Research graph
References from Inhibition of histone acetyltransferase KAT7 suppresses proliferation and migration of breast cancer cells. Local targets link to admitted publications; unresolved targets remain external evidence.
Exchange of associated factors directs a switch in Hbo1 acetyltransferase histone tail specificity
10.1101/gad.223396.113 · 2013 · External reference
Hbo1 is required for H3k14 acetylation and normal transcriptional activity during embryonic development
10.1128/mcb.00159-10 · 2011 · External reference
Histone acetyltransferase 7 (Kat7)-dependent intragenic histone acetylation regulates endothelial cell gene regulation
10.1074/jbc.ra117.001383 · 2018 · External reference
Hbo1/Kat7/Myst2 hat complex regulates human adenovirus replicative cycle
10.1016/j.heliyon.2024.e28827 · 2024 · External reference
Cell cycle-dependent chromatin shuttling of Hbo1-Jade1 histone acetyl transferase (Hat) complex
10.4161/cc.28759 · 2014 · External reference
Myst regulates DNA repair and forms a Nua4-like complex in the malaria parasite Plasmodium falciparum
10.1128/msphere.00140-24 · 2024 · External reference
Histone acetyltransferase Hbo1: catalytic activity, cellular abundance, and links to primary cancers
10.1016/j.gene.2009.01.020 · 2009 · External reference
Kat7 promoted gastric cancer progression through promoting Yap1 activation
10.1016/j.prp.2022.154020 · 2022 · External reference
High-expression Hbo1 predicts poor prognosis in gastric cancer
10.1093/ajcp/aqz065 · 2019 · External reference
Targeting Kat7 inhibits the progression of colorectal cancer
10.7150/thno.106085 · 2025 · External reference
Histone acetylation by Hbo1 (Kat7) activates Wnt/B-catenin signaling to promote leukemogenesis in B-cell acute lymphoblastic leukemia
10.1038/s41419-023-06019-0 · 2023 · External reference
Kat7 enhances the proliferation and metastasis of head and neck squamous carcinoma by promoting the acetylation level of Ldha
10.1016/j.canlet.2024.216869 · 2024 · External reference
Kat7-acetylated Ybx1 promotes hepatocellular carcinoma proliferation by reprogramming nucleotide metabolism
10.1186/s12885-025-13708-w · 2025 · External reference
Hbo1 induces histone acetylation and is important for non-small cell lung cancer cell growth
10.7150/ijbs.72526 · 2022 · External reference
Hbo1 promotes cell proliferation in bladder cancer via activation of Wnt/B-catenin signaling
10.1002/mc.22715 · 2018 · External reference
Expression profiles and functional prediction of histone acetyltransferases of the Myst family in kidney renal clear cell carcinoma
10.1186/s12885-023-11076-x · 2023 · External reference
Kat7 suppresses tumorigenesis in clear cell renal cell carcinoma (Ccrcc) by regulating cell cycle and ferroptosis sensitivity
10.1016/j.yexcr.2024.114149 · 2024 · External reference
Global patterns and trends in breast cancer incidence and mortality across 185 countries
10.1038/s41591-025-03502-3 · 2025 · External reference
Kat7 promotes radioresistance through upregulating Pi3k/Akt signaling in breast cancer
10.1093/jrr/rrac107 · 2023 · External reference
Genetic alterations and oncogenic pathways associated with breast cancer subtypes
10.1158/1541-7786.mcr-08-0107 · 2009 · External reference
Estrogen receptor A (Erα) mediates 17β-estradiol (E2)-activated expression of Hbo1
10.1186/1756-9966-29-140 · 2010 · External reference
Histone acetyltransferase Hbo1 destabilizes estrogen receptor A by ubiquitination and modulates proliferation of breast cancers
10.1111/cas.12303 · 2013 · External reference
Hbo1 is a cyclin E/Cdk2 substrate that enriches breast cancer stem-like cells
10.1158/0008-5472.can-13-0013 · 2013 · External reference
Gepia2: an enhanced web server for large-scale expression profiling and interactive analysis
10.1093/nar/gkz430 · 2019 · External reference
Intermittent hypoxia promotes Tam-induced glycolysis in laryngeal cancer cells via regulation of Hk1 expression through activation of Zbtb10
10.3390/ijms241914808 · 2023 · External reference
Global cancer statistics 2022: Globocan estimates of incidence and mortality worldwide for 36 cancers in 185 countries
10.3322/caac.21834 · 2024 · External reference
Breast cancer incidence and mortality in women in China: temporal trends and projections to 2030
10.20892/j.issn.2095-3941.2020.0523 · 2021 · External reference
Multifunctional acyltransferase Hbo1: a key regulatory factor for cellular functions
10.1186/s11658-024-00661-y · 2024 · External reference
Her2 expression in breast cancer: evidence gaps and challenges
10.1038/s41698-025-01209-9 · 2025 · External reference
Breast cancer subtypes and prognosis: answers to subgroup classification questions, identifying the worst subgroup in our single-center series
10.2147/bctt.s380754 · 2022 · External reference
Ki67 in breast cancer: prognostic and predictive potential
10.1016/s1470-2045(09)70262-1 · 2010 · External reference
High Ki-67 expression is associated with increased risk of distant recurrence in Oncotype Dx low risk breast cancer
10.1016/j.clbc.2025.04.001 · 2025 · External reference
Stem cell plasticity, acetylation of H3k14, and de novo gene activation rely on Kat7
10.1016/j.celrep.2022.111980 · 2023 · External reference
Hallmarks of cancer stemness
10.1016/j.stem.2024.04.004 · 2024 · External reference
Regulation of Kat6 acetyltransferases and their roles in cell cycle progression, stem cell maintenance, and human disease
10.1128/mcb.00055-16 · 2016 · External reference
Kat6 inhibitors under investigation for solid tumors: the preclinical and early phase progress
10.1080/13543784.2026.2634346 · 2026 · External reference
Author correction: Inhibition of lysine acetyltransferase Kat6 in Er(+)Her2(-) metastatic breast cancer: a phase 1 trial
10.1038/s41591-024-03129-w · 2024 · External reference
Kat6a and Kat7 histone acetyltransferase complexes are molecular dependencies and therapeutic targets in Nup98-rearranged acute myeloid leukemia
10.1158/2159-8290.cd-24-1772 · 2025 · External reference
Catalytic inhibition of Kat6/Kat7 enhances the efficacy and overcomes primary and acquired resistance to Menin inhibitors in Mll leukemia
10.1158/2159-8290.cd-24-1517 · 2025 · External reference
A first-in-class Hbo1 inhibitor Wm-3835 inhibits castration-resistant prostate cancer cell growth in vitro and in vivo
10.1038/s41419-023-05606-5 · 2023 · External reference
