peroxidation products in humans
10.1172/jci5584 · 1999 · External reference
Methamphetamine increases basal ganglia iron to levels observed in aging
10.1097/wnr.0b013e3282f0d4f4 · 2007 · External reference
Brain antioxidant systems in human methamphetamine users
10.1111/j.1471-4159.2004.02434.x · 2004 · External reference
Nicotine-induced neuroprotection in rotenone in vivo and in vitro models of parkinson's disease: evidences for the involvement of the labile iron pool level as the underlying mechanism
10.1007/s12640-018-9931-1 · 2019 · External reference
Dose- and tissue-dependent effects of cannabidiol on antioxidant status in developing chicken embryos
10.1038/s41598-025-31097-9 · 2025 · External reference
A red carpet for iron metabolism
10.1016/j.cell.2016.12.034 · 2017 · External reference
Increased lipid and protein oxidation and DNA damage in patients with chronic alcoholism
10.1067/mlc.2000.109097 · 2000 · External reference
Study of Serum Malondialdehyde Level in Opioid and Methamphetamine Dependent Patients
2017 · External reference
Morphine-induced modulation of endolysosomal iron mediates upregulation of ferritin heavy chain in cortical neurons
10.1523/eneuro.0237-19.2019 · 2019 · External reference
Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization
10.1126/science.1104742 · 2004 · External reference
Peripheral ammonia and blood brain barrier structure and function after methamphetamine
10.1016/j.neuropharm.2016.03.018 · 2016 · External reference
Toxic effects of opioid and stimulant drugs on undifferentiated PC12 cells
10.1111/j.1749-6632.2002.tb04190.x · 2002 · External reference
Spinal morphine administration reduces the fatty acid contents in spinal cord and brain by increasing oxidative stress
10.1007/s11064-006-9217-5 · 2007 · External reference
Oxidative stress in heroin administered mice and natural antioxidants protection
10.1016/j.lfs.2004.12.025 · 2005 · External reference
The microglial alpha7-acetylcholine nicotinic receptor is a key element in promoting neuroprotection by inducing heme oxygenase-1 via nuclear factor erythroid-2-related factor 2
10.1089/ars.2012.4671 · 2013 · External reference
Perspectives on alcohol consumption: liver polyunsaturated fatty acids and essential fatty acid metabolism
10.1016/j.alcohol.2004.07.009 · 2004 · External reference
Fentanyl dysregulates neuroinflammation and disrupts blood-brain barrier integrity in HIV-1 Tat transgenic mice
10.1007/s13365-023-01186-4 · 2024 · External reference
Attenuation of Oxidative Stress by Cannabinoids and Cannabis Extracts in Differentiated Neuronal Cells
10.3390/ph13110328 · 2020 · External reference
Methamphetamine disrupts blood-brain barrier function by induction of oxidative stress in brain endothelial cells
10.1038/jcbfm.2009.112 · 2009 · External reference
Morphine-induced modulation of Nrf2-antioxidant response element signaling pathway in primary human brain microvascular endothelial cells
10.1038/s41598-022-08712-0 · 2022 · External reference
Decreased activity of brain phospholipid metabolic enzymes in human users of cocaine and methamphetamine
10.1016/s0376-8716(02)00022-4 · 2002 · External reference
Chronic cocaine administration reduces phospholipase A(2) activity in rat brain striatum
10.1054/plef.2002.0385 · 2002 · External reference
Drugs of abuse and blood-brain barrier endothelial dysfunction: A focus on the role of oxidative stress
10.1177/0271678x15616978 · 2016 · External reference
Substance use and common contributors to morbidity: A genetics perspective
10.1016/j.ebiom.2022.104212 · 2022 · External reference
Targeting ferroptosis and necroptosis to treat stroke
10.1007/s11064-026-04751-5 · 2026 · External reference
Cocaine use disorder (cud): current clinical perspectives
10.2147/sar.s337338 · 2022 · External reference
Mitochondrial ROS signaling in organismal homeostasis
10.1016/j.cell.2015.10.001 · 2015 · External reference
Methamphetamine induces apoptosis of microglia via the intrinsic mitochondrial-dependent pathway
10.1007/s11481-018-9787-4 · 2018 · External reference
Antiapoptotic effects of cannabidiol in an experimental model of cognitive decline induced by brain iron overload
10.1038/s41398-018-0232-5 · 2018 · External reference
Cannabinoid-Induced Changes in the Activity of Electron Transport Chain Complexes of Brain Mitochondria
10.1007/s12031-015-0545-2 · 2015 · External reference
N-acetylcysteine in substance use disorder: a lesson from preclinical and clinical research
10.1007/s43440-021-00283-7 · 2021 · External reference
Nicotine mediates expression of genes related to antioxidant capacity and oxidative stress response in HIV-1 transgenic rat brain
10.1007/s13365-015-0375-6 · 2016 · External reference
Effects of (-)-nicotine and (-)-cotinine on 6-hydroxydopamine-induced oxidative stress and neurotoxicity: relevance for Parkinson's disease
10.1016/s0006-2952(02)01070-5 · 2002 · External reference
Ferroptosis: a regulated cell death nexus linking metabolism, redox biology, and disease
10.1016/j.cell.2017.09.021 · 2017 · External reference
A systematic review of minor phytocannabinoids with promising neuroprotective potential
10.1111/bph.15185 · 2020 · External reference
Ethanol-induced cell death by lipid peroxidation in PC12 cells
10.1023/a:1021968526696 · 1997 · External reference
Pseudorabies virus triggers ferritinophagy-mediated ferroptosis and neuroinflammation in viral encephalitis
10.1073/pnas.2508352123 · 2026 · External reference
Cannabidiol attenuates OGD/R-induced damage by enhancing mitochondrial bioenergetics and modulating glucose metabolism via pentose-phosphate pathway in hippocampal neurons
10.1016/j.redox.2016.12.029 · 2017 · External reference
Microglial alpha7 nicotinic acetylcholine receptors drive a phospholipase C/IP3 pathway and modulate the cell activation toward a neuroprotective role
10.1002/jnr.20850 · 2006 · External reference
Wnt7a mediates the Wnt/beta-catenin signaling pathway to influence ferroptosis in T lymphocytes of HIV-infected individuals
10.1016/j.molimm.2026.04.009 · 2026 · External reference
Cannabinoids inhibit N- and P/Q-type calcium channels in cultured rat hippocampal neurons
10.1152/jn.1997.78.1.43 · 1997 · External reference
The neurobiology of addiction
10.1111/nyas.13989 · 2019 · External reference
Acute and chronic administration of cannabidiol increases mitochondrial complex and creatine kinase activity in the rat brain
10.1590/1516-4446-2012-0886 · 2013 · External reference
Substance use disorders: a comprehensive update of classification, epidemiology, neurobiology, clinical aspects, treatment and prevention
10.1002/wps.21073 · 2023 · External reference
Brain ethanol metabolism and mitochondria
2022 · External reference
Targeting ferroptosis in cancer: from mechanistic insights to therapeutic approaches
10.1186/s43556-026-00416-5 · 2026 · External reference
Ferroptosis in Parkinson's disease: a review of molecular mechanisms and emerging therapeutic strategies
10.3389/fnins.2026.1780573 · 2026 · External reference
An overview of ferroptosis in non-alcoholic fatty liver disease
10.1016/j.biopha.2022.113374 · 2022 · External reference
Opioid induces increased DNA damage in prefrontal cortex and nucleus accumbens
10.1016/j.pbb.2023.173535 · 2023 · External reference
The selenoprotein glutathione peroxidase 4: from molecular mechanisms to novel therapeutic opportunities
10.3390/biomedicines10040891 · 2022 · External reference
Role of mitochondrial dynamics in cocaine's neurotoxicity
10.3390/ijms23105418 · 2022 · External reference
Cannabidiol is a potential inhibitor of ferroptosis in human articular chondrocytes
10.1111/jcmm.70592 · 2025 · External reference
Targeting redox regulation to treat substance use disorder using N-acetylcysteine
10.1111/ejn.14130 · 2019 · External reference
Role of Nrf2 in preventing ethanol-induced oxidative stress and lipid accumulation
10.1016/j.taap.2012.05.010 · 2012 · External reference
Investigating the receptor-independent neuroprotective mechanisms of nicotine in mitochondria
10.1074/jbc.m504664200 · 2005 · External reference
Alcohol exposure induces depressive and anxiety-like behaviors via activating ferroptosis in mice
10.3390/ijms232213828 · 2022 · External reference
The role of oxidative stress, metabolic compromise, and inflammation in neuronal injury produced by amphetamine-related drugs of abuse
10.1007/s11481-008-9121-7 · 2008 · External reference
Dysregulation of iron homeostasis and methamphetamine reward behaviors in Clk1-deficient mice
10.1038/s41401-021-00806-1 · 2022 · External reference
Regulation of ferroptotic cancer cell death by GPX4
10.1016/j.cell.2013.12.010 · 2014 · External reference
Ferrostatin 1 exerts multifaceted hepatic protection against alcoholic liver injury by inhibiting ferroptosis
10.1038/s41598-026-39849-x · 2026 · External reference
Regulated neuronal death in Alzheimer's disease: crosstalk and convergence of apoptosis, pyroptosis, senescence, and ferroptosis
10.1177/13872877261430002 · 2026 · External reference
Autophagy inhibition plays a protective role in ferroptosis induced by alcohol via the p62-Keap1-Nrf2 pathway
10.1021/acs.jafc.1c03751 · 2021 · External reference
p38gamma modulates ferroptosis in brain injury caused by ethanol and cerebral ischemia/reperfusion by regulating the p53/SLC7A11 signaling pathway
10.1016/j.cellsig.2025.111728 · 2025 · External reference