Research graph
References from Neuropeptide Y signaling in osteoarthritis pain: neuroimmune mechanisms, joint remodeling, and translational opportunities. Local targets link to admitted publications; unresolved targets remain external evidence.
The discordance between clinical and radiographic knee osteoarthritis: a systematic search and summary of the literature
10.1186/1471-2474-9-116 · 2008 · External reference
Intra-articular drug delivery for osteoarthritis treatment
10.3390/pharmaceutics13122166 · 2021 · External reference
The global burden of hip and knee osteoarthritis: estimates from the global burden of disease 2010 study
10.1136/annrheumdis-2013-204763 · 2014 · External reference
Global, regional prevalence, incidence and risk factors of knee osteoarthritis in population-based studies
10.1016/j.eclinm.2020.100587 · 2020 · External reference
Discordance between pain and radiographic severity in knee osteoarthritis: findings from quantitative sensory testing of central sensitization
10.1002/art.34646 · 2013 · External reference
Global, regional, and national burden of osteoarthritis, 1990−2020 and projections to 2050: a systematic analysis for the Global Burden of Disease Study 2021
10.1016/s2665-9913(23)00163-7 · 2023 · External reference
PGE2 activates EP4 in subchondral bone osteoclasts to regulate osteoarthritis
10.1038/s41413-022-00201-4 · 2022 · External reference
The epidemiology and impact of pain in osteoarthritis
10.1016/j.joca.2013.03.018 · 2013 · External reference
Clinical perspective on pain and pain phenotypes in osteoarthritis
10.1007/s11926-018-0796-3 · 2018 · External reference
Osteoarthritis: epidemiology
10.1016/j.berh.2005.09.007 · 2006 · External reference
Osteoarthritis of the knee
10.1056/nejmcp051726 · 2006 · External reference
Osteoarthritis
10.1016/s0140-6736(14)60802-3 · 2015 · External reference
The individual and socioeconomic impact of osteoarthritis
10.1038/nrrheum.2014.44 · 2014 · External reference
Osteoarthritis
10.1016/s0140-6736(19)30417-9 · 2019 · External reference
Diagnosis and treatment of hip and knee osteoarthritis: a review
10.1001/jama.2020.22171 · 2021 · External reference
Global, regional and national burden of osteoarthritis 1990−2017: a systematic analysis of the Global Burden of Disease Study 2017
10.1136/annrheumdis-2019-216515 · 2020 · External reference
Manual therapy, exercise therapy, or both, in addition to usual care, for osteoarthritis of the hip or knee: a randomized controlled trial
10.1016/j.joca.2012.12.014 · 2013 · External reference
Osteoarthritis: pathology, diagnosis, and treatment options
10.1016/j.mcna.2019.10.007 · 2020 · External reference
OARSI guidelines for the non-surgical management of knee, hip, and polyarticular osteoarthritis
10.1016/j.joca.2019.06.011 · 2019 · External reference
Which risk factors determine cartilage thickness and composition change in radiographically normal knees? Data from the osteoarthritis initiative
10.1016/j.ocarto.2023.100365 · 2023 · External reference
American College of Rheumatology 2012 recommendations for the use of nonpharmacologic and pharmacologic therapies in osteoarthritis of the hand, hip, and knee
10.1002/acr.21596 · 2012 · External reference
2019 American College of Rheumatology/Arthritis Foundation guideline for the management of osteoarthritis of the hand, hip, and knee
10.1002/acr.24131 · 2020 · External reference
New treatment for osteoarthritis: gene therapy
10.1093/pcmedi/pbad014 · 2023 · External reference
OARSI guidelines for the non-surgical management of knee osteoarthritis
10.1016/j.joca.2014.01.003 · 2014 · External reference
Neuropeptide Y receptors: how to get subtype selectivity
10.3389/fendo.2013.00005 · 2013 · External reference
Neuropeptide Y acts directly on cartilage homeostasis and exacerbates progression of osteoarthritis through NPY2R
10.1002/jbmr.3991 · 2020 · External reference
Neuropeptide Y promotes human M2 macrophage polarization and enhances p62/SQSTM1-dependent autophagy and NRF2 activation
10.3390/ijms232113009 · 2022 · External reference
Intermittent fasting targets osteocyte neuropeptide Y to relieve osteoarthritis
10.1002/advs.202400196 · 2024 · External reference
Hypothalamic Y2 receptors regulate bone formation
10.1172/jci14588 · 2002 · External reference
The role of NPY in the regulation of bone metabolism
10.3389/fendo.2022.833485 · 2022 · External reference
Neuropeptide Y, peptide YY and pancreatic polypeptide in the gut-brain axis
10.1016/j.npep.2012.08.005 · 2012 · External reference
Neuropeptide Y and metabolic syndrome: an update on perspectives of clinical therapeutic intervention strategies
10.3389/fcell.2021.695623 · 2021 · External reference
Neuropeptide Y acts directly in the periphery on fat tissue and mediates stress-induced obesity and metabolic syndrome
10.1038/nm1611 · 2007 · External reference
Deficiency of neuropeptide Y attenuates neointima formation after vascular injury in mice
10.1186/s12872-023-03267-y · 2023 · External reference
Neuropeptide Y: a stressful review
10.1016/j.npep.2015.09.008 · 2016 · External reference
Mettl3-m6A-NPY axis governing neuron-microglia interaction regulates sleep amount of mice
10.1038/s41421-024-00756-y · 2025 · External reference
Elevated serum neuropeptide Y levels are associated with carotid plaque formation in Chinese adults: a cross-sectional study
10.1186/s12872-023-03660-7 · 2023 · External reference
Regulation of neuropeptide Y in body microenvironments and its potential application in therapies
10.1186/s13578-021-00657-7 · External reference
Levels of neuropeptide Y in synovial fluid relate to pain in patients with knee osteoarthritis
10.1186/1471-2474-15-319 · 2014 · External reference
Neuropeptide Y promotes mTORC1 to regulate chondrocyte proliferation and hypertrophy
10.1210/endocr/bqac213 · 2023 · External reference
Neuropeptide Y1 receptor in immune cells regulates inflammation and insulin resistance associated with diet-induced obesity
10.2337/db12-0156 · 2012 · External reference
Synovial tissue from sites of joint pain in knee osteoarthritis patients exhibits a differential phenotype with distinct fibroblast subsets
10.1016/j.ebiom.2021.103618 · 2021 · External reference
Activation of the proton-sensing GPCR, GPR65, on fibroblast-like synoviocytes contributes to inflammatory joint pain
10.1073/pnas.2410653121 · 2024 · External reference
Association of synovial innate immune exhaustion with worse pain in knee osteoarthritis
10.1002/art.43089 · 2025 · External reference
Towards a mechanism-based approach to pain management in osteoarthritis
10.1038/nrrheum.2013.138 · 2013 · External reference
Osteoarthritis pain: nociceptive or neuropathic?
10.1038/nrrheum.2014.47 · 2014 · External reference
Facilitation of neuropathic pain by the NPY Y1 receptor-expressing subpopulation of excitatory interneurons in the dorsal horn
10.1038/s41598-019-43493-z · 2019 · External reference
Neuropeptide Y Y2 receptors in sensory neurons tonically suppress nociception and itch but facilitate postsurgical and neuropathic pain hypersensitivity
10.1097/aln.0000000000005184 · 2024 · External reference
An NPY Y1 receptor antagonist unmasks latent sensitization and reveals the contribution of protein kinase A and EPAC to chronic inflammatory pain
10.1097/j.pain.0000000000001557 · 2019 · External reference
Profiling of inflammatory mediators in the synovial fluid related to pain in knee osteoarthritis
10.1186/s12891-020-3120-0 · 2020 · External reference
mTOR-neuropeptide Y signaling sensitizes nociceptors to drive neuropathic pain
10.1172/jci.insight.159247 · 2022 · External reference
Increased vascular penetration and nerve growth in the meniscus: a potential source of pain in osteoarthritis
10.1136/ard.2010.137844 · 2011 · External reference
Contribution of nerves within osteochondral channels to osteoarthritis knee pain in humans and rats
10.1016/j.joca.2020.05.010 · 2020 · External reference
Neurovascular invasion at the osteochondral junction and in osteophytes in osteoarthritis
10.1136/ard.2006.063354 · 2007 · External reference
Angiogenesis and nerve growth factor at the osteochondral junction in rheumatoid arthritis and osteoarthritis
10.1093/rheumatology/keq188 · 2010 · External reference
Macrophages and nociceptor neurons form a sentinel unit around fenestrated capillaries to defend the synovium from circulating immune challenge
10.1038/s41590-024-02011-8 · 2024 · External reference
Neuropathic pain in osteoarthritis: a review of pathophysiological mechanisms and implications for treatment
10.1016/j.semarthrit.2014.05.011 · 2014 · External reference
Pain sensitization in people with knee osteoarthritis: a systematic review and meta-analysis
10.1016/j.joca.2015.02.163 · 2015 · External reference
Psychophysical and functional imaging evidence supporting the presence of central sensitization in a cohort of osteoarthritis patients
10.1002/art.24837 · 2009 · External reference
Somatosensory abnormalities in knee OA
10.1093/rheumatology/ker343 · 2012 · External reference
Immunopathogenesis of osteoarthritis
10.1016/j.clim.2012.12.011 · 2013 · External reference
Histopathological analysis of the synovium in trapeziometacarpal osteoarthritis
10.1177/1753193419848600 · 2019 · External reference
Role of inflammation and the immune system in the progression of osteoarthritis
10.1002/jor.24457 · 2020 · External reference
Synovial lining macrophages mediate osteophyte formation during experimental osteoarthritis
10.1016/j.joca.2004.03.003 · 2007 · External reference
The role of synovial macrophages and macrophage-produced cytokines in driving aggrecanases, matrix metalloproteinases, and other destructive and inflammatory responses in osteoarthritis
10.1186/ar2099 · 2006 · External reference
Direct in vivo evidence of activated macrophages in human osteoarthritis
10.1016/j.joca.2016.04.010 · 2016 · External reference
Rapamycin reveals neuropeptide Y as a regulator of senescence and inflammatory pathways in arthritis
10.1016/j.npep.2025.102533 · 2025 · External reference
Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment
10.1038/nm.4324 · 2017 · External reference
Aging and osteoarthritis: the role of chondrocyte senescence and aging changes in the cartilage matrix
10.1016/j.joca.2009.03.002 · 2009 · External reference
Conditional deletion of hypothalamic Y2 receptors reverts gonadectomy-induced bone loss in adult mice
10.1074/jbc.m604839200 · 2006 · External reference
Leptin regulation of bone resorption by the sympathetic nervous system and CART
10.1038/nature03398 · 2005 · External reference
Neuronal induction of bone-fat imbalance through osteocyte neuropeptide Y
10.1002/advs.202100808 · External reference
Identification of mechanics-responsive osteocyte signature in osteoarthritis subchondral bone
10.1302/2046-3758.116.bjr-2021-0436.r1 · 2022 · External reference
Bone remodelling in osteoarthritis
10.1038/nrrheum.2012.130 · 2012 · External reference
Multiscale bone quality analysis in osteoarthritic knee joints reveals a role of the mechanosensory osteocyte network in osteophytes
10.1038/s41598-019-57303-z · 2020 · External reference
Subchondral bone osteoclasts induce sensory innervation and osteoarthritis pain
10.1172/jci121561 · 2019 · External reference
Cartilage homeostasis in health and rheumatic diseases
10.1186/ar2592 · 2009 · External reference
Osteoarthritis: a disease of the joint as an organ
10.1002/art.34453 · 2012 · External reference
Mechanisms and targets of angiogenesis and nerve growth in osteoarthritis
10.1038/nrrheum.2012.80 · 2012 · External reference
Osteoarthritis as an inflammatory disease (osteoarthritis is not osteoarthrosis!)
10.1016/j.joca.2012.11.012 · 2013 · External reference
Why is obesity associated with osteoarthritis? Insights from mouse models of obesity
2008 · External reference
Metabolic syndrome meets osteoarthritis
10.1038/nrrheum.2012.135 · 2012 · External reference
Intestinal microbiome composition and its relation to joint pain and inflammation
10.1038/s41467-019-12873-4 · 2019 · External reference
The gut microbiome-joint connection: implications in osteoarthritis
10.1097/bor.0000000000000681 · 2020 · External reference
Targeting the gut microbiome to treat the osteoarthritis of obesity
10.1172/jci.insight.95997 · 2018 · External reference
Neuropeptide Y-mediated gut microbiota alterations aggravate postmenopausal osteoporosis
10.1002/advs.202303015 · 2023 · External reference
A comparative study on the effect of exosomes secreted by mesenchymal stem cells derived from adipose and bone marrow tissues in the treatment of osteoarthritis-induced mouse model
10.1155/2021/9688138 · 2021 · External reference
Micro-fragmented adipose tissue (MFAT) in orthopedic regenerative medicine: a narrative review of the biological basis and clinical evidence
10.3390/ijms27146185 · 2021 · External reference
Exosomes rewire the cartilage microenvironment in osteoarthritis: from intercellular communication to therapeutic strategies
10.1038/s41368-022-00187-z · 2022 · External reference
Recent advances in the use of stem cell-derived exosomes for joint regeneration
10.1007/s11033-026-11992-8 · 2022 · External reference
Tanezumab reduces osteoarthritic knee pain: results of a randomized, double-blind, placebo-controlled phase III trial
10.1016/j.jpain.2012.05.006 · 2012 · External reference
When is osteonecrosis not osteonecrosis? Adjudication of reported serious adverse joint events in the tanezumab clinical development program
10.1002/art.39492 · 2016 · External reference
A stimulus-response framework to investigate the influence of continuous versus interval walking exercise on select serum biomarkers in knee osteoarthritis
10.1097/phm.0000000000001068 · 2019 · External reference
Tanezumab for the treatment of pain from osteoarthritis of the knee
10.1056/nejmoa0901510 · 2010 · External reference
Nerve growth factor blockade for the management of osteoarthritis pain: what can we learn from clinical trials and preclinical models?
10.1097/bor.0000000000000354 · 2017 · External reference
A mechanism-based approach to the management of osteoarthritis pain
10.1007/s11914-015-0291-y · 2015 · External reference
Mechanisms of osteoarthritic pain. Studies in humans and experimental models
10.3389/fnmol.2017.00349 · 2017 · External reference
Experimental models to study osteoarthritis pain and develop therapeutics
10.1016/j.ocarto.2022.100306 · 2022 · External reference
Peripheral pain mechanisms in osteoarthritis
10.1097/j.pain.0000000000001923 · 2020 · External reference
The genesis of pain in osteoarthritis: inflammation as a mediator of osteoarthritis pain
10.1016/j.cger.2021.11.013 · 2022 · External reference
Sensitization in patients with painful knee osteoarthritis
10.1016/j.pain.2010.04.003 · 2010 · External reference
Carboxypeptidase E modulates intestinal immune homeostasis and protects against experimental colitis in mice
10.1371/journal.pone.0102347 · 2014 · External reference
Neuropeptide Y enhances proliferation and chondrogenic differentiation of ATDC5 cells
10.1016/j.npep.2020.102022 · 2020 · External reference
Inflammatory biomarkers in osteoarthritis
10.1016/j.joca.2015.02.009 · 2015 · External reference
Synovial inflammation, immune cells and their cytokines in osteoarthritis: a review
10.1016/j.joca.2012.08.027 · 2012 · External reference
Zinc supplementation improved neuropeptide Y, nesfatin−1, leptin, C-reactive protein, and HOMA-IR of diet-induced obese rats
10.1007/s12011-021-02987-6 · 2022 · External reference
Neuropeptide Y and its involvement in chronic pain
10.1016/j.neuroscience.2017.08.050 · 2018 · External reference
Osteoarthritis: the genesis of pain
10.1093/rheumatology/kex419 · 2018 · External reference
Osteoarthritis
10.1002/jcp.21258 · 2007 · External reference
Tanezumab for the treatment of osteoarthritis pain
10.1358/dot.2022.58.4.3352752 · 2022 · External reference
Inflammatory, structural, and pain biochemical biomarkers may reflect radiographic disc space narrowing: the Johnston county osteoarthritis project
10.1002/jor.24534 · 2020 · External reference
Do neuroendocrine peptides and their receptors qualify as novel therapeutic targets in osteoarthritis?
10.3390/ijms19020367 · 2018 · External reference
The coupling of bone and cartilage turnover in osteoarthritis: opportunities for bone antiresorptives and anabolic agents
10.1136/annrheumdis-2013-204111 · 2014 · External reference
The bone-cartilage unit in osteoarthritis
10.1038/nrrheum.2010.197 · 2011 · External reference
Synovitis in osteoarthritis: current understanding with therapeutic implications
10.1186/s13075-017-1229-9 · 2017 · External reference
Neuropeptide Y and pain: insights from brain research
10.1021/acsptsci.4c00333 · 2024 · External reference
Targeting CD44 receptor pathways in degenerative joint diseases: involvement of proteoglycan-4
10.3390/ph16101425 · 2023 · External reference
Low-grade inflammation as a key mediator of the pathogenesis of osteoarthritis
10.1038/nrrheum.2016.136 · 2016 · External reference
Synovial inflammation in osteoarthritis progression
10.1038/s41584-022-00749-9 · 2022 · External reference
The role of synovitis in osteoarthritis pathogenesis
10.1016/j.bone.2012.02.012 · 2012 · External reference
Mechanisms of chronic pain in osteoarthritis
10.1007/s11926-012-0279-x · 2012 · External reference
Ageing and osteoarthritis synergically affect human synoviocyte cells: an in vitro study on sex differences
10.3390/jcm11237125 · 2022 · External reference
Macrophage proliferation distinguishes 2 subgroups of knee osteoarthritis patients
10.1172/jci.insight.125325 · 2019 · External reference
Immunoregulation of synovial macrophages for the treatment of osteoarthritis
10.1515/biol-2022-0567 · 2023 · External reference
Effects of probiotic supplementation on exercise and the underlying mechanisms
10.3390/foods12091787 · 2023 · External reference
