Contact and support
Need help, have a question, or want to contact the ResearchHub team?
© 2026 ResearchHub. Built for responsible scholarly connection.
Privacy-aware community infrastructureResearch graph
References from Comparative Assessment of the Activity of Racemic and Dextrorotatory Forms of Thioctic (Alpha-Lipoic) Acid in Low Back Pain: Preclinical Results and Clinical Evidences From an Open Randomized Trial. Local targets link to admitted publications; unresolved targets remain external evidence.
Lipid oxidation and peroxidation in CNS health and disease: from molecular mechanisms to therapeutic opportunities
10.1089/ars.2009.2668 · 2010 · External reference
Effect of α-lipoic acid on symptoms and quality of life in patients with painful diabetic neuropathy
10.1177/0300060518756540 · 2018 · External reference
Metabolismo e farmacocinetica dell’acido tioctico nell’uomo
2010 · External reference
The sensory symptoms of diabetic polyneuropathy are improved with alpha-lipoic acid: the sydney trial
10.2337/diacare.26.3.770 · 2003 · External reference
EFNS guidelines on the pharmacological treatment of neuropathic pain: 2010 revision
10.1111/j.1468-1331.2010.02999.x · 2010 · External reference
Neuropathic low back pain in clinical practice
10.1002/ejp.838 · 2016 · External reference
Development and validity testing of the neuropathy total symptom score-6: questionnaire for the study of sensory symptoms of diabetic peripheral neuropathy
10.1016/j.clinthera.2005.08.002 · 2005 · External reference
A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man
10.1016/0304-3959(88)90209-6 · 1988 · External reference
The plasma pharmacokinetics of R-(+)-lipoic acid administered as sodium R-(+)-lipoate to healthy human subjects
2007 · External reference
Reactive astrocytosis-induced perturbation of synaptic homeostasis is restored by nerve growth factor
10.1016/j.nbd.2010.11.012 · 2011 · External reference
Purinergic modulation of spinal neuroglial maladaptive plasticity following peripheral nerve injury
10.1007/s12035-014-8943-y · 2015 · External reference
BB14, a Nerve Growth Factor (NGF)-like peptide shown to be effective in reducing reactive astrogliosis and restoring synaptic homeostasis in a rat model of peripheral nerve injury
10.1016/j.biotechadv.2011.05.008 · 2012 · External reference
Targeting reactive astrogliosis by novel biotechnological strategies
10.1016/j.biotechadv.2011.06.016 · 2012 · External reference
Advanced glycation endproducts induce changes in glucose consumption, lactate production, and ATP levels in SH-SY5Y neuroblastoma cells by a redox-sensitive mechanism
10.1097/01.wcb.0000090622.86921.0e · 2003 · External reference
Astrocytes and microglia-mediated immune response in maladaptive plasticity is differently modulated by NGF in the ventral horn of the spinal cord following peripheral nerve injury
10.1007/s10571-015-0218-2 · 2016 · External reference
Low back pain
10.2519/jospt.2012.42.4.a110.2519/jospt.2012.0301 · 2012 · External reference
Back pain prevalence and visit rates: estimates from U.S. national surveys, 2002
10.1097/01.brs.0000244618.06877.cd · 2006 · External reference
Neuroprotective effects of acetyl-L-carnitine on neuropathic pain and apoptosis: a role for the nicotinic receptor
10.1002/jnr.21815 · 2009 · External reference
Pharmacologic management of neuropathic pain: evidence-based recommendations
10.1016/j.pain.2007.08.033 · 2007 · External reference
Electronic case-report forms of symptoms and impairments of peripheral neuropathy
10.1017/s0317167100002043 · 2002 · External reference
Neuropathic pain: principles of diagnosis and treatment
10.1016/j.mayocp.2015.01.018 · 2015 · External reference
Alpha-lipoic acid as a pleiotropic compound with potential therapeutic use in diabetes and other chronic diseases
10.1186/1758-5996-6-80 · 2014 · External reference
Lipoic acid - biological activity and therapeutic potential
10.1016/s1734-1140(11)70600-4 · 2011 · External reference
Remote astrocytic and microglial activation modulates neuronal hyperexcitability and below-level neuropathic pain after spinal injury in rat
10.1016/j.neuroscience.2009.03.055 · 2009 · External reference
The effect of thioctic acid on allodynia in a rat vincristine-induced neuropathy model
10.1177/0300060515569287 · 2015 · External reference
kappa-Opioid agonists produce antinociception after i.v. and i.c.v. but not intrathecal administration in the rat
10.1111/j.1476-5381.1988.tb10310.x · 1988 · External reference
Acido tioctico : farmacologia ed applicazioni terapeutiche di un antiossidante particolare
2010 · External reference
Toxicological profile of the pain-relieving antioxidant compound thioctic acid in its racemic and enantiomeric forms
10.3390/antiox9080749 · 2020 · External reference
Increasing bioavailability of (R)-alpha-lipoic acid to boost antioxidant activity in the treatment of neuropathic pain
2015 · External reference
Thioctic acid and acetyl-L-carnitine in the treatment of sciatic pain caused by a herniated disc: a randomized, double-blind, comparative study
10.2165/00044011-200828080-00004 · 2008 · External reference
Alpha-lipoic acid provides neuroprotection from ischemia-reperfusion injury of peripheral nerve
10.1016/s0022-510x(99)00017-9 · 1999 · External reference
R(+)-Thioctic acid effects on oxidative stress and peripheral neuropathy in type II diabetic patients: preliminary results by electron paramagnetic resonance and electroneurography
10.1155/2018/1767265 · 2018 · External reference
A simple practice guide for dose conversion between animals and human
10.4103/0976-0105.177703 · 2016 · External reference
Antioxidant strategies in the management of diabetic neuropathy
10.1155/2015/515042 · 2015 · External reference
alpha-Lipoic acid as a biological antioxidant
10.1016/0891-5849(95)00017-r · 1995 · External reference
The use of alfa-lipoic acid-R (ALA-R) in patients with mild-moderate carpal tunnel syndrome: a randomised controlled open label prospective study
10.5704/moj.2003.001 · 2020 · External reference
Drugs for relief of pain in patients with sciatica: systematic review and meta-analysis
10.1136/bmj.e497 · 2012 · External reference
The use of alpha-lipoic acid (ALA), gamma linolenic acid (GLA) and rehabilitation in the treatment of back pain: effect on health-related quality of life
10.1177/03946320090220s309 · 2009 · External reference
Dose translation from animal to human studies revisited
10.1096/fj.07-9574lsf · 2008 · External reference
Mechanism implicated in the anti-allodynic and anti-hyperalgesic effects induced by the activation of heme oxygenase 1/carbon monoxide signaling pathway in the central nervous system of mice with neuropathic pain
10.1016/j.bcp.2017.12.007 · 2018 · External reference
Insights on the use of alpha-lipoic acid for therapeutic purposes
10.3390/biom9080356 · 2019 · External reference
A comprehensive review of clinical trials on the efficacy and safety of drugs for the treatment of low back pain
10.1016/j.jpainsymman.2003.10.015 · 2004 · External reference
Alpha-lipoic acid as a dietary supplement: molecular mechanisms and therapeutic potential
10.1016/j.bbagen.2009.07.026 · 2009 · External reference
Differential effects of lipoic acid stereoisomers on glucose metabolism in insulin-resistant skeletal muscle
10.1152/ajpendo.1997.273.1.e185 · 1997 · External reference
Alphalipoic acid prevents oxidative stress and peripheral neuropathy in nab-paclitaxel-treated rats through the Nrf2 signalling pathway
10.1155/2019/3142732 · 2019 · External reference
Choline and choline alphoscerate do not modulate inflammatory processes in the rat brain
10.3390/nu9101084 · 2017 · External reference
Spontaneously hypertensive rat as a model of vascular brain disorder: microanatomy, neurochemistry and behavior
10.1016/j.jns.2012.05.047 · 2012 · External reference
Biochemical and clinical relevance of alpha lipoic acid: antioxidant and anti-inflammatory activity, molecular pathways and therapeutic potential
10.1007/s00011-017-1079-6 · 2017 · External reference
Neuroprotective activity of thioctic acid in central nervous system lesions consequent to peripheral nerve injury
10.1155/2013/985093 · 2013 · External reference
Treatment with acetyl-L-carnitine exerts a neuroprotective effect in the sciatic nerve following loose ligation: a functional and microanatomical study
10.4103/1673-5374.230297 · 2018 · External reference
Dietary α-lipoic acid supplementation lowers blood pressure in spontaneously hypertensive rats
10.1097/00004872-200018050-00009 · 2000 · External reference
Crosstalk between spinal astrocytes and neurons in nerve injury-induced neuropathic pain
10.1371/journal.pone.0006973 · 2009 · External reference
The diagnostic value of neuropathy symptom and change score, neuropathy impairment score and Michigan neuropathy screening instrument for diabetic peripheral neuropathy
10.1159/000441449 · 2015 · External reference
Advances in the treatment of neuropathic pain
10.1007/978-94-017-7537-3_9 · 2016 · External reference
Oral treatment with alpha-lipoic acid improves symptomatic diabetic polyneuropathy: the SYDNEY 2 trial
10.2337/dc06-1216 · 2006 · External reference
