Research graph
References from Herbal hot compress combined with bianstone warm ironing improves anxiety and cognitive impairment via gut-brain-HPA axis in pubertal mesenteric lymphadenitis rats. Local targets link to admitted publications; unresolved targets remain external evidence.
Comparison of clinical and laboratory manifestations between acute appendicitis and mesenteric lymphadenitis in children
10.7759/cureus.62437 · 2024 · External reference
Kynurenine pathway metabolism and the microbiota-gut-brain axis
10.1016/j.neuropharm.2016.07.002 · 2017 · External reference
The gut-brain axis in irritable bowel syndrome and inflammatory bowel disease
10.1016/j.dld.2020.11.026 · 2021 · External reference
Serum biomarkers of intestinal barrier dysfunction predict postoperative endoscopic recurrence in Crohn’s disease patients
10.1186/s12876-025-04273-4 · 2025 · External reference
Leaky gut: mechanisms, measurement and clinical implications in humans
10.1136/gutjnl-2019-318427 · 2019 · External reference
Anxiety and depression in pediatric patients with disorder of brain-gut interaction: the role of diarrhea and abdominal pain as key determinants
10.3389/fped.2025.1628222 · 2025 · External reference
The dual-sensitive period gut-brain crosstalk, neuroinflammation, and the biological roots of adolescent depression
10.3389/fimmu.2026.1821502 · 2026 · External reference
Neuroinflammation, early-life adversity, and brain development
10.1097/hrp.0000000000000325 · 2022 · External reference
Complement dependent synaptic reorganisation during critical periods of brain development and risk for psychiatric disorder
10.3389/fnins.2022.840266 · 2022 · External reference
Treatment of abdominal pain due to deficiency syndrome of the spleen and stomach with bian stone plus TCM iontophoresis: a case report
10.1097/md.0000000000037858 · 2024 · External reference
Application of stone needle therapy based on blood stasis theory in the treatment of 36 cases of knee osteoarthritis in early and middle stage
10.35437/intnur.issn.2663-4481.2019.01.02.02 · 2019 · External reference
The effectiveness of Evodia rutaecarpa hot compress on the recovery of gastrointestinal function after laparoscopic surgery for colorectal cancer: a propensity score-matched retrospective cohort study
10.1371/journal.pone.0303951 · 2025 · External reference
Effect of Yikou-Sizi powder hot compress on gastrointestinal functional recovery in patients after abdominal surgery: study protocol for a randomized controlled trial
10.1097/md.0000000000012438 · 2018 · External reference
Effect of mild moxibustion on intestinal microbiota and NLRP6 inflammasome signaling in rats with post-inflammatory irritable bowel syndrome
10.3748/wjg.v25.i32.4696 · 2019 · External reference
Exploring the interaction between the gut microbiota and cyclic adenosine monophosphate-protein kinase A signaling pathway: a potential therapeutic approach for neurodegenerative diseases
10.4103/nrr.nrr-d-24-00607 · 2025 · External reference
Hypothalamic POMC neurons regulate intestinal glucose absorption via a gut–brain circuit
10.1038/s41467-026-74170-1 · 2026 · External reference
Ketogenic diet administration later in life improves memory by modifying the synaptic cortical proteome via the PKA signaling pathway in aging mice
10.1016/j.xcrm.2024.101593 · 2024 · External reference
Presynaptic cAMP-PKA-mediated potentiation induces reconfiguration of synaptic vesicle pools and channel-vesicle coupling at hippocampal mossy fiber boutons
10.1371/journal.pbio.3002879 · 2024 · External reference
Gut-brain axis-based Polygala tenuifolia and Magnolia officinalis improve D-gal-induced cognitive impairment in mice through cAMP and NF-κB signaling pathways
10.2147/dddt.s506545 · 2025 · External reference
Microbiota modulates behavior and protein kinase C mediated cAMP response element-binding protein signaling
10.1038/srep29998 · 2016 · External reference
Multi-tiered network pharmacology-Drosophila-mouse approach reveals Cyperus esculentus peptide targets cAMP/PKA/CREB pathway and gut Microbiota to counteract cognitive decline
10.1016/j.fbio.2026.109042 · 2026 · External reference
Dopaminergic modulation of dynamic emotion perception
10.1523/jneurosci.2364-21.2022 · 2022 · External reference
Dopaminergic modulation of prefrontal cortex inhibition
10.3390/biomedicines11051276 · 2023 · External reference
Influence of glutamate and GABA transport on brain excitatory/inhibitory balance
10.1177/1535370221989263 · 2021 · External reference
The involvement of the endocannabinoid, glutamatergic, and GABAergic systems in PTSD
10.3390/ijms26135929 · 2025 · External reference
CaMKII: a central molecular organizer of synaptic plasticity, learning and memory
10.1038/s41583-022-00624-2 · 2022 · External reference
Plasticity mechanism and memory formation in the chemical synapse
10.1007/s11071-023-08844-6 · 2023 · External reference
Effects of repeated lipopolysaccharide treatment on growth performance, immune organ index, and blood parameters of Sprague-Dawley rats
10.2478/jvetres-2018-0048 · 2018 · External reference
Effects of lipopolysaccharide on T lymphocyte cell subsets and cytokine secretion in mesenteric lymph nodes of mice: histological and molecular study
10.1016/j.etap.2019.103214 · 2019 · External reference
Injections of lipopolysaccharide into mice to mimic entrance of microbial-derived products after intestinal barrier breach
10.3791/57610 · 2018 · External reference
Lipopolysaccharide modulates neutrophil recruitment and macrophage polarization on lymphatic vessels and impairs lymphatic function in rat mesentery
10.1152/ajpheart.00467.2015 · 2015 · External reference
Changes in adipocytes and dendritic cells in lymph node containing adipose depots during and after many weeks of mild inflammation
10.1111/j.1469-7580.2005.00506.x · 2005 · External reference
Pre-clinical studies investigating the combination of hypofractionated radiation with hyperthermia in a murine tumor and normal skin
10.1080/02656736.2025.2545400 · 2025 · External reference
Testicular photohyperthermia mediated by magnetic nanoparticles: implications for male fertility control
10.3390/molecules31071064 · 2026 · External reference
Rapid hippocampal synaptic potentiation induced by ketamine metabolite (2R,6R)-hydroxynorketamine persistently primes synaptic plasticity
10.1038/s41386-025-02085-4 · 2025 · External reference
Selective PDE4B and PDE4D inhibitors produce distinct behavioral responses to ethanol and GABAergic drugs in mice
10.1016/j.neuropharm.2023.109508 · 2023 · External reference
Osthole pretreatment alleviates TNBS-induced colitis in mice via both cAMP/PKA-dependent and independent pathways
10.1038/aps.2017.71 · 2017 · External reference
Protein kinase inhibitor-mediated immunoprophylactic and immunotherapeutic control of colon cancer
10.3389/fimmu.2022.875764 · 2022 · External reference
Chronic melamine cyanurate exposure impairs spatial learning and memory by altering autophagy-mediated synaptic plasticity and oxidative stress in the hippocampus of adolescent rats
10.1007/s00204-025-04289-5 · 2026 · External reference
Subchronic cyanuric acid treatment impairs spatial flexible behavior in female adolescent rats through depressing GluN2B-dependent neuronal and synaptic function
10.1016/j.ecoenv.2024.117513 · 2025 · External reference
Intestinal permeability–a new target for disease prevention and therapy
10.1186/s12876-014-0189-7 · 2014 · External reference
From synapse to system: mechanistic pathways of neural signaling dysfunction in psychiatric disorders
10.3389/fcell.2026.1762930 · 2026 · External reference
Mechanisms of synaptic transmission dysregulation in the prefrontal cortex: pathophysiological implications
10.1038/s41380-021-01092-3 · 2022 · External reference
Gastrodin prevents stress-induced synaptic plasticity impairment and behavioral dysfunction via cAMP/PKA/CREB signaling pathway
10.1016/j.phymed.2025.156661 · 2025 · External reference
Atractyloside-A ameliorates spleen deficiency diarrhea by interfering with TLR4/MyD88/NF-κB signaling activation and regulating intestinal flora homeostasis
10.1016/j.intimp.2022.108679 · 2022 · External reference
The rhizome of Atractylodes macrocephala Koidz.: a comprehensive review on the traditional uses, phytochemistry and pharmacology
10.1002/cbdv.202401879 · 2025 · External reference
Review of recent advances on health benefits, microbial transformations, and authenticity identification of Citri reticulatae pericarpium bioactive compounds
10.1080/10408398.2023.2222834 · 2024 · External reference
Botany, traditional uses, phytochemistry and pharmacological activity of Crataegus pinnatifida (Chinese hawthorn): a review
10.1093/jpp/rgac050 · 2022 · External reference
Maillard reaction products of stir fried Hordei Fructus Germinatus are important for its efficacy in treating functional dyspepsia
10.1089/jmf.2019.4430 · 2020 · External reference
Child compound Endothelium corneum attenuates gastrointestinal dysmotility through regulating the homeostasis of brain-gut-microbiota axis in functional dyspepsia rats
10.1016/j.jep.2019.111953 · 2019 · External reference
Exploration of the oxidative-inflammatory potential targets of Coicis Semen in osteoarthritis: data mining and systematic pharmacology
10.32604/biocell.2023.028331 · 2023 · External reference
The effect of Dioscoreae Rhizoma on gastrointestinal function: a systematic review
10.3390/nu17182943 · 2025 · External reference
Evaluation of the anti-inflammatory activity of ethanolic rhizome extract of Curcuma longa in Wistar albino rats using the formalin-induced paw edema model
10.69613/npmjs539 · 2026 · External reference
Toosendanin inhibits T-cell proliferation through the P38 MAPK signalling pathway
10.1016/j.ejphar.2024.176562 · 2024 · External reference
Anti-tumor effects and toxicity reduction mechanisms of Prunella vulgaris: a comprehensive review
10.3390/molecules29081843 · 2024 · External reference
Prunella vulgaris L. attenuates experimental autoimmune thyroiditis by inhibiting HMGB1/TLR9 signaling
10.2147/dddt.s325814 · 2021 · External reference
Prunella vulgaris can improve the pregnancy outcomes of experimental autoimmune thyroiditis rats by inhibiting Th1/Th17 immune responses
10.1016/j.jri.2021.103469 · 2022 · External reference
Protective effect of ursolic acid in Prunella vulgaris L. On LPS-induced asthenozoospermia via Bcl-2/Bax apoptosis signaling pathway
10.2174/1389201021666201027155413 · 2021 · External reference
Therapeutic potential and mechanisms of rosmarinic acid and the extracts of Lamiaceae plants for the treatment of fibrosis of various organs
10.3390/antiox13020146 · 2024 · External reference
Progress of ursolic acid on the regulation of macrophage: summary and prospect
10.3389/fimmu.2025.1576771 · 2025 · External reference
Comparison of electroacupuncture and mild-warm moxibustion on brain-gut function in patients with constipation-predominant irritable bowel syndrome: a randomized controlled trial
10.1007/s11655-018-2838-0 · 2018 · External reference
Long-term effect of moxibustion on irritable bowel syndrome with diarrhea: a randomized clinical trial
10.1177/17562848221075131 · 2022 · External reference
Chinese herbal medicine for functional abdominal pain syndrome: from clinical findings to basic understandings
10.1155/2016/8652523 · 2016 · External reference
Study on the mechanism of Huangqin decoction on rats with ulcerative colitis of damp-heat type base on mtDNA, TLR4, p-PI3K, p-Akt protein expression and microbiota
10.1016/j.jep.2022.115356 · 2022 · External reference
Role of neuroimmune crosstalk in mediating the anti-inflammatory and analgesic effects of acupuncture on inflammatory pain
10.3389/fnins.2021.695670 · 2021 · External reference
Theory of traditional Chinese medicine and therapeutic method of diseases
10.3748/wjg.v10.i13.1854 · 2004 · External reference
Current advances in the pain treatment and mechanisms of traditional Chinese medicine
10.1002/ptr.8259 · 2024 · External reference
Norepinephrine stabilizes translation-dependent, homosynaptic long-term potentiation through mechanisms requiring the cAMP sensor Epac, mTOR and MAPK
10.1111/ejn.14735 · 2020 · External reference
PKA drives an increase in AMPA receptor unitary conductance during LTP in the hippocampus
10.1038/s41467-020-20523-3 · 2021 · External reference
Tgr5 agonist inhibits intestinal epithelial cell apoptosis via cAMP/PKA/c-FLIP/JNK signaling pathway and ameliorates dextran sulfate sodium-induced ulcerative colitis
10.1038/s41401-023-01081-y · 2023 · External reference
Cyclic adenosine 3’, 5’-monophosphate (cAMP) signaling is a crucial therapeutic target for ulcerative colitis
10.1016/j.lfs.2024.122901 · 2024 · External reference
Arrestin-dependent nuclear export of phosphodiesterase 4D promotes GPCR-induced nuclear cAMP signaling required for learning and memory
10.1126/scisignal.ade3380 · 2023 · External reference
Lactobacillus plantarum improves LPS-induced Caco2 cell line intestinal barrier damage via cyclic AMP-PKA signaling
10.1371/journal.pone.0267831 · 2022 · External reference
Targeting cAMP signaling and phosphodiesterase 4 for liver disease treatment
10.1007/s00044-024-03267-3 · 2024 · External reference
Sitagliptin attenuates intestinal ischemia/reperfusion injury via cAMP/PKA, PI3K/Akt pathway in a glucagon-like peptide 1 receptor-dependent manner
10.1016/j.lfs.2018.09.013 · 2018 · External reference
Activation of serotonin 5-HT7 receptors modulates hippocampal synaptic plasticity by stimulation of adenylate cyclases and rescues learning and behavior in a mouse model of Fragile X syndrome
10.3389/fnmol.2018.00353 · 2018 · External reference
Targeting beta-2 adrenergic receptor attenuates schizophrenia-like behavioral effects induced by ketamine in mice: cAMP/PKA/BDNF-PEA-3 and RIM-1α signaling pathways involvement
10.1007/s44446-026-00079-x · 2026 · External reference
cAMP-dependent synaptic plasticity at the hippocampal mossy fiber terminal
10.3389/fnsyn.2022.861215 · 2022 · External reference
Inhibition of phosphodiesterase-4 by rolipram alleviates anxiety-like behavior in mice with PTSD by modulating neuroinflammation and synaptic plasticity via cAMP signaling
10.1016/j.intimp.2025.115116 · 2025 · External reference
Zhinao capsule improved sleep and memory disorders in APP/PS1 mice via cAMP/PKA/CREB signaling pathway modulation
10.2147/dddt.s542074 · 2025 · External reference
Microglia-dependent alteration of glutamatergic synaptic transmission and plasticity in the hippocampus during peripheral inflammation
10.1523/jneurosci.4485-14.2015 · 2015 · External reference
Effects of acute pro-inflammatory stimulation and 25-hydroxycholesterol on hippocampal plasticity and learning involve NLRP3 inflammasome and cellular stress responses
10.1038/s41598-025-90149-2 · 2025 · External reference
Interleukin-1β modulates synaptic transmission and synaptic plasticity during the acute phase of sepsis in the senescence-accelerated mouse hippocampus
10.3389/fnagi.2021.637703 · 2021 · External reference
Hypothalamus-pituitary-adrenal and gut-brain axes in biological interaction pathway of the depression
10.3389/fnins.2025.1541075 · 2025 · External reference
Role of the probiotic supplementation on intestinal inflammation and structural integrity in Wistar rats subjected to a cafeteria diet during development
10.29261/pakvetj/2025.002 · 2025 · External reference
Appendicitis, mesenteric lymphadenitis, and subsequent risk of ulcerative colitis: cohort studies in Sweden and Denmark
10.1136/bmj.b716 · 2009 · External reference
The role of the hypothalamic-pituitary-adrenal axis in depression across the female reproductive lifecycle: current knowledge and future directions
10.3389/fendo.2023.1295261 · 2023 · External reference