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References from Preclinical evaluation of JQ1 in esophageal squamous cell carcinoma: growth and migration suppression with BRD4-associated DNA damage and apoptotic signaling. Local targets link to admitted publications; unresolved targets remain external evidence.
Epidemiology of esophageal squamous cell carcinoma
10.1053/j.gastro.2017.08.023 · 2018 · External reference
Phosphorylation by JNK switches BRD4 functions
10.1016/j.molcel.2024.09.030 · 2024 · External reference
EZH2 inhibitor Tazemetostat synergizes with JQ-1 in esophageal cancer by inhibiting c-Myc signaling pathway
10.1007/s12032-023-02147-x · 2023 · External reference
Discovery of novel JQ1 derivatives as dual ferroptosis and apoptosis inducers for the treatment of triple-negative breast cancer
10.1016/j.ejmech.2025.117275 · 2025 · External reference
BRD4 regulates cellular senescence in gastric cancer cells via E2F/miR-106b/p21 axis
10.1038/s41419-017-0181-6 · 2018 · External reference
p53 gain-of-function mutation induces metastasis via BRD4-Dependent CSF-1 expression
10.1158/2159-8290.cd-23-0601 · 2023 · External reference
The role of γ-H2AX in replication stress-induced carcinogenesis: possible links and recent developments
10.21873/cdp.10266 · 2023 · External reference
JQ1 induces DNA damage and apoptosis, and inhibits tumor growth in a patient-derived xenograft model of cholangiocarcinoma
10.1158/1535-7163.mct-16-0922 · 2018 · External reference
Research techniques made simple: analysis of collective cell migration using the wound healing assay
10.1016/j.jid.2016.11.020 · 2017 · External reference
Synthesis and biological evaluation of a novel c-Myc inhibitor against colorectal cancer via blocking c-Myc/Max heterodimerization and disturbing its DNA binding
10.1016/j.ejmech.2022.114779 · 2022 · External reference
In vitro cell migration and invasion assays
10.3791/51046 · 2014 · External reference
Immunotherapy for esophageal squamous cell carcinoma
10.1007/s11912-017-0590-9 · 2017 · External reference
High expression level of BRD4 is associated with a poor prognosis and immune infiltration in esophageal squamous cell carcinoma
10.1007/s10620-023-07907-3 · 2023 · External reference
Inhibition of BRD4 suppresses the malignancy of breast cancer cells via regulation of Snail
10.1038/s41418-019-0353-2 · 2020 · External reference
Structure-based rational design and evaluation of BET-Aurora kinase dual-inhibitors for treatment of cancers
10.1021/acs.jmedchem.4c01933 · 2025 · External reference
Stabilization of miRNAs in esophageal cancer contributes to radioresistance and limits efficacy of therapy
10.1016/j.biochi.2018.10.006 · 2019 · External reference
The global landscape of esophageal squamous cell carcinoma and esophageal adenocarcinoma incidence and mortality in 2020 and projections to 2040: new estimates from GLOBOCAN 2020
10.1053/j.gastro.2022.05.054 · 2022 · External reference
BRD4 induces esophageal squamous cell carcinoma progression via the Wnt/β-catenin pathway
10.1007/s10528-025-11043-0 · 2025 · External reference
Potent molecular-targeted therapies for advanced esophageal squamous cell carcinoma
10.1177/17588359221138377 · 2023 · External reference
The BRD4 inhibitor JQ1 suppresses tumor growth by reducing c-Myc expression in endometrial cancer
10.1186/s12967-022-03545-x · 2022 · External reference
H2AX: a key player in DNA damage response and a promising target for cancer therapy
10.1016/j.biopha.2024.116663 · 2024 · External reference
Enhancing therapeutic efficacy in homologous recombination-proficient pancreatic cancer via the combination of PARP1-PROTAC and a BRD4 inhibitor
10.1016/j.bmc.2024.117970 · 2024 · External reference
How we treat esophageal squamous cell carcinoma
10.1016/j.esmoop.2023.100789 · 2023 · External reference
The bromodomain inhibitor JQ1 and the histone deacetylase inhibitor panobinostat synergistically reduce N-Myc expression and induce anticancer effects
10.1158/1078-0432.ccr-15-1666 · 2016 · External reference
BET proteins as targets for anticancer treatment
10.1158/2159-8290.cd-17-0605 · 2018 · External reference
The bromodomain and extra-terminal domain (BET) family: functional anatomy of BET paralogous proteins
10.3390/ijms17111849 · 2016 · External reference
BET bromodomain inhibitors: novel design strategies and therapeutic applications
10.3390/molecules28073043 · 2023 · External reference
Safety and efficacy of conversion therapy for esophageal squamous cell carcinoma
10.1200/jco.2023.41.4_suppl.362 · 2023 · External reference
Mitochondrial DNA damage, repair, and replacement in cancer
10.1016/j.trecan.2024.09.010 · 2025 · External reference
CDK4/6 inhibitor-SHR6390 exerts potent antitumor activity in esophageal squamous cell carcinoma by inhibiting phosphorylated Rb and inducing G1 cell cycle arrest
10.1186/s12967-017-1231-7 · 2017 · External reference
BRD4 inhibition suppresses cell growth, migration and invasion of salivary adenoid cystic carcinoma
10.1186/s40659-017-0124-9 · 2017 · External reference
Targeting c-Myc: JQ1 as a promising option for c-Myc-amplified esophageal squamous cell carcinoma
10.1016/j.canlet.2018.01.051 · 2018 · External reference
BET bromodomain inhibitor JQ1 promotes immunogenic cell death in tongue squamous cell carcinoma
10.1016/j.intimp.2019.105921 · 2019 · External reference
Mechanisms of esophageal cancer metastasis and treatment progress
10.3389/fimmu.2023.1206504 · 2023 · External reference
Bromodomain and extraterminal (BET) protein inhibition suppresses tumor progression and inhibits HGF-MET signaling through targeting cancer-associated fibroblasts in colorectal cancer
10.1016/j.bbadis.2020.165923 · 2020 · External reference
Therapeutic targeting of BRD4 in head neck squamous cell carcinoma
10.7150/thno.31581 · 2019 · External reference
Opposing functions of BRD4 isoforms in breast cancer
10.1016/j.molcel.2020.04.034 · 2020 · External reference
BRD4 drives esophageal squamous cell carcinoma growth by promoting RCC2 expression
10.1038/s41388-021-02099-4 · 2022 · External reference
Inhibition of BRD4 triggers cellular senescence through suppressing aurora kinases in oesophageal cancer cells
10.1111/jcmm.15901 · 2020 · External reference
Inhibition of bromodomain-containing protein 4 enhances the migration of esophageal squamous cell carcinoma cells by inducing cell autophagy
10.4251/wjgo.v14.i12.2340 · 2022 · External reference
A folic acid-decorated nanoparticles loaded JQ1 for oral squamous cell carcinoma therapy
10.1016/j.cclet.2023.108433 · 2024 · External reference
A new Mfn-2 related synthetic peptide promotes vascular smooth muscle cell apoptosis via regulating the mitochondrial apoptotic pathway by inhibiting Akt signaling
10.1186/s12967-021-03064-1 · 2021 · External reference
Bromodomain protein BRD4-Mediated mutant p53 transcription promotes TNBC progression
10.3390/ijms232315163 · 2022 · External reference
