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References from Advances in protein microarray–based proteomics for gastric cancer applications in biomarker discovery, molecular subtyping, and precision oncology. Local targets link to admitted publications; unresolved targets remain external evidence.
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Current treatment and recent progress in gastric cancer
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Advanced gastric cancer: Current treatment landscape and future perspectives
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Japanese gastric cancer treatment guidelines 2025 (7th edition)
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Screening of gastric cancer: Who, when, and how
10.1016/j.cgh.2013.09.064 · 2014 · External reference
Gastric cancer: A review
10.1001/jama.2025.20034 · 2026 · External reference
Clinical significance of serum tumor markers for gastric cancer: A systematic review of literature by the task force of the Japanese Gastric Cancer Association
10.1007/s10120-013-0259-5 · 2014 · External reference
Comparative study of CEA and CA19-9 in esophageal, gastric and colon cancers individually and in combination (Roc curve analysis)
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Limited usefulness of serum carcinoembryonic antigen and carbohydrate antigen 19-9 levels for gastrointestinal and whole-body cancer screening
10.1038/s41598-020-75319-8 · 2020 · External reference
Carcinoembryonic antigen as a marker for colorectal cancer: Is it clinically useful
10.1093/clinchem/47.4.624 · 2001 · External reference
Carcinoembryonic antigen, a human tumor marker, functions as an intercellular adhesion molecule
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Cell adhesion activity of non-specific cross-reacting antigen (Nca) and carcinoembryonic antigen (CEA) expressed on Cho cell surface: Homophilic and heterophilic adhesion
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Difference in prognostic value between sialyl Lewis(a) and sialyl Lewis(X) antigen levels in the preoperative serum of gastric cancer patients
10.1097/00004836-200204000-00005 · 2002 · External reference
Carbohydrate antigen sialyl Lewis a--its pathophysiological significance and induction mechanism in cancer progression
2007 · External reference
Comparison of serum CA72-4, CEA, TPA, CA19-9 and CA125 levels in gastric cancer patients and correlation with recurrence
2002 · External reference
Clinical significance and prognostic value of CA72-4 compared with CEA and CA19-9 in patients with gastric cancer
10.1155/2000/595492 · 2000 · External reference
A well-known marker for predicting peritoneal metastasis in gastric cancer: Carbohydrate antigen 125
10.24875/ciru.230005371 · 2026 · External reference
Diagnostic laparoscopy, serum CA125, and peritoneal metastasis in gastric cancer
10.1055/s-2002-33228 · 2002 · External reference
The combination of CA125, CA19-9, CEA, and AFP is an effective diagnostic biomarker for gastric cancer in elderly individuals
10.1186/s12957-025-03789-z · 2025 · External reference
Evaluation of the value of combined detection of tumor markers CA72-4, carcinoembryonic antigen, CA24-2, and CA19-9 in gastric cancer
10.4251/wjgo.v16.i5.1737 · 2024 · External reference
Clinical significance and diagnostic value of serum CEA, CA19-9 and CA72-4 in patients with gastric cancer
10.18632/oncotarget.10391 · 2016 · External reference
CA72-4 combined with CEA, CA125 and CAl9-9 improves the sensitivity for the early diagnosis of gastric cancer
10.1016/j.cca.2014.07.034 · 2014 · External reference
Serum biomarker panels for diagnosis of gastric cancer
10.2147/ott.s86139 · 2016 · External reference
Serum biomarker panels for the diagnosis of gastric cancer
10.1002/cam4.2055 · 2019 · External reference
Combination detection of IgG- and IgA-related autoantibodies for the early diagnosis of gastric cancer
10.1177/18758592251363414 · 2025 · External reference
Discovery and validation of serum autoantibodies against tumor-associated antigens as biomarkers in gastric adenocarcinoma based on the focused protein arrays
10.14309/ctg.0000000000000284 · 2020 · External reference
Identification of serum biomarkers for gastric cancer diagnosis using a human proteome microarray
10.1074/mcp.m115.051250 · 2016 · External reference
An integrated transcriptomic and computational analysis for biomarker identification in gastric cancer
10.1093/nar/gkq960 · 2011 · External reference
Integrative proteogenomics maps multifactorial aetiology, progression and therapeutic vulnerabilities in gastric cancer
10.1136/gutjnl-2025-337247 · 2026 · External reference
Identification of multiomics and immune infiltration-associated biomarkers for early gastric cancer: A machine learning-based diagnostic model development study
10.1186/s12885-025-14396-2 · 2025 · External reference
Detection and localization of surgically resectable cancers with a multi-analyte blood test
10.1126/science.aar3247 · 2018 · External reference
New blood markers detection technology: A leap in the diagnosis of gastric cancer
10.3748/wjg.v22.i3.1202 · 2016 · External reference
Novel biomarkers for early detection of gastric cancer
10.3748/wjg.v29.i17.2515 · 2023 · External reference
Emerging blood-based biomarkers for detection of gastric cancer
10.3748/wjg.v21.i41.11636 · 2015 · External reference
Comprehensive molecular characterization of gastric adenocarcinoma
10.1038/nature13480 · 2014 · External reference
Molecular analysis of gastric cancer identifies subtypes associated with distinct clinical outcomes
10.1038/nm.3850 · 2015 · External reference
A liquid biopsy signature for the early detection of gastric cancer in patients
10.1053/j.gastro.2023.02.044 · 2023 · External reference
Insights into the regulation of protein abundance from proteomic and transcriptomic analyses
10.1038/nrg3185 · 2012 · External reference
Antibody arrays--an emerging tool in cancer proteomics
10.1016/j.biocel.2007.04.029 · 2007 · External reference
Protein microarrays for personalized medicine
10.1373/clinchem.2009.137158 · 2010 · External reference
Mass-spectrometric exploration of proteome structure and function
10.1038/nature19949 · 2016 · External reference
An array of possibilities in cancer research using cytokine antibody arrays
10.1586/14789450.4.2.299 · 2007 · External reference
Oncoproteomic profiling with antibody microarrays
10.1186/gm68 · 2009 · External reference
Mechanisms of therapy resistance in the tumor microenvironment: Insights from antibody array-based cytokine profiling
10.1016/j.drup.2026.101378 · 2026 · External reference
Mass spectrometry-based proteomics to study gastric carcinogenesis: Pathophysiological molecular characterization
10.1038/s41598-026-45298-3 · 2026 · External reference
Plasma proteomics-based liquid biopsy for predicting efficacy of PD-1-based immunochemotherapy in advanced gastric cancer: A prospective cohort study
10.1186/s43556-026-00510-8 · 2026 · External reference
Revisiting biomarker discovery by plasma proteomics
10.15252/msb.20156297 · 2017 · External reference
Identification of a high molecular weight kininogen fragment as a marker for early gastric cancer by serum proteome analysis
10.1007/s00535-010-0369-3 · 2011 · External reference
Data-independent acquisition mass spectrometry identification of extracellular vesicle biomarkers for gastric adenocarcinoma
10.3389/fonc.2022.1051450 · 2022 · External reference
Plasma proteome profiling to assess human health and disease
10.1016/j.cels.2016.02.015 · 2016 · External reference
Sample preparation of human serum for the analysis of tumor markers. Comparison of different approaches for albumin and gamma-globulin depletion
10.1016/s0021-9673(03)00921-x · 2003 · External reference
Characterization of the low molecular weight human serum proteome
10.1074/mcp.m300031-mcp200 · 2003 · External reference
Secretome analysis using affinity proteomics and immunoassays: A focus on tumor biology
10.1016/j.mcpro.2024.100830 · 2024 · External reference
Proteomics technologies for cancer liquid biopsies
10.1186/s12943-022-01526-8 · 2022 · External reference
Antibody arrays: Technical considerations and clinical applications in cancer
10.1373/clinchem.2005.059592 · 2006 · External reference
Plasma proteomic signatures improve risk stratification and personalized screening for gastric cancer
10.1007/s10120-026-01749-4 · 2026 · External reference
Methods and applications of antibody microarrays in cancer research
10.1002/pmic.200300595 · 2003 · External reference
Multiplexed protein measurement: Technologies and applications of protein and antibody arrays
10.1038/nrd2006 · 2006 · External reference
Antibody array-based technologies for cancer protein profiling and functional proteomic analyses using serum and tissue specimens
10.1007/s13277-009-0014-z · 2010 · External reference
Protein microarrays: Promising tools for proteomic research
10.1002/pmic.200300600 · 2003 · External reference
Antibody arrays in biomarker discovery
10.1016/bs.acc.2015.01.002 · 2015 · External reference
IL-1β-associated NNt acetylation orchestrates iron-sulfur cluster maintenance and cancer immunotherapy resistance
10.1016/j.molcel.2023.05.011 · 2023 · External reference
Overview of protein microarrays
10.1002/0471140864.ps2701s72 · 2013 · External reference
Unraveling tumor cell-tumor microenvironment crosstalk through antibody array technologies (review)
10.3892/ijo.2025.5787 · 2025 · External reference
Protein microarrays as an application for disease biomarkers
10.1002/prca.200800149 · 2009 · External reference
The promise of cytokine antibody arrays in the drug discovery process
10.1517/14728222.9.3.601 · 2005 · External reference
A biotin label-based antibody array for high-content profiling of protein expression
10.1158/1538-7445.am10-4625 · 2010 · External reference
Applications of antibody array platforms
10.1016/j.copbio.2006.06.013 · 2006 · External reference
Utility of reverse phase protein arrays: Applications to signalling pathways and human body arrays
10.1093/bfgp/1.3.305 · 2002 · External reference
Reverse phase protein microarrays which capture disease progression show activation of pro-survival pathways at the cancer invasion front
10.1038/sj.onc.1204265 · 2001 · External reference
Applications of protein microarrays for biomarker discovery
10.1002/prca.200800032 · 2008 · External reference
Harnessing the potential of reverse-phase protein array technology: Advancing precision oncology strategies
10.1111/cas.16123 · 2024 · External reference
Validation of reverse phase protein array for practical screening of potential biomarkers in serum and plasma: Accurate detection of CA19-9 levels in pancreatic cancer
10.1002/pmic.200700951 · 2008 · External reference
The screening and analysis of protein signatures and signaling associated with chemoresistance based on protein pathway array technology in gastric cancer
10.3892/or.2017.6078 · 2018 · External reference
A protein expression atlas on tissue samples and cell lines from cancer patients provides insights into tumor heterogeneity and dependencies
10.1038/s43018-024-00817-x · 2024 · External reference
Integrated multi-omics analyses on patient-derived CRC organoids highlight altered molecular pathways in colorectal cancer progression involving PTEN
10.1186/s13046-021-01986-8 · 2021 · External reference
Discovery and validation of an inflammatory protein-driven gastric cancer signature (Inprogas) using antibody microarray-based oncoproteomics
10.18632/oncotarget.1879 · 2014 · External reference
Current applications of antibody microarrays
10.1186/s12014-018-9184-2 · 2018 · External reference
Uncovering the depths of the human proteome: Antibody-based technologies for ultrasensitive multiplexed protein detection and quantification
10.1016/j.mcpro.2021.100155 · 2021 · External reference
Expression profile of cytokines in gastric cancer patients using proteomic antibody microarray
10.3892/ol.2017.7104 · 2017 · External reference
Antibody-based proteomics: Fast-tracking molecular diagnostics in oncology
10.1038/nrc2902 · 2010 · External reference
Screening of novel serum biomarkers for gastric cancer in coastal populations using a protein microarray
10.1111/cas.15876 · 2023 · External reference
Serum biomarker panels for the diagnosis of gastric adenocarcinoma
10.1038/bjc.2011.592 · 2012 · External reference
Discovery and validation of biomarkers for Epstein-Barr virus associated gastric cancer
10.3724/abbs.2026046 · 2026 · External reference
Urinary ADAM12 and MMP-9/NGAL complex detect the presence of gastric cancer
10.1158/1940-6207.capr-14-0229 · 2015 · External reference
A computational method for prediction of excretory proteins and application to identification of gastric cancer markers in urine
10.1371/journal.pone.0016875 · 2011 · External reference
Identification and validation of genes involved in gastric tumorigenesis
10.1186/1475-2867-10-45 · 2010 · External reference
Role of serum matrix metalloproteinase in the diagnosis of gastric cancer
10.12669/pjms.36.5.2059 · 2020 · External reference
Serum IGFBP-1 as a potential biomarker for diagnosis of early-stage upper gastrointestinal tumour
10.1016/j.ebiom.2019.11.027 · 2020 · External reference
CLIC2 regulates immunosuppression and macrophage differentiation in genomically stable gastric cancer
10.1186/s13062-025-00666-3 · 2025 · External reference
Caveolin-1 is a modulator of fibroblast activation and a potential biomarker for gastric cancer
10.7150/ijbs.10666 · 2015 · External reference
Down-regulation of KLF5 in cancer-associated fibroblasts inhibit gastric cancer cells progression by CCL5/CCR5 axis
10.1080/15384047.2017.1373219 · 2017 · External reference
JWA suppresses tumor angiogenesis via Sp1-activated matrix metalloproteinase-2 and its prognostic significance in human gastric cancer
10.1093/carcin/bgt311 · 2014 · External reference
An essential NRP1-mediated role for Tagln2 in gastric cancer angiogenesis
10.3389/fonc.2021.653246 · 2021 · External reference
MAPK4 silencing in gastric cancer drives liver metastasis by positive feedback between cancer cells and macrophages
10.1038/s12276-023-00946-w · 2023 · External reference
Gastroesophageal circulating tumor cell crosstalk with peripheral immune system guides CTC survival and proliferation
10.1038/s41419-025-07530-2 · 2025 · External reference
A gastric cancer cell derived extracellular compounds suppresses CD161+CD3- lymphocytes and aggravates tumor formation in a syngeneic mouse model
10.1016/j.molimm.2020.02.016 · 2020 · External reference
Crosstalk between bone marrow-derived myofibroblasts and gastric cancer cells regulates cancer stemness and promotes tumorigenesis
10.1038/onc.2016.76 · 2016 · External reference
Periostin secreted from podoplanin-positive cancer-associated fibroblasts promotes metastasis of gastric cancer by regulating cancer stem cells via AKT and YAP signaling pathway
10.1002/mc.23517 · 2023 · External reference
Gastric cancer mesenchymal stem cells derived IL-8 induces PD-L1 expression in gastric cancer cells via STAT3/mTOR-c-Myc signal axis
10.1038/s41419-018-0988-9 · 2018 · External reference
PDPN+ cancer-associated fibroblasts enhance gastric cancer angiogenesis via AKT/NF-κB activation and the CCL2-ACKR1 axis
10.1002/mco2.70037 · 2025 · External reference
Ephrin A1 stimulates CCL2 secretion to facilitate premetastatic niche formation and promote gastric cancer liver metastasis
10.1158/0008-5472.can-24-1254 · 2025 · External reference
Regulation of tumor metastasis and lipid metabolism reprogramming via the CCL55/GGT5 axis in gastric cancer
10.1016/j.ijbiomac.2026.151812 · 2026 · External reference
Omental adipocytes promote peritoneal metastasis of gastric cancer through the CXCL2-VEGFA axis
10.1038/s41416-020-0898-3 · 2020 · External reference
Hypoxia-autophagy axis induces Vegfa by peritoneal mesothelial cells to promote gastric cancer peritoneal metastasis through an integrin A5-fibronectin pathway
10.1186/s13046-020-01703-x · 2020 · External reference
Hypoxia-driven TCF21/CCL11 axis in Gcmscs orchestrates macrophage polarization and lymphatic remodeling to promote gastric cancer lymph node metastasis
10.1016/j.bcp.2026.118056 · 2026 · External reference
Regulation of CXCR4-mediated invasion by DARPP-32 in gastric cancer cells
10.1158/1541-7786.mcr-12-0243-t · 2013 · External reference
Exosomal MiR-27a derived from gastric cancer cells regulates the transformation of fibroblasts into cancer-associated fibroblasts
10.1159/000493218 · 2018 · External reference
Gastric cancer-derived extracellular vesicles (Evs) promote angiogenesis via angiopoietin-2
10.3390/cancers14122953 · 2022 · External reference
Knockdown of serine/threonine-protein kinase 24 promotes tumorigenesis and myeloid-derived suppressor cell expansion in an orthotopic immunocompetent gastric cancer animal model
10.7150/jca.35821 · 2020 · External reference
CCL2-Sqstm1 positive feedback loop suppresses autophagy to promote chemoresistance in gastric cancer
10.7150/ijbs.25349 · 2018 · External reference
Lncrna Malat1 promotes gastric cancer progression via inhibiting autophagic flux and inducing fibroblast activation
10.1038/s41419-021-03645-4 · 2021 · External reference
Clofoctol impairs the stemness of gastric cancer and induces TNF-mediated necroptosis by directly binding to RanBP2
10.1007/s00018-025-05723-8 · 2025 · External reference
Calcipotriol abrogates cancer-associated fibroblast-derived IL-8-mediated oxaliplatin resistance in gastric cancer cells via blocking PI3K/AKT signaling
10.1038/s41401-022-00927-1 · 2023 · External reference
Omental tissue-mediated tumorigenesis of gastric cancer peritoneal metastases
10.3389/fonc.2019.01267 · 2019 · External reference
Soluble factors in Malignant ascites promote the metastatic adhesion of gastric adenocarcinoma cells
10.1007/s10120-022-01338-1 · 2023 · External reference
Peiminine serves as an adriamycin chemosensitizer in gastric cancer by modulating the EGFR/FAK pathway
10.3892/or.2018.6184 · 2018 · External reference
DARPP-32 increases interactions between epidermal growth factor receptor and ERBB3 to promote tumor resistance to gefitinib
10.1053/j.gastro.2011.06.070 · 2011 · External reference
Sunitinib synergizes the antitumor effect of cisplatin via modulation of ERCC1 expression in models of gastric cancer
10.1016/j.canlet.2012.01.019 · 2012 · External reference
A preclinical algorithm of soluble surrogate biomarkers that correlate with therapeutic inhibition of the Met oncogene in gastric tumors
10.1002/ijc.26137 · 2012 · External reference
Targeting the Sting pathway in tumor-associated macrophages regulates innate immune sensing of gastric cancer cells
10.7150/thno.37745 · 2020 · External reference
CCL8-dependent recruitment of natural killer cells enhances the antitumor activity of neoadjuvant chemotherapy in gastric cancer
10.1007/s00262-026-04326-x · 2026 · External reference
Targeting ZFP64/GAL-1 axis promotes therapeutic effect of Nab-paclitaxel and reverses immunosuppressive microenvironment in gastric cancer
10.1186/s13046-021-02224-x · 2022 · External reference
The antidiabetic drug metformin inhibits gastric cancer cell proliferation in vitro and in vivo
10.1158/1535-7163.mct-11-0594 · 2012 · External reference
Targeting the differentiation of gastric cancer cells (Kato-Iii) downregulates epithelial-mesenchymal and cancer stem cell markers
10.3892/or.2019.7198 · 2019 · External reference
Suppression of cancer-associated fibroblasts and endothelial cells by itraconazole in bevacizumab-resistant gastrointestinal cancer
2016 · External reference
Intravenous administration is an effective and safe route for cancer gene therapy using the Bifidobacterium-mediated recombinant HSV-1 thymidine kinase and ganciclovir
10.3390/ijms17060891 · 2016 · External reference
Functional characterization of a potent anti-tumor polysaccharide in a mouse model of gastric cancer
10.1016/j.lfs.2019.01.003 · 2019 · External reference
Cross-reactivity in antibody microarrays and multiplexed sandwich assays: Shedding light on the dark side of multiplexing
10.1016/j.cbpa.2013.11.012 · 2014 · External reference
