Research graph
References from GPR55 deletion increases anxiety- and depression-like behaviors and modifies amygdalar GABAAα2 expression. Local targets link to admitted publications; unresolved targets remain external evidence.
Modulation of neuroinflammation and oxidative stress by targeting GPR55 - new approaches in the treatment of psychiatric disorders
10.1038/s41380-024-02614-5 · 2024 · External reference
Preliminary report of a simple animal behavior model for the anxiolytic effects of benzodiazepines
10.1016/0091-3057(80)90067-2 · 1980 · External reference
Stress, genes and the mechanism of programming the brain for later life
10.1016/j.neubiorev.2004.10.008 · 2005 · External reference
Different benzodiazepines bind with distinct binding modes to GABA(A) receptors
10.1021/acschembio.8b00144 · 2018 · External reference
Unresolved reference
2001 · External reference
Overexpression of CB2 cannabinoid receptors decreased vulnerability to anxiety and impaired anxiolytic action of alprazolam in mice
10.1177/0269881110379507 · 2011 · External reference
Depression-resistant endophenotype in mice overexpressing cannabinoid CB(2) receptors
10.1111/j.1476-5381.2010.00819.x · 2010 · External reference
Alterations in gene and protein expression of cannabinoid CB(2) and GPR55 receptors in the dorsolateral prefrontal cortex of suicide victims
10.1007/s13311-018-0610-y · 2018 · External reference
GPR55 is expressed in glutamate neurons and functionally modulates drug taking and seeking in rats and mice
10.1038/s41398-024-02820-3 · 2024 · External reference
Activation of GPR55 induces neuroprotection of hippocampal neurogenesis and immune responses of neural stem cells following chronic, systemic inflammation
10.1016/j.bbi.2018.11.017 · 2019 · External reference
Psychiatric implications of altered limbic-hypothalamic-pituitary-adrenocortical activity
10.1007/bf00449812 · 1989 · External reference
Region-specific dysregulation of endocannabinoid system in learned helplessness model of depression
10.1097/wnr.0000000000001601 · 2021 · External reference
The G protein-coupled receptor 55 ligand l-alpha-lysophosphatidylinositol exerts microglia-dependent neuroprotection after excitotoxic lesion
10.1002/glia.22560 · 2013 · External reference
The use of a plus-maze to measure anxiety in the mouse
10.1007/bf00177912 · 1987 · External reference
GPR55-dependent stimulation of insulin secretion from isolated mouse and human islets of Langerhans
10.1111/dom.12780 · 2016 · External reference
Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method
10.1006/meth.2001.1262 · 2001 · External reference
The GABAergic deficit hypothesis of major depressive disorder
10.1038/mp.2010.120 · 2011 · External reference
Cannabidiol and positive effects on object recognition memory in an in vivo model of Fragile X syndrome: obligatory role of hippocampal GPR55 receptors
10.1016/j.phrs.2024.107176 · 2024 · External reference
Consequences of early life stress on the expression of endocannabinoid-related genes in the rat brain
10.1097/fbp.0000000000000068 · 2014 · External reference
Advances in the physiology of GPR55 in the central nervous system
10.2174/1570159x14666160729155441 · 2017 · External reference
Possible role of hippocampal GPR55 in spatial learning and memory in rats
10.21307/ane-2018-001 · 2018 · External reference
The HPA axis as target for depression
10.2174/1570159x21666230811141557 · 2024 · External reference
A novel crosstalk within the endocannabinoid system controls GABA transmission in the striatum
10.1038/s41598-017-07519-8 · 2017 · External reference
Regulation of glucocorticoid receptor transcription and nuclear translocation during single and repeated immobilization stress
10.1210/en.2010-0266 · 2010 · External reference
Anxiety disorders and GABA neurotransmission: a disturbance of modulation
10.2147/ndt.s58841 · 2015 · External reference
Punch sampling biopsy technique
10.1016/s0076-6879(83)03025-6 · 1983 · External reference
GPR55: a new member of the cannabinoid receptor clan?
10.1038/sj.bjp.0707464 · 2007 · External reference
Central administration of GPR55 receptor agonist and antagonist modulates anxiety-related behaviors in rats
10.1111/fcp.12099 · 2015 · External reference
The cannabinoid ligands SR141716A and AM251 enhance human and mouse islet function via GPR55-independent signalling
10.1007/s00018-019-03433-6 · 2020 · External reference
Anti-neuroinflammatory effects of GPR55 antagonists in LPS-activated primary microglial cells
10.1186/s12974-018-1362-7 · 2018 · External reference
Presynaptic nigral GPR55 receptors stimulate [(3) H]-GABA release through [(3) H]-cAMP production and PKA activation and promote motor behavior
10.1002/syn.22246 · 2022 · External reference
GPR55 in the bed nucleus of stria terminalis modulates anxiety-like behavior, amphetamine self-administration and inflammatory response
10.1016/j.pnpbp.2025.111418 · 2025 · External reference
Use of the open field maze to measure locomotor and anxiety-like behavior in mice
10.3791/52434 · 2015 · External reference
The neuroprotective effects of GPR55 against hippocampal neuroinflammation and impaired adult neurogenesis in CSDS mice
10.1016/j.nbd.2022.105743 · 2022 · External reference
The novel cannabinoid receptor GPR55 mediates anxiolytic-like effects in the medial orbital cortex of mice with acute stress
10.1186/s13041-017-0318-7 · 2017 · External reference
Anti-inflammatory effects of GPR55 agonists and antagonists in LPS-treated BV2 microglial cells
10.3390/ph17060674 · 2024 · External reference
Activation of GPR55 ameliorates maternal separation-induced learning and memory deficits by augmenting 5-HT synthesis in the dorsal raphe nucleus of juvenile mice
10.1021/acsomega.3c08934 · 2024 · External reference
Cannabinoid- and lysophosphatidylinositol-sensitive receptor GPR55 boosts neurotransmitter release at central synapses
10.1073/pnas.1211204110 · 2013 · External reference
MCH11, a new monoacylglycerol lipase inhibitor, reduces ethanol consumption and motivation to drink in mice, with sex-dependent differences
10.1016/j.biopha.2025.118662 · 2025 · External reference
Impaired action of anxiolytic drugs in mice deficient in cannabinoid CB1 receptors
10.1016/j.neuropharm.2004.01.003 · 2004 · External reference
Individual differences in response to imipramine in the mouse tail suspension test
10.1007/s002130050475 · 1997 · External reference
Blockade of GPR55 in dorsal periaqueductal gray produces anxiety-like behaviors and evocates defensive aggressive responses in alcohol-pre-exposed rats
10.1016/j.neulet.2021.136218 · 2021 · External reference
Pharmacological activation of GPR55 improved cognitive impairment induced by lipopolysaccharide in mice
10.1007/s12031-022-02020-y · 2022 · External reference
O-1602, an agonist of atypical cannabinoid receptors GPR55, reverses the symptoms of depression and detrusor overactivity in rats subjected to corticosterone treatment
10.3389/fphar.2020.01002 · 2020 · External reference
GPR55 activation improves anxiety- and depression-like behaviors of mice during methamphetamine withdrawal
10.1016/j.heliyon.2024.e30462 · 2024 · External reference
