Research graph
References from A neuroprotective target in the shadows: a scoping review of pharmacological gaps in σ1R agonists for glutamate-induced neurotoxicity. Local targets link to admitted publications; unresolved targets remain external evidence.
Sigma-1 receptor activation by fluvoxamine ameliorates ER stress, synaptic dysfunction and behavioral deficits in a ketamine model of schizophrenia
10.1007/s10787-025-10231-4 · 2025 · External reference
Sigma-1 receptor ligand PRE-084 reduced infarct volume, neurological deficits, pro-inflammatory cytokines and enhanced anti-inflammatory cytokines after embolic stroke in rats
10.1016/j.brainresbull.2011.03.019 · 2011 · External reference
Immunocytochemical localization of the sigma1 receptor in the adult rat central nervous system
10.1016/s0306-4522(00)00014-2 · 2000 · External reference
Pharmacological modulation of sigma-1 receptor ameliorates pathological neuroinflammation in rats with diabetic neuropathic pain via the AKT/GSK-3β/NF-κB pathway
10.1016/j.neuropharm.2024.109508 · 2025 · External reference
Blocking the anoxic depolarization protects without functional compromise following simulated stroke in cortical brain slices
10.1152/jn.00654.2004 · 2005 · External reference
Anti-amnesic and neuroprotective actions of the Sigma-1 receptor agonist (-)-MR22 in rats with selective cholinergic lesion and amyloid infusion
10.3233/jad-2011-101794 · 2011 · External reference
The cholinergic system, sigma-1 receptors and cognition
10.1016/j.bbr.2009.12.043 · 2011 · External reference
Modulation of [3H]dopamine release from rat nucleus accumbens by neuropeptide Y may involve a Sigma1-like receptor
10.1016/s0022-3565(24)37286-6 · 1998 · External reference
Sigma-1 receptor expression in sensory neurons and the effect of painful peripheral nerve injury
10.1186/1744-8069-9-47 · 2013 · External reference
The pain of pain: challenges of animal behavior models
10.1016/j.ejphar.2014.11.046 · 2015 · External reference
Distinct modulatory roles of sigma receptor subtypes on glutamatergic responses in the dorsal hippocampus
10.1002/syn.20085 · 2005 · External reference
Impact of two neuronal sigma-1 receptor modulators, PRE084 and DMT, on neurogenesis and neuroinflammation in an Aβ1–42-injected wild-type mouse model
10.3390/ijms23052514 · 2022 · External reference
What do citation counts measure? A review of studies on citing behavior
10.1108/00220410810844150 · 2008 · External reference
Cocaine self-administration specifically increases A2AR-D2R and D2R-sigma1R heteroreceptor complexes in the rat nucleus accumbens shell. Relevance for cocaine use disorder
10.1016/j.pbb.2017.03.003 · 2017 · External reference
Sigma-1 receptors & disease (S1RaD) 2025
10.1080/2994399x.2024.2454759 · 2025 · External reference
Dipentylammonium binds to the sigma-1 receptor and protects against glutamate toxicity, attenuates dopamine toxicity and potentiates neurite outgrowth in various neuronal cell models
10.1007/s12640-018-9883-5 · 2018 · External reference
Sigma-1 receptor: a new player in neuroprotection against chemotherapy-induced peripheral neuropathy
10.4103/1673-5374.232469 · 2018 · External reference
Effects of neurosteroids on ischemia-reperfusion injury in the rat retina: role of σ1 recognition sites
10.1016/j.ejphar.2004.06.067 · 2004 · External reference
Sigma receptor ligands protect human retinal cells against oxidative stress
10.1097/01.wnr.0000199469.21734.e1 · 2006 · External reference
Drugs of abuse, immune modulation, and AIDS
10.1007/s11481-006-9023-5 · 2006 · External reference
Two different molecular mechanisms underlying progesterone neuroprotection against ischemic brain damage
10.1016/j.neuropharm.2008.04.023 · 2008 · External reference
Dehydroepiandrosterone and allopregnanolone protect sympathoadrenal medulla cells against apoptosis via antiapoptotic Bcl-2 proteins
10.1073/pnas.0306631101 · 2004 · External reference
Neurosteroids as endogenous inhibitors of neuronal cell apoptosis in aging
10.1196/annals.1366.003 · 2006 · External reference
Chronic administration of dehydroepiandrosterone sulfate (DHEAS) primes for facilitated induction of long-term potentiation via sigma 1 (σ1) receptor: optical imaging study in rat hippocampal slices
10.1016/j.neuropharm.2005.10.015 · 2006 · External reference
The neuroprotective effect of activation of sigma-1 receptor on neural injury by optic nerve crush
10.1167/tvst.12.4.6 · 2023 · External reference
Central role of sigma-1 receptor in ochratoxin A-induced ferroptosis
10.1007/s00204-024-03805-3 · 2024 · External reference
Pharmacology and therapeutic potential of Sigma1 receptor ligands
10.2174/157015908787386113 · 2008 · External reference
Sigma receptor modulators: a patent review (2006–2011)
10.1517/13543776.2013.769522 · 2013 · External reference
Sigma-1 receptor is a key genetic modulator in amyotrophic lateral sclerosis
10.1093/hmg/ddz302 · 2020 · External reference
JAM-A-independent, antibody-mediated uptake of reovirus into cells leads to apoptosis
10.1128/jvi.80.3.1261-1270.2006 · 2006 · External reference
Sigma-1 receptors and animal studies centered on pain and analgesia
10.1517/17460441.2015.1051961 · 2015 · External reference
At the crossing of ER stress and MAMs: a key role of sigma-1 receptor?
2019 · External reference
Sigma-1 receptor targeting inhibits connexin 43-based intercellular communication in chronic neuropathic pain
10.1007/s10753-024-01924-6 · External reference
Sigma-1 receptor inhibition reduces mechanical allodynia and modulates neuroinflammation in chronic neuropathic pain
10.1007/s12035-024-04006-3 · External reference
Neurosteroid dehydroepiandrosterone sulfate enhances spontaneous glutamate release in rat prelimbic cortex through activation of dopamine D1 and sigma-1 receptors
10.1016/j.neuropharm.2006.10.015 · 2007 · External reference
Pharmacological and pathological implications of sigma-1 receptor in neurodegenerative diseases
10.3390/biomedicines13061409 · 2025 · External reference
Prevention of excitotoxicity in primary retinal ganglion cells by (+)-pentazocine, a sigma receptor-1–specific ligand
10.1167/iovs.07-0298 · 2007 · External reference
Pridopidine protects neurons from mutant-huntingtin toxicity via the sigma-1 receptor
10.1016/j.nbd.2019.05.009 · 2019 · External reference
Involvement of the sigma1 receptor in inhibiting activity of fluvoxamine on marble-burying behavior: Comparison with paroxetine
10.1016/j.ejphar.2007.02.019 · 2007 · External reference
Synthesis and evaluation of [18F]fluoroethyl SA4503 as a PET ligand for the sigma receptor
10.1002/syn.10045 · 2002 · External reference
Repurposing sigma-1 receptor-targeting drugs for therapeutic advances in neurodegenerative disorders
10.3390/ph18050700 · 2025 · External reference
Involvement of the sigma1 (σ1) receptor in the anti-amnesic, but not antidepressant-like, effects of the aminotetrahydrofuran derivative ANAVEX1-41
10.1038/sj.bjp.0707386 · 2007 · External reference
Comparison of PubMed, scopus, web of science, and Google scholar: strengths and weaknesses
10.1096/fj.07-9492lsf · 2008 · External reference
Safinamide [Review of Safinamide]
10.1016/j.nurt.2006.11.011 · 2007 · External reference
Effects of long-term alcohol drinking on the dopamine D2 receptor: gene expression and heteroreceptor complexes in the striatum in rats
10.1111/acer.13568 · 2018 · External reference
Pharmacological stimulation of sigma-1 receptors has neurorestorative effects in experimental parkinsonism
10.1093/brain/awu107 · 2014 · External reference
Pridopidine induces functional neurorestoration via the Sigma-1 receptor in a mouse model of parkinson
10.1007/s13311-018-00699-9 · 2019 · External reference
Novel dithiolane-based ligands combining sigma and NMDA receptor interactions as potential neuroprotective agents
10.1021/acsmedchemlett.0c00129 · 2020 · External reference
A possibly sigma-1 receptor mediated role of dimethyltryptamine in tissue protection, regeneration, and immunity
10.1007/s00702-013-1024-y · 2013 · External reference
Sigma1 receptor antagonist BD1047 enhances reversal of conditioned place preference from cocaine to social interaction
10.1159/000322534 · 2011 · External reference
Sigma-1 receptor chaperones regulate the secretion of brain-derived neurotrophic factor
10.1002/syn.21549 · 2012 · External reference
Sigma-1 receptor is a pharmacological target to promote neuroprotection in the SOD1G93A ALS mice
10.3389/fphar.2021.780588 · 2021 · External reference
Cocaine modulates cytokine and enhances tumor growth through sigma receptors
10.1016/j.jneuroim.2003.10.020 · 2004 · External reference
Glutamate receptor dysregulation and platelet glutamate dynamics in Alzheimer’s and Parkinson’s diseases: insights into current medications
10.3390/biom13111609 · 2025 · External reference
Neuroprotection of retinal ganglion cells by the sigma-1 receptor agonist pridopidine in models of experimental glaucoma
10.1038/s41598-021-01077-w · 2021 · External reference
Sigma-1 receptor agonists induce oxidative stress in mitochondria and enhance complex I activity in physiological condition but protect against pathological oxidative stress
10.1007/s12640-017-9838-2 · 2017 · External reference
Release of [3H]dopamine from Guinea pig striatal slices is modulated by sigma1 receptor agonists
10.1007/pl00005076 · 1997 · External reference
Regulation of [3H]dopamine release from rat striatal slices by sigma receptor ligands
10.1016/s0022-3565(25)22758-6 · 1994 · External reference
σ1 receptors in rat striatum regulate NMDA-stimulated [3H]dopamine release via a presynaptic mechanism
10.1016/0014-2999(95)00617-6 · 1995 · External reference
Selective serotonin reuptake inhibitors in affective disorders—I. Basic pharmacology
10.1177/0269881198012003021 · 1998 · External reference
Involvement of σ receptors in the modulation of the glutamatergic/NMDA neurotransmission in the dopaminergic systems
10.1016/s0014-2999(99)00025-4 · 1999 · External reference
Regulation of ionotropic glutamate receptor subunits in different rat brain areas by a preferential sigma1 receptor ligand and potential atypical antipsychotic
10.1016/s0893-133x(00)00142-1 · 2000 · External reference
SKF83959 is a potent allosteric modulator of Sigma-1 receptor
10.1124/mol.112.083840 · 2013 · External reference
Selective sigma receptor agonist PRE084 promotes neuroprotection and neurite elongation in vitro and in vivo
10.1016/j.expneurol.2009.09.005 · 2009 · External reference
The role of Google scholar in evidence reviews and its applicability to grey literature searching
10.1371/journal.pone.0138237 · 2015 · External reference
PRISMA 2020: an R package and shiny app for producing PRISMA 2020-compliant flow diagrams, with interactivity for optimised digital transparency and open synthesis campbell
10.1002/cl2.1230 · 2022 · External reference
Purification, molecular cloning, and expression of the mammalian sigma1-binding site
10.1073/pnas.93.15.8072 · 1996 · External reference
Sigma-1 receptors and selective serotonin reuptake inhibitors: clinical implications of their relationship
10.2174/187152409788680713 · 2009 · External reference
Activation of sigma-1 receptor chaperone in the treatment of neuropsychiatric diseases and its clinical implication
10.1016/j.jphs.2014.11.010 · 2015 · External reference
Targeting the sigma-1 receptor chaperone in the treatment of perinatal brain injury
10.1016/j.brainresbull.2015.06.007 · 2015 · External reference
Sigma-1 receptor ligands
10.2165/00023210-200418050-00001 · 2004 · External reference
The sigma receptor: evolution of the concept in neuropsychopharmacology
10.2174/1871527053507851 · 2005 · External reference
Sigma-1 receptor chaperones at the ER- mitochondrion interface regulate Ca2+ signaling and cell survival
10.1016/j.cell.2007.08.036 · 2007 · External reference
Modulation by sigma ligands of intracellular free Ca++ mobilization by N-methyl-D-aspartate in primary culture of rat frontal cortical neurons
10.1016/s0022-3565(25)12037-5 · 1995 · External reference
Targeting ligand-operated chaperone sigma-1 receptors in the treatment of neuropsychiatric disorders
10.1517/14728222.2011.560837 · 2011 · External reference
Sigma-1 receptor as a therapeutic target for amyotrophic lateral sclerosis
10.1111/bph.15224 · 2021 · External reference
σ-1 receptor modulation of acid-sensing ion channel a (ASIC1a) and ASIC1a-Induced Ca2+ influx in rat cortical neurons
10.1124/jpet.108.143974 · 2008 · External reference
Chloroquine inhibits glutamate-induced death of a neuronal cell line by reducing reactive oxygen species through sigma-1 receptor
10.1111/j.1471-4159.2011.07464.x · 2011 · External reference
Sigma-1 receptor deficiency reduces MPTP-induced parkinsonism and death of dopaminergic neurons
10.1038/cddis.2015.194 · 2015 · External reference
Glutamate excitotoxicity: a key secondary injury mechanism of traumatic brain injury and spinal cord injury
10.31083/fbl38904 · 2025 · External reference
Ethanol and N-methyl-D-aspartate receptor complex interactions: a detailed drug discrimination study in the rat
10.1007/s002130050484 · 1998 · External reference
Hypothesis: the psychedelic ayahuasca heals traumatic memories via a sigma 1 receptor-mediated epigenetic-mnemonic process
10.3389/fphar.2018.00330 · 2018 · External reference
The role of sigma-1 receptors in the pathophysiology of neuropsychiatric diseases
10.1080/10799890802657467 · 2009 · External reference
σ 1 -Receptor ligand 4-Phenyl-1-(4-Phenylbutyl)-Piperidine affords neuroprotection from focal ischemia with prolonged reperfusion
10.1161/01.str.31.4.976 · 2000 · External reference
Activation of sigma-1 receptor ameliorates anxiety-like behavior and cognitive impairments in a rat model of post-traumatic stress disorder
10.1016/j.bbr.2016.05.039 · 2016 · External reference
Sigma-1 receptor activation ameliorates anxiety-like behavior through NR2A-CREB-BDNF signaling pathway in a rat model submitted to single-prolonged stress
10.3892/mmr.2017.7224 · 2017 · External reference
Expression, subcellular localization, and regulation of sigma receptor in retinal Müller cells
10.1167/iovs.06-0608 · 2006 · External reference
Roles of sigma-1 receptors in Alzheimer’s disease
2015 · External reference
Inflammatory signaling mechanisms in bipolar disorder
10.1186/s12929-021-00742-6 · 2021 · External reference
Sigma-1 receptor activation prevents intracellular calcium dysregulation in cortical neurons during in vitro ischemia
10.1124/jpet.106.107557 · 2006 · External reference
A role for sigma receptors in stimulant self administration and addiction
10.3390/ph4060880 · 2011 · External reference
Role of sigma receptors in methamphetamine-induced neurotoxicity
10.2174/187152711798072299 · 2011 · External reference
Synthesis and in vivo evaluation of [11C]SA6298 as a PET sigma1 receptor ligand
10.1016/s0969-8051(99)00069-4 · 1999 · External reference
In vivo evaluation of [11C]SA4503 as a PET ligand for mapping CNS sigma1 receptors
10.1016/s0969-8051(00)00081-0 · 2000 · External reference
Evaluation of [11C]SA5845 and [11C]SA4503 for imaging of sigma receptors in tumors by animal PET
10.1007/bf02985120 · 2005 · External reference
Synthesis and evaluation of fluorine-18-labeled SA4503 as a selective sigma1 receptor ligand for positron emission tomography
10.1016/j.nucmedbio.2007.03.009 · 2007 · External reference
Contribution of lysosome and sigma receptors to neuroprotective effects of memantine against beta-amyloid in SH-SY5Y cells
10.1080/01616412.2020.1770413 · 2020 · External reference
Sigma1 pharmacology in the context of cancer
10.1007/164_2017_38 · 2017 · External reference
Activation of the spinal sigma-1 receptor enhances NMDA-induced pain via PKC- and PKA-dependent phosphorylation of the NR1 subunit in mice
10.1038/bjp.2008.159 · 2008 · External reference
Inhibition of tumor cell growth by Sigma1 ligand mediated translational repression
10.1016/j.bbrc.2012.08.052 · 2012 · External reference
Sigma-1 receptor enhances neurite elongation of cerebellar granule neurons via TrkB signaling
10.1371/journal.pone.0075760 · 2013 · External reference
Sigma-1 receptor alters the kinetics of Kv1.3 voltage gated potassium channels but not the sensitivity to receptor ligands
10.1016/j.brainres.2012.02.070 · 2012 · External reference
Expression of the purported sigma1 (σ1) receptor in the mammalian brain and its possible relevance in deficits induced by antagonism of the NMDA receptor complex as revealed using an antisense strategy
10.1016/s0891-0618(00)00106-x · 2000 · External reference
Sigma1 receptor antagonists determine the behavioral pattern of the methamphetamine-induced stereotypy in mice
10.1007/s00213-008-1425-z · 2009 · External reference
Neuroprotective sigma ligands attenuate NMDA and trans-ACPD-induced calcium signaling in rat primary neurons
10.1016/s0006-8993(97)00142-x · 1997 · External reference
Protection of cellular and mitochondrial functions against liver ischemia by N-benzyl-N′-(2-hydroxy-3,4-dimethoxybenzyl)-piperazine (BHDP), a sigma1 ligand
10.1016/j.ejphar.2007.09.038 · 2008 · External reference
Enantiomerically pure 1,3-dioxanes as highly selective NMDA and σ1 receptor ligands
10.1021/jm301166m · 2012 · External reference
Knockdown of interleukin-10 induces redistribution of sigma-1 receptor and increases glutamate-dependent NADPH-oxidase activity in mouse brain neurons
10.1007/s12031-015-0548-1 · 2015 · External reference
The antiparkinsonian drug budipine binds to NMDA and sigma receptors in postmortem human brain tissue
1995 · External reference
The sigma-1 receptor: roles in neuronal plasticity and disease
10.1016/j.tins.2012.09.007 · 2012 · External reference
Normalization of calcium balance in striatal neurons in Huntington’s disease: sigma-1 receptor as a potential target for therapy
10.1134/s0006297921040076 · 2021 · External reference
On the mechanism of antidepressant-like action of berberine chloride
10.1016/j.ejphar.2008.05.043 · 2008 · External reference
β-Estradiol, dehydroepiandrosterone, and dehydroepiandrosterone sulfate protect against N-Methyl-d-aspartate-Induced neurotoxicity in rat hippocampal neurons by different mechanisms
10.1124/jpet.104.067629 · 2004 · External reference
Overview of sigma-1R subcellular specific biological functions and role in neuroprotection
10.3390/ijms24031971 · 2023 · External reference
Cocaine occupancy of sigma1 receptors and dopamine transporters in mice
10.1002/syn.21877 · 2016 · External reference
Dehydroepiandrosterone sulfate prevents ischemia-induced impairment of long-term potentiation in rat hippocampal CA1 by up-regulating tyrosine phosphorylation of NMDA receptor
10.1016/j.neuropharm.2006.06.007 · 2006 · External reference
DHEA prevents Aβ25–35-impaired survival of newborn neurons in the dentate gyrus through a modulation of PI3K-Akt-mTOR signaling
10.1016/j.neuropharm.2010.02.009 · 2010 · External reference
Novel S1R agonists counteracting NMDA excitotoxicity and oxidative stress: a step forward in the discovery of neuroprotective agents
10.1016/j.ejmech.2023.115292 · 2023 · External reference
Neuroprotective effects of high-affinity sigma-1 receptor selective compounds
10.1016/j.brainres.2012.01.046 · 2012 · External reference
Neuroprotective effects of high affinity sigma 1 receptor selective compounds
10.1016/j.brainres.2011.12.047 · 2012 · External reference
DHEA and cognitive function in the elderly
10.1016/j.jsbmb.2014.03.014 · 2014 · External reference
Small-molecule sigma1 modulator induces autophagic degradation of PD-L1
10.1158/1541-7786.mcr-17-0166 · 2018 · External reference
Targeting sigma receptors for the treatment of neurodegenerative and neurodevelopmental disorders
10.1007/s40263-023-01007-6 · 2023 · External reference
Sigma-1 receptor in motoneuron disease
2017 · External reference
Sigma-1R agonist improves motor function and motoneuron survival in ALS mice
10.1007/s13311-012-0140-y · 2012 · External reference
Neuroprotective effects of sigma-1 receptor agonists against beta-amyloid-induced toxicity
10.1097/01.wnr.0000174066.63944.40 · 2005 · External reference
The sigma receptor ligand (+)-pentazocine prevents apoptotic retinal ganglion cell death induced in vitro by homocysteine and glutamate
10.1016/j.neulet.2003.12.089 · 2004 · External reference
An emerging role for sigma-1 receptors in the treatment of developmental and epileptic encephalopathies
10.3390/ijms22168416 · 2021 · External reference
Differential effects of σ1 receptor blockade on self-administration and conditioned reinstatement motivated by cocaine vs natural reward
10.1038/sj.npp.1301323 · 2007 · External reference
SA4503: a novel sigma1 receptor agonist
10.1111/j.1527-3458.1998.tb00038.x · 1998 · External reference
SA4503, a novel cognitive enhancer, with σ1 receptor agonistic properties
10.1016/s0166-4328(97)86074-3 · 1997 · External reference
Beneficial effect of the σ1 receptor agonist PRE-084 against the spatial learning deficits in aged rats
10.1016/s0014-2999(01)01436-4 · 2001 · External reference
Protection by sigma-1 receptor agonists is synergic with donepezil, but not with memantine, in a mouse model of amyloid-induced memory impairments
10.1016/j.bbr.2015.09.020 · 2016 · External reference
Bi-phasic dose response in the preclinical and clinical developments of sigma-1 receptor ligands for the treatment of neurodegenerative disorders
10.1080/17460441.2021.1838483 · 2021 · External reference
Role of σ1 receptors in learning and memory and Alzheimer’s disease-type dementia
2017 · External reference
Neuroprotective and anti-amnesic potentials of sigma (σ) receptor ligands
10.1016/s0278-5846(96)00160-1 · 1997 · External reference
Involvement of the sigma1 receptor in the appetitive effects of cocaine
10.1055/s-2004-832678 · 2004 · External reference
The pharmacology of sigma-1 receptors
10.1016/j.pharmthera.2009.07.001 · 2009 · External reference
Sigma1 (σ1) receptor agonists and neurosteroids attenuate β25–35-amyloid peptide-induced amnesia in mice through a common mechanism
10.1016/s0306-4522(97)00405-3 · 1998 · External reference
Neuroactive neurosteroids as endogenous effectors for the Sigma1 (.SIGMA.1) receptor
10.1254/jjp.81.125 · 1999 · External reference
The anti-amnesic effects of sigma1 (σ1) receptor agonists confirmed by in vivo antisense strategy in the mouse
10.1016/s0006-8993(01)02152-7 · 2001 · External reference
The interaction between neuroactive steroids and the sigma1 receptor function: behavioral consequences and therapeutic opportunities
10.1016/s0165-0173(01)00112-6 · 2001 · External reference
Sigma1 (σ1) receptor antagonists represent a new strategy against cocaine addiction and toxicity
10.1016/s0149-7634(02)00017-9 · 2002 · External reference
Neuro(active)steroids actions at the neuromodulatory sigma1 (σ1) receptor: biochemical and physiological evidences, consequences in neuroprotection
10.1016/j.pbb.2006.07.009 · 2006 · External reference
Interaction with σ1 protein, but not N-Methyl-d-aspartate receptor, is involved in the pharmacological activity of donepezil
10.1124/jpet.105.097394 · 2006 · External reference
Neuroprotection in non-transgenic and transgenic mouse models of Alzheimer’s disease by positive modulation of σ1 receptors
10.1016/j.phrs.2019.04.026 · 2019 · External reference
Peeking into sigma-1 receptor functions through the retina
2017 · External reference
Role of the sigma-1 receptor in amyotrophic lateral sclerosis (ALS)
10.1016/j.jphs.2014.11.001 · 2015 · External reference
The sigma-1 receptor—A therapeutic target for the treatment of ALS?
2017 · External reference
Molecular cloning and pharmacological characterization of the rat sigma1 receptor
10.1016/s0006-2952(01)00666-9 · 2001 · External reference
Beneficial effects of the sigma1 receptor agonists igmesine and dehydroepiandrosterone against learning impairments in rats prenatally exposed to cocaine
10.1016/j.ntt.2004.07.003 · 2004 · External reference
Compensatory effect by sigma1 (σ1) receptor stimulation during alcohol withdrawal in mice performing an object recognition task
10.1016/j.bbr.2005.07.019 · 2006 · External reference
The anti amnesic and neuroprotective effects of donepezil against amyloid β 25‐35 peptide‐induced toxicity in mice involve an interaction with the σ 1 receptor
10.1038/sj.bjp.0706927 · 2006 · External reference
Neurosteroids enhance spontaneous glutamate release in hippocampal neurons: possible role of metabotropic sigma1-like receptors
10.1074/jbc.m202592200 · 2002 · External reference
Acute and chronic administration of the selective sigma1 receptor agonist SA4503 significantly alters the activity of midbrain dopamine neurons in rats: an in vivo electrophysiological study
10.1002/(sici)1098-2396(199908)33:2<129::aid-syn3>3.0.co;2-e · 1999 · External reference
Functional polymorphisms in the sigma1 receptor gene associated with alcoholism
10.1016/j.biopsych.2003.07.008 · 2004 · External reference
Yeast sterol C8−C7 isomerase: identification and characterization of a high-affinity binding site for enzyme inhibitors
10.1021/bi961996m · 1996 · External reference
Cloning of an emopamil-binding protein (EBP)-like protein that lacks sterol Δ8–Δ7 isomerase activity
10.1042/bj20030465 · 2003 · External reference
NMDA receptors are upregulated and trafficked to the plasma membrane after Sigma-1 receptor activation in the Rat Hippocampus
10.1523/jneurosci.0458-14.2014 · 2014 · External reference
Intrastriatal administration of sigma ligands inhibits basal dopamine release in vivo
10.1016/s0028-3908(03)00253-3 · 2003 · External reference
The journal coverage of web of science and Scopus: a comparative analysis
10.1007/s11192-015-1765-5 · 2016 · External reference
Sigma-1 receptor as regulator of neuronal intracellular Ca2+: clinical and therapeutic relevance
10.1042/bst20051368 · 2005 · External reference
The sigma1 protein as a target for the non-genomic effects of neuro(active)steroids: molecular, physiological, and behavioral aspects
10.1254/jphs.cr0050032 · 2006 · External reference
Protein kinase C-Dependent potentiation of intracellular calcium influx by σ1Receptor agonists in rat hippocampal neurons
10.1124/jpet.103.053447 · 2003 · External reference
Phencyclidine-induced discriminative stimulus is mediated via phencyclidine binding sites on the N-methyl-D-aspartate receptor-ion channel complex, not via sigma1 receptors
10.1016/s0166-4328(00)00333-8 · 2001 · External reference
Sigma-1 receptor stimulation by dehydroepiandrosterone ameliorates cognitive impairment through activation of CaM kinase II, protein kinase C and extracellular signal-regulated kinase in olfactory bulbectomized mice
10.1111/j.1471-4159.2011.07256.x · 2011 · External reference
PRE-084 as a tool to uncover potential therapeutic applications for selective sigma-1 receptor activation
10.1016/j.biocel.2020.105803 · 2020 · External reference
A presynaptic action of the neurosteroid pregnenolone sulfate on GABAergic synaptic transmission
10.1124/mol.64.4.857 · 2003 · External reference
The role of sigma-1 receptor as a neuroprotective target in glaucoma
2017 · External reference
The sigma-1 receptor mediates pridopidine rescue of mitochondrial function in Huntington disease models
10.1007/s13311-021-01022-9 · 2021 · External reference
Activation of sigma1 receptor subtype leads to neuroprotection in the rat primary neuronal cultures
10.1016/s0197-0186(97)00105-8 · 1998 · External reference
N,N-dimethyltryptamine reduces infarct size and improves functional recovery following transient focal brain ischemia in rats
10.1016/j.expneurol.2020.113245 · 2020 · External reference
Sigma-1 receptor signaling: a potential therapeutic approach for ischemic stroke
10.1177/0271678x241281547 · 2024 · External reference
Sigma receptors as potential therapeutic targets for neuroprotection
10.1016/j.ejphar.2014.09.022 · 2014 · External reference
Role of sigma-1 receptors in neurodegenerative diseases
10.1016/j.jphs.2014.12.005 · 2015 · External reference
Sigma-1 receptors and neurodegenerative diseases: towards a Hypothesis of Sigma-1 receptors as amplifiers of neurodegeneration and neuroprotection
10.1007/978-3-319-50174-1_10 · 2017 · External reference
Neurosteroids ameliorate conditioned fear stress: an association with sigma1 receptors
10.1016/s0893-133x(00)00103-2 · 2000 · External reference
Phencyclidine impairs latent learning in mice: interaction between glutamatergic systems and sigma1 receptors
10.1016/s0893-133x(00)00192-5 · 2001 · External reference
Small-molecule modulators of sigma1 and sigma2/TMEM97 in the context of cancer: foundational concepts and emerging themes
10.3389/fphar.2019.01141 · 2019 · External reference
Sigma-1 and N-methyl-D-aspartate receptors: a partnership with beneficial outcomes
10.1159/000381765 · 2015 · External reference
Immunohistochemical localization of the sigma1 receptor in Schwann cells of rat sciatic nerve
10.1016/j.brainres.2004.02.013 · 2004 · External reference
Recent advance of peptide-based molecules and nonpeptidic small-molecules modulating PD-1/PD-L1 protein-protein interaction or targeting PD-L1 protein degradation
10.1016/j.ejmech.2021.113170 · 2021 · External reference
Sigma receptor agonist 2-(4-morpholinethyl)1 phenylcyclohexanecarboxylate (Pre084) increases GDNF and BiP expression and promotes neuroprotection after root avulsion injury
10.1089/neu.2010.1674 · 2011 · External reference
The role of sigma-1 receptor, an intracellular chaperone in neurodegenerative diseases
10.2174/1570159x15666170529104323 · 2018 · External reference
Neuroprotective effects of the Sigma-1 receptor (S1R) agonist PRE-084, in a mouse model of motor neuron disease not linked to SOD1 mutation
10.1016/j.nbd.2013.10.010 · 2014 · External reference
Strain differences in σ1 receptor-mediated behaviours are related to neurosteroid levels
10.1046/j.1460-9568.2002.01989.x · 2002 · External reference
Sigma receptors and neurological disorders
10.1007/s43440-021-00310-7 · 2021 · External reference
Sigma-1 receptor ligands for CNS cancer treatment
10.1007/s40263-025-01223-2 · 2025 · External reference
The role of the sigma-1 receptor in neuroprotection: comment on Nrf-2 as a therapeutic target in ischemic stroke
10.1080/14728222.2021.1948016 · 2021 · External reference
A neuroactive steroid, dehydroepiandrosterone sulfate, prevents the development of morphine dependence and tolerance via c-fos expression linked to the extracellular signal-regulated protein kinase
10.1016/j.bbr.2003.10.013 · 2004 · External reference
Sigma-1 receptor activation produces faster antidepressant-like effect through enhancement of hippocampal neuroplasticity: focus on sigma-1-5-HT1A heteroreceptor complex
10.1016/j.neuint.2025.105937 · 2025 · External reference
The σ1 receptor engages the redox-regulated HINT1 protein to bring opioid analgesia under NMDA receptor negative control
10.1089/ars.2014.5993 · 2015 · External reference
The ON:OFF switch, σ1R–HINT1 protein, controls GPCR–NMDA receptor cross-regulation: implications in neurological disorders
10.3389/fnmol.2015.00052 · 2015 · External reference
Endocannabinoid control of glutamate NMDA receptors: the therapeutic potential and consequences of dysfunction
10.18632/oncotarget.10095 · 2016 · External reference
Cannabidiol enhances morphine antinociception, diminishes NMDA-mediated seizures and reduces stroke damage via the sigma 1 receptor
10.1186/s13041-018-0395-2 · 2018 · External reference
Trends in Sigma-1 receptor research: a 25-Year bibliometric analysis
10.3389/fphar.2019.00564 · 2019 · External reference
Involvement of the σ1 receptor in the cocaine-induced conditioned place preference
10.1097/00001756-200009110-00011 · 2000 · External reference
Involvement of the sigma1 receptor in cocaine-induced conditioned place preference: possible dependence on dopamine uptake blockade
10.1016/s0893-133x(01)00391-8 · 2002 · External reference
The sigma1 (σ1) receptor activation is a key step for the reactivation of cocaine conditioned place preference by drug priming
10.1007/s00213-004-1814-x · 2004 · External reference
Setup and validation of a reliable docking protocol for the development of neuroprotective agents by targeting the sigma-1 receptor (S1R)
10.3390/ijms21207708 · 2020 · External reference
Sigma receptors [σRs]: biology in normal and diseased states
10.3109/10799893.2015.1015737 · 2016 · External reference
The sigma-1 receptor curtails endogenous opioid analgesia during sensitization of TRPV1 nociceptors
10.1111/bph.16003 · 2023 · External reference
The involvement of the sigma-1 receptor in neurodegeneration and neurorestoration
10.1016/j.jphs.2014.11.011 · 2015 · External reference
The sigma-1 receptor enhances brain plasticity and functional recovery after experimental stroke
10.1093/brain/awq367 · 2011 · External reference
Sigma1 binding in a human neuroblastoma cell line
10.1007/bf02532372 · 1996 · External reference
The sigma-1 receptor mediates the beneficial effects of pridopidine in a mouse model of Huntington disease
10.1016/j.nbd.2016.10.006 · 2017 · External reference
Neuronal Sigma-1 receptors: signaling functions and protective roles in neurodegenerative diseases
10.3389/fnins.2019.00862 · 2019 · External reference
Behavioral profiles of SSRIs in animal models of depression, anxiety and aggression. Are they all alike?
10.1007/s002130050181 · 1997 · External reference
The calcium-sensitive Sigma-1 receptor prevents cannabinoids from provoking glutamate NMDA receptor hypofunction: implications in antinociception and psychotic diseases
10.1017/s1461145714000029 · 2014 · External reference
A prototypical Sigma-1 receptor antagonist protects against brain ischemia
10.1016/j.brainres.2007.08.068 · 2007 · External reference
Effect of SA4503, a novel sigma1 receptor agonist, against glutamate neurotoxicity in cultured rat retinal neurons
10.1016/s0014-2999(97)01450-7 · 1998 · External reference
Dimemorfan protects rats against ischemic stroke through activation of sigma-1 receptor-mediated mechanisms by decreasing glutamate accumulation
10.1111/j.1471-4159.2007.05058.x · 2008 · External reference
Sigma-1 receptor: a potential therapeutic target for traumatic brain injury
10.3389/fncel.2021.685201 · 2021 · External reference
Activation of sigma-1 receptor alleviates ER-associated cell death and microglia activation in traumatically injured mice
10.3390/jcm11092348 · 2022 · External reference
The dextromethorphan analog dimemorfan attenuates kainate-induced seizures via σ1 receptor activation: Comparison with the effects of dextromethorphan
10.1038/sj.bjp.0705998 · 2005 · External reference
Vasoconstrictive neurovascular coupling during focal ischemic depolarizations
10.1038/sj.jcbfm.9600252 · 2005 · External reference
Expression of a truncated form of the endoplasmic reticulum chaperone protein, σ1 receptor, promotes mitochondrial energy depletion and apoptosis
10.1074/jbc.m112.349142 · 2012 · External reference
Sigma-1 receptor and its pivotal role in neurological disorders
10.1021/acsptsci.4c00564 · 2024 · External reference
Targeting Sigma-1 receptor: a promising strategy in the treatment of parkinson’s disease
10.1007/s11064-023-03960-6 · 2023 · External reference
Sigma1 receptor antagonists attenuate antidepressant-like effect induced by co-administration of 1,3 di-o-tolylguanidine (DTG) and memantine in the forced swimming test in rats
2003 · External reference
The synergistic effect of selective sigma receptor agonists and uncompetitive NMDA receptor antagonists in the forced swim test in rats
2006 · External reference
Inhibition of sigma-1 receptor reduces N-methyl-D-aspartate-induced neuronal injury in methamphetamine-exposed and naive hippocampi
10.1016/j.neulet.2010.06.018 · 2010 · External reference
The involvement of sigma1 receptors in donepezil-induced rescue of hippocampal LTP impaired by beta-amyloid peptide
10.1016/j.brainresbull.2014.06.002 · 2014 · External reference
A new 18F-labeled fluoroacetylmorpholino derivative of vesamicol for neuroimaging of the vesicular acetylcholine transporter
10.1016/j.nucmedbio.2007.10.004 · 2008 · External reference
Pharmacological analysis of the anti-epileptic mechanisms of fenfluramine in scn1a mutant zebrafish
10.3389/fphar.2017.00191 · 2017 · External reference
Pridopidine, a dopamine stabilizer, improves motor performance and shows neuroprotective effects in Huntington disease R6/2 mouse model
10.1111/jcmm.12604 · 2015 · External reference
Sigma1 receptors inhibit store-operated Ca2+ entry by attenuating coupling of STIM1 to Orai1
10.1083/jcb.201506022 · 2016 · External reference
Sigma1 receptor upregulation after chronic methamphetamine self-administration in rats: a study with yoked controls
10.1007/s00213-004-1779-9 · 2004 · External reference
Cocaine affects the dynamics of cytoskeletal proteins via sigma1 receptors
10.1016/s0165-6147(00)01740-5 · 2001 · External reference
The sigma-1 receptor–zinc finger protein 179 pathway protects against hydrogen peroxide-induced cell injury
10.1016/j.neuint.2016.04.012 · 2016 · External reference
The sigma-1 receptor as a pluripotent modulator in living systems
10.1016/j.tips.2016.01.003 · 2016 · External reference
N,N-Dimethyltryptamine attenuates spreading depolarization and restrains neurodegeneration by sigma-1 receptor activation in the ischemic rat brain
10.1016/j.neuropharm.2021.108612 · 2021 · External reference
Pharmacology of dextromethorphan: relevance to dextromethorphan/quinidine (Nuedexta®) clinical use
10.1016/j.pharmthera.2016.04.010 · 2016 · External reference
sigma-1 receptors protect RGC-5 cells from apoptosis by regulating intracellular calcium, Bax levels, and caspase-3 activation
10.1167/iovs.07-1101 · 2008 · External reference
Sigma-1 receptor regulation of voltage-gated calcium channels involves a direct interaction
10.1167/iovs.08-1867 · 2008 · External reference
Neuroprotective effect of σ 1 -Receptor ligand 4-Phenyl-1-(4-Phenylbutyl) piperidine (PPBP) is linked to reduced neuronal nitric oxide production
10.1161/01.str.32.7.1613 · 2001 · External reference
PRISMA extension for scoping reviews (PRISMA-ScR): checklist and explanation
10.7326/m18-0850 · 2018 · External reference
Sigma-1 receptors regulate hippocampal dendritic spine formation via a free radical-sensitive mechanism involving Rac1·GTP pathway
10.1073/pnas.0909089106 · 2009 · External reference
Sigma-1 receptor chaperones in neurodegenerative and psychiatric disorders
10.1517/14728222.2014.972939 · 2014 · External reference
SA4503, a sigma-1 receptor agonist, prevents cultured cortical neurons from oxidative stress-induced cell death via suppression of MAPK pathway activation and glutamate receptor expression
10.1016/j.neulet.2009.12.013 · 2010 · External reference
[3H]YM-09151-2 (nemonapride), a potent radioligand for both sigma1 and sigma2 receptor subtypes
10.1097/00001756-199604100-00021 · 1996 · External reference
Beneficial effects of acute and repeated administrations of σ receptor agonists on behavioral despair in mice exposed to tail suspension
10.1016/s0091-3057(98)00093-8 · 1999 · External reference
The antidepressant-like effect induced by the sigma1 (σ1) receptor agonist igmesine involves modulation of intracellular calcium mobilization
10.1007/s00213-002-1150-y · 2002 · External reference
Enhanced antidepressant effect of sigma1 (σ1) receptor agonists in β25–35-amyloid peptide-treated mice
10.1016/s0166-4328(02)00033-5 · 2002 · External reference
Sigma 1 receptor agonists act as neuroprotective drugs through inhibition of inducible nitric oxide synthase
10.1213/01.ane.0000226133.85114.91 · 2006 · External reference
Measuring science: basic principles and application of advanced bibliometrics
10.1007/978-3-030-02511-3_10 · 2019 · External reference
Novel positive allosteric modulators of sigma-1 receptor
10.1186/2193-1801-4-s1-p51 · 2015 · External reference
Repurposing sigma-1 receptor ligands for COVID-19 therapy?
10.3389/fphar.2020.582310 · 2020 · External reference
Quetiapine abuse fourteen years later: where are we now? A systematic review
10.1080/10826084.2019.1668013 · 2020 · External reference
Anti-amnesic and neuroprotective potentials of the mixed muscarinic receptor/sigma1 (σ1) ligand ANAVEX2-73, a novel aminotetrahydrofuran derivative
10.1177/0269881110379286 · 2011 · External reference
Pharmacological interaction with the sigma1 (σ1)-receptor in the acute behavioral effects of antidepressants
10.1254/jphs.10191fp · 2011 · External reference
Sigma-1 receptor and neuroprotection: current outlook and potential therapeutic effects
10.4103/1673-5374.194707 · 2016 · External reference
Chaperone-dependent mechanisms as a pharmacological target for neuroprotection
10.3390/ijms24010823 · 2023 · External reference
A novel mechanism of sigma-1 receptor neuroprotection: modulation of miR-214-3p
2019 · External reference
Sigma 1 receptor regulates the oxidative stress response in primary retinal Müller glial cells via NRF2 signaling and system xc(-), the Na(+)-independent glutamate-cystine exchanger
10.1016/j.freeradbiomed.2015.04.009 · 2015 · External reference
Activation of the molecular chaperone, sigma 1 receptor, preserves cone function in a murine model of inherited retinal degeneration
10.1073/pnas.1521749113 · 2016 · External reference
The molecular chaperone sigma 1 receptor mediates rescue of retinal cone photoreceptor cells via modulation of NRF2
10.1016/j.freeradbiomed.2019.02.001 · 2019 · External reference
Sigma-1 receptor regulates mitophagy in dopaminergic neurons and contributes to dopaminergic protection
10.1016/j.neuropharm.2020.108451 · 2021 · External reference
Activation of sigma-1 receptor preserves visual function after optic nerve injury
10.1167/iovs.66.9.13 · 2025 · External reference
Loss of sigma-1 receptor chaperone promotes astrocytosis and enhances the Nrf2 antioxidant defense
10.1155/2017/4582135 · 2017 · External reference
Roles of sigma-1 receptors on mitochondrial functions relevant to neurodegenerative diseases
10.1186/s12929-017-0380-6 · 2017 · External reference
Dextromethorphan as a potential neuroprotective agent with unique mechanisms of action
10.1097/nrl.0b013e3180f60bd8 · 2007 · External reference
Emerging benefits: pathophysiological functions and target drugs of the sigma-1 receptor in neurodegenerative diseases
10.1007/s12035-021-02524-5 · 2021 · External reference
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External reference
Comparison of neuroprotective effects of monomethylfumarate to the sigma-1 receptor ligand (+)-pentazocine in a murine model of retinitis pigmentosa
10.1167/tvst.9.10.20 · 2020 · External reference
The sigma-1 receptor: a mechanistically informed therapeutic target for antidepressants
10.1080/14728222.2025.2500424 · 2025 · External reference
Sigma-1 receptor activation regulates brain-derived neurotrophic factor through NR2A–CaMKIV–TORC1 pathway to rescue the impairment of learning and memory
10.1007/s00213-014-3809-6 · 2015 · External reference
Sigma-1 receptor in retina: neuroprotective effects and potential mechanisms
10.3390/ijms23147572 · 2022 · External reference
Neuroprotective effects of cutamesine, a ligand of the sigma-1 receptor chaperone, against noise-induced hearing loss
10.1002/jnr.23543 · 2015 · External reference
Sigma receptor agonists provide neuroprotection in vitro by preserving bcl-2
10.1213/01.ane.0000260267.71185.73 · 2007 · External reference
Anti-amnesic effect of neurosteroid PREGS in Aβ25-35-injected mice through σ1 receptor- and α7nAChR-mediated neuroprotection
10.1016/j.neuropharm.2012.07.035 · 2012 · External reference
Dehydroepiandrosterone administration improves memory deficits following transient brain ischemia through sigma-1 receptor stimulation
10.1016/j.brainres.2015.05.006 · 2015 · External reference
Small molecules selectively targeting sigma-1 receptor for the treatment of neurological diseases
10.1021/acs.jmedchem.0c00898 · 2020 · External reference
Up-regulation of sigma1 receptor mRNA in rat brain by a putative atypical antipsychotic and sigma receptor ligand
10.1016/s0304-3940(00)00884-3 · 2000 · External reference
Cytotoxicity profiles and neuroprotective properties of novel ifenprodil analogues as sigma ligands
10.3390/molecules28083431 · 2023 · External reference
Dexmedetomidine inhibits neuronal apoptosis by inducing sigma-1 receptor signaling in cerebral ischemia–reperfusion injury
10.1007/s12035-019-1530-0 · 2019 · External reference
Activation of the sigma receptor 1 suppresses NMDA responses in rat retinal ganglion cells
10.1016/j.neulet.2011.09.009 · 2011 · External reference
Sigma-1 receptor agonists provide neuroprotection against gp120 via a change in Bcl-2 expression in mouse neuronal cultures
10.1016/j.brainres.2012.07.010 · 2012 · External reference
Involvement of sigma-1 receptor in astrocyte activation induced by methamphetamine via up-regulation of its own expression
10.1186/s12974-015-0250-7 · 2015 · External reference
Activation of Sigma-1 receptor enhanced pericyte survival via the interplay between apoptosis and autophagy: implications for blood–brain barrier integrity in stroke
10.1007/s12975-019-00711-0 · 2019 · External reference
Arketamine, a new rapid-acting antidepressant: a historical review and future directions
10.1016/j.neuropharm.2022.109219 · 2022 · External reference
An intraocular drug delivery system using targeted nanocarriers attenuates retinal ganglion cell degeneration
10.1016/j.jconrel.2016.12.038 · 2017 · External reference
Sigma-1 receptor contributes to astrocyte-mediated retinal ganglion cell protection
10.1167/iovs.63.7.10 · 2022 · External reference
Dual-target inhibitors based on acetylcholinesterase: novel agents for Alzheimer’s disease
10.1016/j.ejmech.2024.116810 · 2024 · External reference
Neuroactive steroid regulation of neurotransmitter release in the CNS: action, mechanism and possible significance
10.1016/j.pneurobio.2009.07.001 · 2009 · External reference
IL-10 mediates sigma1 receptor-dependent suppression of antitumor immunity
10.4049/jimmunol.170.7.3585 · 2003 · External reference
