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References from Research progress on plant-derived bioactive compounds and late-life depression: from neuroprotective mechanisms to dietary patterns. Local targets link to admitted publications; unresolved targets remain external evidence.
Geriatric depression.
10.1016/j.pop.2022.10.010 · 2023 · External reference
Characterizing heterogeneity in neuroimaging, cognition, clinical symptoms, and genetics among patients with late-life depression.
10.1001/jamapsychiatry.2022.0020 · 2022 · External reference
Three-year prognosis of late-life depression in an outpatient geriatric psychiatry clinic: medical comorbidities worsen outcomes.
10.1007/s11126-023-10053-8 · 2023 · External reference
Predictors of cognitive improvement following treatment for late-life depression.
10.1177/0891988720915515 · 2021 · External reference
Geriatric depression and cognitive impairment-an update.
10.1177/0253717620981556 · 2021 · External reference
Methylphenidate use in geriatric depression: a systematic review.
10.1002/gps.5536 · 2021 · External reference
Molecular basis of late-life depression.
10.3390/ijms22147421 · 2021 · External reference
Adherence to the mediterranean diet, inflammatory biomarkers and cognitive status in older Italian adults.
10.3389/fnut.2026.1809163 · 2026 · External reference
Research progress on medicinal plants with antidepressant effects.
2016 · External reference
Proteomic study on CUMS-induced senile depression mice’s frontal lobe cortex and the regulating effect of KTLD formula.
10.26355/eurrev_202304_31922 · 2023 · External reference
New insights into anti-depression effects of bioactive phytochemicals.
10.1016/j.phrs.2024.107566 · 2025 · External reference
Depression and its phytopharmacotherapy-a narrative review.
10.3390/ijms24054772 · 2023 · External reference
Medicinal plants: a complementary and alternative antidepressant therapy.
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10.1016/j.radonc.2021.12.047 · 2022 · External reference
Dietary polyphenols and human health.
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Polyphenols as potential geroprotectors.
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Clinical research progress of curcumin in the prevention and treatment of cognitive impairment-related diseases.
2020 · External reference
Phytochemicals in the treatment of patients with depression: a systemic review.
10.3389/fpsyt.2024.1509109 · 2024 · External reference
Curcumin-rich curry consumption and life expectancy: Singapore longitudinal ageing study.
10.1007/s11357-023-00842-1 · 2024 · External reference
Dietary flavonoid intake and risk of incident depression in midlife and older women.
10.3945/ajcn.115.124545 · 2016 · External reference
Early intervention in cognitive aging with strawberry supplementation.
10.3390/nu15204431 · 2023 · External reference
The relationship between plant-based diet indices and sleep health in older adults: the mediating role of depressive symptoms and anxiety.
10.3390/nu16193386 · 2024 · External reference
Influence of equol and resveratrol supplementation on health-related quality of life in menopausal women: a randomized, placebo-controlled study.
10.1016/j.maturitas.2016.11.016 · 2017 · External reference
Polyphenols, alkaloids, and terpenoids against neurodegeneration: evaluating the neuroprotective effects of phytocompounds through a comprehensive review of the current evidence.
10.3390/metabo15020124 · 2025 · External reference
Comparison of the effects of ginsenoside Rg1 and Rb1 on improving depression- and anxiety-like behaviors in rats induced by chronic unpredictable stress.
2024 · External reference
Effects of lifetime cumulative ginseng intake on cognitive function in late life.
10.1186/s13195-018-0380-0 · 2018 · External reference
An updated review on the properties of melissa officinalis L.: not exclusively anti-anxiety.
10.31083/j.fbs1402016 · 2022 · External reference
Sceletium tortuosum: a review on its phytochemistry, pharmacokinetics, biological, pre-clinical and clinical activities.
10.1016/j.jep.2021.114711 · 2022 · External reference
A review on the neuroprotective effect of berberine against chemotherapy- induced cognitive impairment.
10.2174/1389450123666220303094752 · 2022 · External reference
Depression in Alzheimer’s disease: epidemiology, mechanisms, and treatment.
10.1016/j.biopsych.2023.10.008 · 2024 · External reference
Neuroinflammation: a modifiable pathway linking obesity, Alzheimer’s disease, and depression.
10.1016/j.jagp.2023.06.001 · 2023 · External reference
Depressive symptoms and amyloid pathology.
10.1001/jamapsychiatry.2024.4305 · 2025 · External reference
[Astragalus polysaccharides improve adipose tissue aging in naturally aged mice via indole-3-lactic acid].
10.19540/j.cnki.cjcmm.20240508.401 · 2024 · External reference
Ketogenic diet is less effective in ameliorating depression and anxiety in obesity than Mediterranean diet: a pilot study for exploring the GUT-brain axis.
10.1016/j.bbi.2025.106167 · 2026 · External reference
Discovering the potentials of medicinal mushrooms in combating depression - a review.
10.2174/1389557520666200526125534 · 2020 · External reference
Neuroprotective natural products’ regulatory effects on depression via gut-brain axis targeting tryptophan.
10.3390/nu14163270 · 2022 · External reference
Association between sucrose and fiber intake and symptoms of depression in older people.
10.1080/1028415x.2020.1819106 · 2022 · External reference
Gut microbiota and late-life depression: from mechanistic insights to clinical rehabilitation.
10.1016/j.lfs.2025.124041 · 2025 · External reference
Ginkgo biloba L. leaf extract (EGb 761) alleviates reserpine-induced depression-like symptoms in aged rats by enhancing serotonin/norepinephrine levels and reducing oxidative/nitrosative stress.
10.1007/s00210-025-03972-9 · 2025 · External reference
Fruit, vegetable, and antioxidant intakes are lower in older adults with depression.
10.1016/j.jand.2012.08.026 · 2012 · External reference
Study on the effect and mechanism of kaempferol on depressive-like behaviors in elderly rats with chronic stress-induced depression model.
2020 · External reference
The effect of lavender herbal tea on the anxiety and depression of the elderly: a randomized clinical trial.
10.1016/j.ctim.2020.102393 · 2020 · External reference
Methodological development and validation of the Thai traditional medicine-based depression care program for older adults.
10.1016/j.mex.2026.103916 · 2026 · External reference
Inflammation and late-life depression: unraveling the complex relationship and potential therapeutic strategies.
10.31083/j.fbl2812356 · 2023 · External reference
Dietary inflammatory potential and depression in middle-aged and older adults: a population-based study of associations and comorbid disease network.
10.1016/j.jad.2025.120987 · 2026 · External reference
Plant-derived bioactive compounds in the management of neurodegenerative disorders: challenges, future directions and molecular mechanisms involved in neuroprotection.
10.3390/pharmaceutics15030749 · 2023 · External reference
Berries and steps: a protocol of a randomized, placebo-controlled pilot study testing freeze-dried blueberry powder in sedentary older adults with mild depressive symptoms.
10.1186/s12937-025-01154-0 · 2025 · External reference
Herbal terpenoids activate autophagy and mitophagy through modulation of bioenergetics and protect from metabolic stress, sarcopenia and epigenetic aging.
10.1038/s43587-025-00957-4 · 2025 · External reference
Association between dietary antioxidant capacity in midlife and depressive symptoms in late life: the Singapore Chinese health study.
10.3390/antiox13050576 · 2024 · External reference
Shared mechanisms in dementia and depression: the modulatory role of physical exercise.
10.1111/jnc.70185 · 2025 · External reference
Green tea polyphenols produce antidepressant-like effects in adult mice.
10.1016/j.phrs.2011.09.007 · 2012 · External reference
Ginsenoside Rg1 in neurological diseases: From bench to bedside.
10.1038/s41401-022-01022-1 · 2023 · External reference
The protective role of ginsenoside Rg3 in heart diseases and mental disorders.
10.3389/fphar.2024.1327033 · 2024 · External reference
Biological factors influencing depression in later life: role of aging processes and treatment implications.
10.1038/s41398-023-02464-9 · 2023 · External reference
Mechanisms and treatment of late-life depression.
10.1038/s41398-019-0514-6 · 2019 · External reference
Efficacy and safety of transcranial magnetic stimulation for treating late-life depression: a scoping review.
10.3390/jcm14103609 · 2025 · External reference
Effects of tea polyphenols on brain structure and function of hippocampus in aged type 2 diabetes mellitus rats with anxiety and depression-like behavior.
10.1016/j.brainres.2026.150223 · 2026 · External reference
Ganoderma lucidum triterpenes ameliorate age-related cognitive impairment via regulating Eubacterium lentum-mediated serine metabolism.
10.1016/j.phymed.2025.157557 · 2025 · External reference
Probiotic supplementation improves cognitive function and mood with changes in gut microbiota in community-dwelling older adults: a randomized, double-blind, placebo-controlled, multicenter trial.
10.1093/gerona/glaa090 · 2021 · External reference
Differences in gut microbiota correlate with symptoms and regional brain volumes in patients with late-life depression.
10.3389/fnagi.2022.885393 · 2022 · External reference
The aging gastrointestinal tract: epidemiology and clinical significance of disorders of gut-brain interaction in the older general population.
10.1111/apt.18103 · 2024 · External reference
The gut microbiota as a mediator in the relationship between dietary patterns and depression.
10.1002/mco2.70562 · 2026 · External reference
The gut microbiota links dietary polyphenols with management of psychiatric mood disorders.
10.3389/fnins.2019.01196 · 2019 · External reference
Lepidium meyenii Walp (Maca)-derived extracellular vesicles ameliorate depression by promoting 5-HT synthesis via the modulation of gut-brain axis.
10.1002/imt2.116 · 2023 · External reference
Prophylactic effects of betaine on depression and anxiety behaviors in mice with dextran sulfate sodium-induced colitis.
10.1021/acs.jafc.4c05547 · 2024 · External reference
Does food intake mediate the association between mindful eating and change in depressive symptoms?
10.1017/s1368980019003732 · 2020 · External reference
Phenolic composition and antioxidant activity of purple sweet potato (Ipomoea batatas (L.) Lam.): varietal comparisons and physical distribution.
10.3390/antiox10030462 · 2021 · External reference
Patterns of polyphenol intake and risk of depressive symptomatology in a population-based cohort of older adults.
10.1016/j.clnu.2022.10.006 · 2022 · External reference
Dietary polyphenols and human health: sources, biological activities, nutritional and immunological aspects, and bioavailability- a comprehensive review.
10.3389/fimmu.2025.1653378 · 2025 · External reference
Association between weekly fruit and vegetable consumption and depressive symptoms: results from the Korean Elderly Environmental Panel study.
10.4178/epih.e2021029 · 2021 · External reference
Longitudinal correlates of fruit and vegetable consumption with depressive symptoms among middle-aged and older adults in South Africa.
10.1186/s40359-022-00960-z · 2022 · External reference
Association between dietary patterns and the risk of depressive symptoms in the older adults in rural China.
10.3390/nu14173538 · 2022 · External reference
Dietary habits and depression in community-dwelling chinese older adults: cross-sectional analysis of the moderating role of physical exercise.
10.3390/nu16050740 · 2024 · External reference
Adherence to mediterranean diet moderates the association between multimorbidity and depressive symptoms in older adults.
10.1016/j.archger.2020.104022 · 2020 · External reference
A prospective cohort study to examine the association between dietary patterns and depressive symptoms in older Chinese people in Hong Kong.
10.1371/journal.pone.0105760 · 2014 · External reference
Association between consumption of fruits and vegetables in midlife and depressive symptoms in late life: the Singapore Chinese health study.
10.1016/j.jnha.2024.100275 · 2024 · External reference
Association of vision and hearing impairment and dietary diversity among the oldest old in China: findings from the Chinese longitudinal healthy longevity survey.
10.1186/s12889-024-19482-x · 2024 · External reference
Association between adherence to the dietary approaches to stop hypertension diet and depression and anxiety severity in the Mashhad stroke and heart atherosclerotic disorder study population.
10.1017/s1368980026102110 · 2026 · External reference
Nutrition and healthy ageing in asia: a systematic review.
10.3390/nu15143153 · 2023 · External reference
Adherence to the MIND diet and longitudinal brain structural changes over a decade: evidence from the Framingham heart study offspring cohort.
10.1136/jnnp-2025-336957 · 2026 · External reference
Associations of cMIND Diet with depressive and anxiety symptoms among old people in China: a nationwide study.
10.1007/s00394-025-03628-7 · 2025 · External reference
Effects of dietary patterns on geriatric depression.
2025 · External reference
Understanding the gastrointestinal tract of the elderly to develop dietary solutions that prevent malnutrition.
10.18632/oncotarget.4030 · 2015 · External reference
Plant-based diets and depression: epidemiological evidence, biological mechanisms, and implications for prevention.
10.3389/fnut.2026.1763010 · 2026 · External reference
Association of plant-based diet indices and abdominal obesity with mental disorders among older Chinese adults.
10.3390/nu15122721 · 2023 · External reference
Association between plant-based dietary patterns and the long-term trajectory of depressive symptoms: a 10-year longitudinal study.
10.1016/j.jamda.2025.105712 · 2025 · External reference
Flexitarian dietary patterns and neuropsychiatric multimorbidity among the oldest-old in China.
10.3389/fnut.2026.1789764 · 2026 · External reference
Preparation and evaluation of curcumin derivatives nanoemulsion based on turmeric extract and its antidepressant effect.
10.2147/ijn.s430769 · 2023 · External reference
A critical review of cytochrome P450 enzyme inhibition by herbal phytochemicals: implications for drug interaction prediction and herbal safety.
10.1002/ptr.70414 · 2026 · External reference
St John’s wort: a potential therapy for elderly depressed patients?
10.2165/00002512-200016030-00004 · 2000 · External reference
St. John’s wort extract with a high hyperforin content does not induce P-glycoprotein activity at the human blood-brain barrier.
10.1111/cts.13804 · 2024 · External reference
Screening indicators to evaluate the clinical significance of drug-drug interactions in polypharmacy among older adults with psychiatric disorders: a delphi study.
10.1186/s12888-024-05872-3 · 2024 · External reference
Health effects of dietary risks in 195 countries, 1990-2017: a systematic analysis for the Global burden of disease study 2017.
10.1016/s0140-6736(19)30041-8 · 2019 · External reference
The effectiveness of Bacopa monnieri (Linn.) Wettst. as a nootropic, neuroprotective, or antidepressant supplement: analysis of the available clinical data.
10.1038/s41598-020-80045-2 · 2021 · External reference
The effect of black mulberry (Morus nigra) consumption on cognition in patients with mild-to-moderate Alzheimer’s dementia: a pilot feasibility study.
10.1016/j.gerinurse.2023.11.014 · 2024 · External reference
Gastrodia elata Blume water extract modulates neurotransmitters and alters the gut microbiota in a mild social defeat stress-induced depression mouse model.
10.1002/ptr.7091 · 2021 · External reference
Neuroprotective effects of Hericium erinaceus (Bull.: Fr.) Pers. against high-dose corticosterone-induced oxidative stress in PC-12 cells.
10.1186/s12906-020-03132-x · 2020 · External reference
The impact of nutrition and intestinal microbiome on elderly depression-a systematic review.
10.3390/nu12030710 · 2020 · External reference
Total glycosides from stems of Cistanche tubulosa alleviate depression-like behaviors: bidirectional interaction of the phytochemicals and gut microbiota.
10.1016/j.phymed.2021.153471 · 2021 · External reference
Network pharmacology-based research of active components of albiziae flos and mechanisms of its antidepressant effect.
10.1007/s11596-020-2155-7 · 2020 · External reference
Deciphering the multi-scale mechanisms of Tephrosia purpurea against polycystic ovarian syndrome (PCOS) and its major psychiatric comorbidities: studies from network pharmacological perspective.
10.1016/j.gene.2020.145385 · 2021 · External reference
Antidepressant mechanism of classical herbal formula lily bulb and Rehmannia decoction: insights from gene expression profile of medial prefrontal cortex of mice with stress-induced depression-like behavior.
10.1111/gbb.12649 · 2020 · External reference
Determination of lutein from fruit and vegetables through an alkaline hydrolysis extraction method and HPLC analysis.
10.1111/1750-3841.13122 · 2015 · External reference
Total phenol, catechin, and caffeine contents of teas commonly consumed in the United Kingdom.
10.1021/jf010153l · 2002 · External reference
Concentrations of choline-containing compounds and betaine in common foods.
10.1093/jn/133.5.1302 · 2003 · External reference