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References from The deubiquitinating enzyme UCHL3 promotes bladder cancer progression and glycolysis through enhancing PKM2 protein stability. Local targets link to admitted publications; unresolved targets remain external evidence.
Bladder cancer incidence and mortality: A global overview and recent trends
10.1016/j.eururo.2025.12.011 · 2025 · External reference
Bladder cancer
10.2139/ssrn.3372965 · 2023 · External reference
Bladder cancer: A review
10.1001/jama.2020.17598 · 2020 · External reference
Cancer metabolism: Looking forward
10.1038/s41568-021-00378-6 · 2021 · External reference
Pyruvate kinase M2 (PKM2) in cancer and cancer therapeutics
10.1016/j.canlet.2020.11.018 · 2021 · External reference
The role of the HIF-1α/ALYREF/PKM2 axis in glycolysis and tumorigenesis of bladder cancer
10.1002/cac2.12158 · 2021 · External reference
DDX39B drives colorectal cancer progression by promoting the stability and nuclear translocation of PKM2
10.1038/s41392-022-01096-7 · 2022 · External reference
RNF112 facilitates ubiquitin-mediated degradation of c-Myc, suppressing proliferation, migration and lipid synthesis in bladder cancer
10.1002/advs.202408311 · 2025 · External reference
E3 ubiquitin ligase TRIM2 identified as a novel suppressor of CYP11B2 and aldosterone production
10.1007/s00018-024-05545-0 · 2024 · External reference
Phosphoglycerate dehydrogenase activates PKM2 to phosphorylate histone H3T11 and attenuate cellular senescence
10.1038/s41467-023-37094-8 · 2023 · External reference
KHK-A promotes fructose-dependent colorectal cancer liver metastasis by facilitating the phosphorylation and translocation of PKM2
10.1016/j.apsb.2024.04.024 · 2024 · External reference
PKM2 is essential for bladder cancer growth and maintenance
10.1158/0008-5472.can-21-0403 · 2022 · External reference
Tumor-associated macrophage enhances PD-L1-mediated immune escape of bladder cancer through PKM2 dimer-STAT3 complex nuclear translocation
10.1016/j.canlet.2024.216964 · 2024 · External reference
USP8 positively regulates hepatocellular carcinoma tumorigenesis and confers ferroptosis resistance through β-catenin stabilization
10.1038/s41419-023-05747-7 · 2023 · External reference
Nuclear PKM2 regulates β-catenin transactivation upon EGFR activation
10.1038/nature10598 · 2011 · External reference
PKM2 controls cochlear development through lactate-dependent transcriptional regulation
10.1073/pnas.2410829122 · 2025 · External reference
Role of LDH in tumor glycolysis: Regulation of LDHA by small molecules for cancer therapeutics
10.1016/j.semcancer.2022.11.007 · 2022 · External reference
Structural basis for allosteric regulation of human phosphofructokinase-1
10.1038/s41467-024-51808-6 · 2024 · External reference
PKM2-TMEM33 axis regulates lipid homeostasis in cancer cells by controlling SCAP stability
10.15252/embj.2021108065 · 2021 · External reference
Mediation of PKM2-dependent glycolytic and non-glycolytic pathways by ENO2 in head and neck cancer development
10.1186/s13046-022-02574-0 · 2023 · External reference
ESM1 enhances fatty acid synthesis and vascular mimicry in ovarian cancer by utilizing the PKM2-dependent warburg effect within the hypoxic tumor microenvironment
10.1186/s12943-024-02009-8 · 2024 · External reference
Targeting glycolysis in prostate cancer: Molecular mechanisms and therapeutic advances
10.1016/j.bbcan.2026.189537 · 2026 · External reference
Tumor pyruvate kinase M2 modulators: A comprehensive account of activators and inhibitors as anticancer agents
10.1039/d1md00045d · 2021 · External reference
Ubiquitin ligases: Guardians of mammalian development
10.1038/s41580-021-00448-5 · 2022 · External reference
Ubiquitination and deubiquitination in cancer: From mechanisms to novel therapeutic approaches
10.1186/s12943-024-02046-3 · 2024 · External reference
UCHL3 promotes aerobic glycolysis of pancreatic cancer through upregulating LDHA expression
10.1007/s12094-021-02565-1 · 2021 · External reference
USP21 deubiquitinates and stabilizes HSP90 and ENO1 to promote aerobic glycolysis and proliferation in cholangiocarcinoma
10.7150/ijbs.90774 · 2024 · External reference
USP28 promotes tumor progression and glycolysis by stabilizing PKM2/Hif1-α in cholangiocarcinoma
10.1007/s13402-024-01002-z · 2024 · External reference
The deubiquitinating enzyme UCHL3 promotes anaplastic thyroid cancer progression and metastasis through Hippo signaling pathway
10.1038/s41418-023-01134-z · 2023 · External reference
UCHL3: A crucial deubiquitinase in DNA damage repair and tumor progression
10.1186/s12935-025-03884-x · 2025 · External reference
UCHL3 promotes ovarian cancer progression by stabilizing TRAF2 to activate the NF-κB pathway
10.1038/s41388-019-0987-z · 2020 · External reference
The deubiquitylase UCHL3 maintains cancer stem-like properties by stabilizing the aryl hydrocarbon receptor
10.1038/s41392-020-0181-3 · 2020 · External reference
The deubiquitinase UCHL3 mediates p300-dependent chemokine signaling in alveolar type II cells to promote pulmonary fibrosis
10.1038/s12276-023-01066-1 · 2023 · External reference
Deubiquitinase OTUB2 exacerbates the progression of colorectal cancer by promoting PKM2 activity and glycolysis
10.1038/s41388-021-02071-2 · 2022 · External reference
UCHL3 augments cuproptosis via PKM2 deubiquitination in hepatocellular carcinoma
10.1016/j.freeradbiomed.2025.05.429 · 2025 · External reference
Activation of CTNNB1 by deubiquitinase UCHL3-mediated stabilization facilitates bladder cancer progression
10.1186/s12967-023-04311-3 · 2023 · External reference
Bladder cancer: A review
10.1001/jama.2020.17598 · ExternalCitation · doi-reference
RNF112 facilitates ubiquitin-mediated degradation of c-Myc, suppressing proliferation, migration and lipid synthesis in bladder cancer
10.1002/advs.202408311 · ExternalCitation · doi-reference
The role of the HIF-1α/ALYREF/PKM2 axis in glycolysis and tumorigenesis of bladder cancer
10.1002/cac2.12158 · ExternalCitation · doi-reference
E3 ubiquitin ligase TRIM2 identified as a novel suppressor of CYP11B2 and aldosterone production
10.1007/s00018-024-05545-0 · ExternalCitation · doi-reference
UCHL3 promotes aerobic glycolysis of pancreatic cancer through upregulating LDHA expression
10.1007/s12094-021-02565-1 · ExternalCitation · doi-reference
USP28 promotes tumor progression and glycolysis by stabilizing PKM2/Hif1-α in cholangiocarcinoma
10.1007/s13402-024-01002-z · ExternalCitation · doi-reference
KHK-A promotes fructose-dependent colorectal cancer liver metastasis by facilitating the phosphorylation and translocation of PKM2
10.1016/j.apsb.2024.04.024 · ExternalCitation · doi-reference
Targeting glycolysis in prostate cancer: Molecular mechanisms and therapeutic advances
10.1016/j.bbcan.2026.189537 · ExternalCitation · doi-reference
Pyruvate kinase M2 (PKM2) in cancer and cancer therapeutics
10.1016/j.canlet.2020.11.018 · ExternalCitation · doi-reference
Tumor-associated macrophage enhances PD-L1-mediated immune escape of bladder cancer through PKM2 dimer-STAT3 complex nuclear translocation
10.1016/j.canlet.2024.216964 · ExternalCitation · doi-reference
Bladder cancer incidence and mortality: A global overview and recent trends
10.1016/j.eururo.2025.12.011 · ExternalCitation · doi-reference
UCHL3 augments cuproptosis via PKM2 deubiquitination in hepatocellular carcinoma
10.1016/j.freeradbiomed.2025.05.429 · ExternalCitation · doi-reference
Role of LDH in tumor glycolysis: Regulation of LDHA by small molecules for cancer therapeutics
10.1016/j.semcancer.2022.11.007 · ExternalCitation · doi-reference
Nuclear PKM2 regulates β-catenin transactivation upon EGFR activation
10.1038/nature10598 · ExternalCitation · doi-reference
The deubiquitinase UCHL3 mediates p300-dependent chemokine signaling in alveolar type II cells to promote pulmonary fibrosis
10.1038/s12276-023-01066-1 · ExternalCitation · doi-reference
UCHL3 promotes ovarian cancer progression by stabilizing TRAF2 to activate the NF-κB pathway
10.1038/s41388-019-0987-z · ExternalCitation · doi-reference
Deubiquitinase OTUB2 exacerbates the progression of colorectal cancer by promoting PKM2 activity and glycolysis
10.1038/s41388-021-02071-2 · ExternalCitation · doi-reference
The deubiquitylase UCHL3 maintains cancer stem-like properties by stabilizing the aryl hydrocarbon receptor
10.1038/s41392-020-0181-3 · ExternalCitation · doi-reference
DDX39B drives colorectal cancer progression by promoting the stability and nuclear translocation of PKM2
10.1038/s41392-022-01096-7 · ExternalCitation · doi-reference
The deubiquitinating enzyme UCHL3 promotes anaplastic thyroid cancer progression and metastasis through Hippo signaling pathway
10.1038/s41418-023-01134-z · ExternalCitation · doi-reference
USP8 positively regulates hepatocellular carcinoma tumorigenesis and confers ferroptosis resistance through β-catenin stabilization
10.1038/s41419-023-05747-7 · ExternalCitation · doi-reference
Phosphoglycerate dehydrogenase activates PKM2 to phosphorylate histone H3T11 and attenuate cellular senescence
10.1038/s41467-023-37094-8 · ExternalCitation · doi-reference
Structural basis for allosteric regulation of human phosphofructokinase-1
10.1038/s41467-024-51808-6 · ExternalCitation · doi-reference
Cancer metabolism: Looking forward
10.1038/s41568-021-00378-6 · ExternalCitation · doi-reference
Ubiquitin ligases: Guardians of mammalian development
10.1038/s41580-021-00448-5 · ExternalCitation · doi-reference
Tumor pyruvate kinase M2 modulators: A comprehensive account of activators and inhibitors as anticancer agents
10.1039/d1md00045d · ExternalCitation · doi-reference
PKM2 controls cochlear development through lactate-dependent transcriptional regulation
10.1073/pnas.2410829122 · ExternalCitation · doi-reference
PKM2 is essential for bladder cancer growth and maintenance
10.1158/0008-5472.can-21-0403 · ExternalCitation · doi-reference
UCHL3: A crucial deubiquitinase in DNA damage repair and tumor progression
10.1186/s12935-025-03884-x · ExternalCitation · doi-reference
ESM1 enhances fatty acid synthesis and vascular mimicry in ovarian cancer by utilizing the PKM2-dependent warburg effect within the hypoxic tumor microenvironment
10.1186/s12943-024-02009-8 · ExternalCitation · doi-reference
Ubiquitination and deubiquitination in cancer: From mechanisms to novel therapeutic approaches
10.1186/s12943-024-02046-3 · ExternalCitation · doi-reference
Activation of CTNNB1 by deubiquitinase UCHL3-mediated stabilization facilitates bladder cancer progression
10.1186/s12967-023-04311-3 · ExternalCitation · doi-reference
Mediation of PKM2-dependent glycolytic and non-glycolytic pathways by ENO2 in head and neck cancer development
10.1186/s13046-022-02574-0 · ExternalCitation · doi-reference
PKM2-TMEM33 axis regulates lipid homeostasis in cancer cells by controlling SCAP stability
10.15252/embj.2021108065 · ExternalCitation · doi-reference
Bladder cancer
10.2139/ssrn.3372965 · ExternalCitation · doi-reference
USP21 deubiquitinates and stabilizes HSP90 and ENO1 to promote aerobic glycolysis and proliferation in cholangiocarcinoma
10.7150/ijbs.90774 · ExternalCitation · doi-reference
