Research graph
References from Apocynum venetum leaf extract alleviated doxorubicin-induced cardiotoxicity by regulating organic acid metabolism in gut microbiota. Local targets link to admitted publications; unresolved targets remain external evidence.
Gut microbiota and cardiovascular diseases: a critical review
10.1097/crd.0000000000000327 · 2021 · External reference
Phytochemical screening of Alstonia venenata leaf and bark extracts and their antimicrobial activities
10.14715/cmb/2020.66.4.27 · 2020 · External reference
Short-chain fatty acid propionate protects from hypertensive cardiovascular damage
10.1161/circulationaha.118.036652 · 2019 · External reference
Activin A in mammalian physiology
10.1152/physrev.00002.2018 · 2019 · External reference
Fecal metabonomics combined with 16S rRNA gene sequencing to analyze the changes of gut microbiota in rats with kidney-yang deficiency syndrome and the intervention effect of You-gui pill
10.1016/j.jep.2019.112139 · 2019 · External reference
Interactions between gut microbiota and polyphenols: a mechanistic and metabolomic review
10.1016/j.phymed.2023.154979 · 2023 · External reference
Regulated cell death pathways in doxorubicin-induced cardiotoxicity
10.1038/s41419-021-03614-x · 2021 · External reference
The cardiovascular effect of the uremic solute indole-3 acetic acid
10.1681/asn.2013121283 · 2015 · External reference
UPLC-ESI-MS/MS based characterization of active flavonoids from Apocynum spp. and anti-bacteria assay
10.3390/antiox10121901 · 2021 · External reference
Gut-derived metabolite indole-3-propionic acid modulates mitochondrial function in cardiomyocytes and alters cardiac function
10.3389/fmed.2021.648259 · 2021 · External reference
The interactions between gut microbiota and bioactive ingredients of traditional Chinese medicines: a review
10.1016/j.phrs.2020.104824 · 2020 · External reference
Gut microbiota and cardiovascular disease: opportunities and challenges
10.1186/s40168-020-00821-0 · 2020 · External reference
Daidzein alleviates doxorubicin-induced heart failure via the SIRT3/FOXO3a signaling pathway
10.1039/d2fo00772j · 2022 · External reference
A circular RNA derived from the insulin receptor locus protects against doxorubicin-induced cardiotoxicity
10.1093/eurheartj/ehac337 · 2022 · External reference
Toll-like receptor (TLR) 2 and TLR4 differentially regulate doxorubicin induced cardiomyopathy in mice
10.1371/journal.pone.0040763 · 2012 · External reference
Identification of drug transporter genomic variants and inhibitors that protect against doxorubicin-induced cardiotoxicity
10.1161/circulationaha.121.055801 · 2022 · External reference
High-fiber diet and acetate supplementation change the gut microbiota and prevent the development of hypertension and heart failure in hypertensive mice
10.1161/circulationaha.116.024545 · 2017 · External reference
Extracellular matrix in heart disease: focus on circulating collagen type I and III derived peptides as biomarkers of myocardial fibrosis and their potential in the prognosis of heart failure: a concise review
10.3390/metabo12040297 · 2022 · External reference
Sustained alternate-day fasting potentiates doxorubicin cardiotoxicity
10.1016/j.cmet.2023.02.006 · 2023 · External reference
Acetate mediates a microbiome-brain-β-cell axis to promote metabolic syndrome
10.1038/nature18309 · 2016 · External reference
A novel SCFA receptor, the microbiota, and blood pressure regulation
10.4161/gmic.27492 · 2014 · External reference
An overview of doxorubicin formulations in cancer therapy
10.4103/0973-1482.139267 · 2014 · External reference
Doxorubicin-induced cardiotoxicity: an overview on pre-clinical therapeutic approaches
10.1007/s12012-022-09721-1 · 2022 · External reference
Dietary metabolism, the gut microbiome, and heart failure
10.1038/s41569-018-0108-7 · 2019 · External reference
The role of AMPK activation for cardioprotection in doxorubicin-induced cardiotoxicity
10.1007/s10557-020-06941-x · 2020 · External reference
Mitochondrial determinants of doxorubicin-induced cardiomyopathy
10.1161/circresaha.119.314681 · 2020 · External reference
Genus unclassified_Muribaculaceae and microbiota-derived butyrate and indole-3-propionic acid are involved in benzene-induced hematopoietic injury in mice
10.1016/j.chemosphere.2022.137499 · 2023 · External reference
Probiotic lactobacillus plantarum promotes intestinal barrier function by strengthening the epithelium and modulating gut microbiota
10.3389/fmicb.2018.01953 · 2018 · External reference
Ghrelin protected neonatal rat cardiomyocyte against hypoxia/reoxygenation injury by inhibiting apoptosis through Akt-mTOR signal
10.1007/s11033-017-4098-z · 2017 · External reference
Oral berberine improves brain dopa/dopamine levels to ameliorate Parkinson's disease by regulating gut microbiota
10.1038/s41392-020-00456-5 · 2021 · External reference
Vagotomy dissociates short- and long-term controls of circulating ghrelin
10.1210/en.2003-1059 · 2003 · External reference
In vitro and in vivo studies reveal that hesperetin-7-O-glucoside, a naturally occurring monoglucoside, exhibits strong anti-inflammatory capacity
10.1021/acs.jafc.1c05793 · 2021 · External reference
Daidzein ameliorates doxorubicin-induced cardiac injury by inhibiting autophagy and apoptosis in rats
10.1039/d2fo03416f · 2023 · External reference
Apocynum venetum leaf extract exerts antidepressant-like effects and inhibits hippocampal and cortical apoptosis of rats exposed to chronic unpredictable mild stress
10.1155/2018/5916451 · 2018 · External reference
Apocynum venetum, a medicinal, economical and ecological plant: a review update
10.7717/peerj.14966 · 2023 · External reference
Botany, traditional uses, phytochemistry and pharmacology of Apocynum venetum L. (Luobuma): a review
10.1016/j.jep.2012.02.003 · 2012 · External reference
Gut microbially produced indole-3-propionic acid inhibits atherosclerosis by promoting reverse cholesterol transport and its deficiency is causally related to atherosclerotic cardiovascular disease
10.1161/circresaha.122.321253 · 2022 · External reference
Ghrelin suppresses cardiac fibrosis of post-myocardial infarction heart failure rats by adjusting the activin A-follistatin imbalance
10.1016/j.peptides.2017.10.018 · 2018 · External reference
Beneficial effects of polysaccharide-rich extracts from Apocynum venetum leaves on hypoglycemic and gut microbiota in type 2 diabetic mice
10.1016/j.biopha.2020.110182 · 2020 · External reference
Apocynum venetum leaf extract alleviated doxorubicin-induced cardiotoxicity through the AKT/Bcl-2 signaling pathway
10.1016/j.phymed.2021.153815 · 2022 · External reference
TMAO: how gut microbiota contributes to heart failure
10.1016/j.trsl.2020.08.007 · 2021 · External reference
Gut-brain axis metabolic pathway regulates antidepressant efficacy of albiflorin
10.7150/thno.28068 · 2018 · External reference
Astragaloside IV improves the pharmacokinetics of febuxostat in rats with hyperuricemic nephropathy by regulating urea metabolism in gut microbiota
10.3389/fphar.2022.1031509 · 2022 · External reference
