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References from Targeting cancer hallmarks with microbiome-derived bacteriocins and postbiotics: molecular mechanisms and translational opportunities in oncology. Local targets link to admitted publications; unresolved targets remain external evidence.
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Changing profiles of cancer burden worldwide and in China: a secondary analysis of the global cancer statistics 2020
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Global, regional, and national lifetime risks of developing and dying from gastrointestinal cancers in 185 countries: a population-based systematic analysis of GLOBOCAN
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Global, regional, and national cancer incidence and death for 29 cancer groups in 2019 and trends analysis of the global cancer burden, 1990–2019
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Burden of six major types of digestive system cancers globally and in China
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Comprehensive overview of therapeutic strategies in colon cancer: chemotherapy, targeted therapy, and immunotherapy
10.1002/cbf.70196 · 2026 · External reference
Cutting-edge approaches for targeted drug delivery in breast cancer: beyond conventional therapies
10.1039/d4na00086b · 2024 · External reference
Breakthroughs in modern cancer therapy and elusive cardiotoxicity: critical research‐practice gaps, challenges, and insights
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Molecular mechanisms and therapeutic strategies in overcoming chemotherapy resistance in cancer
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10.3390/biomedicines12010183 · 2024 · External reference
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Drug resistance and cancer stem cells
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Drug-metabolizing enzymes: role in drug resistance in cancer
10.1007/s12094-020-02325-7 · 2020 · External reference
The role of ABC transporters in drug resistance, metabolism and toxicity
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Natural product based anticancer drug combination discovery assisted by deep learning and network analysis
10.3389/fntpr.2023.1309994 · 2024 · External reference
Rising above: exploring the therapeutic potential of natural product-based compounds in human cancer treatment
10.53388/tmr20240618001 · 2025 · External reference
Exploring natural products as apoptosis modulators in cancers: insights into natural product-based therapeutic strategies
10.1007/s00210-025-03876-8 · 2025 · External reference
Cheminformatics in natural product‐based drug discovery
10.1002/minf.202000171 · 2020 · External reference
Role of natural products in developing novel anticancer agents: a perspective
10.1002/cbdv.202200535 · 2022 · External reference
Microbes and cancer
10.1146/annurev-immunol-051116-052133 · 2017 · External reference
Microbes and cancer: friends or faux
10.3390/ijms21093115 · 2020 · External reference
Role of signaling pathways in the interaction between microbial, inflammation and cancer
10.1007/s44178-023-00064-7 · 2023 · External reference
Microbial and metabolic profiles unveil mutualistic microbe-microbe interaction in obesity-related colorectal cancer
10.1016/j.xcrm.2024.101429 · 2024 · External reference
Metabolic modeling of host–microbe interactions for therapeutics in colorectal cancer
10.1038/s41540-021-00210-9 · 2022 · External reference
The interaction between microbes and cytokines in cancer: unraveling the underlying effects
10.1186/s12967-026-08174-2 · 2026 · External reference
Microbial interactions and interventions in colorectal cancer
10.1128/9781555819705.ch4 · 2018 · External reference
Cancer-promoting effects of microbial dysbiosis
10.1007/s11912-014-0406-0 · 2014 · External reference
Crosstalk between intratumoral microbes and tumor immunity: implications for tumor therapy
10.1002/cam4.71575 · 2026 · External reference
Metabolic interactions: how gut microbial metabolites influence colorectal cancer
10.3389/fmicb.2025.1611698 · 2025 · External reference
Efficacy of probiotics, paraprobiotics, and postbiotics in colorectal cancer cell line and their role in immune response
10.1590/1806-9282.20240226 · 2024 · External reference
Lactic acid bacteria-derived postbiotics as adjunctive agents in breast cancer treatment to boost the antineoplastic effect of a conventional therapeutic comprising tamoxifen and a new drug candidate: an aziridine–hydrazide hydrazone derivative
10.3390/molecules29102292 · 2024 · External reference
Anticarcinogenic potential of probiotic, postbiotic metabolites and paraprobiotics on human cancer cells
10.1007/978-981-16-0223-8_6 · 2021 · External reference
Human commensal bacteria: next-generation pro-and post-biotics for anticancer therapy
10.31083/fbe26809 · 2025 · External reference
Recent advances in the area of plant-based anti-cancer drug discovery using computational approaches
10.1007/s11030-022-10590-7 · 2024 · External reference
Discovering anti-cancer drugs via computational methods
10.3389/fphar.2020.00733 · 2020 · External reference
Computational drug discovery of medicinal compounds for cancer management
10.3389/978-2-8325-4180-7 · 2023 · External reference
Computational approaches: a new frontier in cancer research
10.2174/0113862073265604231106112203 · 2024 · External reference
Anticancer drug discovery based on natural products: from computational approaches to clinical studies
10.3390/biomedicines12010201 · 2024 · External reference
Circular and leaderless bacteriocins: biosynthesis, mode of action, applications, and prospects
10.3389/fmicb.2018.02085 · 2018 · External reference
Quorum sensing circuits in the communicating mechanisms of bacteria and its implication in the biosynthesis of bacteriocins by lactic acid bacteria: a review
10.1007/s12602-019-09555-4 · 2020 · External reference
The microbiome-shaping roles of bacteriocins
10.1038/s41579-021-00569-w · 2021 · External reference
Lactic acid bacteria bacteriocins: classification, biosynthesis, health benefits, and strategies for enhanced efficacy
10.1021/acs.jafc.5c14047 · 2026 · External reference
Bacteriocins of lactic acid bacteria: extending the family
10.1007/s00253-016-7343-9 · 2016 · External reference
Pediocin‐like antimicrobial peptides (class IIa bacteriocins) and their immunity proteins: biosynthesis, structure, and mode of action
10.1002/psc.699 · 2005 · External reference
Peptide bacteriocins-structure activity relationships
10.2174/1568026615666150812121103 · 2016 · External reference
Structural features, mechanisms of action, and prospects for practical application of class II bacteriocins
10.1134/s0006297922110165 · 2022 · External reference
Structure-function relationships of the non-lanthionine-containing peptide (class II) bacteriocins produced by gram-positive bacteria
10.2174/138920109787048661 · 2009 · External reference
Structural basis of the immunity mechanisms of pediocin-like bacteriocins
10.1128/aem.00481-22 · 2022 · External reference
Structural basis of the mechanisms of action and immunity of lactococcin A, a class IId bacteriocin
10.1128/aem.00066-23 · 2023 · External reference
Recent insights into structure–function relationships of antimicrobial peptides
10.1111/jfbc.12546 · 2019 · External reference
Pediocin-like bacteriocins: new perspectives on mechanism of action and immunity
10.1007/s00294-017-0757-9 · 2018 · External reference
Antioxidant and antimicrobial activity of bacteriocin-producing strains of lactic acid bacteria isolated from the human gastrointestinal tract
10.23751/pn.v19i1.5147 · 2017 · External reference
Effect of crude bacteriocin isolated from locally Lactococcus lactis on cancer cell lines
10.37506/ijfmt.v14i1.57 · 2020 · External reference
Bacteriocins as potential therapeutic approaches in the treatment of various cancers: a review of in vitro studies
10.3390/cancers14194758 · 2022 · External reference
Use of bacteriocins and bacteriocinogenic beneficial organisms in food products: benefits, challenges, concerns
10.3390/foods11193145 · 2022 · External reference
Emerging lactic acid bacteria bacteriocins as anti-cancer and anti-tumor agents for human health
10.1016/j.heliyon.2024.e37054 · 2024 · External reference
Bacteriocins in cancer treatment: mechanisms and clinical potentials
10.3390/biom14070831 · 2024 · External reference
Bacterial peptides and bacteriocins as novel treatment for prostate cancer
10.1007/s10989-023-10544-z · 2023 · External reference
Postbiotics combination synergises the antiproliferative effects of doxorubicin in gastric cancer cells: a cellular and molecular deep dive
10.3390/ijms27010362 · 2025 · External reference
A natural metabolite, nuevamine alkaloid: synthesis, in vitro anticancer, wound healing, DFT and molecular docking studies
10.1016/j.prenap.2026.100797 · 2026 · External reference
Gut microbial postbiotics as potential therapeutics for lymphoma: proteomics insights of the synergistic effects of nisin and urolithin B against human lymphoma cells
10.3390/ijms26146829 · 2025 · External reference
Postbiotics in colorectal cancer: intervention mechanisms and perspectives
10.3389/fmicb.2024.1360225 · 2024 · External reference
Bio‐inspired smart elastin‐like polypeptides (ELPs) for precision drug delivery: molecular strategies, thermal responsiveness, and translational advances
10.1002/adhm.202504112 · 2026 · External reference
Postbiotics: emerging bioactive agents in cancer therapy
10.20892/j.issn.2095-3941.2025.0511 · 2026 · External reference
Postbiotic metabolites produced by Lactobacillus plantarum strains exert selective cytotoxicity effects on cancer cells
10.1186/s12906-019-2528-2 · 2019 · External reference
Using postbiotics from functional foods for managing colorectal cancer: mechanisms, sources, therapeutic potential, and clinical perspectives
10.3390/microorganisms13061335 · 2025 · External reference
Postbiotics, metabolic signaling, and cancer
10.3390/molecules26061528 · 2021 · External reference
Bacteriocin diversity, function, discovery and application as antimicrobials
10.1038/s41579-024-01045-x · 2024 · External reference
Postbiotics as promising tools for cancer adjuvant therapy
10.34172/apb.2021.007 · 2020 · External reference
Investigating postbiotics as innovative adjuvants: deciphering the gut-breast connection in breast cancer therapy, from gut microbiome to personalized medicine
10.1007/s11033-025-10626-9 · 2025 · External reference
Natural bioactive compounds targeting FABP4 in adipogenesis and obesity: evidence from in vitro and in vivo studies
10.3390/ijms27031306 · 2026 · External reference
Harnessing honey bee venom for breast cancer treatment: from molecular insights to nano formulations
10.1016/j.ntm.2026.100120 · 2026 · External reference
Postbiotics and phage synergy in precision oral microbiome engineering: systems biology strategies targeting Streptococcus mutans in dental caries
10.3389/fmolb.2026.1766853 · 2026 · External reference
Human microbiota peptides: important roles in human health
10.1039/d4np00042k · 2025 · External reference
Signaling pathways that control cell proliferation
10.1101/cshperspect.a008904 · 2013 · External reference
From signalling pathways to targeted therapies: unravelling glioblastoma’s secrets and harnessing two decades of progress
10.1038/s41392-023-01637-8 · 2023 · External reference
Targeting Lactobacillus plantarum metabolites to brain cancer cell line pathway
10.21608/ejmm.2026.463892.2146 · 2026 · External reference
Targeting compensatory proliferation signals in oral cancer
10.1016/j.jobcr.2024.05.014 · 2024 · External reference
Cadmium-induced hepatotoxicity: interconnecting molecular and cellular pathways
10.1016/j.tox.2026.154475 · 2026 · External reference
Overcoming resistance to apoptosis in cancer therapy
10.1007/978-1-4020-6554-5_6 · 2008 · External reference
Cancer-associated inflammation: pathophysiology and clinical significance
10.1007/s00432-022-04399-y · 2023 · External reference
Broad targeting of resistance to apoptosis in cancer
10.1016/j.semcancer.2015.03.001 · 2015 · External reference
Targeting mitochondrial apoptosis to overcome treatment resistance in cancer
10.3390/cancers12030574 · 2020 · External reference
Enhanced biomineralization and bone apatite growth formation capacity of chitosan-based electrospun scaffold for bone tissue engineering application
10.1142/s1793984425500059 · 2026 · External reference
Deciphering autophagy-metabolism interactions in cancer drug resistance: a comprehensive review
10.1007/s00280-026-04894-w · 2026 · External reference
Lactobacillus plantarum and its derived bacteriocin exhibits potent antitumor activity against esophageal cancer cells
10.3389/fmicb.2023.1306192 · 2024 · External reference
Postbiotic production: harnessing the power of microbial metabolites for health applications
10.3389/fmicb.2023.1306192 · 2023 · External reference
Targeting inflammation and immune regulation in chronic inflammation associated cancers
10.1111/cas.70360 · 2026 · External reference
Salivary biomarkers and their diagnostic importance in oral diseases
10.1016/j.archoralbio.2026.106595 · 2026 · External reference
Bacteriocins: perspective for the development of novel anticancer drugs
10.1007/s00253-018-9420-8 · 2018 · External reference
Natural resources in oral healthcare: therapeutic potential, clinical evidence, and translational challenges — a scoping review
10.1177/1934578x261449325 · 2026 · External reference
Recombinant bacteriocin rhamnosin suppresses Malignant phenotypes of colorectal cancer cells
10.48048/tis.2025.10057 · 2025 · External reference
Cyanobacterial fatty acid esters disrupt polymicrobial oral biofilms and exhibit potential interactions with adhesion proteins and virulence-associated targets
10.1016/j.archoralbio.2026.106666 · 2026 · External reference
Application of molecular dynamics simulation in self-assembled cancer nanomedicine
10.1186/s40824-023-00386-7 · 2023 · External reference
Targeting glutaminase by natural compounds: structure-based virtual screening and molecular dynamics simulation approach to suppress cancer progression
10.3390/molecules27155042 · 2022 · External reference
Synthesis, characterization, molecular docking and molecular dynamics simulations of benzamide derivatives as potential anti-ovarian cancer agents
10.1016/j.molstruc.2022.133785 · 2022 · External reference
Bacteriocins as natural weapon against cancer: in vitro, in vivo, and in silico perspectives
10.1007/s42452-025-06929-y · 2025 · External reference
Promising future of engineered probiotics for antimicrobial peptides and protein production: prospects and industrial challenges
10.1007/s12602-025-10883-x · 2025 · External reference
Lactic acid bacteria-derived bacteriocins: a promising antimicrobial strategy against multidrug-resistant for neonatal sepsis pathogens
10.1007/s12602-026-10934-x · 2026 · External reference
Commercial utilization of bacteriocins: tackling challenges and exploring their potential as alternatives to antibiotics
10.1080/17460913.2025.2520693 · 2025 · External reference
Bacteriocins in the era of antibiotic resistance: rising to the challenge
10.3390/pharmaceutics13020196 · 2021 · External reference
Assessing the efficacy of postbiotics derived from Lactobacillus plantarum on antibiotic resistance genes in nosocomial pathogens such as Enterococcus faecalis and Pseudomonas aeruginosa
10.1093/lambio/ovae127 · 2024 · External reference
Effect of bacteriocin-like inhibitory substance (BLIS) from Enterococcus faecium DB1 on cariogenic Streptococcus mutans biofilm formation
10.5851/kosfa.2022.e49 · 2022 · External reference