Research graph
References from KAT5: the epigenetic regulator of central nervous system diseases. Local targets link to admitted publications; unresolved targets remain external evidence.
Epigenetics: A link between addiction and social environment.
10.1007/s00018-017-2493-1 · 2017 · External reference
HDAC1 regulates fear extinction in mice.
10.1523/jneurosci.0079-12.2012 · 2012 · External reference
Disruption of Tip60 HAT mediated neural histone acetylation homeostasis is an early common event in neurodegenerative diseases.
10.1038/s41598-020-75035-3 · 2020 · External reference
Tip60 HAT activators as therapeutic modulators for Alzheimer’s disease.
10.1038/s41467-025-58496-w · 2025 · External reference
Mechanisms and therapeutic challenges in autism spectrum disorders: Insights from Rett syndrome.
10.1097/wco.0b013e32835f19a7 · 2013 · External reference
Characterisation of a Tip60 specific inhibitor, NU9056, in prostate cancer.
10.1371/journal.pone.0045539 · 2012 · External reference
Cancer epigenetics: From mechanism to therapy.
10.1016/j.cell.2012.06.013 · 2012 · External reference
Histone deacetylases (HDACs): Characterization of the classical HDAC family.
10.1042/bj20021321 · 2003 · External reference
The potential use of histone deacetylase inhibitors in the treatment of depression.
10.1016/j.pnpbp.2015.03.010 · 2016 · External reference
Partial loss of Tip60 slows mid-stage neurodegeneration in a spinocerebellar ataxia type 1 (SCA1) mouse model.
10.1093/hmg/ddr108 · 2011 · External reference
CREB-binding protein/p300 are transcriptional coactivators of p65.
10.1073/pnas.94.7.2927 · 1997 · External reference
Neurobehavioural effects of developmental toxicity.
10.1016/s1474-4422(13)70278-3 · 2014 · External reference
Transgenerational epigenetic inheritance: Myths and mechanisms.
10.1016/j.cell.2014.02.045 · 2014 · External reference
DNA repair factor KAT5 prevents ischemic acute kidney injury through glomerular filtration regulation.
10.1016/j.isci.2021.103436 · 2021 · External reference
De novo KAT5 variants cause a syndrome with recognizable facial dysmorphisms, cerebellar atrophy, sleep disturbance, and epilepsy.
10.1016/j.ajhg.2020.08.002 · 2020 · External reference
Activating PPARβ/δ protects against endoplasmic reticulum stress-induced astrocytic apoptosis via UCP2-dependent mitophagy in depressive model.
10.3390/ijms231810822 · 2022 · External reference
A bivalent role of TIP60 histone acetyl transferase in human cancer.
10.2217/epi.15.76 · 2015 · External reference
Spinocerebellar ataxia.
10.1038/s41572-019-0074-3 · 2019 · External reference
Extensive nuclear sphere generation in the human Alzheimer’s brain.
10.1016/j.neurobiolaging.2016.08.016 · 2016 · External reference
Cellular depletion of BRD8 causes p53-dependent apoptosis and induces a DNA damage response in non-stressed cells.
10.1038/s41598-018-32323-3 · 2018 · External reference
CNS-peripheral immune interactions in hemorrhagic stroke.
10.1177/0271678x221145089 · 2023 · External reference
KAT5 knockdown alleviates microglial inflammatory injury following acute cerebral ischemia through enhanced STAT6 activity.
10.1016/j.brainresbull.2025.111467 · 2025 · External reference
TIP60 in aging and neurodegeneration.
10.1016/j.arr.2020.101195 · 2020 · External reference
Nuclear spheres modulate the expression of BEST1 and GADD45G.
10.1016/j.cellsig.2015.10.019 · 2016 · External reference
Microarray analysis uncovers a role for Tip60 in nervous system function and general metabolism.
10.1371/journal.pone.0018412 · 2011 · External reference
Modulating cognition-linked histone acetyltransferases (HATs) as a therapeutic strategy for neurodegenerative diseases: Recent advances and future trends.
10.3390/cells14120873 · 2025 · External reference
Consensus paper: pathological mechanisms underlying neurodegeneration in spinocerebellar ataxias.
10.1007/s12311-013-0539-y · 2014 · External reference
KAT5 regulates neurodevelopmental states associated with G0-like populations in glioblastoma.
10.1038/s41467-025-59503-w · 2025 · External reference
Metabolic reprogramming by class I and II histone deacetylases.
10.1016/j.tem.2012.09.003 · 2013 · External reference
Lysine acetyltransferase 6 complexes in neurodevelopmental disorders and different types of cancer.
10.1007/978-3-031-91459-1_14 · 2025 · External reference
MYC oncogenes and human neoplastic disease.
10.1038/sj.onc.1202746 · 1999 · External reference
Pituitary adenomas and cerebrovascular disease: A review on pathophysiology, prevalence, and treatment.
10.3389/fendo.2022.1064216 · 2022 · External reference
Restoring Tip60 HAT/HDAC2 balance in the neurodegenerative brain relieves epigenetic transcriptional repression and reinstates cognition.
10.1523/jneurosci.2840-17.2018 · 2018 · External reference
Histone deacetylases in memory and cognition.
10.1126/scisignal.aaa0069 · 2014 · External reference
Neurodegeneration: What is it and where are we?
10.1172/jci17522 · 2003 · External reference
Cellular functions of TIP60.
10.1016/j.biocel.2006.03.003 · 2006 · External reference
RORalpha-mediated Purkinje cell development determines disease severity in adult SCA1 mice.
10.1016/j.cell.2006.09.036 · 2006 · External reference
Histone deactylase 1 expression is increased in the prefrontal cortex of schizophrenia subjects: analysis of the National Brain Databank microarray collection.
10.1016/j.schres.2007.09.020 · 2008 · External reference
Activation of galanin receptor 1 with M617 attenuates neuronal apoptosis via ERK/GSK-3β/TIP60 pathway after subarachnoid hemorrhage in rats.
10.1007/s13311-021-01066-x · 2021 · External reference
Lactic acid induces transcriptional repression of macrophage inflammatory response via histone acetylation.
10.1016/j.celrep.2024.113746 · 2024 · External reference
Management of depression in adults: A review.
10.1001/jama.2024.5756 · 2024 · External reference
KAT5 acetylates cGAS to promote innate immune response to DNA virus.
10.1073/pnas.1922330117 · 2020 · External reference
Alzheimer’s disease.
10.1016/b978-0-12-804766-8.00013-3 · 2019 · External reference
The antitumorigenic roles of BRCA1-BARD1 in DNA repair and replication.
10.1038/s41580-020-0218-z · 2020 · External reference
Pathogenic mechanisms underlying spinocerebellar ataxia type 1.
10.1007/s00018-020-03520-z · 2020 · External reference
The glioblastoma CircularRNAome.
10.3390/ijms241914545 · 2023 · External reference
Tip60/KAT5 histone acetyltransferase is required for maintenance and neurogenesis of embryonic neural stem cells.
10.3390/ijms24032113 · 2023 · External reference
TIP60 buffers acute stress response and depressive behaviour by controlling PPARγ-mediated transcription.
10.1016/j.bbi.2022.01.022 · 2022 · External reference
Insights into neuroepigenetics through human histone deacetylase PET imaging.
10.1126/scitranslmed.aaf7551 · 2016 · External reference
PDCD5 interacts with Tip60 and functions as a cooperator in acetyltransferase activity and DNA damage-induced apoptosis.
10.1593/neo.81524 · 2009 · External reference
Epigenetic control of learning and memory in Drosophila by Tip60 HAT action.
10.1534/genetics.114.171660 · 2014 · External reference
Pathogenicity of mediator complex subunit 27 (MED27) in a neurodevelopmental disorder with cerebellar atrophy.
10.1002/advs.202505535 · 2025 · External reference
Deficiency of the chromatin regulator BRPF1 causes abnormal brain development.
10.1074/jbc.m114.635250 · 2015 · External reference
Lymphatic endothelial-like cells promote glioblastoma stem cell growth through cytokine-driven cholesterol metabolism.
10.1038/s43018-023-00658-0 · 2024 · External reference
