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References from Stress granule phase transitions and neuronal fate in cerebral ischemia-reperfusion injury. Local targets link to admitted publications; unresolved targets remain external evidence.
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Intrinsically disordered proteins and liquid–liquid phase separation in drug discovery
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Stress granule formation inhibits stress-induced apoptosis by selectively sequestering executioner caspases
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Cell organization by liquid phase separation
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Hsp70 chaperones TDP-43 in dynamic, liquid-like phase and prevents it from amyloid aggregation
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Structural basis for reversible amyloids of hnRNPA1 elucidates their role in stress granule assembly
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RNA-induced conformational switching and clustering of G3BP drive stress granule assembly by condensation
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ALS-linked FUS mutations dysregulate G-quadruplex-dependent liquid–liquid phase separation and liquid-to-solid transition
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Targeting HDAC6 to overcome autophagy-promoted anti-cancer drug resistance
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Histone deacetylase 6 interference protects mice against experimental stroke-induced brain injury via activating Nrf2/HO-1 pathway
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Targeting G3BP1 condensate topology promotes stress granule assembly via m6 A-IGF2BP1 for ischemic stroke rescue
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Hsp70 exhibits a liquid-liquid phase separation ability and chaperones condensed FUS against amyloid aggregation
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Small molecules modulate the biomolecular condensates and liquid–liquid phase separation
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ALS/FTD-linked mutation in FUS suppresses intra-axonal protein synthesis and drives disease without nuclear loss-of-function of FUS
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Melatonin offers dual-phase protection to brain vessel endothelial cells in prolonged cerebral ischemia-recanalization through ameliorating ER stress and resolving refractory stress granule
10.1007/s12975-022-01084-7 · 2023 · External reference
Role of histone deacetylases and sirtuins in the ischaemic stroke: a systematic review and meta-analysis of animal studies
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Hofmeister vs. neuberg: is ATP really a biological hydrotrope?
10.1016/j.xcrp.2021.100343 · 2021 · External reference
Phosphorylation of the FUS low-complexity domain disrupts phase separation, aggregation, and toxicity
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Phase separation and pathologic transitions of RNP condensates in neurons: implications for amyotrophic lateral sclerosis, frontotemporal dementia and other neurodegenerative disorders
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Protein aggregates and biomolecular condensates: implications for human health and disease
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Spatiotemporal gene expression trajectories reveal developmental hierarchies of the human cortex
10.1126/science.aap8809 · 2017 · External reference
Phosphorylation of G3BP1-S149 does not influence stress granule assembly
10.1083/jcb.201801214 · 2019 · External reference
TDP-43 in neurodegeneration and cancer: Decoding the mechanism of mRNA localization and translation
10.1016/j.bbrep.2026.102464 · 2026 · External reference
A liquid-to-solid phase transition of the ALS Protein FUS accelerated by disease mutation
10.1016/j.cell.2015.07.047 · 2015 · External reference
ATP as a biological hydrotrope
10.1126/science.aaf6846 · 2017 · External reference
Lost in local translation: TDP-43 and FUS in axonal/neuromuscular junction maintenance and dysregulation in amyotrophic lateral sclerosis
10.1016/j.neuron.2023.02.028 · 2023 · External reference
Principles and properties of stress granules
10.1016/j.tcb.2016.05.004 · 2016 · External reference
The proteostasis network in proteinopathies
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Casein kinase 2 is linked to stress granule dynamics through phosphorylation of the stress granule nucleating protein G3BP1
10.1128/mcb.00596-16 · 2017 · External reference
Uncovering the molecular mechanism for dual effect of ATP on phase separation in FUS solution
10.1126/sciadv.abo7885 · 2022 · External reference
RNA-binding proteins in ALS and FTD: from pathogenic mechanisms to therapeutic insights
10.1186/s13024-025-00851-y · 2025 · External reference
DDX3X acts as a live-or-die checkpoint in stressed cells by regulating NLRP3 inflammasome
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Competing protein-RNA interaction networks control multiphase intracellular organization
10.1016/j.cell.2020.03.050 · 2020 · External reference
Liquid phase condensation in cell physiology and disease
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Stress granules and neurodegeneration
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FUS aggregation following ischemic stroke favors brain astrocyte activation through inducing excessive autophagy
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Cell death mechanisms in cerebral ischemia–reperfusion injury
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Molecular imaging reveals antineuroinflammatory effects of HDAC6 inhibition in stroke models
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