Research graph
References from Synaptic plasticity in affective comorbidities of neuropathic pain: a bibliometric analysis based on WoSCC and PubMed (2003–2025). Local targets link to admitted publications; unresolved targets remain external evidence.
Preclinical research on pain comorbidity with affective disorders and cognitive deficits: challenges and perspectives
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Treating neuropathic pain and comorbid affective disorders: preclinical and clinical evidence
10.1111/papr.13370 · 2024 · External reference
Contribution of synaptic plasticity in the insular cortex to chronic pain
10.1016/j.neuroscience.2016.08.014 · 2016 · External reference
Synaptic plasticity in the anterior cingulate cortex in acute and chronic pain
10.1038/nrn.2016.68 · 2016 · External reference
Reactive oxygen species affect spinal cell type-specific synaptic plasticity in a model of neuropathic pain
10.1097/j.pain.0000000000001014 · 2017 · External reference
Sensitization of neurons in the central nucleus of the amygdala via the decreased GABAergic inhibition contributes to the development of neuropathic pain-related anxiety-like behaviors in rats
10.1186/s13041-014-0072-z · 2014 · External reference
Contribution of AMPA receptor-mediated LTD in LA/BLA-CeA pathway to comorbid aversive and depressive symptoms in neuropathic pain
10.1523/jneurosci.2678-20.2021 · 2021 · External reference
GluA1 phosphorylation contributes to postsynaptic amplification of neuropathic pain in the insular cortex
10.1523/jneurosci.1431-14.2014 · 2014 · External reference
Altered hippocampal long-term potentiation after peripheral nerve injury in mice
10.1016/j.ejphar.2007.07.054 · 2007 · External reference
Neuronal adenylyl cyclase targeting central plasticity for the treatment of chronic pain
10.1007/s13311-020-00927-1 · 2020 · External reference
Neuronal and microglial mechanisms for neuropathic pain in the spinal dorsal horn and anterior cingulate cortex
10.1111/jnc.14001 · 2017 · External reference
Neuropathic pain causes memory deficits and dendrite tree morphology changes in mouse Hippocampus
10.2147/jpr.s238458 · 2020 · External reference
Cognitive and affective dysregulation in neuropathic pain: associated hippocampal remodeling and microglial activation
10.3390/ijms26136460 · 2025 · External reference
Citation-based clustering of publications using CitNetExplorer and VOSviewer
10.1007/s11192-017-2300-7 · 2017 · External reference
CiteSpace II: detecting and visualizing emerging trends and transient patterns in scientific literature
10.1002/asi.20317 · 2006 · External reference
X-ray structure of dopamine transporter elucidates antidepressant mechanism
10.1038/nature12533 · 2013 · External reference
Plasticity in the human central nervous system
10.1093/brain/awl082 · 2006 · External reference
The physiology, pathology, and pharmacology of voltage-gated calcium channels and their future therapeutic potential
10.1124/pr.114.009654 · 2015 · External reference
A swift expanding trend of extracellular vesicles in spinal cord injury research: a bibliometric analysis
10.1186/s12951-023-02051-6 · 2023 · External reference
Coexistence of two forms of LTP in ACC provides a synaptic mechanism for the interactions between anxiety and chronic pain
10.1016/j.neuron.2014.12.021 · 2015 · External reference
Oxytocin in the anterior cingulate cortex attenuates neuropathic pain and emotional anxiety by inhibiting presynaptic long-term potentiation
10.1016/j.celrep.2021.109411 · 2021 · External reference
Neural mechanisms underlying anxiety–chronic pain interactions
10.1016/j.tins.2016.01.006 · 2016 · External reference
Palmitoylethanolamide reduces pain-related behaviors and restores glutamatergic synapses homeostasis in the medial prefrontal cortex of neuropathic mice
10.1186/s13041-015-0139-5 · 2015 · External reference
Role of Neurotrophins in neuropathic pain
10.2174/157015911798376208 · 2011 · External reference
5-HT2C receptor knockdown in the amygdala inhibits neuropathic-pain-related plasticity and behaviors
10.1523/jneurosci.2468-16.2016 · 2017 · External reference
Fear extinction learning ability predicts neuropathic pain behaviors and amygdala activity in male rats
10.1177/1744806918804441 · 2018 · External reference
Hmgb1 silencing in the amygdala inhibits pain-related behaviors in a rat model of neuropathic pain
10.3390/ijms241511944 · 2023 · External reference
High-mobility group box 1-mediated microglial activation induces anxiodepressive-like behaviors in mice with neuropathic pain
10.1016/j.pnpbp.2019.02.005 · 2019 · External reference
Restoration of cingulate long-term depression by enhancing non-apoptotic caspase 3 alleviates peripheral pain hypersensitivity
10.1016/j.celrep.2020.108369 · 2020 · External reference
Extracellular matrix protein laminin β1 regulates pain sensitivity and anxiodepression-like behaviors in mice
10.1172/jci146323 · 2021 · External reference
Nociceptor-localized cGMP-dependent protein kinase I is a critical generator for central sensitization and neuropathic pain
10.1097/j.pain.0000000000002013 · 2021 · External reference
Presynaptic NMDARs on spinal nociceptor terminals state-dependently modulate synaptic transmission and pain
10.1038/s41467-022-28429-y · 2022 · External reference
Calcium-permeable AMPA receptors in the nucleus Accumbens regulate depression-like behaviors in the chronic neuropathic pain state
10.1523/jneurosci.2454-13.2013 · 2013 · External reference
Persistent pain alters AMPA receptor subunit levels in the nucleus accumbens
10.1186/s13041-015-0140-z · 2015 · External reference
Long-term synaptic plasticity in the spinal dorsal horn and its modulation by electroacupuncture in rats with neuropathic pain
10.1016/j.expneurol.2007.09.004 · 2007 · External reference
Chronic stress exacerbates neuropathic pain via the integration of stress-affect–related information with nociceptive information in the central nucleus of the amygdala
10.1097/j.pain.0000000000000827 · 2017 · External reference
Interleukin-1β overproduction is a common cause for neuropathic pain, memory deficit, and depression following peripheral nerve injury in rodents
10.1177/1744806916646784 · 2016 · External reference
The direction of synaptic plasticity mediated by C-fibers in spinal dorsal horn is decided by Src-family kinases in microglia: the role of tumor necrosis factor-α
10.1016/j.bbi.2010.01.007 · 2010 · External reference
Regular aerobic exercise attenuates pain and anxiety in mice by restoring serotonin-modulated synaptic plasticity in the anterior cingulate cortex
10.1249/mss.0000000000002841 · 2022 · External reference
A glutamatergic DRN–VTA pathway modulates neuropathic pain and comorbid anhedonia-like behavior in mice
10.1038/s41467-023-40860-3 · 2023 · External reference
Chemokine receptor CCR2 contributes to neuropathic pain and the associated depression via increasing NR2B-mediated currents in both D1 and D2 dopamine receptor-containing medium spiny neurons in the nucleus accumbens shell
10.1038/s41386-018-0115-8 · 2018 · External reference
CCL2/CCR2 contributes to the altered excitatory-inhibitory synaptic balance in the nucleus Accumbens Shell following peripheral nerve injury-induced neuropathic pain
10.1007/s12264-021-00697-6 · 2021 · External reference
Enhanced function of NR2C/2D-containing NMDA receptor in the nucleus accumbens contributes to peripheral nerve injury-induced neuropathic pain and depression in mice
10.1177/17448069211053255 · 2022 · External reference
Abnormalities in hippocampal functioning with persistent pain
10.1523/jneurosci.0587-12.2012 · 2012 · External reference
Plasticity of α2-adrenergic spinal antinociception following nerve injury: selective, bidirectional interaction with the delta opioid receptor
10.1016/j.brainres.2014.11.009 · 2015 · External reference
Morphological and functional reorganization of rat medial prefrontal cortex in neuropathic pain
10.1073/pnas.0809897106 · 2009 · External reference
External noninvasive peripheral nerve stimulation treatment of neuropathic pain: a prospective audit
10.1111/ner.12244 · 2015 · External reference
Mechanistically informed non-invasive peripheral nerve stimulation for peripheral neuropathic pain: a randomised double-blind sham-controlled trial
10.1186/s12967-021-03128-2 · 2021 · External reference
Pharmacology and mechanism of action of pregabalin: the calcium channel α2–δ (alpha2–delta) subunit as a target for antiepileptic drug discovery
10.1016/j.eplepsyres.2006.09.008 · 2007 · External reference
Ca2+ channel α2δ ligands: novel modulators of neurotransmission
10.1016/j.tips.2006.12.006 · 2007 · External reference
Asymmetric activation of microglia in the hippocampus drives anxiodepressive consequences of trigeminal neuralgia in rodents
10.1111/bph.15994 · 2023 · External reference
Pregabalin as a pain therapeutic: beyond calcium channels
10.3389/fncel.2020.00083 · 2020 · External reference
Single-dose P2 X4R single-chain fragment variable antibody permanently reverses chronic pain in male mice
10.3390/ijms222413612 · 2021 · External reference
Impaired ventrolateral periaqueductal gray-ventral tegmental area pathway contributes to chronic pain-induced depression-like behavior in mice
10.1007/s12035-023-03439-z · 2023 · External reference
Cognitive impairment in pain through amygdala-driven prefrontal cortical deactivation
10.1523/jneurosci.0225-10.2010 · 2010 · External reference
Alleviating neuropathic pain hypersensitivity by inhibiting PKMzeta in the anterior cingulate cortex
10.1126/science.1191792 · 2010 · External reference
Brain indoleamine 2,3-dioxygenase contributes to the comorbidity of pain and depression
10.1172/jci61884 · 2012 · External reference
Long-term potentiation in the anterior cingulate cortex and chronic pain
10.1098/rstb.2013.0146 · 2014 · External reference
Cognitive and emotional control of pain and its disruption in chronic pain
10.1038/nrn3516 · 2013 · External reference
The anterior cingulate cortex is a critical hub for pain-induced depression
10.1016/j.biopsych.2014.08.004 · 2015 · External reference
Neuropathic pain-induced depressive-like behavior and hippocampal neurogenesis and plasticity are dependent on TNFR1 signaling
10.1016/j.bbi.2014.04.003 · 2014 · External reference
TNF-α differentially regulates synaptic plasticity in the Hippocampus and spinal cord by microglia-dependent mechanisms after peripheral nerve injury
10.1523/jneurosci.2235-16.2016 · 2017 · External reference
Top-down descending facilitation of spinal sensory excitatory transmission from the anterior cingulate cortex
10.1038/s41467-018-04309-2 · 2018 · External reference
Hyperactivity of anterior cingulate cortex areas 24a/24b drives chronic pain-induced Anxiodepressive-like consequences
10.1523/jneurosci.3195-17.2018 · 2018 · External reference
A neural circuit for comorbid depressive symptoms in chronic pain
10.1038/s41593-019-0468-2 · 2019 · External reference
How to study anxiety and depression in rodent models of chronic pain?
10.1111/ejn.14686 · 2021 · External reference
Chronic pain: an update on burden, best practices, and new advances
10.1016/s0140-6736(21)00393-7 · 2021 · External reference
Neuropathic pain: from mechanisms to treatment
10.1152/physrev.00045.2019 · 2021 · External reference
Role of the anterior cingulate cortex in translational pain research
10.1007/s12264-020-00615-2 · 2021 · External reference
Targeting long-term depression of excitatory synaptic transmission for the treatment of neuropathic pain
10.1111/febs.16200 · 2022 · External reference
The cAMP response element- binding protein/brain-derived neurotrophic factor pathway in anterior cingulate cortex regulates neuropathic pain and Anxiodepression like behaviors in rats
10.3389/fnmol.2022.831151 · 2022 · External reference
Characterization of the sensory, affective, cognitive, biochemical, and neuronal alterations in a modified chronic constriction injury model of neuropathic pain in mice
10.1002/jnr.24501 · 2020 · External reference
Are the emergence of affective disturbances in neuropathic pain states contingent on supraspinal neuroinflammation?
10.1016/j.bbi.2016.04.012 · 2016 · External reference
Quantitative assessment of tactile allodynia in the rat paw
10.1016/0165-0270(94)90144-9 · 1994 · External reference
Spared nerve injury: an animal model of persistent peripheral neuropathic pain
10.1016/s0304-3959(00)00276-1 · 2000 · External reference
Cortical excitation and chronic pain
10.1016/j.tins.2008.01.003 · 2008 · External reference
Presynaptic and postsynaptic amplifications of neuropathic pain in the anterior cingulate cortex
10.1523/jneurosci.1812-08.2008 · 2008 · External reference
Pain and emotion interactions in subregions of the cingulate gyrus
10.1038/nrn1704 · 2005 · External reference
A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man
10.1016/0304-3959(88)90209-6 · 1988 · External reference
Understanding LTP in pain pathways
10.1186/1744-8069-3-9 · 2007 · External reference
Central sensitization and LTP: do pain and memory share similar mechanisms?
10.1016/j.tins.2003.09.017 · 2003 · External reference
Long-term potentiation and long-term depression of primary afferent neurotransmission in the rat spinal cord
10.1523/jneurosci.13-12-05228.1993 · 1993 · External reference
Synaptic amplifier of inflammatory pain in the spinal dorsal horn
10.1126/science.1127233 · 2006 · External reference
Bulleyaconitine a depresses neuropathic pain and potentiation at C-fiber synapses in spinal dorsal horn induced by paclitaxel in rats
10.1016/j.expneurol.2015.09.006 · 2015 · External reference
Sex-specific transcriptomic signatures in brain regions critical for neuropathic pain-induced depression
10.3389/fnmol.2022.886916 · 2022 · External reference
The use of ketamine in complex regional pain syndrome: possible mechanisms
10.1586/ern.11.31 · 2011 · External reference
Theta-burst stimulation of primary afferents drives long-term potentiation in the spinal cord and persistent pain via α2δ-1-bound NMDA receptors
10.1523/jneurosci.1968-21.2021 · 2022 · External reference
Riluzole induces LTD of spinal nociceptive signaling via postsynaptic GluR2 receptors
10.2147/jpr.s169686 · 2018 · External reference
Induction of long-term potentiation and long-term depression is cell-type specific in the spinal cord
10.1097/01.j.pain.0000460354.09622.ec · 2015 · External reference
Statistical power for cluster analysis
10.1186/s12859-022-04675-1 · 2022 · External reference
Central sensitization: a generator of pain hypersensitivity by central neural plasticity
10.1016/j.jpain.2009.06.012 · 2009 · External reference
Modulation of pain, nociception, and analgesia by the brain reward center
10.1016/j.neuroscience.2016.05.017 · 2016 · External reference
Long-term neuropathic pain behaviors correlate with synaptic plasticity and limbic circuit alteration: a comparative observational study in mice
10.1097/j.pain.0000000000002549 · 2022 · External reference
TIAM1-mediated synaptic plasticity underlies comorbid depression-like and ketamine antidepressant-like actions in chronic pain
10.1172/jci158545 · 2022 · External reference
Long-lasting, pathway-specific impairment of a novel form of spike-timing-dependent long-term depression by neuropathic pain in the anterior cingulate cortex
10.1523/jneurosci.0326-21.2022 · 2022 · External reference
Activation of CRF/CRFR1 signaling in the central nucleus of the amygdala contributes to chronic stress-induced exacerbation of neuropathic pain by enhancing GluN2B-NMDA receptor-mediated synaptic plasticity in adult male rats
10.1016/j.jpain.2024.02.009 · 2024 · External reference
Bidirectional dysregulation of AMPA receptor-mediated synaptic transmission and plasticity in brain disorders
10.3389/fnsyn.2020.00026 · 2020 · External reference
Visualizing a field of research: a methodology of systematic scientometric reviews
10.1371/journal.pone.0223994 · 2019 · External reference
Muscimol prevents long-lasting potentiation of dorsal horn field potentials in rats with chronic constriction injury exhibiting decreased levels of the GABA transporter GAT-1
10.1016/s0304-3959(03)00250-1 · 2003 · External reference
Upregulation of prefrontal metabotropic glutamate receptor 5 mediates neuropathic pain and negative mood symptoms after spinal nerve injury in rats
10.1038/s41598-017-09991-8 · 2017 · External reference
Optogenetic manipulations of CeA-CRF neurons modulate pain- and anxiety-like behaviors in neuropathic pain and control rats
10.1016/j.neuropharm.2022.109031 · 2022 · External reference
Electroacupuncture reduces microglial hyperactivity and synaptic phagocytosis in the medial prefrontal cortex to treat chronic pain comorbid with anxiety and depression
10.1016/j.brainresbull.2025.111521 · 2025 · External reference
Enriched environment mitigates anxiety and depression-like behaviors induced by SNI via restoration of AMPA and NMDA receptors function in mice
10.1016/j.jpsychires.2025.05.051 · 2025 · External reference
Combined metabolomics and transcriptomics analysis of rats under neuropathic pain and pain-related depression
10.3389/fphar.2023.1320419 · 2023 · External reference
Cingulate retinoic acid signaling regulates neuropathic pain and comorbid anxiodepression via extracellular matrix homeostasis
10.1172/jci190539 · 2025 · External reference
Tuina alleviates anxiety-like behaviors associated with neuropathic pain through the modulation of synaptic plasticity in the anterior cingulate cortex
10.1002/brb3.70965 · 2025 · External reference
Neuropathic pain caused contextual fear generalization by reducing RIN1 expression in dorsal hippocampal CA1 pyramidal neurons
10.1016/j.neuropharm.2025.110644 · 2025 · External reference
Deep brain stimulation of the dorsal anterior cingulate cortex for the treatment of chronic neuropathic pain
10.3171/2015.3.focus1543 · 2015 · External reference
Voluntary running improves synaptic degeneration of the anterior cingulate cortex in knee osteoarthritis
10.1186/s13041-025-01207-9 · 2025 · External reference
BDNF in neuropathic pain; the culprit that cannot be apprehended
10.1016/j.neuroscience.2024.02.020 · 2024 · External reference