Research graph
References from Intravenous vitamin C as micronutrient therapy in patients with sepsis or septic shock: an updated systematic review and meta-analysis of randomized controlled trials. Local targets link to admitted publications; unresolved targets remain external evidence.
Assessment of global incidence and mortality of hospital-treated sepsis. Current estimates and limitations.
10.1164/rccm.201504-0781oc · 2016 · External reference
The third international consensus definitions for sepsis and septic shock (sepsis-3).
10.1001/jama.2016.0287 · 2016 · External reference
Oxidative stress and endothelial dysfunction in sepsis and acute inflammation.
10.1089/ars.2021.0027 · 2021 · External reference
Mortality in sepsis and septic shock in Europe, North America and Australia between 2009 and 2019- results from a systematic review and meta-analysis.
10.1186/s13054-020-02950-2 · 2020 · External reference
Vitamin C supplementation in the critically ill patient.
10.1097/mco.0000000000000148 · 2015 · External reference
Role of vitamin C in the function of the vascular endothelium.
10.1089/ars.2013.5205 · 2013 · External reference
Modulation of TNF-α-induced icam-1 expression, NO and H2O2 production by alginate, allicin and ascorbic acid in human endothelial cells.
10.1007/bf02976837 · 2003 · External reference
Ascorbate-dependent vasopressor synthesis: a rationale for vitamin C administration in severe sepsis and septic shock?
10.1186/s13054-015-1131-2 · 2015 · External reference
Hypovitaminosis C and vitamin C deficiency in critically ill patients despite recommended enteral and parenteral intakes.
10.1186/s13054-017-1891-y · 2017 · External reference
Attenuation of sepsis-induced organ injury in mice by vitamin C.
10.1177/0148607113497760 · 2014 · External reference
Hydrocortisone, vitamin C, and thiamine for the treatment of severe sepsis and septic shock: a retrospective before-after study.
10.1016/j.chest.2016.11.036 · 2017 · External reference
Efficacy of dietary supplements on mortality and clinical outcomes in adults with sepsis and septic shock: a systematic review and network meta-analysis.
10.1016/j.clnu.2024.03.030 · 2024 · External reference
Intravenous vitamin C in adults with sepsis in the intensive care unit.
10.1056/nejmoa2200644 · 2022 · External reference
Early administration of vitamin C in patients with sepsis or septic shock in emergency departments: a multicenter, double-blind, randomized controlled trial: the C-EASIE trial.
10.1186/s13054-025-05383-x · 2025 · External reference
Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2026.
10.1097/ccm.0000000000007075 · 2026 · External reference
PRISMA 2020 explanation and elaboration: updated guidance and exemplars for reporting systematic reviews.
10.1136/bmj.n160 · 2021 · External reference
Optimally estimating the sample mean from the sample size, median, mid-range, and/or mid-quartile range.
10.1177/0962280216669183 · 2018 · External reference
Effect of adjunctive vitamin C, glucocorticoids, and vitamin B1 on longer-term mortality in adults with sepsis or septic shock: a systematic review and a component network meta-analysis.
10.1007/s00134-021-06558-0 · 2022 · External reference
Effect of vitamin C, thiamine, and hydrocortisone on ventilator- and vasopressor-free days in patients with sepsis: the VICTAS randomized clinical trial.
10.1001/jama.2020.24505 · 2021 · External reference
Effect of vitamin C infusion on organ failure and biomarkers of inflammation and vascular injury in patients with sepsis and severe acute respiratory failure: the CITRIS-ALI randomized clinical trial.
10.1001/jama.2019.11825 · 2019 · External reference
Phase I safety trial of intravenous ascorbic acid in patients with severe sepsis.
10.1186/1479-5876-12-32 · 2014 · External reference
GRADE: an emerging consensus on rating quality of evidence and strength of recommendations.
10.1136/bmj.39489.470347.ad · 2008 · External reference
GRADE guidelines: 1. Introduction-GRADE evidence profiles and summary of findings tables.
10.1016/j.jclinepi.2010.04.026 · 2011 · External reference
High-dose vitamin C improves norepinephrine level in patients with septic shock: a single-center, prospective, randomized controlled trial.
10.1097/md.0000000000037838 · 2024 · External reference
Impact of vitamin C on inflammatory response and myocardial injury in sepsis patients.
2024 · External reference
Mega-dose sodium ascorbate: a pilot, single-dose, physiological effect, double-blind, randomized, controlled trial.
10.1186/s13054-023-04644-x · 2023 · External reference
Evaluating vitamin C in septic shock: a randomized controlled trial of vitamin C monotherapy.
10.1097/ccm.0000000000005427 · 2022 · External reference
Intravenous vitamin C administration to patients with septic shock: a pilot randomised controlled trial.
10.1186/s13054-022-03900-w · 2022 · External reference
Efficacy of high-dose vitamin C infusion on outcomes in sepsis requiring mechanical ventilation: a double-blind randomized controlled trial.
10.1155/2022/4057215 · 2022 · External reference
Pilot trial of high-dose vitamin C in critically ill COVID-19 patients.
10.1186/s13613-020-00792-3 · 2021 · External reference
Effect of high-dose ascorbic acid on vasopressor’s requirement in septic shock.
10.4103/2279-042x.179569 · 2016 · External reference
High-dose intravenous vitamin C in early stages of severe acute respiratory syndrome coronavirus 2 infection: a double-blind, randomized, controlled clinical trial.
10.4103/jrpp.jrpp_30_22 · 2022 · External reference
Effect of Vitamin C on mortality of critically ill patients with severe pneumonia in intensive care unit: a preliminary study.
10.1186/s12879-021-06288-0 · 2021 · External reference
“Vitamin S” (steroids) and vitamin C for the treatment of severe sepsis and septic shock!
10.1097/ccm.0000000000001684 · 2016 · External reference
Mechanisms of ascorbic acid stimulation of norepinephrine synthesis in neuronal cells.
10.1016/j.bbrc.2012.08.054 · 2012 · External reference
Antioxidant-independent ascorbate enhancement of catecholamine-induced contractions of vascular smooth muscle.
10.1152/ajpheart.00968.2003 · 2004 · External reference
Ascorbic acid transport and accumulation in human neutrophils.
10.1016/s0021-9258(19)47256-6 · 1989 · External reference
Enhancement of antiviral T-cell responses by vitamin c suggests new strategies to improve manufacturing of virus-specific T cells for adoptive immunotherapy.
10.3390/biology11040536 · 2022 · External reference
Vitamin C suppresses TNF alpha-induced NF kappa B activation by inhibiting I kappa B alpha phosphorylation.
10.1021/bi0263210 · 2002 · External reference
Ascorbate protects against impaired arteriolar constriction in sepsis by inhibiting inducible nitric oxide synthase expression.
10.1016/j.freeradbiomed.2004.06.025 · 2004 · External reference
Inflammation-induced vasoconstrictor hyporeactivity is caused by oxidative stress.
10.1016/j.jacc.2003.06.002 · 2003 · External reference
Mechanisms and treatment of organ failure in sepsis.
10.1038/s41581-018-0005-7 · 2018 · External reference
Vitamin C enters mitochondria via facilitative glucose transporter 1 (Glut1) and confers mitochondrial protection against oxidative injury.
10.1096/fj.05-4107com · 2005 · External reference
Publication and non-publication of clinical trials: longitudinal study of applications submitted to a research ethics committee.
10.4414/smw.2008.12027 · 2008 · External reference
Publication and related bias in meta-analysis: power of statistical tests and prevalence in the literature.
10.1016/s0895-4356(00)00242-0 · 2000 · External reference
Empirical evidence of bias in treatment effect estimates in controlled trials with different interventions and outcomes: meta-epidemiological study.
10.1136/bmj.39465.451748.ad · 2008 · External reference
Vitamin C pharmacokinetics: implications for oral and intravenous use.
10.7326/0003-4819-140-7-200404060-00010 · 2004 · External reference
Schedule dependence in cancer therapy: intravenous vitamin C and the systemic saturation hypothesis.
2012 · External reference
Catalytic metals, ascorbate and free radicals: combinations to avoid.
10.2307/3579271 · 1996 · External reference
Antioxidative and anti-inflammatory activity of ascorbic acid.
10.3390/antiox11101993 · 2022 · External reference
Mitochondrial dysfunction in sepsis: mechanisms and therapeutic perspectives.
10.1186/s13054-024-05069-w · 2024 · External reference
Oxidative stress and mitochondrial dysfunction in sepsis.
10.1093/bja/aer093 · 2011 · External reference
Supplementation with vitamin C and N-acetyl-cysteine increases oxidative stress in humans after an acute muscle injury induced by eccentric exercise.
10.1016/s0891-5849(01)00640-2 · 2001 · External reference
Assessment of clinical criteria for sepsis: for the third international consensus definitions for sepsis and septic shock (sepsis-3).
10.1001/jama.2016.0288 · 2016 · External reference
Vitamin C in sepsis: a latest systematic review and meta-analysis.
10.1155/2023/6733465 · 2023 · External reference
Efficacy and safety of hydrocortisone, ascorbic acid, and thiamine combination therapy for the management of sepsis and septic shock: a systematic review and meta-analysis of randomised controlled trials.
10.1159/000538959 · 2024 · External reference
Hydrocortisone combined with vitamin C and thiamine in the treatment of sepsis/septic shock: a systematic review with meta-analysis and trial sequential analysis.
10.25011/cim.v46i1.40275 · 2023 · External reference
Efficacy of ascorbic acid, thiamine, and hydrocortisone combination therapy: meta-analysis of randomized controlled trials.
10.21873/invivo.13200 · 2023 · External reference