Research graph
References from The RBP2–BECN1–VEGFA axis orchestrates a self-amplifying circuit to drive malignant progression in gastric carcinoma. Local targets link to admitted publications; unresolved targets remain external evidence.
Efficacy of a real-time intelligent quality-control system for the detection of early upper gastrointestinal neoplasms: a multicentre, single-blinded, randomised controlled trial
10.1016/j.eclinm.2024.102803 · 2024 · External reference
ALKBH5 suppresses gastric cancer tumorigenesis and metastasis by inhibiting the translation of uncapped WRAP53 RNA isoforms in an m6A-dependent manner
10.1186/s12943-024-02223-4 · 2025 · External reference
Efficacy and safety of glecirasib in solid tumors with KRAS G12C mutation: A pooled analysis of two phase I/II trials
10.1002/cac2.70056 · 2025 · External reference
Gastric cancer: a review
10.1001/jama.2025.20034 · 2026 · External reference
The SIAH2-NRF1 axis spatially regulates tumor microenvironment remodeling for tumor progression
10.1038/s41467-019-08618-y · 2019 · External reference
Osteopontin is a therapeutic target that drives breast cancer recurrence
10.1038/s41467-024-53023-9 · 2024 · External reference
The novel GINS4 axis promotes gastric cancer growth and progression by activating Rac1 and CDC42
10.7150/thno.36256 · 2019 · External reference
IRF1 suppresses gastric tumorigenesis via dual PI3K/AKT-ERK pathway modulation and functional antagonism of oncogenic MX2
10.1007/s13402-025-01134-w · 2026 · External reference
Autophagy and autophagy-related proteins in cancer
10.1186/s12943-020-1138-4 · 2020 · External reference
The role of autophagy in regulating metabolism in the tumor microenvironment
10.1016/j.gendis.2021.10.010 · 2023 · External reference
Notch signaling pathway in cancer: from mechanistic insights to targeted therapies
10.1038/s41392-024-01828-x · 2024 · External reference
The pro-angiogenesis effect of miR33a-5p/Ets-1/DKK1 signaling in ox-LDL induced HUVECs
10.7150/ijbs.60302 · 2021 · External reference
Dual roles and therapeutic targeting of tumor-associated macrophages in tumor microenvironments
10.1038/s41392-025-02325-5 · 2025 · External reference
Autophagy: regulator of cell death
10.1038/s41419-023-06154-8 · 2023 · External reference
Endothelial DGKG promotes tumor angiogenesis and immune evasion in hepatocellular carcinoma
10.1016/j.jhep.2023.10.006 · 2024 · External reference
Autophagy in endothelial cells and tumor angiogenesis
10.1038/s41418-019-0287-8 · 2019 · External reference
Inhibiting autophagy selectively prunes dysfunctional tumor vessels and optimizes the tumor immune microenvironment
10.7150/thno.98285 · 2025 · External reference
Targeting autophagy in dysfunctional tumor vasculature
10.1016/j.isci.2025.114084 · 2025 · External reference
Sexual dimorphism in the expression of GKN2 and FOXA2 genes in the human stomach
10.1007/s11033-019-04692-z · 2019 · External reference
FOXA2 is required for enhancer priming during pancreatic differentiation
10.1016/j.celrep.2019.06.034 · 2019 · External reference
RBP2 belongs to a family of demethylases, specific for tri-and dimethylated lysine 4 on histone 3
10.1016/j.cell.2007.02.003 · 2007 · External reference
The emerging role of KDM5A in human cancer
10.1186/s13045-021-01041-1 · 2021 · External reference
Histone demethylase RBP2 promotes lung tumorigenesis and cancer metastasis
10.1158/0008-5472.can-12-3165 · 2013 · External reference
Lysine demethylase 5A promotes prostate adenocarcinoma progression by suppressing microRNA-330-3p expression and activating the COPB2/PI3K/AKT axis in an ETS1-dependent manner
10.1007/s12079-022-00671-5 · 2022 · External reference
KDM5A suppresses PML-RARα target gene expression and APL differentiation through repressing H3K4me2
10.1182/bloodadvances.2020002819 · 2021 · External reference
The ARID domain of the H3K4 demethylase RBP2 binds to a DNA CCGCCC motif
10.1038/nsmb.1400 · 2008 · External reference
Diverse functions of KDM5 in cancer: transcriptional repressor or activator
10.3390/cancers14133270 · 2022 · External reference
Critical role of histone demethylase RBP2 in human gastric cancer angiogenesis
10.1186/1476-4598-13-81 · 2014 · External reference
Canonical and noncanonical vascular endothelial growth factor pathways: new developments in biology and signal transduction
10.1161/atvbaha.114.303215 · 2015 · External reference
VEGF signaling: role in angiogenesis and beyond
10.1016/j.bbcan.2024.189079 · 2024 · External reference
JNK in tumor microenvironment: present findings and challenges in clinical translation
10.3390/cancers13092196 · 2021 · External reference
MicroRNA-212 inhibits proliferation of gastric cancer by directly repressing retinoblastoma binding protein 2
10.1002/jcb.24613 · 2013 · External reference
Leptin-STAT3-G9a signaling promotes obesity-mediated breast cancer progression
10.1158/0008-5472.can-14-3076 · 2015 · External reference
Endoplasmic reticulum stress: molecular mechanism and therapeutic targets
10.1038/s41392-023-01570-w · 2023 · External reference
The retinoblastoma binding protein RBP2 is an H3K4 demethylase
10.1016/j.cell.2007.02.013 · 2007 · External reference
Loss of the retinoblastoma binding protein 2 (RBP2) histone demethylase suppresses tumorigenesis in mice lacking Rb1 or Men1
10.1073/pnas.1110104108 · 2011 · External reference
Dynamic site-specific recruitment of RBP2 by pocket protein p130 modulates H3K4 methylation on E2F-responsive promoters
10.1093/nar/gkx961 · 2018 · External reference
The histone demethylase KDM5 activates gene expression by recognizing chromatin context through its PHD reader motif
10.1016/j.celrep.2015.11.007 · 2015 · External reference
The KDM5 family is required for activation of pro-proliferative cell cycle genes during adipocyte differentiation
10.1093/nar/gkw1156 · 2017 · External reference
Hypoxia-autophagy axis induces VEGFA by peritoneal mesothelial cells to promote gastric cancer peritoneal metastasis through an integrin α5-fibronectin pathway
10.1186/s13046-020-01703-x · 2020 · External reference
Myo1b promotes tumor progression and angiogenesis by inhibiting autophagic degradation of HIF-1α in colorectal cancer
10.1038/s41419-022-05397-1 · 2022 · External reference
The role of autophagy in bone metabolism and clinical significance
10.1080/15548627.2023.2186112 · 2023 · External reference
CoQ(10) reduces glioblastoma growth and infiltration through proteome remodeling and inhibition of angiogenesis and inflammation
10.1007/s13402-022-00734-0 · 2023 · External reference
Zolbetuximab plus CAPOX in CLDN18.2-positive gastric or gastroesophageal junction adenocarcinoma: the randomized, phase 3 GLOW trial
10.1038/s41591-023-02465-7 · 2023 · External reference
Bevacizumab in combination with chemotherapy as first-line therapy in advanced gastric cancer: a randomized, double-blind, placebo-controlled phase III study
10.1200/jco.2011.36.2236 · 2011 · External reference
KDM5 family as therapeutic targets in breast cancer: pathogenesis and therapeutic opportunities and challenges
10.1186/s12943-024-02011-0 · 2024 · External reference
KDM5 inhibition offers a novel therapeutic strategy for the treatment of KMT2D mutant lymphomas
10.1182/blood.2020008743 · 2021 · External reference
