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References from Nobiletin ameliorates diabetic nephropathy by modulating TP53-associated PANoptosis: an experimental study. Local targets link to admitted publications; unresolved targets remain external evidence.
Association between the prognostic nutritional index and chronic microvascular complications in patients with type 2 diabetes mellitus.
10.3390/jcm12185952 · 2023 · External reference
The association of cell adhesion molecules and selectins (VCAM-1, ICAM-1, E-selectin, L-selectin, and P-selectin) with microvascular complications in patients with type 2 diabetes: a follow-up study.
10.3389/fendo.2023.1072288 · 2023 · External reference
Unlocking the mechanistic potential of Thuja occidentalis for managing diabetic neuropathy and nephropathy.
10.1016/j.jtcme.2024.04.009 · 2024 · External reference
Thioredoxin (Trx): a redox target and modulator of cellular senescence and aging-related diseases.
10.1016/j.redox.2024.103032 · 2024 · External reference
Transforming diabetes care: the molecular pathways through which GLP1-RAs impact the kidneys in diabetic kidney disease.
10.3390/biomedicines12030657 · 2024 · External reference
Targeting programmed cell death in diabetic kidney disease: from molecular mechanisms to pharmacotherapy.
10.1186/s10020-024-01020-5 · 2024 · External reference
Cell death signaling and immune regulation: new perspectives on targeted therapy for sepsis.
10.1186/s11658-025-00784-w · 2025 · External reference
Dying to defend: neutrophil death pathways and their implications in immunity.
10.1002/advs.202306457 · 2024 · External reference
Caspase-8 in inflammatory diseases: a potential therapeutic target.
10.1186/s11658-024-00646-x · 2024 · External reference
Bimetallic peroxide nanoparticles induce PANoptosis by disrupting ion homeostasis for enhanced immunotherapy.
10.1126/sciadv.adp7160 · 2024 · External reference
The potential therapeutic prospect of PANoptosis in heart failure.
10.2147/jir.s485901 · 2024 · External reference
Mechanisms of PANoptosis and relevant small-molecule compounds for fighting diseases.
10.1038/s41419-023-06370-2 · 2023 · External reference
Cuproptosis, ferroptosis and PANoptosis in tumor immune microenvironment remodeling and immunotherapy: culprits or new hope.
10.1186/s12943-024-02130-8 · 2024 · External reference
Comparative analysis of chemical constituents in Citri Exocarpium Rubrum, Citri Reticulatae Endocarpium Alba, and Citri Fructus Retinervus.
10.1002/fsn3.2897 · 2022 · External reference
Nobiletin restores HFD-induced enteric nerve injury by regulating enteric glial activation and the GDNF/AKT/FOXO3a/P21 pathway.
10.1186/s10020-024-00841-8 · 2024 · External reference
Beneficial effects of citrus-derived polymethoxylated flavones for central nervous system disorders.
10.3390/nu13010145 · 2021 · External reference
Flavonoids as immunoregulators: molecular mechanisms in regulating immune cells and their therapeutic applications in inflammatory diseases.
10.3389/fimmu.2025.1703672 · 2025 · External reference
p53-regulated non-apoptotic cell death pathways and their relevance in cancer and other diseases.
10.1038/s41580-025-00842-3 · 2025 · External reference
The role of p53 in regulating chronic inflammation and PANoptosis in diabetic wounds.
10.14336/ad.2024.0212 · 2024 · External reference
PPAR gamma and PGC-1alpha activators protect against diabetic nephropathy by suppressing the inflammation and NF-kappaB activation.
10.1111/nep.14381 · 2024 · External reference
Protective effects of ethanolic extract from rhizome of Polygoni avicularis against renal fibrosis and inflammation in a diabetic nephropathy model.
10.3390/ijms22137230 · 2021 · External reference
The role of claudins in the pathogenesis of dextran sulfate sodium-induced experimental colitis: the effects of nobiletin.
10.3390/biom14091122 · 2024 · External reference
Analgesic effect of nobiletin against neuropathic pain induced by the chronic constriction injury of the sciatic nerve in mice.
10.1002/ptr.7532 · 2022 · External reference
Nobiletin resolves left ventricular and renal changes in 2K-1C hypertensive rats.
10.1038/s41598-022-13513-6 · 2022 · External reference
Nobiletin, a citrus flavonoid, improves cognitive impairment and reduces soluble Aβ levels in a triple transgenic mouse model of Alzheimer’s disease (3XTg-AD).
10.1016/j.bbr.2015.04.028 · 2015 · External reference
Polyphenols and their metabolites in renal diseases: an overview.
10.3390/foods11071060 · 2022 · External reference
ANXA1 improves mitochondrial homeostasis through uncoupling protein 1 in diabetic nephropathy.
10.1016/j.jare.2025.11.039 · 2026 · External reference
The potential of flavonoids in hepatic fibrosis: a comprehensive review.
10.1016/j.phymed.2024.155932 · 2024 · External reference
Discovery of dietary beneficial compounds for healthy aging: from worm to human.
10.1016/j.foodres.2025.116916 · 2025 · External reference
A review on recent advances on nobiletin in central and peripheral nervous system diseases.
10.1186/s40001-023-01450-7 · 2023 · External reference
Potential and mechanism of nobiletin in diabetes mellitus and associated complications.
10.3390/ph18101528 · 2025 · External reference
Design and discovery of a highly potent ultralong-acting GLP-1 and glucagon co-agonist for attenuating renal fibrosis.
10.1016/j.apsb.2023.11.020 · 2024 · External reference
Regulated cell death (RCD) in cancer: key pathways and targeted therapies.
10.1038/s41392-022-01110-y · 2022 · External reference
Cell fate regulation governed by p53: friends or reversible foes in cancer therapy.
10.1002/cac2.12520 · 2024 · External reference
Mitochondrial DNA variants in the pathogenesis and metabolic alterations of diabetes mellitus.
10.1016/j.ymgmr.2024.101183 · 2024 · External reference
Role of mitochondria in reno-cardiac diseases: a study of bioenergetics, biogenesis, and GSH signaling in disease transition.
10.1016/j.redox.2024.103340 · 2024 · External reference
Paeonol ameliorates diabetic nephropathy by promoting TFEB-mediated lysosome biogenesis and lipophagy.
10.1016/j.phymed.2025.156901 · 2025 · External reference
Inflammasomes in neurodegenerative diseases.
10.1186/s40035-024-00459-0 · 2024 · External reference
Network pharmacology: a bright guiding light on the way to explore the personalized precise medication of traditional Chinese medicine.
10.1186/s13020-023-00853-2 · 2023 · External reference
Protein-ligand interactions using SPR systems.
10.1007/978-1-62703-398-5_6 · 2013 · External reference
Death never dies: increasing impact of programmed cell death.
10.1007/s10495-025-02189-8 · 2025 · External reference
Advances in mechanism and regulation of PANoptosis: prospects in disease treatment.
10.3389/fimmu.2023.1120034 · 2023 · External reference
Targeting the NF-κB p65-MMP28 axis: wogonoside as a novel therapeutic agent for attenuating podocyte injury in diabetic nephropathy.
10.1016/j.phymed.2025.156406 · 2025 · External reference
Wogonoside ameliorates oxidative damage in tubular epithelial cells of diabetic nephropathy by modulating the HNF4A-NRF2 axis.
10.1016/j.intimp.2025.114481 · 2025 · External reference
Mechanistic exploration of the anticancer activity of justicia adhatoda plant leaf ethanolic extract against colon cancer cells: an in silico and in vitro approach.
10.31557/apjcp.2026.27.3.1069 · 2026 · External reference
KDM1A facilitates oncogenic potential in colorectal cancer progression through the activation of AXIN/GSK3β/β-catenin signaling pathways: evidence from integrated transcriptomics and in vitro studies.
10.1002/jgm.70053 · 2025 · External reference
Phytochemical insights, antioxidant activity and therapeutic potential of Cassia senna against prostate cancer in Wistar albino rats.
10.1007/s42452-025-07392-5 · 2025 · External reference
Exploring the anticancer potential of Jerantinine A from Tabernaemontana coronaria against prostate, breast, and ovarian cancers: a computational approach.
10.1515/jcim-2024-0443 · 2025 · External reference
Isolation, structural characterization, and molecular docking studies on the bioactive compound from n-Hexane extract of Emilia sonchifolia (L.) DC against the pancreatic cancer target Aurora 2 Kinase.
10.1515/jcim-2024-0290 · 2024 · External reference
Machine learning-driven multimodal optimization of selenium biotransformation and flavor profiling in fermented apple–Yacon functional beverages.
10.1016/j.ifset.2025.104198 · 2025 · External reference
Toward personalized cancer management: role of precision nutrition–diet interventions.
10.1016/j.jff.2024.106584 · 2024 · External reference
Sustainable fabrication of biopolymer-based (starch/PVA) nanoscaffolds loaded with green-synthesized CuO nanoparticles from Sargassum wightii (marine macroalgae): cytocompatibility and antioxidant activity.
10.1016/j.bioadv.2025.214660 · 2026 · External reference
Antioxidant and biocompatible CuO-starch/PVA nanoscaffolds via ultrasonic green synthesis using Turbinaria conoides (brown marine macroalgae).
10.1016/j.medidd.2025.100238 · 2025 · External reference
Clinical applications and therapeutic potentials of advanced nanoparticles: a comprehensive review on completed human clinical trials.
10.3389/fnano.2024.1479993 · 2024 · External reference
Integrating engineered nanomaterials with extracellular vesicles: advancing targeted drug delivery and biomedical applications.
10.3389/fnano.2024.1513683 · 2025 · External reference
Materials-based drug delivery approaches: recent advances and future perspectives.
10.1515/gps-2023-0094 · 2024 · External reference
Neuroendocrine-associated epigenetic factors in cellular senescence: mechanisms and therapeutic implications.
10.1007/s10522-026-10402-7 · 2026 · External reference
PDX1 phosphorylation at S61 by mTORC1 links nutrient signaling to β cell function and metabolic disease.
10.1016/j.celrep.2025.116811 · 2026 · External reference
Nuclear mTOR signaling orchestrates transcriptional programs underlying cellular growth and metabolism.
10.3390/cells13090781 · 2024 · External reference
Amino acids control blood glucose levels through mTOR signaling.
10.1016/j.ejcb.2022.151240 · 2022 · External reference
Mechanisms underlying muscle-related diseases and aging: insights into pathophysiology and therapeutic strategies.
10.3390/muscles4030026 · 2025 · External reference
Molecular mechanisms underlying the lifespan and healthspan benefits of dietary restriction across species.
10.3389/fgene.2026.1771707 · 2026 · External reference