Research graph
References from LP533401 treatment alters vitamin K metabolism, bone Gla-OC/Glu-OC ratios, and improves mineral status of the skeleton in rats with chronic kidney disease. Local targets link to admitted publications; unresolved targets remain external evidence.
The importance of vitamin K and the combination of vitamins K and D for calcium metabolism and bone health: a review
10.3390/nu16152420 · 2024 · External reference
Vitamin K promotes mineralization, osteoblast-to-osteocyte transition, and an anticatabolic phenotype by γ-carboxylation-dependent and -independent mechanisms
10.1152/ajpcell.00216.2009 · 2009 · External reference
Role of vitamin K in chronic kidney disease: a focus on bone and cardiovascular health
10.3390/ijms23095282 · 2022 · External reference
Antioxidant properties of green plants with different vitamin K contents
10.3390/molecules29153655 · 2024 · External reference
Relationship between structure and biological activity of various vitamin K forms
10.3390/foods10123136 · 2021 · External reference
Evaluation of vitamin K status and rationale for vitamin K supplementation in dialysis patients
10.1093/ndt/gfy373 · 2020 · External reference
Naturally occurring UBIAD1 mutations differentially affect menaquinone biosynthesis and vitamin K-dependent carboxylation
10.1111/febs.16291 · 2022 · External reference
Vitamin K role in mineral and bone disorder of chronic kidney disease
10.1016/j.cca.2019.11.040 · 2020 · External reference
Increased bone formation in osteocalcin-deficient mice
10.1038/382448a0 · 1996 · External reference
Vitamin K: metabolism, genetic influences, and chronic disease outcomes
10.1002/fsn3.70431 · 2025 · External reference
GGCX and VKORC1 inhibit osteocalcin endocrine functions
10.1083/jcb.201409111 · 2015 · External reference
Vitamin K plasma levels determination in human health
10.1515/cclm-2016-0783 · 2017 · External reference
Evaluating the influence of vitamin K supplementation on bone markers in hemodialysis patients
10.1097/ms9.0000000000003283 · 2025 · External reference
The effect of treatment with PTH on undercarboxylated osteocalcin and energy metabolism in hypoparathyroidism
10.1210/jc.2015-1477 · 2015 · External reference
Functional characterization of the vitamin K2 biosynthetic enzyme UBIAD1
10.1371/journal.pone.0125737 · 2015 · External reference
Mineral bone disorders in kidney disease patients: the ever-current topic
10.3390/ijms232012223 · 2022 · External reference
A single number for advocacy and communication-worldwide more than 850 million individuals have kidney diseases
10.1016/j.kint.2019.07.012 · 2019 · External reference
Chronic kidney disease-mineral and bone disorder: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) controversies conference
10.1016/j.kint.2024.11.013 · 2025 · External reference
KDIGO 2024 clinical practice guideline for the evaluation and management of chronic kidney disease
10.1016/j.kint.2023.10.018 · 2024 · External reference
KDIGO 2017 clinical practice guideline update for the diagnosis, evaluation, prevention, and treatment of chronic kidney disease-mineral and bone disorder (CKD-MBD)
10.1016/j.kisu.2017.10.001 · 2017 · External reference
Bone health of adult hemodialysis patients is related to vitamin K status
10.1038/ki.1997.166 · 1997 · External reference
What is the function of osteocalcin?
10.1016/j.job.2020.05.004 · 2020 · External reference
Epidemiology of chronic kidney disease: an update 2022
10.1016/j.kisu.2021.11.003 · 2022 · External reference
Kidney function-dependence of vitamin K-status parameters: results from the TransplantLines Biobank and cohort studies
10.3390/nu13093069 · 2021 · External reference
Increased trabecular bone and improved biomechanics in an osteocalcin-null rat model created by CRISPR/Cas9 technology
10.1242/dmm.025247 · 2016 · External reference
A multi-imaging modality study of bone density, bone structure and the muscle - bone unit in end-stage renal disease
10.1016/j.bone.2019.05.022 · 2019 · External reference
Vitamin K supplementation and bone mineral density in dialysis: results of the double-blind, randomized, placebo-controlled RenaKvit trial
10.1093/ndt/gfac315 · 2023 · External reference
Effect of parathyroidectomy on osteopontin and undercarboxylated osteocalcin in patients with primary hyperparathyroidism
10.1080/07435800.2017.1369432+ · 2018 · External reference
Combining phosphate binder therapy with vitamin K2 inhibits vascular calcification in an experimental animal model of kidney failure
10.1093/ndt/gfab314 · 2022 · External reference
Cortical or trabecular bone: what’s the difference?
10.1159/000489672 · 2018 · External reference
The association between elevated levels of peripheral serotonin and its metabolite - 5-hydroxyindoleacetic acid and bone strength and metabolism in growing rats with mild experimental chronic kidney disease
10.1371/journal.pone.0163526 · 2016 · External reference
The impact of peripheral serotonin on leptin-brain serotonin axis, bone metabolism and strength in growing rats with experimental chronic kidney disease
10.1016/j.bone.2017.08.004 · 2017 · External reference
LP533401 restores bone health in 5/6 nephrectomized rats by a decrease of gut-derived serotonin and regulation of serum phosphate through the inhibition of phosphate co-transporters expression in the kidneys
10.1016/j.bone.2018.05.022 · 2018 · External reference
Fractures in patients with CKD-diagnosis, treatment, and prevention: a review by members of the European Calcified Tissue Society and the European Renal Association of Nephrology Dialysis and Transplantation
10.1016/j.kint.2017.07.021 · 2017 · External reference
The role of vitamin K in humans: implication in aging and age-associated diseases
10.3390/antiox10040566 · 2021 · External reference
Epidemiological shifts in chronic kidney disease: a 30-year global and regional assessment
10.1186/s12889-024-21065-9 · 2024 · External reference
Correlations between osteocalcin content, degree of mineralization, and mechanical properties of C. carpio rib bone
10.1002/1097-4636(20010315)54:4<547::aid-jbm110>3.0.co;2-2 · 2001 · External reference
MK-7 and its effects on bone quality and strength
10.3390/nu12040965 · 2020 · External reference
Determination of phylloquinone and menaquinones in food. Effect of food matrix on circulating vitamin K concentrations
10.1159/000054147 · 2000 · External reference
Vitamin K
10.1093/advances/nmab133 · 2022 · External reference
Vitamin K dependent proteins in kidney disease
10.3390/ijms20071571 · 2019 · External reference
First evidence of octacalcium phosphate@osteocalcin nanocomplex as skeletal bone component directing collagen triple-helix nanofibril mineralization
10.1038/s41598-018-31983-5 · 2018 · External reference
Cardiovascular parameters in rat model of chronic renal failure induced by subtotal nephrectomy
10.33549/physiolres.932003 · 2010 · External reference
Structural and functional insights into enzymes of the vitamin K cycle
10.1111/jth.13217 · 2016 · External reference
B. vulgatus ameliorates high-fat diet-induced obesity through modulating intestinal serotonin synthesis and lipid absorption in mice
10.1080/19490976.2024.2423040 · 2024 · External reference
Effects of combined menaquinone-4 and PTH1-34 treatment on osteogenesis and angiogenesis in calvarial defect in osteopenic rats
10.1007/s12020-018-1761-7 · 2019 · External reference
Unexpected role of matrix gla protein in osteoclasts: inhibiting osteoclast differentiation and bone resorption
10.1128/mcb.00012-19 · 2019 · External reference
Vitamin K-dependent carboxylation of osteocalcin in bone - ally or adversary of bone mineral status in rats with experimental chronic kidney disease?
10.3390/nu14194082 · 2022 · External reference
