Research graph
References from Early socially isolated rats of both sexes reduce alcohol consumption and seeking by the Galanin (1–15) and naltrexone combination. Local targets link to admitted publications; unresolved targets remain external evidence.
Loneliness and alcohol abuse: a review of evidences of an interplay
10.1016/0277-9536(92)90300-f · 1992 · External reference
Strategies and methods for research on sex differences in brain and behavior
10.1210/en.2004-1142 · 2005 · External reference
Opioid neuroscience for addiction medicine: from animal models to FDA approval for alcohol addiction
10.1016/bs.pbr.2015.07.030 · 2016 · External reference
Preferential activation by galanin 1-15 fragment of the GalR1 protomer of a GalR1-GalR2 heteroreceptor complex
10.1016/j.bbrc.2014.08.061 · 2014 · External reference
Galanin receptor subtypes
10.1016/s0165-6147(00)01446-2 · 2000 · External reference
Adolescent social isolation does not lead to persistent increases in anxiety-like behavior or ethanol intake in female long-evans rats
10.1111/acer.12476 · 2014 · External reference
Mouse estrous cycle identification tool and images
10.1371/journal.pone.0035538 · 2012 · External reference
Opioid-galanin receptor heteromers mediate the dopaminergic effects of opioids
10.1172/jci126912 · 2019 · External reference
The combination of Galanin (1-15) and escitalopram in rats suggests a new strategy for alcohol use disorder comorbidity with depression
10.3390/biomedicines10020412 · External reference
Galanin N-terminal fragment (1-15) reduces alcohol seeking and alcohol relapse in rats: involvement of mesocorticolimbic system
10.1016/j.biopha.2022.113508 · External reference
Intranasal Galanin(1-15) influences depression- and anxiety-related behaviors through sex-dependent mechanisms in rats
10.1186/s13293-026-00901-0 · 2026 · External reference
Alcohol use disorders
10.1016/s0140-6736(19)31775-1 · 2019 · External reference
Adolescent rearing conditions influence the relationship between initial anxiety-like behavior and ethanol drinking in male Long Evans rats
10.1111/j.1530-0277.2012.01926.x · 2013 · External reference
Increased mood disorder symptoms, perceived stress, and alcohol use among college students during the COVID-19 pandemic
10.1016/j.psychres.2021.113706 · 2021 · External reference
Alcohol use and misuse during the COVID-19 pandemic: a potential public health crisis?
10.1016/s2468-2667(20)30088-8 · 2020 · External reference
Preferential Gs protein coupling of the galanin Gal1 receptor heterotetramer
10.1016/j.phrs.2022.106322 · 2022 · External reference
A motivational learning hypothesis of the role of mesolimbic dopamine in compulsive drug use
10.1177/026988119801200108 · 1998 · External reference
Galanin receptor/neuropeptide y receptor interactions in the central nervous system
10.2174/1389203715666140901111709 · 2014 · External reference
The runway model of drug self-administration
10.1016/j.pbb.2008.11.003 · 2009 · External reference
Isolation and loneliness as pathways to heavy drinking early in the pandemic
10.1093/alcalc/agae012 · 2024 · External reference
Galanin(1-15) and naltrexone: a novel approach for alcohol use disorder in rats, involving the mesolimbic system
10.1016/j.biopha.2025.118170 · 2025 · External reference
Suppressant effects of naltrexone on water intake in rats
10.1016/0091-3057(79)90112-6 · 1979 · External reference
Evidence for specific N-terminal galanin fragment binding sites in the rat brain
10.1016/0014-2999(92)90806-f · 1992 · External reference
Galanin negatively modulates opiate withdrawal via galanin receptor 1
10.1007/s00213-011-2515-x · 2012 · External reference
Advancing social connection as a public health priority in the United States
10.1037/amp0000103 · 2017 · External reference
Opioids excite dopamine neurons by hyperpolarization of local interneurons
10.1523/jneurosci.12-02-00483.1992 · 1992 · External reference
Changes in alcohol use during the COVID-19 pandemic in Europe: a meta-analysis of observational studies
10.1111/dar.13446 · 2022 · External reference
Neural mechanisms of drug reinforcement
10.1111/j.1749-6632.1992.tb25966.x · 1992 · External reference
Alcohol use disorder treatment: problems and solutions
10.1146/annurev-pharmtox-031323-115847 · 2024 · External reference
Recent perceived stress, amygdala reactivity to acute psychosocial stress, and alcohol and cannabis use in adolescents and young adults with bipolar disorder
10.3389/fpsyt.2021.767309 · 2021 · External reference
Ethanol consumption: how should we measure it? Achieving consilience between human and animal phenotypes
10.1111/j.1369-1600.2009.00192.x · 2010 · External reference
Early social isolation augments alcohol consumption in rats
10.1097/fbp.0000000000000165 · 2015 · External reference
Galanin microinjection in the third ventricle increases voluntary ethanol intake
10.1097/01.alc.0000148099.12344.c8 · 2004 · External reference
Estrous cycle influences the response of female rats in the elevated plus-maze test
10.1016/s0031-9384(01)00593-5 · 2001 · External reference
Early social isolation in male Long-Evans rats alters both appetitive and consummatory behaviors expressed during operant ethanol self-administration
10.1111/j.1530-0277.2008.00830.x · 2009 · External reference
Age-dependent effects of social isolation on mesolimbic dopamine release
10.1007/s00221-022-06449-w · 2022 · External reference
A role for galanin N-terminal fragment (1-15) in anxiety- and depression-related behaviors in rats
10.1093/ijnp/pyu064 · 2014 · External reference
Galanin (1-15) enhances the antidepressant effects of the 5-HT1A receptor agonist 8-OH-DPAT: involvement of the raphe-hippocampal 5-HT neuron system
10.1007/s00429-015-1180-y · 2016 · External reference
Central administration of galanin N-terminal fragment 1-15 decreases the voluntary alcohol intake in rats
10.1111/adb.12582 · 2019 · External reference
Galanin, galanin receptors and drug targets
10.1007/978-3-0346-0228-0_2 · 2008 · External reference
Functional μ-Opioid-Galanin receptor heteromers in the ventral tegmental area
10.1523/jneurosci.2442-16.2016 · 2017 · External reference
Galanin and Addiction
10.1007/s00018-008-8151-x · 2008 · External reference
Galanin and addiction
10.1007/978-3-0346-0228-0_14 · 2010 · External reference
A new pharmacological strategy against treatment-resistant depression
10.1016/j.pnpbp.2024.111191 · 2025 · External reference
Galanin in the hypothalamus raises dopamine and lowers acetylcholine release in the nucleus accumbens: a possible mechanism for hypothalamic initiation of feeding behavior
10.1016/s0006-8993(98)00315-1 · 1998 · External reference
Ethanol intake is increased by injection of galanin in the paraventricular nucleus and reduced by a galanin antagonist
10.1016/j.alcohol.2004.05.002 · 2004 · External reference
Alcohol use in times of the COVID 19: implications for monitoring and policy
10.1111/dar.13074 · 2020 · External reference
Behavioural assessment of drug reinforcement and addictive features in rodents: an overview
10.1111/j.1369-1600.2006.00012.x · 2006 · External reference
Attitudes toward harm reduction and abstinence-only approaches to alcohol misuse among Alaskan college students
10.3402/ijch.v72i0.21143 · 2013 · External reference
Implementing LEARN: comprehensive suicide prevention training for high school students, parents, and school personnel
10.1111/josh.13516 · 2024 · External reference
Drinking to cope during COVID-19 pandemic: the role of external and internal factors in coping motive pathways to alcohol use, solitary drinking, and alcohol problems
10.1111/acer.14425 · 2020 · External reference
Social deprivation enhances VTA synaptic plasticity and drug-induced contextual learning
10.1016/j.neuron.2012.11.022 · 2013 · External reference
Unresolved reference
2024 · External reference
Advancing precision medicine for alcohol use disorder: replication and extension of reward drinking as a predictor of naltrexone response
10.1111/acer.14183 · 2019 · External reference
A randomized, controlled, pilot study of acamprosate added to escitalopram in adults with major depressive disorder and alcohol use disorder
10.1097/jcp.0b013e3182726764 · 2012 · External reference
Sobering perspectives on the treatment of alcohol use disorder
10.1001/jamanetworkopen.2024.3340 · 2024 · External reference
Estradiol, dopamine and motivation
10.2174/1871524914666141226103135 · 2014 · External reference
Sobering perspectives on the treatment of alcohol use disorder
10.1001/jamanetworkopen.2024.3340 · ExternalCitation · doi-reference
Galanin and addiction
10.1007/978-3-0346-0228-0_14 · ExternalCitation · doi-reference
Galanin, galanin receptors and drug targets
10.1007/978-3-0346-0228-0_2 · ExternalCitation · doi-reference
Galanin and Addiction
10.1007/s00018-008-8151-x · ExternalCitation · doi-reference
Galanin negatively modulates opiate withdrawal via galanin receptor 1
10.1007/s00213-011-2515-x · ExternalCitation · doi-reference
Age-dependent effects of social isolation on mesolimbic dopamine release
10.1007/s00221-022-06449-w · ExternalCitation · doi-reference
Galanin (1-15) enhances the antidepressant effects of the 5-HT1A receptor agonist 8-OH-DPAT: involvement of the raphe-hippocampal 5-HT neuron system
10.1007/s00429-015-1180-y · ExternalCitation · doi-reference
Evidence for specific N-terminal galanin fragment binding sites in the rat brain
10.1016/0014-2999(92)90806-f · ExternalCitation · doi-reference
Suppressant effects of naltrexone on water intake in rats
10.1016/0091-3057(79)90112-6 · ExternalCitation · doi-reference
Loneliness and alcohol abuse: a review of evidences of an interplay
10.1016/0277-9536(92)90300-f · ExternalCitation · doi-reference
Opioid neuroscience for addiction medicine: from animal models to FDA approval for alcohol addiction
10.1016/bs.pbr.2015.07.030 · ExternalCitation · doi-reference
Ethanol intake is increased by injection of galanin in the paraventricular nucleus and reduced by a galanin antagonist
10.1016/j.alcohol.2004.05.002 · ExternalCitation · doi-reference
Preferential activation by galanin 1-15 fragment of the GalR1 protomer of a GalR1-GalR2 heteroreceptor complex
10.1016/j.bbrc.2014.08.061 · ExternalCitation · doi-reference
Galanin N-terminal fragment (1-15) reduces alcohol seeking and alcohol relapse in rats: involvement of mesocorticolimbic system
10.1016/j.biopha.2022.113508 · ExternalCitation · doi-reference
Galanin(1-15) and naltrexone: a novel approach for alcohol use disorder in rats, involving the mesolimbic system
10.1016/j.biopha.2025.118170 · ExternalCitation · doi-reference
Social deprivation enhances VTA synaptic plasticity and drug-induced contextual learning
10.1016/j.neuron.2012.11.022 · ExternalCitation · doi-reference
The runway model of drug self-administration
10.1016/j.pbb.2008.11.003 · ExternalCitation · doi-reference
Preferential Gs protein coupling of the galanin Gal1 receptor heterotetramer
10.1016/j.phrs.2022.106322 · ExternalCitation · doi-reference
A new pharmacological strategy against treatment-resistant depression
10.1016/j.pnpbp.2024.111191 · ExternalCitation · doi-reference
Increased mood disorder symptoms, perceived stress, and alcohol use among college students during the COVID-19 pandemic
10.1016/j.psychres.2021.113706 · ExternalCitation · doi-reference
Galanin in the hypothalamus raises dopamine and lowers acetylcholine release in the nucleus accumbens: a possible mechanism for hypothalamic initiation of feeding behavior
10.1016/s0006-8993(98)00315-1 · ExternalCitation · doi-reference
Estrous cycle influences the response of female rats in the elevated plus-maze test
10.1016/s0031-9384(01)00593-5 · ExternalCitation · doi-reference
Alcohol use disorders
10.1016/s0140-6736(19)31775-1 · ExternalCitation · doi-reference
Galanin receptor subtypes
10.1016/s0165-6147(00)01446-2 · ExternalCitation · doi-reference
Alcohol use and misuse during the COVID-19 pandemic: a potential public health crisis?
10.1016/s2468-2667(20)30088-8 · ExternalCitation · doi-reference
Advancing social connection as a public health priority in the United States
10.1037/amp0000103 · ExternalCitation · doi-reference
Isolation and loneliness as pathways to heavy drinking early in the pandemic
10.1093/alcalc/agae012 · ExternalCitation · doi-reference
A role for galanin N-terminal fragment (1-15) in anxiety- and depression-related behaviors in rats
10.1093/ijnp/pyu064 · ExternalCitation · doi-reference
Galanin microinjection in the third ventricle increases voluntary ethanol intake
10.1097/01.alc.0000148099.12344.c8 · ExternalCitation · doi-reference
Early social isolation augments alcohol consumption in rats
10.1097/fbp.0000000000000165 · ExternalCitation · doi-reference
A randomized, controlled, pilot study of acamprosate added to escitalopram in adults with major depressive disorder and alcohol use disorder
10.1097/jcp.0b013e3182726764 · ExternalCitation · doi-reference
Adolescent social isolation does not lead to persistent increases in anxiety-like behavior or ethanol intake in female long-evans rats
10.1111/acer.12476 · ExternalCitation · doi-reference
Advancing precision medicine for alcohol use disorder: replication and extension of reward drinking as a predictor of naltrexone response
10.1111/acer.14183 · ExternalCitation · doi-reference
Drinking to cope during COVID-19 pandemic: the role of external and internal factors in coping motive pathways to alcohol use, solitary drinking, and alcohol problems
10.1111/acer.14425 · ExternalCitation · doi-reference
Central administration of galanin N-terminal fragment 1-15 decreases the voluntary alcohol intake in rats
10.1111/adb.12582 · ExternalCitation · doi-reference
Alcohol use in times of the COVID 19: implications for monitoring and policy
10.1111/dar.13074 · ExternalCitation · doi-reference
Changes in alcohol use during the COVID-19 pandemic in Europe: a meta-analysis of observational studies
10.1111/dar.13446 · ExternalCitation · doi-reference
Behavioural assessment of drug reinforcement and addictive features in rodents: an overview
10.1111/j.1369-1600.2006.00012.x · ExternalCitation · doi-reference
Ethanol consumption: how should we measure it? Achieving consilience between human and animal phenotypes
10.1111/j.1369-1600.2009.00192.x · ExternalCitation · doi-reference
Early social isolation in male Long-Evans rats alters both appetitive and consummatory behaviors expressed during operant ethanol self-administration
10.1111/j.1530-0277.2008.00830.x · ExternalCitation · doi-reference
Adolescent rearing conditions influence the relationship between initial anxiety-like behavior and ethanol drinking in male Long Evans rats
10.1111/j.1530-0277.2012.01926.x · ExternalCitation · doi-reference
Neural mechanisms of drug reinforcement
10.1111/j.1749-6632.1992.tb25966.x · ExternalCitation · doi-reference
Implementing LEARN: comprehensive suicide prevention training for high school students, parents, and school personnel
10.1111/josh.13516 · ExternalCitation · doi-reference
Alcohol use disorder treatment: problems and solutions
10.1146/annurev-pharmtox-031323-115847 · ExternalCitation · doi-reference
Opioid-galanin receptor heteromers mediate the dopaminergic effects of opioids
10.1172/jci126912 · ExternalCitation · doi-reference
A motivational learning hypothesis of the role of mesolimbic dopamine in compulsive drug use
10.1177/026988119801200108 · ExternalCitation · doi-reference
Intranasal Galanin(1-15) influences depression- and anxiety-related behaviors through sex-dependent mechanisms in rats
10.1186/s13293-026-00901-0 · ExternalCitation · doi-reference
Strategies and methods for research on sex differences in brain and behavior
10.1210/en.2004-1142 · ExternalCitation · doi-reference
Mouse estrous cycle identification tool and images
10.1371/journal.pone.0035538 · ExternalCitation · doi-reference
Opioids excite dopamine neurons by hyperpolarization of local interneurons
10.1523/jneurosci.12-02-00483.1992 · ExternalCitation · doi-reference
Functional μ-Opioid-Galanin receptor heteromers in the ventral tegmental area
10.1523/jneurosci.2442-16.2016 · ExternalCitation · doi-reference
Galanin receptor/neuropeptide y receptor interactions in the central nervous system
10.2174/1389203715666140901111709 · ExternalCitation · doi-reference
Estradiol, dopamine and motivation
10.2174/1871524914666141226103135 · ExternalCitation · doi-reference
Recent perceived stress, amygdala reactivity to acute psychosocial stress, and alcohol and cannabis use in adolescents and young adults with bipolar disorder
10.3389/fpsyt.2021.767309 · ExternalCitation · doi-reference
The combination of Galanin (1-15) and escitalopram in rats suggests a new strategy for alcohol use disorder comorbidity with depression
10.3390/biomedicines10020412 · ExternalCitation · doi-reference
Attitudes toward harm reduction and abstinence-only approaches to alcohol misuse among Alaskan college students
10.3402/ijch.v72i0.21143 · ExternalCitation · doi-reference
