Research graph
References from The role of apolipoprotein E4 on calcium homeostasis in primary hippocampal neurons: an in vitro study. Local targets link to admitted publications; unresolved targets remain external evidence.
Apolipoprotein E and Alzheimer’s disease in Italian population: Systematic review and meta-analysis.
10.3390/brainsci14090908 · 2024 · External reference
The possible role of ursolic acid in Covid-19: A real game changer.
10.1016/j.clnesp.2021.12.030 · 2022 · External reference
Unlocking Alzheimer’s disease: The role of BDNF signaling in neuropathology and treatment.
10.1007/s12017-025-08857-x · 2025 · External reference
Compartmentalized necroptosis activation in excitotoxicity-induced axonal degeneration: A novel mechanism implicated in neurodegenerative disease pathology.
10.4103/1673-5374.253520 · 2019 · External reference
Post-translational modifications of hnRNP A1 differentially modulate retroviral IRES-mediated translation initiation.
10.1093/nar/gkaa765 · 2020 · External reference
CaMKIIα-driven, phosphatase-checked postsynaptic plasticity via phase separation.
10.1038/s41422-020-00439-9 · 2021 · External reference
Mitochondria and calcium in Alzheimer’s disease: From cell signaling to neuronal cell death.
10.1016/j.tins.2020.10.004 · 2021 · External reference
NMDA receptor-mediated Ca2 + flux attenuated by the NMDA receptor/TRPM4 interface inhibitor brophenexin.
10.1002/prp2.70038 · 2024 · External reference
NMDA receptor functions in health and disease: Old actor, new dimensions.
10.1016/j.neuron.2023.05.002 · 2023 · External reference
APOE4 expression is associated with impaired autophagy and mitophagy in astrocytes.
10.4103/1673-5374.322452 · 2022 · External reference
Mechanosensitivity of N-methyl-D-aspartate receptors (NMDAR) is the key through which amyloid beta oligomers activate them.
10.4103/1673-5374.327341 · 2022 · External reference
Calcium-permeable AMPA receptors: An underestimated pharmacological target for the therapy of brain pathologies.
10.4103/1673-5374.373714 · 2023 · External reference
Molecular mechanisms of cell death: Recommendations of the nomenclature committee on cell death 2018.
10.1038/s41418-017-0012-4 · 2018 · External reference
Mitochondrial calcium uptake declines during aging and is directly activated by oleuropein to boost energy metabolism and skeletal muscle performance.
10.1016/j.cmet.2024.10.021 · 2025 · External reference
Immunofluorescence staining of phosphoinositides in primary mouse hippocampal neurons in dissociated culture.
10.1016/j.xpro.2022.101549 · 2022 · External reference
Functional specificity of liquid-liquid phase separation at the synapse.
10.1038/s41467-024-54423-7 · 2024 · External reference
Comparison of Ca2 + transients and [Ca2 +]i in the dendrites and boutons of non-fast-spiking GABAergic hippocampal interneurons using two-photon laser microscopy and high- and low-affinity dyes.
10.1113/jphysiol.2013.258863 · 2013 · External reference
Impact of apolipoprotein E ε4 in Alzheimer’s disease: Insights from a meta-analysis.
10.3988/jcn.2024.0353 · 2024 · External reference
Sex-dependent calcium hyperactivity due to lysosomal-related dysfunction in astrocytes from APOE4 versus APOE3 gene targeted replacement mice.
10.1186/s13024-020-00382-8 · 2020 · External reference
Neuroprotective effects of exogenous brain-derived neurotrophic factor on amyloid-beta 1-40-induced retinal degeneration.
10.4103/1673-5374.346546 · 2023 · External reference
Zinc reverses glycine-dependent inactivation of NMDARs in cultured rat hippocampal neurons.
10.1007/s11427-012-4421-9 · 2012 · External reference
Death-associated protein kinase 1 is associated with cognitive dysfunction in major depressive disorder.
10.4103/1673-5374.361532 · 2023 · External reference
APOE4 enhances age-dependent decline in cognitive function by down-regulating an NMDA receptor pathway in EFAD-Tg mice.
10.1186/s13024-015-0002-2 · 2015 · External reference
CaMK II/Ca2 + dependent endoplasmic reticulum stress mediates apoptosis of hepatic stellate cells stimulated by transforming growth factor beta 1.
10.1016/j.ijbiomac.2021.01.071 · 2021 · External reference
Inhibition of GluN2B pathway is involved in the neuroprotective effect of silibinin on streptozotocin-induced Alzheimer’s disease models.
10.1016/j.phymed.2022.154594 · 2023 · External reference
Effect of the PGD2-DP signaling pathway on primary cultured rat hippocampal neuron injury caused by aluminum overload.
10.1038/srep24646 · 2016 · External reference
Microglial APOE4 promotes neuron degeneration in Alzheimer’s disease through inhibition of lipid droplet autophagy.
10.1016/j.apsb.2024.10.009 · 2025 · External reference
Implication of 14-3-3ζ-BDNF pathway in long-lasting memory enhancement and the rescue from memory deficits.
10.4103/1673-5374.335817 · 2022 · External reference
APOE4 leads to blood-brain barrier dysfunction predicting cognitive decline.
10.1038/s41586-020-2247-3 · 2020 · External reference
Genetic inhibition of nuclear factor of activated T-cell c2 prevents atrial fibrillation in CREM transgenic mice.
10.1093/cvr/cvab325 · 2022 · External reference
Pharmacological modulation of septins restores calcium homeostasis and is neuroprotective in models of Alzheimer’s disease.
10.1126/science.add6260 · 2024 · External reference
Dysregulation of BDNF/TrkB signaling mediated by NMDAR/Ca2 +/calpain might contribute to postoperative cognitive dysfunction in aging mice.
10.1186/s12974-019-1695-x · 2020 · External reference
APOE4 affects basal and NMDAR-mediated protein synthesis in neurons by perturbing calcium homeostasis.
10.1523/jneurosci.0435-21.2021 · 2021 · External reference
The PANoptosome: A deadly protein complex driving pyroptosis, apoptosis, and necroptosis (PANoptosis).
10.3389/fcimb.2020.00238 · 2020 · External reference
The protective effects of Achyranthes bidentata polypeptides against NMDA-induced cell apoptosis in cultured hippocampal neurons through differential modulation of NR2A- and NR2B-containing NMDA receptors.
10.1016/j.brainresbull.2008.08.002 · 2008 · External reference
N-methyl-D-aspartate receptor functions altered by neuronal PTP1B activation in Alzheimer’s disease and schizophrenia models.
10.4103/1673-5374.335793 · 2022 · External reference
DAPK1 interaction with NMDA receptor NR2B subunits mediates brain damage in stroke
10.1016/j.cell.2009.12.055 · 2010 · External reference
Neurotoxic effects of apolipoprotein E4 are mediated via dysregulation of calcium homeostasis
10.1002/jnr.10138 · 2002 · External reference
Calcium signaling hypothesis: A non-negligible pathogenesis in Alzheimer’s disease.
10.1016/j.jare.2025.01.007 · 2025 · External reference
Anti-epileptic effect of Ganoderma lucidum polysaccharides by inhibition of intracellular calcium accumulation and stimulation of expression of CaMKII α in epileptic hippocampal neurons.
10.1371/journal.pone.0102161 · 2014 · External reference
Do pyroptosis, apoptosis, and necroptosis (PANoptosis) exist in cerebral ischemia? Evidence from cell and rodent studies.
10.4103/1673-5374.331539 · 2022 · External reference
Acute and chronic excitotoxicity in ischemic stroke and late-onset Alzheimer’s disease.
10.4103/nrr.nrr-d-24-00398 · 2025 · External reference
Necroptosis and RIPK1-mediated neuroinflammation in CNS diseases.
10.1038/s41583-018-0093-1 · 2019 · External reference
Death-associated protein kinase 1 as a therapeutic target for Alzheimer’s disease.
10.1186/s40035-023-00395-5 · 2024 · External reference
Ratio-based indicators for cytosolic Ca2 + with visible light excitation.
10.1073/pnas.2410436122 · 2025 · External reference
