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References from Ansofaxine hydrochloride inhibits tumor growth and enhances Anti-TNFR2 in murine colon cancer model. Local targets link to admitted publications; unresolved targets remain external evidence.
Immunomodulatory effects mediated by dopamine
10.1155/2016/3160486 · 2016 · External reference
Immunomodulatory effects mediated by serotonin
10.1155/2015/354957 · 2015 · External reference
Interaction of TNF with TNF receptor type 2 promotes expansion and function of mouse CD4+CD25+ T regulatory cells
10.4049/jimmunol.179.1.154 · 2007 · External reference
Dopamine signaling promotes tissue-resident memory differentiation of CD8+ T cells and antitumor immunity
10.1158/0008-5472.can-21-4084 · 2022 · External reference
Immunomodulatory effects of fluoxetine: a new potential pharmacological action for a classic antidepressant drug?
10.1016/j.phrs.2015.11.021 · 2016 · External reference
Beneficial effect of fluoxetine and sertraline on chronic stress-induced tumor growth and cell dissemination in a mouse model of lymphoma: crucial role of antitumor immunity
10.3389/fimmu.2018.01341 · 2018 · External reference
CD8+ T cell exhaustion in cancer
10.3389/fimmu.2021.715234 · 2021 · External reference
Modulation of the extraneuronal cholinergic system on main innate response leukocytes
10.1016/j.jneuroim.2019.01.008 · 2019 · External reference
Depressive and anxiety symptoms among Japanese cancer survivors: Japan cancer survivorship research project
10.1186/s12885-022-09215-x · 2022 · External reference
Development of immune checkpoint therapy for cancer
10.1084/jem.20182395 · 2019 · External reference
Impaired Th1 immunity in ovarian cancer patients is mediated by TNFR2+ Tregs within the tumor microenvironment
10.1016/j.clim.2013.07.003 · 2013 · External reference
Reducing TNF receptor 2+ regulatory T cells via the combined action of azacitidine and the HDAC inhibitor, panobinostat for clinical benefit in acute myeloid leukemia patients
10.1158/1078-0432.ccr-13-1576 · 2014 · External reference
TNFR2 antagonistic antibody induces the death of tumor infiltrating CD4+Foxp3+ regulatory T cells
10.1007/s13402-022-00742-0 · 2023 · External reference
TNFR2 signaling enhances suppressive abilities of human circulating T follicular regulatory cells
10.4049/jimmunol.2100323 · 2022 · External reference
Antidepressants and colorectal cancer: a population-based nested case-control study
10.1016/j.jad.2016.09.057 · 2017 · External reference
TNFR2 deficiency impairs the growth of mouse colon cancer
10.7150/ijbs.72606 · 2023 · External reference
TNFR2 expression predicts the responses to immune checkpoint inhibitor treatments
10.3389/fimmu.2023.1097090 · 2023 · External reference
The effect of chronic stress on anti-angiogenesis of sunitinib in colorectal cancer models
10.1016/j.psyneuen.2014.11.008 · 2015 · External reference
Fluoxetine selectively induces p53-independent apoptosis in human colorectal cancer cells
10.1016/j.ejphar.2019.172441 · 2019 · External reference
Efficacy, safety, and tolerability of ansofaxine (LY03005) extended-release tablet for major depressive disorder: a randomized, double-blind, placebo-controlled, dose-finding, phase 2 clinical trial
10.1093/ijnp/pyab074 · 2022 · External reference
TNFR2 blockade of regulatory T cells unleashes an antitumor immune response after hematopoietic stem-cell transplantation
10.1136/jitc-2021-003508 · 2022 · External reference
Attenuation of peripheral serotonin inhibits tumor growth and enhances immune checkpoint blockade therapy in murine tumor models
10.1126/scitranslmed.abc8188 · 2021 · External reference
Triple reuptake inhibitors: a patent review (2006 - 2012)
10.1517/13543776.2014.859676 · 2014 · External reference
Triple reuptake inhibitors as potential next-generation antidepressants: a new hope?
10.4155/fmc.15.134 · 2015 · External reference
Chronic stress suppresses anti-tumor TCD8+ responses and tumor regression following cancer immunotherapy in a mouse model of melanoma
10.1016/j.bbi.2017.04.021 · 2017 · External reference
Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries
10.3322/caac.21660 · 2021 · External reference
Roles of regulatory T cells in cancer immunity
10.1093/intimm/dxw025 · 2016 · External reference
Antibody-mediated targeting of TNFR2 activates CD8+ T cells in mice and promotes antitumor immunity
10.1126/scitranslmed.aax0720 · 2019 · External reference
Targeted killing of TNFR2-expressing tumor cells and Tregs by TNFR2 antagonistic antibodies in advanced Sézary syndrome
10.1038/s41375-018-0292-9 · 2019 · External reference
Efficacy and tolerability of the novel triple reuptake inhibitor amitifadine in the treatment of patients with major depressive disorder: a randomized, double-blind, placebo-controlled trial
10.1016/j.jpsychires.2011.09.003 · 2012 · External reference
TNFR2: a novel target for cancer immunotherapy
10.1016/j.molmed.2017.09.007 · 2017 · External reference
Targeting monoamine oxidase A for T cell-based cancer immunotherapy
10.1126/sciimmunol.abh2383 · External reference
Targeting monoamine oxidase A-regulated tumor-associated macrophage polarization for cancer immunotherapy
10.1038/s41467-021-23164-2 · External reference
Molecular and cellular insights into T cell exhaustion
10.1038/nri3862 · 2015 · External reference
FOXP3+ Treg as a therapeutic target for promoting anti-tumor immunity
10.1080/14728222.2018.1451514 · 2018 · External reference
Peripheral T cell expansion predicts tumour infiltration and clinical response
10.1038/s41586-020-2056-8 · 2020 · External reference
Association between anxiety, depression, and comorbid chronic diseases among cancer survivors
10.1002/pon.5078 · 2019 · External reference
Anxiety and depression in patients with physical diseases and associated factors: a large-scale field survey in general hospitals in China
10.3389/fpsyt.2021.689787 · External reference
Antitumor effect of fluoxetine on chronic stress-promoted lung cancer growth via suppressing kynurenine pathway and enhancing cellular immunity
10.3389/fphar.2021.685898 · External reference
Chronic stress-induced immune dysregulation in cancer: implications for initiation, progression, metastasis, and treatment
2020 · External reference
Treg: a promising immunotherapeutic target in oral diseases
10.3389/fimmu.2021.667862 · 2021 · External reference
Anti-TNFR2 enhanced the antitumor activity of a new HMGN1/3M-052 stimulated dendritic cell vaccine in a mouse model of colon cancer
10.1016/j.bbrc.2023.02.039 · 2023 · External reference