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References from Loss of RanBP9 cooperates with p53 deficiency to promote sarcomagenesis. Local targets link to admitted publications; unresolved targets remain external evidence.
Hallmarks of cancer: New dimensions
10.1158/2159-8290.cd-21-1059 · 2022 · External reference
The ubiquitin code
10.1146/annurev-biochem-060310-170328 · 2012 · External reference
E3 ubiquitin ligases in cancer and implications for therapies
10.1007/s10555-017-9703-z · 2017 · External reference
An expanded lexicon for the ubiquitin code
10.1038/s41580-022-00543-1 · 2023 · External reference
Ubiquitin ligases in oncogenic transformation and cancer therapy
10.1038/nrc.2017.105 · 2018 · External reference
Cell signalling pathway regulation by RanBPM: Molecular insights and disease implications
10.1098/rsob.170081 · 2017 · External reference
The CTLH complex in cancer cell plasticity
10.1155/2019/4216750 · 2019 · External reference
Structural and functional insights into GID/CTLH E3 ligase complexes
10.3390/ijms23115863 · 2022 · External reference
The Gid-complex: An emerging player in the ubiquitin ligase league
10.1515/hsz-2019-0139 · 2019 · External reference
Interconversion between anticipatory and active GID E3 ubiquitin ligase conformations via metabolically driven substrate receptor assembly
10.1016/j.molcel.2019.10.009 · 2020 · External reference
GID E3 ligase supramolecular chelate assembly configures multipronged ubiquitin targeting of an oligomeric metabolic enzyme
10.1016/j.molcel.2021.03.025 · 2021 · External reference
mTORC1-CTLH E3 ligase regulates the degradation of HMG-CoA synthase 1 through the Pro/N-degron pathway
10.1016/j.molcel.2024.04.026 · 2024 · External reference
A chemical probe to modulate human GID4 Pro/N-degron interactions
10.1038/s41589-024-01618-0 · 2024 · External reference
Chemical tools for the Gid4 subunit of the human E3 ligase C-terminal to LisH (CTLH) degradation complex
10.1039/d3md00633f · 2024 · External reference
The human GID complex engages two independent modules for substrate recruitment
10.15252/embr.202152981 · 2021 · External reference
RanBP9 controls the oligomeric state of CTLH complex assemblies
10.1016/j.jbc.2023.102869 · 2023 · External reference
Interplay between beta-propeller subunits WDR26 and muskelin regulates the CTLH E3 ligase supramolecular complex
10.1038/s42003-024-07371-3 · 2024 · External reference
Non-canonical substrate recognition by the human WDR26-CTLH E3 ligase regulates prodrug metabolism
10.1016/j.molcel.2024.04.014 · 2024 · External reference
FAM72A degrades UNG2 through the GID/CTLH complex to promote mutagenic repair during antibody maturation
10.1038/s41467-024-52009-x · 2024 · External reference
mTORC1 regulates the pyrimidine salvage pathway by controlling UCK2 turnover via the CTLH-WDR26 E3 ligase
10.1016/j.celrep.2024.115179 · 2025 · External reference
Muskelin is a substrate adaptor of the highly regulated Drosophila embryonic CTLH E3 ligase
10.1038/s44319-025-00397-6 · 2025 · External reference
Armc8 expression was elevated during atypia-to-carcinoma progression and associated with cancer development of breast carcinoma
10.1007/s13277-014-2473-0 · 2014 · External reference
ARMC8alpha promotes proliferation and invasion of non-small cell lung cancer cells by activating the canonical Wnt signaling pathway
10.1007/s13277-014-2162-z · 2014 · External reference
A novel biomarker ARMc8 promotes the Malignant progression of ovarian cancer
10.1016/j.humpath.2015.06.004 · 2015 · External reference
ARMc8 indicates aggressive colon cancers and promotes invasiveness and migration of colon cancer cells
10.1007/s13277-015-3664-z · 2015 · External reference
Ran Binding Protein 9 (RanBP9) is a novel mediator of cellular DNA damage response in lung cancer cells
10.18632/oncotarget.7813 · 2016 · External reference
Twa1/Gid8 is a beta-catenin nuclear retention factor in Wnt signaling and colorectal tumorigenesis
10.1038/cr.2017.107 · 2017 · External reference
Upregulated WDR26 serves as a scaffold to coordinate PI3K/ AKT pathway-driven breast cancer cell growth, migration, and invasion
10.18632/oncotarget.7439 · 2016 · External reference
RANBP9 and RANBP10 cooperate in regulating non-small cell lung cancer proliferation
10.1186/s13046-025-03491-8 · 2025 · External reference
RANBP9 suppresses tumor proliferation in colorectal cancer
10.3892/ol.2019.10134 · 2019 · External reference
RanBPM has proapoptotic activities that regulate cell death pathways in response to DNA damage
10.1158/1541-7786.mcr-09-0098 · 2009 · External reference
Regulation of c-Raf stability through the CTLH complex
10.3390/ijms20040934 · 2019 · External reference
Protein stability and function of p73 are modulated by a physical interaction with RanBPM in mammalian cultured cells
10.1038/sj.onc.1208257 · 2005 · External reference
Cooperative role of RanBP9 and P73 in mitochondria-mediated apoptosis
10.1038/cddis.2012.203 · 2013 · External reference
Pivotal role of RanBP9 in integrin-dependent focal adhesion signaling and assembly
10.1096/fj.11-194423 · 2012 · External reference
Reduced RanBPM expression is associated with distant metastasis in gastric cancer and chemoresistance
2016 · External reference
Cilia-localized GID/CTLH ubiquitin ligase complex regulates protein homeostasis of sonic hedgehog signaling components
10.1242/jcs.259209 · 2022 · External reference
WNK regulates Wnt signalling and beta-Catenin levels by interfering with the interaction between beta-Catenin and GID
10.1038/s42003-020-01386-2 · 2020 · External reference
Proteomic analysis of ubiquitination substrates reveals a CTLH E3 ligase complex-dependent regulation of glycolysis
10.1096/fj.202100664r · 2021 · External reference
WDR26 is a new partner of Axin1 in the canonical Wnt signaling pathway
10.1002/1873-3468.12180 · 2016 · External reference
RanBPM is an inhibitor of ERK signaling
10.1371/journal.pone.0047803 · 2012 · External reference
The ARRIVE guidelines 2.0: Updated guidelines for reporting animal research
10.1371/journal.pbio.3000410 · 2020 · External reference
RanBPM is essential for mouse spermatogenesis and oogenesis
10.1242/dev.062505 · 2011 · External reference
RanBP9 plays a critical role in neonatal brain development in mice
10.1371/journal.pone.0066908 · 2013 · External reference
Tumor spectrum analysis in p53-mutant mice
10.1016/s0960-9822(00)00002-6 · 1994 · External reference
Preparation of mouse embryonic fibroblast cells suitable for culturing human embryonic and induced pluripotent stem cells
10.3791/3854 · 2012 · External reference
Inflammatory microenvironment and tumor necrosis factor alpha as modulators of periostin and CCN2 expression in human non-healing skin wounds and dermal fibroblasts
10.1016/j.matbio.2015.03.003 · 2015 · External reference
Detection of galectin-3 and localization of advanced glycation end products (AGE) in human chronic skin wounds
10.14670/hh-29.251 · 2014 · External reference
ilastik: Interactive machine learning for (bio)image analysis
10.1038/s41592-019-0582-9 · 2019 · External reference
Single-pot, solid-phase-enhanced sample preparation for proteomics experiments
10.1038/s41596-018-0082-x · 2019 · External reference
Solvent precipitation SP3 (SP4) enhances recovery for proteomics sample preparation without magnetic beads
10.1021/acs.analchem.1c04200 · 2022 · External reference
Acquiring and analyzing data independent acquisition proteomics experiments without spectrum libraries
10.1074/mcp.p119.001913 · 2020 · External reference
Chromatogram libraries improve peptide detection and quantification by data independent acquisition mass spectrometry
10.1038/s41467-018-07454-w · 2018 · External reference
The cBio cancer genomics portal: an open platform for exploring multidimensional cancer genomics data
10.1158/2159-8290.cd-12-0095 · 2012 · External reference
GEPIA: a web server for cancer and normal gene expression profiling and interactive analyses
10.1093/nar/gkx247 · 2017 · External reference
TSGene: a web resource for tumor suppressor genes
10.1093/nar/gks937 · 2013 · External reference
WDR26 depletion alters chromatin accessibility and gene expression profiles in mammalian cells
10.1016/j.ygeno.2025.111001 · 2025 · External reference
Pathogenic variants in MAEA disrupt DNA replication fork stability and are associated with developmental abnormalities in humans
10.1126/sciadv.adv0381 · 2025 · External reference
RanBPM (RanBP9) regulates mouse c-Kit receptor level and is essential for normal development of bone marrow progenitor cells
10.18632/oncotarget.13198 · 2016 · External reference
Modular UBE2H-CTLH E2-E3 complexes regulate erythroid maturation
10.7554/elife.77937 · 2022 · External reference
The mammalian CTLH complex is an E3 ubiquitin ligase that targets its subunit muskelin for degradation
10.1038/s41598-019-46279-5 · 2019 · External reference
A proteomic approach identifies isoform-specific and nucleotide-dependent RAS interactions
10.1016/j.mcpro.2022.100268 · 2022 · External reference
Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity
10.1101/gad.331231.119 · 2019 · External reference
Prosaposin facilitates sortilin-independent lysosomal trafficking of progranulin
10.1083/jcb.201502029 · 2015 · External reference
Paralogue interference affects the dynamics after gene duplication
10.1016/j.tplants.2015.10.003 · 2015 · External reference
The microtubule modulator RanBP10 plays a critical role in regulation of platelet discoid shape and degranulation
10.1182/blood-2009-04-216804 · 2009 · External reference
Altered microtubule equilibrium and impaired thrombus stability in mice lacking RanBP10
10.1182/blood-2012-01-401737 · 2012 · External reference
RanBPM expression regulates transcriptional pathways involved in development and tumorigenesis
2012 · External reference
High throughput profiling of undifferentiated pleomorphic sarcomas identifies two main subgroups with distinct immune profile, clinical outcome and sensitivity to targeted therapies
10.1016/j.ebiom.2020.103131 · 2020 · External reference
MAPK-targeted therapies in non-gastrointestinal stromal tumor soft tissue sarcomas: current landscape and future directions
10.3389/fonc.2025.1418537 · 2025 · External reference
Genetic screen in a preclinical model of sarcoma development defines drivers and therapeutic vulnerabilities
10.1158/1078-0432.ccr-24-1238 · 2024 · External reference
The jun proto-oncogene is positively autoregulated by its product, Jun/AP-1
10.1016/0092-8674(88)90143-2 · 1988 · External reference
eIF3 targets cell-proliferation messenger RNAs for translational activation or repression
10.1038/nature14267 · 2015 · External reference
10.1371/journal.pone.0299779 · 2024 · Admitted local publication
c-Jun, at the crossroad of the signaling network
10.1007/s13238-011-1113-3 · 2011 · External reference
TP53 in bone and soft tissue sarcomas
10.1016/j.pharmthera.2019.06.010 · 2019 · External reference
p53-deficient cells rely on ATM- and ATR-mediated checkpoint signaling through the p38MAPK/MK2 pathway for survival after DNA damage
10.1016/j.ccr.2006.11.024 · 2007 · External reference
Two subunits of human ORC are dispensable for DNA replication and proliferation
10.7554/elife.19084 · 2016 · External reference
The many faces of the origin recognition complex
10.1016/j.ceb.2007.04.007 · 2007 · External reference
DNA replication origins
10.1101/cshperspect.a010116 · 2013 · External reference
Novel candidate biomarkers of origin recognition complex 1, 5 and 6 for survival surveillance in patients with hepatocellular carcinoma
10.7150/jca.39163 · 2020 · External reference
Clinical relevance of ORCs in predicting prognosis and immunotherapy outcomes: a pan-cancer analysis
10.1016/j.imbio.2024.152783 · 2024 · External reference
Systemic analysis of the DNA replication regulator origin recognition complex in lung adenocarcinomas identifies prognostic and expression significance
10.1002/cam4.5238 · 2023 · External reference
Replication licensing and cancer--a fatal entanglement
10.1038/nrc2500 · 2008 · External reference
Dynamics of replication origin over-activation
10.1038/s41467-021-23835-0 · 2021 · External reference
Orc5 induces large-scale chromatin decondensation in a GCN5-dependent manner
10.1242/jcs.178889 · 2016 · External reference
The hGID(GID4) E3 ubiquitin ligase complex targets ARHGAP11A to regulate cell migration
10.26508/lsa.202403046 · 2024 · External reference
Concise review: mesenchymal tumors: when stem cells go mad
10.1002/stem.596 · 2011 · External reference
Gene Expression Omnibus: NCBI gene expression and hybridization array data repository
10.1093/nar/30.1.207 · 2002 · External reference
The PRIDE database at 20 years: 2025 update
10.1093/nar/gkae1011 · 2025 · External reference
Loss of CTLH component MAEA impairs DNA repair and replication and leads to developmental delay
10.1038/s44321-025-00352-x · 2026 · External reference