References

Metastasis

10.1016/j.cell.2023.03.003 · 2023 · External reference

Cancer metastasis: therapeutic challenges and opportunities

10.1007/s12032-025-03072-x · 2025 · External reference

Migrastatics—anti-metastatic and anti-invasion drugs: promises and challenges

10.1016/j.trecan.2017.04.008 · 2017 · External reference

Metastasis initiating cells and ecosystems

10.1158/2159-8290.cd-21-0010 · 2021 · External reference

Combination therapy in combating cancer

10.18632/oncotarget.16723 · 2017 · External reference

Dissecting cytoskeletal crosstalk through reconstituted actin–microtubule systems

10.1091/mbc.e25-08-0396 · 2026 · External reference

Biochemical and mechanical regulation of actin dynamics

10.1038/s41580-022-00508-4 · 2022 · External reference

Mechanisms of actin disassembly and turnover

10.1083/jcb.202309021 · 2023 · External reference

Actin filament dynamics at barbed ends: new structures, new insights

10.1016/j.ceb.2024.102419 · 2024 · External reference

Roles of cytoskeleton in metastasis: from its mechanism to therapeutic strategies

10.1038/s12276-025-01608-9 · 2026 · External reference

Matrix mechano-sensing at the invasive front induces a cytoskeletal and transcriptional memory supporting metastasis

10.1038/s41467-025-56299-7 · 2025 · External reference

Early events in actin cytoskeleton dynamics and E-cadherin-mediated cell-cell adhesion during epithelial-mesenchymal transition

10.3390/cells9030578 · 2020 · External reference

Phenotypic plasticity of cancer cells based on remodeling of the actin cytoskeleton and adhesive structures

10.3390/ijms22041821 · 2021 · External reference

Invadopodia in cancer metastasis: dynamics, regulation, and targeted therapies

10.1186/s12967-025-06526-y · 2025 · External reference

Secretion of active membrane type 1 matrix metalloproteinase (MMP-14) into extracellular space in microvesicular exosomes

10.1002/jcb.21923 · 2008 · External reference

The molecular mechanisms of transition between mesenchymal and amoeboid invasiveness in tumor cells

10.1007/s00018-009-0132-1 · 2010 · External reference

Rho-associated coiled-coil containing kinases (ROCK): structure, regulation, and functions

10.4161/sgtp.29846 · 2014 · External reference

Mechanisms of 3D cell migration

10.1038/s41580-019-0172-9 · 2019 · External reference

Invadopodia are required for cancer cell extravasation and are a therapeutic target for metastasis

10.1016/j.celrep.2014.07.050 · 2014 · External reference

Notch-1 signaling promotes reattachment of suspended cancer cells by cdc42-dependent microtentacles formation

10.1111/cas.15146 · 2021 · External reference

Crossing the endothelial barrier during metastasis

10.1038/nrc3628 · 2013 · External reference

Fluid shear stress regulates the survival of circulating tumor cells via nuclear expansion

10.1242/jcs.259586 · 2022 · External reference

Are we ready for migrastatics

10.3390/cells10081845 · 2021 · External reference

Engine shutdown: migrastatic strategies and prevention of metastases

10.1016/j.trecan.2023.01.001 · 2023 · External reference

Unresolved reference

External reference

Educate, not kill: treating cancer without triggering its defenses

10.1016/j.molmed.2024.04.003 · 2024 · External reference

Editorial: therapy-induced metastasis

10.1007/s10585-018-9914-x · 2018 · External reference

Association of granulocyte colony-stimulating factor treatment with risk of brain metastasis in advanced stage breast cancer

10.3390/ijms251910756 · 2024 · External reference

A phase II study of paclitaxel, carboplatin, and hyperfractionated radiation therapy for locally advanced inoperable non-small-cell lung cancer (a Vanderbilt Cancer Center Affiliate Network Study)

10.1016/s0360-3016(00)00420-x · 2000 · External reference

Zampanolide, a microtubule-stabilizing agent, is active in resistant cancer cells and inhibits cell migration

10.3390/ijms18050971 · 2017 · External reference

In vivo evaluation of (-)-zampanolide demonstrates potent and persistent antitumor efficacy when targeted to the tumor site

10.3390/molecules27134244 · 2022 · External reference

Microtubule-targeting agents and their impact on cancer treatment

10.1016/j.ejcb.2020.151075 · 2020 · External reference

Microtubule targeting agents in disease: classic drugs, novel roles

10.3390/cancers13225650 · 2021 · External reference

Recent advances in microtubule targeting agents for cancer therapy

10.3390/molecules30163314 · 2025 · External reference

Spontaneous migration of cancer cells under conditions of mechanical confinement

10.1039/b908595e · 2009 · External reference

Vincetoxicum arnottianum modulates motility features and metastatic marker expression in pediatric rhabdomyosarcoma by stabilizing the actin cytoskeleton

10.1186/s12906-021-03299-x · 2021 · External reference

Bj-PRO-10c, as an allosteric regulator of argininosuccinate synthase, is a potential therapy for neuroblastoma metastasis

10.1016/j.toxicon.2023.107228 · 2023 · External reference

Design and synthesis of ROCK2-selective inhibitors bearing 6-indazolamino-2-pyrrolidinylpyridine for the treatment of breast cancer metastasis

10.1016/j.bioorg.2025.108862 · 2025 · External reference

Rho kinase inhibitors block melanoma cell migration and inhibit metastasis

10.1158/0008-5472.can-14-2156 · 2015 · External reference

Cytochalasin inhibits the rate of elongation of actin filament fragments

10.1083/jcb.83.3.657 · 1979 · External reference

Mechanism of action of cytochalasin B on actin

10.1016/0092-8674(80)90619-4 · 1980 · External reference

Cytochalasin B slows but does not prevent monomer addition at the barbed end of the actin filament

10.1083/jcb.102.1.282 · 1986 · External reference

Effects of cytochalasin and phalloidin on actin

10.1083/jcb.105.4.1473 · 1987 · External reference

The potential of cytochalasins and other cytochalasans as drugs targeting cancer cell invasiveness and metastasis

10.1016/j.ejmech.2025.118502 · 2026 · External reference

Cytochalasin D promotes pulmonary metastasis of B16 melanoma through expression of tissue factor

10.3892/or.2013.2423 · 2013 · External reference

Cytochalasins suppress 3D migration of ECM-embedded tumoroids at non-toxic concentrations

10.3390/ijms26147021 · 2025 · External reference

NQO1-responsive prodrug for in cellulo release of cytochalasin B as cancer cell-targeted migrastatic

10.1002/smll.202410861 · 2026 · External reference

Immune cell migration to cancer

10.3390/cells13100844 · 2024 · External reference

Rescuing dendritic cell interstitial motility sustains antitumour immunity

10.1038/s41586-025-09202-9 · 2025 · External reference

Migrating into the tumor: a roadmap for T cells

10.1016/j.trecan.2017.09.006 · 2017 · External reference

The role of the immune tumor microenvironment in shaping metastatic dissemination, dormancy, and outgrowth

10.1016/j.tcb.2025.05.006 · 2026 · External reference

Inhibition of MMPs supports amoeboid angiogenesis hampering VEGF-targeted therapies via MLC and ERK 1/2 signaling

10.1186/s12967-023-03954-6 · 2023 · External reference

Rac1 and RhoA: Networks, loops and bistability

10.1080/21541248.2016.1224399 · 2016 · External reference

Bistability in the Rac1, PAK, and RhoA signaling network drives actin cytoskeleton dynamics and cell motility switches

10.1016/j.cels.2016.01.003 · 2016 · External reference

FDA approval: ado-trastuzumab emtansine for the treatment of patients with HER2-positive metastatic breast cancer

10.1158/1078-0432.ccr-14-0012 · 2014 · External reference

Cyclodextrin-based metal–organic framework as an application platform for bioactive ruthenium(III) complexes

10.1021/acs.inorgchem.5c00813 · 2025 · External reference

Translation in solid cancer: are size‐based response criteria an anachronism

10.1007/s12094-014-1207-5 · 2015 · External reference

Drugs for solid cancer: the productivity crisis prompts a rethink

10.2147/ott.s45177 · 2013 · External reference

A preclinical pipeline to evaluate migrastatics as therapeutic agents in metastatic melanoma

10.1038/s41416-021-01442-6 · 2021 · External reference

Enhanced paclitaxel oral delivery by astragalus polysaccharide-based nanoplatform for triple-negative breast cancer treatment

10.1016/j.nano.2026.102947 · 2026 · External reference

Synthesis, screening and characterization of novel potent Arp2/3 inhibitory compounds analogous to CK-666

10.3389/fphar.2022.896994 · 2022 · External reference

CK-666 and CK-869 differentially inhibit Arp2/3 iso-complexes

10.1038/s44319-024-00201-x · 2024 · External reference

Identification and characterization of a small molecule inhibitor of formin-mediated actin assembly

10.1016/j.chembiol.2009.10.006 · 2009 · External reference

Investigating mammalian formins with SMIFH2 fifteen years in: novel targets and unexpected biology

10.3390/ijms24109058 · 2023 · External reference

Unresolved reference

2026 · External reference

Adenomatous polyposis coli protein nucleates actin assembly and synergizes with the formin mDia1

10.1083/jcb.201001016 · 2010 · External reference

Adenomatous polyposis coli nucleates actin assembly to drive cell migration and microtubule-induced focal adhesion turnover

10.1083/jcb.201702007 · 2017 · External reference

Cytoskeletal control and Wnt signaling—APC’s dual contributions in stem cell division and colorectal cancer

10.3390/cancers12123811 · 2020 · External reference

APC-driven actin nucleation powers collective cell dynamics in colorectal cancer cells

10.1016/j.isci.2023.106583 · 2023 · External reference

Tumor invasiveness is regulated by the concerted function of APC, formins, and Arp2/3 complex

10.1016/j.isci.2024.109687 · 2024 · External reference

Selective targeting of mutant adenomatous polyposis coli (APC) in colorectal cancer

10.1126/scitranslmed.aaf8127 · 2016 · External reference

Cholesterol depletion by TASIN-1 induces apoptotic cell death through the ER stress/ROS/JNK signaling in colon cancer cells

10.1158/1535-7163.mct-17-0887 · 2018 · External reference

New zampanolide mimics: design, synthesis, and antiproliferative evaluation

10.3390/molecules25020362 · 2020 · External reference

Unresolved reference

External reference

Proliferation, migration and invasion of human glioma cells exposed to paclitaxel (Taxol) in vitro

10.1038/bjc.1997.298 · 1997 · External reference

EB1 and cytoplasmic dynein mediate protrusion dynamics for efficient 3-dimensional cell migration

10.1096/fj.201700444rr · 2018 · External reference

Unresolved reference

External reference

Docetaxel combined with targeted therapies in metastatic breast cancer

10.1016/j.ctrv.2011.08.001 · 2012 · External reference

Unresolved reference

External reference

The cytochalasans: potent fungal natural products with application from bench to bedside

10.1039/d4np00076e · 2025 · External reference

Synthesis of cytochalasan analogues with aryl substituents at position 10

10.1039/d4ob00634h · 2024 · External reference

Performance of a label-free image-based 2D scratch wound healing assay to monitor cell migration and its inhibition

External reference

Differential interference with actin-binding protein function by acute cytochalasin B

10.1016/j.cub.2025.08.023 · 2025 · External reference

Design and synthesis of actin-targeting 10-phenoxy cytochalasan analogues: balancing cytotoxicity and migrastatic activity

10.1021/acsmedchemlett.5c00629 · 2026 · External reference