Research graph
References from USP26-mediated stabilization of RAD51 promotes endometrial cancer progression and limits ferroptosis. Local targets link to admitted publications; unresolved targets remain external evidence.
Proteomic and functional characterization of intra-tumor heterogeneity in human endometrial cancer
10.1016/j.xcrm.2022.100738 · 2022 · External reference
Advances in the management of endometrial cancer
10.1136/bmj-2024-080978 · 2025 · External reference
Molecular classification of endometrial cancer and its impact on therapy selection
10.3390/ijms25115893 · 2024 · External reference
Lipid metabolism reprogramming in endometrial cancer: biological functions and therapeutic implications
10.1186/s12964-024-01792-7 · 2024 · External reference
Ferroptosis: an iron-dependent form of nonapoptotic cell death
10.1016/j.cell.2012.03.042 · 2012 · External reference
Ferroptosis: a regulated cell death nexus linking metabolism, redox biology, and disease
10.1016/j.cell.2017.09.021 · 2017 · External reference
Regulation of ferroptotic cancer cell death by GPX4
10.1016/j.cell.2013.12.010 · 2014 · External reference
Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice
10.1038/ncb3064 · 2014 · External reference
ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition
10.1038/nchembio.2239 · 2017 · External reference
Ferroptosis as a p53-mediated activity during tumour suppression
10.1038/nature14344 · 2015 · External reference
USP8-governed GPX4 homeostasis orchestrates ferroptosis and cancer immunotherapy
10.1073/pnas.2315541121 · 2024 · External reference
4EBP1-mediated SLC7A11 protein synthesis restrains ferroptosis triggered by MEK inhibitors in advanced ovarian cancer
10.1172/jci.insight.177857 · 2024 · External reference
PHLDA2-mediated phosphatidic acid peroxidation triggers a distinct ferroptotic response during tumor suppression
10.1016/j.cmet.2024.01.006 · 2024 · External reference
Turning off the ferroptosis switch: ACAA1-driven PI3K/AKT/Nrf2 signaling as a novel driver of endometrial cancer progression
10.1016/j.freeradbiomed.2025.09.054 · 2025 · External reference
Medroxyprogesterone acetate-resistant endometrial cancer cells are susceptible to ferroptosis inducers
10.1016/j.lfs.2023.121753 · 2023 · External reference
RAB17 promotes endometrial cancer progression by inhibiting TFRC-dependent ferroptosis
10.1038/s41419-024-07013-w · 2024 · External reference
Sodium butyrate induces ferroptosis in endometrial cancer cells via the RBM3/SLC7A11 axis
10.1007/s10495-023-01850-4 · 2023 · External reference
Small molecule MIF modulation enhances ferroptosis by impairing DNA repair mechanisms
10.1002/advs.202403963 · 2024 · External reference
RAD51 succinylation regulates homologous recombination and contributes to the chemosensitivity in cancer
10.1016/j.molcel.2026.01.020 · 2026 · External reference
TOPORS-mediated RAD51 SUMOylation facilitates homologous recombination repair
10.1093/nar/gkac009 · 2022 · External reference
A phosphorylation-deubiquitination cascade regulates the BRCA2-RAD51 axis in homologous recombination
10.1101/gad.289439.116 · 2016 · External reference
FBH1 influences DNA replication fork stability and homologous recombination through ubiquitylation of RAD51
10.1038/ncomms6931 · 2015 · External reference
RFWD3-mediated ubiquitination promotes timely removal of both RPA and RAD51 from DNA damage sites to facilitate homologous recombination
10.1016/j.molcel.2017.04.022 · 2017 · External reference
Acetylation-dependent deubiquitinase USP26 stabilizes BAG3 to promote breast cancer progression
10.1016/j.canlet.2024.217005 · 2024 · External reference
USP26 promotes colorectal cancer tumorigenesis by restraining PRKN-mediated mitophagy
10.1038/s41388-024-03009-0 · 2024 · External reference
USP26 as a hepatitis B virus-induced deubiquitinase primes hepatocellular carcinogenesis by epigenetic remodeling
10.1038/s41467-024-52201-z · 2024 · External reference
Machine learning-based classification of deubiquitinase USP26 and its cell proliferation inhibition through stabilizing KLF6 in cervical cancer
10.1016/j.compbiomed.2023.107745 · 2024 · External reference
An RNF12-USP26 amplification loop drives germ cell specification and is disrupted by disease-associated mutations
10.1126/scisignal.abm5995 · 2022 · External reference
USP26 promotes anaplastic thyroid cancer progression by stabilizing TAZ
10.1038/s41419-022-04781-1 · 2022 · External reference
RAD51-mediated homologous recombination is a pro-tumour driver pathway
10.1038/s41388-025-03583-x · 2025 · External reference
A novel small-molecule inhibitor GSK-F1 confers radiosensitivity by inhibiting the NSUN2/TP53/RAD51 axis-mediated DNA homologous recombination repair in nasopharyngeal carcinoma
10.7150/ijbs.130087 · 2026 · External reference
UHRF1 controls the timing of RAD51 removal during DNA damage repair through suppressing RFWD3
10.1002/advs.202509901 · 2025 · External reference
CircRAPGEF5 interacts with RBFOX2 to confer ferroptosis resistance by modulating alternative splicing of TFRC in endometrial cancer
10.1016/j.redox.2022.102493 · 2022 · External reference
Small molecule MIF modulation enhances ferroptosis by impairing DNA repair mechanisms
10.1002/advs.202403963 · ExternalCitation · doi-reference
UHRF1 controls the timing of RAD51 removal during DNA damage repair through suppressing RFWD3
10.1002/advs.202509901 · ExternalCitation · doi-reference
Sodium butyrate induces ferroptosis in endometrial cancer cells via the RBM3/SLC7A11 axis
10.1007/s10495-023-01850-4 · ExternalCitation · doi-reference
Acetylation-dependent deubiquitinase USP26 stabilizes BAG3 to promote breast cancer progression
10.1016/j.canlet.2024.217005 · ExternalCitation · doi-reference
Ferroptosis: an iron-dependent form of nonapoptotic cell death
10.1016/j.cell.2012.03.042 · ExternalCitation · doi-reference
Regulation of ferroptotic cancer cell death by GPX4
10.1016/j.cell.2013.12.010 · ExternalCitation · doi-reference
Ferroptosis: a regulated cell death nexus linking metabolism, redox biology, and disease
10.1016/j.cell.2017.09.021 · ExternalCitation · doi-reference
PHLDA2-mediated phosphatidic acid peroxidation triggers a distinct ferroptotic response during tumor suppression
10.1016/j.cmet.2024.01.006 · ExternalCitation · doi-reference
Machine learning-based classification of deubiquitinase USP26 and its cell proliferation inhibition through stabilizing KLF6 in cervical cancer
10.1016/j.compbiomed.2023.107745 · ExternalCitation · doi-reference
Turning off the ferroptosis switch: ACAA1-driven PI3K/AKT/Nrf2 signaling as a novel driver of endometrial cancer progression
10.1016/j.freeradbiomed.2025.09.054 · ExternalCitation · doi-reference
Medroxyprogesterone acetate-resistant endometrial cancer cells are susceptible to ferroptosis inducers
10.1016/j.lfs.2023.121753 · ExternalCitation · doi-reference
RFWD3-mediated ubiquitination promotes timely removal of both RPA and RAD51 from DNA damage sites to facilitate homologous recombination
10.1016/j.molcel.2017.04.022 · ExternalCitation · doi-reference
RAD51 succinylation regulates homologous recombination and contributes to the chemosensitivity in cancer
10.1016/j.molcel.2026.01.020 · ExternalCitation · doi-reference
CircRAPGEF5 interacts with RBFOX2 to confer ferroptosis resistance by modulating alternative splicing of TFRC in endometrial cancer
10.1016/j.redox.2022.102493 · ExternalCitation · doi-reference
Proteomic and functional characterization of intra-tumor heterogeneity in human endometrial cancer
10.1016/j.xcrm.2022.100738 · ExternalCitation · doi-reference
Ferroptosis as a p53-mediated activity during tumour suppression
10.1038/nature14344 · ExternalCitation · doi-reference
Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice
10.1038/ncb3064 · ExternalCitation · doi-reference
ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition
10.1038/nchembio.2239 · ExternalCitation · doi-reference
FBH1 influences DNA replication fork stability and homologous recombination through ubiquitylation of RAD51
10.1038/ncomms6931 · ExternalCitation · doi-reference
USP26 promotes colorectal cancer tumorigenesis by restraining PRKN-mediated mitophagy
10.1038/s41388-024-03009-0 · ExternalCitation · doi-reference
RAD51-mediated homologous recombination is a pro-tumour driver pathway
10.1038/s41388-025-03583-x · ExternalCitation · doi-reference
USP26 promotes anaplastic thyroid cancer progression by stabilizing TAZ
10.1038/s41419-022-04781-1 · ExternalCitation · doi-reference
RAB17 promotes endometrial cancer progression by inhibiting TFRC-dependent ferroptosis
10.1038/s41419-024-07013-w · ExternalCitation · doi-reference
USP26 as a hepatitis B virus-induced deubiquitinase primes hepatocellular carcinogenesis by epigenetic remodeling
10.1038/s41467-024-52201-z · ExternalCitation · doi-reference
USP8-governed GPX4 homeostasis orchestrates ferroptosis and cancer immunotherapy
10.1073/pnas.2315541121 · ExternalCitation · doi-reference
TOPORS-mediated RAD51 SUMOylation facilitates homologous recombination repair
10.1093/nar/gkac009 · ExternalCitation · doi-reference
A phosphorylation-deubiquitination cascade regulates the BRCA2-RAD51 axis in homologous recombination
10.1101/gad.289439.116 · ExternalCitation · doi-reference
An RNF12-USP26 amplification loop drives germ cell specification and is disrupted by disease-associated mutations
10.1126/scisignal.abm5995 · ExternalCitation · doi-reference
Advances in the management of endometrial cancer
10.1136/bmj-2024-080978 · ExternalCitation · doi-reference
4EBP1-mediated SLC7A11 protein synthesis restrains ferroptosis triggered by MEK inhibitors in advanced ovarian cancer
10.1172/jci.insight.177857 · ExternalCitation · doi-reference
Lipid metabolism reprogramming in endometrial cancer: biological functions and therapeutic implications
10.1186/s12964-024-01792-7 · ExternalCitation · doi-reference
Molecular classification of endometrial cancer and its impact on therapy selection
10.3390/ijms25115893 · ExternalCitation · doi-reference
A novel small-molecule inhibitor GSK-F1 confers radiosensitivity by inhibiting the NSUN2/TP53/RAD51 axis-mediated DNA homologous recombination repair in nasopharyngeal carcinoma
10.7150/ijbs.130087 · ExternalCitation · doi-reference
