Research graph
References from Single-cell and single-nucleus transcriptomics in ischemic stroke: cellular mechanisms and therapeutic implications. Local targets link to admitted publications; unresolved targets remain external evidence.
Stroke
10.1016/s0140-6736(24)00642-1 · 2024 · External reference
China stroke prevention and control report 2024: an executive summary
10.4103/bc.bc_198_25 · 2025 · External reference
Projected global trends in ischemic stroke incidence, deaths and disability-adjusted life years from 2020 to 2030
10.1161/strokeaha.122.040073 · 2023 · External reference
Clinically ineffective reperfusion after endovascular therapy in acute ischemic stroke
10.1161/strokeaha.122.038466 · 2023 · External reference
Forward thinking in reperfusion therapy for acute ischemic stroke
10.4103/bc.bc_161_25 · 2025 · External reference
Impacts of futile reperfusion and reperfusion injury in acute ischemic stroke
10.4103/bc.bc_9_24 · 2024 · External reference
Signaling pathways involved in ischemic stroke: molecular mechanisms and therapeutic interventions
10.1038/s41392-022-01064-1 · 2022 · External reference
Angiogenesis and neuronal remodeling after ischemic stroke
10.4103/1673-5374.264442 · 2020 · External reference
From bulk, single-cell to spatial RNA sequencing
10.1038/s41368-021-00146-0 · 2021 · External reference
MRNA-Seq whole-transcriptome analysis of a single cell
10.1038/nmeth.1315 · 2009 · External reference
RNA-sequencing from single nuclei
10.1073/pnas.1319700110 · 2013 · External reference
Single-cell RNA sequencing technologies and applications: a brief overview
10.1002/ctm2.694 · 2022 · External reference
Tutorial: Guidelines for the computational analysis of single-cell RNA sequencing data
10.1038/s41596-020-00409-w · 2021 · External reference
Analytical methods and application of single-cell and single-nucleus transcriptomics in the study of ischemic stroke
10.3390/biom16071054 · 2026 · External reference
Beyond the ischemic brain: expanding single-cell transcriptomics in stroke research to extra-CNS systems, biological contexts, and post-stroke complications
10.4103/bc.bc_130_26 · 2026 · External reference
Immune responses to stroke: mechanisms, modulation, and therapeutic potential
10.1172/jci135530 · 2020 · External reference
Immune pathways in etiology, acute phase, and chronic sequelae of ischemic stroke
10.1161/circresaha.121.319994 · 2022 · External reference
Single-cell RNA-Seq reveals the transcriptional landscape in ischemic stroke
10.1177/0271678x211026770 · 2022 · External reference
Novel Ch25h(+) and Oasl(+) Microglia Subclusters play distinct roles in cerebral ischemic stroke
10.1186/s12974-023-02799-6 · 2023 · External reference
Microglia exhibit distinct heterogeneity rather than M1/M2 polarization within the early stage of acute ischemic stroke
10.14336/ad.2023.0505 · 2023 · External reference
The role of microglial/macrophagic salt-inducible kinase 3 on normal and excessive phagocytosis after transient focal cerebral ischemia
10.1007/s00018-022-04465-1 · 2022 · External reference
Single-cell RNA-Seq reveals changes in cell subsets in the cortical microenvironment during acute phase of ischemic stroke rats
10.31083/j.jin2205128 · 2023 · External reference
Effects and mechanisms of long-acting glucagon-like peptide-1 receptor agonist semaglutide on microglia phenotypic transformation and neuroinflammation after cerebral ischemia/reperfusion in rats
10.4103/bc.bc_38_24 · 2024 · External reference
Phenotypic and spatial heterogeneity of brain myeloid cells after stroke is associated with cell ontogeny, tissue damage, and brain connectivity
10.1016/j.celrep.2024.114250 · 2024 · External reference
Single-cell RNA sequencing reveals microglial heterogeneity and functional states after cerebral ischemia-reperfusion injury
10.2147/jir.s539404 · 2025 · External reference
Integrative transcriptomic analysis reveals Cd72 as a novel pro-inflammatory factor in microglia following experimental ischemic stroke
10.1016/j.expneurol.2024.114974 · 2024 · External reference
Targeting Cd74 in microglia to modulate experimental cerebral ischemia and reperfusion injury: insights from single-cell and bulk transcriptomics
10.1186/s13041-025-01197-8 · 2025 · External reference
Roles of adam8 in neuroinflammation in experimental ischemic stroke: insights from single-cell and ribosome-bound MRNA sequencing
10.1016/j.expneurol.2025.115207 · 2025 · External reference
Loss of Plxdc2 exacerbates microglia-mediated neuroinflammation and ischemic brain injury
10.1016/j.expneurol.2025.115302 · 2025 · External reference
Single-cell sequencing and transcriptomic data reveal that P65 activation significantly promotes microglia-mediated neuroinflammation after ischemic stroke
10.1038/s41598-025-00524-2 · 2025 · External reference
Sting activation in macrophages and microglia drives poststroke inflammation: implications for neuroinflammatory mechanisms and therapeutic interventions
10.1111/cns.70106 · 2024 · External reference
Single-nucleus transcriptome unveils the role of ferroptosis in ischemic stroke
10.1016/j.heliyon.2024.e32727 · 2024 · External reference
Inhibition of microglial Slc2a5 attenuates ischemic brain injury
10.1016/j.metabol.2025.156429 · 2026 · External reference
Single-cell RNA sequencing unveils Lrg1's role in cerebral ischemia–reperfusion injury by modulating various cells
10.1186/s12974-023-02941-4 · 2023 · External reference
A stroke organoids-multiomics platform to study injury mechanism and drug response
10.1016/j.bioactmat.2024.09.038 · 2025 · External reference
Response of astrocytes and their interaction with surrounding brain cells after acute ischemia-reperfusion analyzed by single-cell transcriptome sequencing
10.1016/j.brainresbull.2025.111355 · 2025 · External reference
Acupuncture regulates astrocyte neurotoxic polarization to protect blood-brain barrier integrity in delayed thrombolysis through mediating Erk1/2/Cx43 axis
10.1016/j.ibneur.2025.04.005 · 2025 · External reference
Nogoa-expressing astrocytes limit peripheral macrophage infiltration after ischemic brain injury in primates
10.1038/s41467-021-27245-0 · 2021 · External reference
Immune pathway activation in neurons triggers neural damage after stroke
10.1016/j.celrep.2023.113368 · 2023 · External reference
Changes in border-associated macrophages after stroke: single-cell sequencing analysis
10.4103/nrr.nrr-d-24-01092 · 2026 · External reference
Foxp3+ Macrophage represses acute ischemic stroke-induced neural inflammation
10.1080/15548627.2022.2116833 · 2023 · External reference
Comprehensive transcriptomic analysis integrating bulk and single-cell RNA-Seq with machine learning to identify and validate mitochondrial unfolded protein response biomarkers in patients with ischemic stroke
10.3389/fcell.2025.1582252 · 2025 · External reference
Mapping neutrophil fate and function in ischemic stroke: a single-cell roadmap for translational insights
10.1016/j.bbrc.2025.152659 · 2025 · External reference
Single-cell RNA sequencing reveals S100a8/A9(Hi) neutrophils-induced endothelial cell death and lymphocyte infiltration after ischemic stroke
10.1016/j.bbrc.2024.151023 · 2024 · External reference
Shuanglu Tongnao formula alleviates cerebral ischemia/reperfusion injury by rebuilding inflammatory microenvironment after cerebral ischemia
10.1016/j.jep.2025.119640 · 2025 · External reference
Bulk and single-cell transcriptomics reveal neuroprotective molecular mechanism of rosa roxburghii polysaccharides in cerebral ischemia-reperfusion injury
10.1016/j.jrras.2025.101937 · 2025 · External reference
Identification and validation of microglia-associated genes in ischemic stroke using single-cell and bulk RNA-seq
10.1186/s13041-025-01259-x · 2025 · External reference
The high-affinity Il-2 receptor affects white matter damage after cerebral ischemia by regulating Cd8 + T lymphocyte differentiation
10.1007/s11481-025-10169-7 · 2025 · External reference
Decoding monocyte signatures in ischemic stroke: a multi-scale transcriptomic approach
10.4103/nrr.nrr-d-24-01669 · 2026 · External reference
The blood-brain barrier in health and disease: important unanswered questions
10.1084/jem.20190062 · 2020 · External reference
Angiogenesis and Blood-Brain Barrier Permeability in Vascular Remodeling after Stroke
10.2174/1570159x18666200720173316 · 2020 · External reference
Identification of brain endothelial cell-specific genes and pathways in ischemic stroke by integrated bioinformatical analysis
10.4103/bc.bc_40_23 · 2023 · External reference
Dynamic changes in cerebral blood flow and angiogenesis after transient focal cerebral ischemia in rats
10.1161/01.str.0000037675.97888.9d · 2002 · External reference
Hypoxia-induced vascular endothelial growth factor expression precedes neovascularization after cerebral ischemia
10.1016/s0002-9440(10)64964-4 · 2000 · External reference
The transcriptional landscape of pericytes in acute ischemic stroke
10.1007/s12975-023-01169-x · 2024 · External reference
Critical role of Slc22a8 in maintaining blood-brain barrier integrity after experimental cerebral ischemia-reperfusion
10.1177/0271678x241264401 · 2025 · External reference
Cross-species multi-omics analysis reveals myeloid-driven endothelial oxidative stress in ischemic stroke
10.31083/fbl37429 · 2025 · External reference
Angiogenesis after ischemic stroke
10.1038/s41401-023-01061-2 · 2023 · External reference
X-box binding protein 1 as a key modulator in “healing endothelial cells”, a novel Ec phenotype promoting angiogenesis after mcao
10.1186/s11658-022-00399-5 · 2022 · External reference
Leveraging single-cell RNA sequencing to unravel the impact of aging on stroke recovery mechanisms in mice
10.1073/pnas.2300012120 · 2023 · External reference
Single-cell profiling of brain pericyte heterogeneity following ischemic stroke unveils distinct pericyte subtype-targeted neural reprogramming potential and its underlying mechanisms
10.7150/thno.97165 · 2024 · External reference
Transient astrocyte-like Ng2 glia subpopulation emerges solely following permanent brain ischemia
10.1002/glia.24064 · 2021 · External reference
Characterizing hypoxia-orchestrated post-stroke changes in oligodendrocyte precursor cells for optimized cell therapy
10.1016/j.stemcr.2025.102687 · 2025 · External reference
Cell death pathways in ischemic stroke and targeted pharmacotherapy
10.1007/s12975-020-00806-z · 2020 · External reference
Characterizing stroke-related cellular changes in the surviving neurons of mouse ischemic stroke
10.1016/j.neuint.2025.106086 · 2025 · External reference
A Molecular brain atlas reveals cellular shifts during the repair phase of stroke
10.1186/s12974-025-03437-z · 2025 · External reference
Manf enhances the pyroptosis inhibition of bone marrow-derived mesenchymal stem cells to relieve cerebral infarction injury
10.1016/j.neuroscience.2022.11.002 · 2023 · External reference
The deubiquitinase otud3 plays a neuroprotective role by reducing ferroptosis induced by cerebral ischaemia reperfusion via stabilizing Plk1 via deubiquitination
10.1002/ctm2.70347 · 2025 · External reference
Perilipin-2 mediates ferroptosis in oligodendrocyte progenitor cells and myelin injury after ischemic stroke
10.4103/nrr.nrr-d-23-01540 · 2025 · External reference
Exploring the potential molecular intersection of stroke and major depression disorder
10.1016/j.bbrc.2024.150079 · 2024 · External reference
Huanglian jiedu decoction treats ischemic stroke by regulating pyroptosis: insights from multi-omics and drug-target relationship analysis
10.3390/ph18060775 · 2025 · External reference
S-Propargyl-cysteine attenuates stroke heterogeneity via promoting protective autophagy across multiple neural cell types: insights from single-cell sequencing
10.1111/cns.70399 · 2025 · External reference
Cuproptosis-related genes are involved in immunodeficiency following ischemic stroke
10.5114/aoms/182909 · 2024 · External reference
Identification of disulfidptosis-related genes in ischemic stroke by combining single-cell sequencing, machine learning algorithms, and in vitro experiments
10.1007/s12017-024-08804-2 · 2024 · External reference
Integrating single-cell sequencing and transcriptome analysis to investigate the role of ferroptosis in ischemic stroke and the molecular mechanisms of immune checkpoints
10.1016/j.wneu.2025.123908 · 2025 · External reference
Perspectives on single-nucleus RNA sequencing in different cell types and tissues
10.4132/jptm.2022.12.19 · 2023 · External reference
Guidelines for bioinformatics of single-cell sequencing data analysis in Alzheimer's disease: review, recommendation, implementation and application
10.1186/s13024-022-00517-z · 2022 · External reference
Neuroinflammation and energy metabolism: a dual perspective on ischemic stroke
10.1186/s12967-025-06440-3 · 2025 · External reference
The effects of stress hyperglycemia in diabetic and nondiabetic patients with large vessel occlusions undergoing mechanical thrombectomy
10.4103/bc.bc_97_23 · 2024 · External reference
Identification of endoplasmic reticulum stress genes in human stroke based on bioinformatics and machine learning
10.1016/j.nbd.2024.106583 · 2024 · External reference
Acute ischemia induces spatially and transcriptionally distinct microglial subclusters
10.1186/s13073-023-01257-5 · 2023 · External reference
Integrated Single Cell-Rna Sequencing and Mendelian Randomization for Ischemic Stroke and Metabolic Syndrome
10.1016/j.isci.2024.110240 · 2024 · External reference
E2f1/Cdk5/Drp1 axis mediates microglial mitochondrial division and autophagy in the pathogenesis of cerebral ischemia-reperfusion injury
10.1002/ctm2.70197 · 2025 · External reference
Deletion of Slc9a1 in Cx3cr1(+) cells stimulated microglial subcluster creb1 signaling and microglia-oligodendrocyte crosstalk
10.1186/s12974-024-03065-z · 2024 · External reference
Scrna-Seq and experimental analyses unveil Lrg1 regulating the oxidative phosphorylation pathway to affect neutrophil accumulation after cerebral ischemia-reperfusion
10.32604/biocell.2025.068507 · 2025 · External reference
The antioxidant enzyme peroxiredoxin-1 controls stroke-associated microglia against acute ischemic stroke
10.1016/j.redox.2022.102347 · 2022 · External reference
Cholesterol metabolic reprogramming mediates microglia-induced chronic neuroinflammation and hinders neurorestoration following stroke
10.1038/s42255-025-01379-7 · 2025 · External reference
Choline consumption reduces Cvd risk via body composition modification
10.1038/s41598-024-66039-4 · 2024 · External reference
Dynamic changes in lactate-related genes in microglia and their role in immune cell interactions after ischemic stroke
10.1515/med-2025-1178 · 2025 · External reference
Integrated analysis of single cell-RNA sequencing and mendelian randomization identifies lactate dehydrogenase B as a target of melatonin in ischemic stroke
10.1111/cns.14741 · 2024 · External reference
Single-cell RNA-sequencing analyses revealed heterogeneity and dynamic changes of metabolic pathways in astrocytes at the acute phase of ischemic stroke
10.1155/2022/1817721 · 2022 · External reference
Shared metabolic shifts in endothelial cells in stroke and Alzheimer's disease revealed by integrated analysis
10.1038/s41597-023-02512-5 · 2023 · External reference
Lcp1 knockdown in monocyte-derived macrophages: mitigating ischemic brain injury and shaping immune cell signaling and metabolism
10.7150/thno.88678 · 2024 · External reference
Age and sex are critical factors in ischemic stroke pathology
10.1210/en.2018-00465 · 2018 · External reference
Brain cell senescence: a new therapeutic target for the acute treatment of ischemic stroke
10.1093/jnen/nlac048 · 2022 · External reference
Single-cell transcriptomic analysis of the immune cell landscape in the aged mouse brain after ischemic stroke
10.1186/s12974-022-02447-5 · 2022 · External reference
Single-cell analysis identifies Ifi27l2a as a gene regulator of microglial inflammation in the context of aging and stroke in mice
10.1038/s41467-025-56847-1 · 2025 · External reference
Age-related alterations in peripheral immune landscape with magnified impact on post-stroke brain
10.34133/research.0287 · 2023 · External reference
Integrative analysis of single-cell and bulk RNA sequencing unveils the senescence landscape in ischemic stroke
10.18632/aging.204804 · 2023 · External reference
Endogenous defense mechanism-based neuroprotection in large-vessel acute ischemic stroke: a hope for future
10.4103/bc.bc_56_23 · 2024 · External reference
Wnt/Beta-catenin signaling promotes differentiation of ischemia-activated adult neural stem/progenitor cells to neuronal precursors
10.3389/fnins.2021.628983 · 2021 · External reference
Deciphering molecular heterogeneity and dynamics of human hippocampal neural stem cells at different ages and injury states
10.7554/elife.89507.4 · 2024 · External reference
Single-cell mapping of brain myeloid cell subsets reveals key transcriptomic changes favoring neuroplasticity after ischemic stroke
10.1007/s12264-023-01109-7 · 2024 · External reference
Trem2-Igf1 mediated glucometabolic enhancement underlies microglial neuroprotective properties during ischemic stroke
10.1002/advs.202305614 · 2024 · External reference
Pla2g2e-mediated lipid metabolism triggers brain-autonomous neural repair after ischemic stroke
10.1016/j.neuron.2023.06.024 · 2023 · External reference
Interaction between subventricular zone microglia and neural stem cells impacts the neurogenic response in a mouse model of cortical ischemic stroke
10.1038/s41467-024-53217-1 · 2024 · External reference
Single-nuclei RNA sequencing unveils astrocyte and oligodendrocyte lineage cells in post-stroke human brain
10.1016/j.expneurol.2025.115550 · 2026 · External reference
Ilc2 instructs neural stem and progenitor cells to potentiate neurorepair after stroke
10.1016/j.neuron.2025.03.014 · 2025 · External reference
Astrocyte-like subpopulation of Ng2 glia in the adult mouse cortex exhibits characteristics of neural progenitor cells
10.1002/glia.24471 · 2024 · External reference
Single-cell and spatial transcriptomics analysis reveals that Pros1(+) oligodendrocytes are involved in endogenous neuroprotection after brainstem stroke
10.1016/j.nbd.2025.106855 · 2025 · External reference
Inhibiting cyclin B1-treated pontine infarction by suppressing proliferation of Spp1+ microglia
10.1007/s12035-022-03183-w · 2023 · External reference
The absolute number of oligodendrocytes in the adult mouse brain
10.3389/fnana.2018.00090 · 2018 · External reference
The Search for True Numbers of Neurons and Glial Cells in the Human Brain: A Review of 150 Years of Cell Counting
10.1002/cne.24040 · 2016 · External reference
Neuroprotective strategies in acute ischemic stroke: a narrative review of recent advances and clinical outcomes
10.4103/bc.bc_165_24 · 2024 · External reference
Narrative review of reperfusion therapy in acute ischemic stroke: emerging advances, current challenges, and future directions
10.4103/bc.bc_161_24 · 2025 · External reference
Low-intensity focused ultrasound stimulation promotes stroke recovery via astrocytic Hmgb1 and Camk2n1 in mice
10.1136/svn-2023-002614 · 2024 · External reference
ScRNAs reveals high-frequency rTMS-induced pericyte differentiation: potential implications for vascular regeneration and blood-brain barrier stability in stroke
10.1016/j.heliyon.2024.e35339 · 2024 · External reference
Effect of acupuncture on brain microenvironment in rats with post-stroke limb spasticity based on single-cell transcriptome sequencing technology
10.19852/j.cnki.jtcm.20250314.001 · 2025 · External reference
Novel synergistic mechanism of 11-keto-beta-boswellic acid and Z-guggulsterone on ischemic stroke revealed by single-cell transcriptomics
10.1016/j.phrs.2023.106803 · 2023 · External reference
Repopulating microglia suppress peripheral immune cell infiltration to promote poststroke recovery
10.1111/cns.70565 · 2025 · External reference
Repair-associated macrophages increase after early-phase microglia attenuation to promote ischemic stroke recovery
10.1038/s41467-025-58254-y · 2025 · External reference
Single-cell RNA-seq revealed the immune microenvironment reprogramming by dexmedetomidine treatment in ischemic stroke
10.1007/s12035-025-05237-1 · 2025 · External reference
Neuroprotective effects, mechanisms of action and therapeutic potential of the Kv7/Kcnq channel opener Qo-83 in ischemic stroke
10.1007/s12975-025-01329-1 · 2025 · External reference
Soluble Pd-L1 reprograms blood monocytes to prevent cerebral edema and facilitate recovery after ischemic stroke
10.1016/j.bbi.2023.12.007 · 2024 · External reference
Vegf-C Prophylaxis favors lymphatic drainage and modulates neuroinflammation in a stroke model
10.1084/jem.20221983 · 2024 · External reference
Modulation of double-negative T cells by Huang-Lian-Jie-Du decoction attenuates neuroinflammation in ischemic stroke: insights from single-cell transcriptomics
10.3389/fimmu.2025.1537277 · 2025 · External reference
et al. Dalbergia odorifera TC chen leaf extract promotes microglial energy expenditure to phagocytize neutrophils after cerebral ischemia-reperfusion
10.1016/j.phymed.2025.157508 · 2025 · External reference
Single-cell RNA sequencing reveals that vim and Ifitm3 are vital targets of Dengzhan Shengmai capsule to protect against cerebral ischemic injury
10.1016/j.jep.2023.116439 · 2023 · External reference
Buyang Huanwu decoction promotes angiogenesis after cerebral ischemia through modulating caveolin-1-mediated exosome malat1/Yap1/Hif-1alpha axis
10.1016/j.phymed.2024.155609 · 2024 · External reference
Bm-Msc-Derived Migrasomes reverse stroke-induced thymic atrophy and immunosuppression via pin1 delivery to thymic epithelial cells
10.1186/s12974-025-03604-2 · 2025 · External reference
Forebrain neural progenitors effectively integrate into host brain circuits and improve neural function after ischemic stroke
10.1038/s41467-025-60187-5 · 2025 · External reference
Neuron-targeted Ros-responsive liposomes for puerarin delivery remodel ischemic microenvironment via microglial modulation and neurovascular regeneration
10.1186/s12951-025-03730-2 · 2025 · External reference
Neutrophil membrane-camouflaged polyprodrug nanomedicine for inflammation suppression in ischemic stroke therapy
10.1002/adma.202311803 · 2024 · External reference
Nociceptive neurons promote myeloid-derived suppressor cell mobilization to alleviate post-stroke neuroinflammation
10.7150/thno.119474 · 2025 · External reference
Oligodendrocyte progenitor cell-specific delivery of lipid nanoparticles loaded with olig2 synthetically modified messenger RNA for ischemic stroke therapy
10.1016/j.actbio.2023.12.009 · 2024 · External reference
Bacteria-derived outer-membrane vesicles hitchhike neutrophils to enhance ischemic stroke therapy
10.1002/adma.202301779 · 2023 · External reference
Targeting Atf4 for Enhanced neuroprotection: role of quercetin-loaded EVS in ischemic stroke
10.1016/j.jpha.2025.101312 · 2025 · External reference
Bacteria-derived outer-membrane vesicles hitchhike neutrophils to enhance ischemic stroke therapy
10.1002/adma.202301779 · ExternalCitation · doi-reference
Neutrophil membrane-camouflaged polyprodrug nanomedicine for inflammation suppression in ischemic stroke therapy
10.1002/adma.202311803 · ExternalCitation · doi-reference
Trem2-Igf1 mediated glucometabolic enhancement underlies microglial neuroprotective properties during ischemic stroke
10.1002/advs.202305614 · ExternalCitation · doi-reference
The Search for True Numbers of Neurons and Glial Cells in the Human Brain: A Review of 150 Years of Cell Counting
10.1002/cne.24040 · ExternalCitation · doi-reference
Single-cell RNA sequencing technologies and applications: a brief overview
10.1002/ctm2.694 · ExternalCitation · doi-reference
E2f1/Cdk5/Drp1 axis mediates microglial mitochondrial division and autophagy in the pathogenesis of cerebral ischemia-reperfusion injury
10.1002/ctm2.70197 · ExternalCitation · doi-reference
The deubiquitinase otud3 plays a neuroprotective role by reducing ferroptosis induced by cerebral ischaemia reperfusion via stabilizing Plk1 via deubiquitination
10.1002/ctm2.70347 · ExternalCitation · doi-reference
Transient astrocyte-like Ng2 glia subpopulation emerges solely following permanent brain ischemia
10.1002/glia.24064 · ExternalCitation · doi-reference
Astrocyte-like subpopulation of Ng2 glia in the adult mouse cortex exhibits characteristics of neural progenitor cells
10.1002/glia.24471 · ExternalCitation · doi-reference
The role of microglial/macrophagic salt-inducible kinase 3 on normal and excessive phagocytosis after transient focal cerebral ischemia
10.1007/s00018-022-04465-1 · ExternalCitation · doi-reference
The high-affinity Il-2 receptor affects white matter damage after cerebral ischemia by regulating Cd8 + T lymphocyte differentiation
10.1007/s11481-025-10169-7 · ExternalCitation · doi-reference
Identification of disulfidptosis-related genes in ischemic stroke by combining single-cell sequencing, machine learning algorithms, and in vitro experiments
10.1007/s12017-024-08804-2 · ExternalCitation · doi-reference
Inhibiting cyclin B1-treated pontine infarction by suppressing proliferation of Spp1+ microglia
10.1007/s12035-022-03183-w · ExternalCitation · doi-reference
Single-cell RNA-seq revealed the immune microenvironment reprogramming by dexmedetomidine treatment in ischemic stroke
10.1007/s12035-025-05237-1 · ExternalCitation · doi-reference
Single-cell mapping of brain myeloid cell subsets reveals key transcriptomic changes favoring neuroplasticity after ischemic stroke
10.1007/s12264-023-01109-7 · ExternalCitation · doi-reference
Cell death pathways in ischemic stroke and targeted pharmacotherapy
10.1007/s12975-020-00806-z · ExternalCitation · doi-reference
The transcriptional landscape of pericytes in acute ischemic stroke
10.1007/s12975-023-01169-x · ExternalCitation · doi-reference
Neuroprotective effects, mechanisms of action and therapeutic potential of the Kv7/Kcnq channel opener Qo-83 in ischemic stroke
10.1007/s12975-025-01329-1 · ExternalCitation · doi-reference
Oligodendrocyte progenitor cell-specific delivery of lipid nanoparticles loaded with olig2 synthetically modified messenger RNA for ischemic stroke therapy
10.1016/j.actbio.2023.12.009 · ExternalCitation · doi-reference
Soluble Pd-L1 reprograms blood monocytes to prevent cerebral edema and facilitate recovery after ischemic stroke
10.1016/j.bbi.2023.12.007 · ExternalCitation · doi-reference
Exploring the potential molecular intersection of stroke and major depression disorder
10.1016/j.bbrc.2024.150079 · ExternalCitation · doi-reference
Single-cell RNA sequencing reveals S100a8/A9(Hi) neutrophils-induced endothelial cell death and lymphocyte infiltration after ischemic stroke
10.1016/j.bbrc.2024.151023 · ExternalCitation · doi-reference
Mapping neutrophil fate and function in ischemic stroke: a single-cell roadmap for translational insights
10.1016/j.bbrc.2025.152659 · ExternalCitation · doi-reference
A stroke organoids-multiomics platform to study injury mechanism and drug response
10.1016/j.bioactmat.2024.09.038 · ExternalCitation · doi-reference
Response of astrocytes and their interaction with surrounding brain cells after acute ischemia-reperfusion analyzed by single-cell transcriptome sequencing
10.1016/j.brainresbull.2025.111355 · ExternalCitation · doi-reference
Immune pathway activation in neurons triggers neural damage after stroke
10.1016/j.celrep.2023.113368 · ExternalCitation · doi-reference
Phenotypic and spatial heterogeneity of brain myeloid cells after stroke is associated with cell ontogeny, tissue damage, and brain connectivity
10.1016/j.celrep.2024.114250 · ExternalCitation · doi-reference
Integrative transcriptomic analysis reveals Cd72 as a novel pro-inflammatory factor in microglia following experimental ischemic stroke
10.1016/j.expneurol.2024.114974 · ExternalCitation · doi-reference
Roles of adam8 in neuroinflammation in experimental ischemic stroke: insights from single-cell and ribosome-bound MRNA sequencing
10.1016/j.expneurol.2025.115207 · ExternalCitation · doi-reference
Loss of Plxdc2 exacerbates microglia-mediated neuroinflammation and ischemic brain injury
10.1016/j.expneurol.2025.115302 · ExternalCitation · doi-reference
Single-nuclei RNA sequencing unveils astrocyte and oligodendrocyte lineage cells in post-stroke human brain
10.1016/j.expneurol.2025.115550 · ExternalCitation · doi-reference
Single-nucleus transcriptome unveils the role of ferroptosis in ischemic stroke
10.1016/j.heliyon.2024.e32727 · ExternalCitation · doi-reference
ScRNAs reveals high-frequency rTMS-induced pericyte differentiation: potential implications for vascular regeneration and blood-brain barrier stability in stroke
10.1016/j.heliyon.2024.e35339 · ExternalCitation · doi-reference
Acupuncture regulates astrocyte neurotoxic polarization to protect blood-brain barrier integrity in delayed thrombolysis through mediating Erk1/2/Cx43 axis
10.1016/j.ibneur.2025.04.005 · ExternalCitation · doi-reference
Integrated Single Cell-Rna Sequencing and Mendelian Randomization for Ischemic Stroke and Metabolic Syndrome
10.1016/j.isci.2024.110240 · ExternalCitation · doi-reference
Single-cell RNA sequencing reveals that vim and Ifitm3 are vital targets of Dengzhan Shengmai capsule to protect against cerebral ischemic injury
10.1016/j.jep.2023.116439 · ExternalCitation · doi-reference
Shuanglu Tongnao formula alleviates cerebral ischemia/reperfusion injury by rebuilding inflammatory microenvironment after cerebral ischemia
10.1016/j.jep.2025.119640 · ExternalCitation · doi-reference
Targeting Atf4 for Enhanced neuroprotection: role of quercetin-loaded EVS in ischemic stroke
10.1016/j.jpha.2025.101312 · ExternalCitation · doi-reference
Bulk and single-cell transcriptomics reveal neuroprotective molecular mechanism of rosa roxburghii polysaccharides in cerebral ischemia-reperfusion injury
10.1016/j.jrras.2025.101937 · ExternalCitation · doi-reference
Inhibition of microglial Slc2a5 attenuates ischemic brain injury
10.1016/j.metabol.2025.156429 · ExternalCitation · doi-reference
Identification of endoplasmic reticulum stress genes in human stroke based on bioinformatics and machine learning
10.1016/j.nbd.2024.106583 · ExternalCitation · doi-reference
Single-cell and spatial transcriptomics analysis reveals that Pros1(+) oligodendrocytes are involved in endogenous neuroprotection after brainstem stroke
10.1016/j.nbd.2025.106855 · ExternalCitation · doi-reference
Characterizing stroke-related cellular changes in the surviving neurons of mouse ischemic stroke
10.1016/j.neuint.2025.106086 · ExternalCitation · doi-reference
Pla2g2e-mediated lipid metabolism triggers brain-autonomous neural repair after ischemic stroke
10.1016/j.neuron.2023.06.024 · ExternalCitation · doi-reference
Ilc2 instructs neural stem and progenitor cells to potentiate neurorepair after stroke
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